Philip Insel, PhD, MS
Assistant Professor
Psychiatry
School of Medicine

Publications (97)

Top publication keywords:
Apolipoprotein E4Aniline CompoundsCognitionAmyloid beta-PeptidesCognitive DysfunctionAlzheimer DiseaseProdromal SymptomsAtrophyApolipoprotein E2Peptide FragmentsDisease ProgressionBrainPositron-Emission Tomographytau ProteinsEthylene Glycols

• Anxiety in late-life depression is associated with poorer performance across multiple cognitive domains.
  Journal of the International Neuropsychological Society : JINS 2024 Kryza-Lacombe M, Kassel MT, Insel PS, Rhodes E, Bickford D, Burns E, Butters MA, Tosun D, Aisen P, Raman R, Saykin AJ, Toga AW, Jack CR, Weiner MW, Nelson C, Mackin RS
• Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Leuzy A, Raket LL, Villemagne VL, Klein G, Tonietto M, Olafson E, Baker S, Saad ZS, Bullich S, Lopresti B, Bohorquez SS, Boada M, Betthauser TJ, Charil A, Collins EC, Collins JA, Cullen N, Gunn RN, …
• A generalizable data-driven model of atrophy heterogeneity and progression in memory clinic settings.
  Brain : a journal of neurology 2024 Baumeister H, Vogel JW, Insel PS, Kleineidam L, Wolfsgruber S, Stark M, Gellersen HM, Yakupov R, Schmid MC, Lüsebrink F, Brosseron F, Ziegler G, Freiesleben SD, Preis L, Schneider LS, Spruth EJ, …
• Speech patterns during memory recall relates to early tau burden across adulthood.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Young CB, Smith V, Karjadi C, Grogan SM, Ang TFA, Insel PS, Henderson VW, Sumner M, Poston KL, Au R, Mormino EC
• Anxiety in late-life depression: Associations with brain volume, amyloid beta, white matter lesions, cognition, and functional ability.
  International psychogeriatrics 2024 Kryza-Lacombe M, Kassel MT, Insel PS, Rhodes E, Bickford D, Burns E, Butters MA, Tosun D, Aisen P, Raman R, Landau S, Saykin AJ, Toga AW, Jack CR, Koeppe R, Weiner MW, Nelson C, Mackin RS

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• Relationship of Hoarding and Depression Symptoms in Older Adults.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2023 Nutley S, Nguyen BK, Mackin RS, Insel PS, Tosun D, Butters M, Aisen P, Raman R, Saykin AJ, Toga AW, Jack C, Weiner MW, Nelson C, Kassel M, Kryza-Lacombe M, Eichenbaum J, Nosheny RL, Mathews CA
• Hoarding Symptoms in Late Life Depression are Associated With Greater Executive Dysfunction and Disability and Poorer Response to Depression Treatment.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2023 Kassel MT, Kryza-Lacombe M, Insel PS, Rhodes E, Satre DD, Nelson JC, Tosun D, Mathews CA, Mackin RS
• Genetic Moderation of the Association of β-Amyloid With Cognition and MRI Brain Structure in Alzheimer Disease.
  Neurology 2023 Insel PS, Kumar A, Hansson O, Mattsson-Carlgren N, Alzheimer's Disease Neuroimaging Initiative
• Tau positron emission tomography in preclinical Alzheimer's disease.
  Brain : a journal of neurology 2023 Insel PS, Young CB, Aisen PS, Johnson KA, Sperling RA, Mormino EC, Donohue MC
• Natural cubic splines for the analysis of Alzheimer's clinical trials.
  Pharmaceutical statistics 2023 Donohue MC, Langford O, Insel PS, van Dyck CH, Petersen RC, Craft S, Sethuraman G, Raman R, Aisen PS, Alzheimer's Disease Neuroimaging Initiative
• APOE effects on regional tau in preclinical Alzheimer's disease.
  Molecular neurodegeneration 2023 Young CB, Johns E, Kennedy G, Belloy ME, Insel PS, Greicius MD, Sperling RA, Johnson KA, Poston KL, Mormino EC, Alzheimer’s Disease Neuroimaging Initiative, A4 Study Team
• The genetic regulation of protein expression in cerebrospinal fluid.
  EMBO molecular medicine 2022 Hansson O, Kumar A, Janelidze S, Stomrud E, Insel PS, Blennow K, Zetterberg H, Fauman E, Hedman ÅK, Nagle MW, Whelan CD, Baird D, Mälarstig A, Mattsson-Carlgren N
• Uncertainties in the PET defined A-/TNeocortical+ subtype.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2022 Mormino EC, Insel PS
• Cognitive outcomes are differentially associated with depression severity trajectories during psychotherapy treatment for late life major depressive disorder.
  International journal of geriatric psychiatry 2022 Kassel MT, Rhodes E, Insel PS, Woodworth K, Garrison-Diehn C, Satre DD, Nelson JC, Tosun D, Mackin RS
• Early stages of tau pathology and its associations with functional connectivity, atrophy and memory.
  Brain : a journal of neurology 2021 Berron D, Vogel JW, Insel PS, Pereira JB, Xie L, Wisse LEM, Yushkevich PA, Palmqvist S, Mattsson-Carlgren N, Stomrud E, Smith R, Strandberg O, Hansson O
• Association of Sleep and β-Amyloid Pathology Among Older Cognitively Unimpaired Adults.
  JAMA network open 2021 Insel PS, Mohlenhoff BS, Neylan TC, Krystal AD, Mackin RS
• Reliability and Validity of a Home-Based Self-Administered Computerized Test of Learning and Memory Using Speech Recognition.
  Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition 2021 Mackin RS, Rhodes E, Insel PS, Nosheny R, Finley S, Ashford M, Camacho MR, Truran D, Mosca K, Seabrook G, Morrison R, Narayan VA, Weiner M
• A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis.
  European journal of nuclear medicine and molecular imaging 2021 Leuzy A, Pascoal TA, Strandberg O, Insel P, Smith R, Mattsson-Carlgren N, Benedet AL, Cho H, Lyoo CH, La Joie R, Rabinovici GD, Ossenkoppele R, Rosa-Neto P, Hansson O
• Strategies to reduce sample sizes in Alzheimer's disease primary and secondary prevention trials using longitudinal amyloid PET imaging.
  Alzheimer's research & therapy 2021 Lopes Alves I, Heeman F, Collij LE, Salvadó G, Tolboom N, Vilor-Tejedor N, Markiewicz P, Yaqub M, Cash D, Mormino EC, Insel PS, Boellaard R, van Berckel BNM, Lammertsma AA, Barkhof F, Gispert JD
• Association Between Apolipoprotein E ε2 vs ε4, Age, and β-Amyloid in Adults Without Cognitive Impairment.
  JAMA neurology 2021 Insel PS, Hansson O, Mattsson-Carlgren N
• Mild behavioral impairment and its relation to tau pathology in preclinical Alzheimer's disease.
  Translational psychiatry 2021 Johansson M, Stomrud E, Insel PS, Leuzy A, Johansson PM, Smith R, Ismail Z, Janelidze S, Palmqvist S, van Westen D, Mattsson-Carlgren N, Hansson O
• The Impact of Amyloid Burden and APOE on Rates of Cognitive Impairment in Late Life Depression.
  Journal of Alzheimer's disease : JAD 2021 Rhodes E, Insel PS, Butters MA, Morin R, Bickford D, Tosun D, Gessert D, Rosen HJ, Aisen P, Raman R, Landau S, Saykin A, Toga A, Jack CR, Weiner MW, Nelson C, Mackin S, Alzheimer’s Disease …
• Time between milestone events in the Alzheimer's disease amyloid cascade.
  NeuroImage 2020 Insel PS, Donohue MC, Berron D, Hansson O, Mattsson-Carlgren N
• Reply to: Brain Amyloid Deposition in Late-Life Depression.
  Biological psychiatry 2020 Mackin RS, Insel PS
• Comparing progression biomarkers in clinical trials of early Alzheimer's disease.
  Annals of clinical and translational neurology 2020 Cullen NC, Zetterberg H, Insel PS, Olsson B, Andreasson U, Alzheimer’s Disease Neuroimaging Initiative, Blennow K, Hansson O, Mattsson-Carlgren N
• Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project.
  Biological psychiatry 2020 Mackin RS, Insel PS, Landau S, Bickford D, Morin R, Rhodes E, Tosun D, Rosen HJ, Butters M, Aisen P, Raman R, Saykin A, Toga A, Jack C, Koeppe R, Weiner MW, Nelson C, Alzheimer’s Disease Neuroimaging …
• The A4 study: β-amyloid and cognition in 4432 cognitively unimpaired adults.
  Annals of clinical and translational neurology 2020 Insel PS, Donohue MC, Sperling R, Hansson O, Mattsson-Carlgren N
• Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease.
  Science advances 2020 Mattsson-Carlgren N, Andersson E, Janelidze S, Ossenkoppele R, Insel P, Strandberg O, Zetterberg H, Rosen HJ, Rabinovici G, Chai X, Blennow K, Dage JL, Stomrud E, Smith R, Palmqvist S, Hansson O
• Neuroanatomical spread of amyloid β and tau in Alzheimer's disease: implications for primary prevention.
  Brain communications 2020 Insel PS, Mormino EC, Aisen PS, Thompson WK, Donohue MC
• Depression Severity, but Not Cognitive Impairment or Frailty, is Associated with Disability in Late-Life Depression.
  Clinical gerontologist 2019 Morin RT, Insel P, Bickford D, Nelson C, Mackin RS
• Study partner-reported decline identifies cognitive decline and dementia risk.
  Annals of clinical and translational neurology 2019 Nosheny RL, Jin C, Neuhaus J, Insel PS, Mackin RS, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative investigators
• Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease.
  EMBO molecular medicine 2019 Palmqvist S, Insel PS, Stomrud E, Janelidze S, Zetterberg H, Brix B, Eichenlaub U, Dage JL, Chai X, Blennow K, Mattsson N, Hansson O
• β-amyloid pathology and hippocampal atrophy are independently associated with memory function in cognitively healthy elderly.
  Scientific reports 2019 Svenningsson AL, Stomrud E, Insel PS, Mattsson N, Palmqvist S, Hansson O
• Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults.
  Neurobiology of aging 2019 Nosheny RL, Insel PS, Mattsson N, Tosun D, Buckley S, Truran D, Schuff N, Aisen PS, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Determining clinically meaningful decline in preclinical Alzheimer disease.
  Neurology 2019 Insel PS, Weiner M, Mackin RS, Mormino E, Lim YY, Stomrud E, Palmqvist S, Masters CL, Maruff PT, Hansson O, Mattsson N
• Latent Classes of Cognitive Functioning Among Depressed Older Adults Without Dementia.
  Journal of the International Neuropsychological Society : JINS 2019 Morin RT, Insel P, Nelson C, Butters M, Bickford D, Landau S, Saykin A, Weiner M, Mackin RS, ADNI Depression Project
• Somatic and anxiety symptoms of depression are associated with disability in late life depression.
  Aging & mental health 2019 Morin RT, Nelson C, Bickford D, Insel PS, Mackin RS
• Predicting diagnosis and cognition with 18F-AV-1451 tau PET and structural MRI in Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2019 Mattsson N, Insel PS, Donohue M, Jögi J, Ossenkoppele R, Olsson T, Schöll M, Smith R, Hansson O
• Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease.
  Neurology 2019 Ossenkoppele R, Smith R, Ohlsson T, Strandberg O, Mattsson N, Insel PS, Palmqvist S, Hansson O
• Serum Neurofilament Light Chain for Prognosis of Outcome After Cardiac Arrest.
  JAMA neurology 2019 Moseby-Knappe M, Mattsson N, Nielsen N, Zetterberg H, Blennow K, Dankiewicz J, Dragancea I, Friberg H, Lilja G, Insel PS, Rylander C, Westhall E, Kjaergaard J, Wise MP, Hassager C, Kuiper MA, Stammet …
• Accurate risk estimation of β-amyloid positivity to identify prodromal Alzheimer's disease: Cross-validation study of practical algorithms.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2018 Palmqvist S, Insel PS, Zetterberg H, Blennow K, Brix B, Stomrud E, Alzheimer's Disease Neuroimaging Initiative, Swedish BioFINDER study, Mattsson N, Hansson O
• Online study partner-reported cognitive decline in the Brain Health Registry.
  Alzheimer's & dementia (New York, N. Y.) 2018 Nosheny RL, Camacho MR, Insel PS, Flenniken D, Fockler J, Truran D, Finley S, Ulbricht A, Maruff P, Yaffe K, Mackin RS, Weiner MW
• Total Sleep Time Interacts With Age to Predict Cognitive Performance Among Adults.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2018 Mohlenhoff BS, Insel PS, Mackin RS, Neylan TC, Flenniken D, Nosheny R, Richards A, Maruff P, Weiner MW
• Effects of APOE ε4 on neuroimaging, cerebrospinal fluid biomarkers, and cognition in prodromal Alzheimer's disease.
  Neurobiology of aging 2018 Mattsson N, Eriksson O, Lindberg O, Schöll M, Lampinen B, Nilsson M, Insel PS, Lautner R, Strandberg O, van Westen D, Zetterberg H, Blennow K, Palmqvist S, Stomrud E, Hansson O
• Chronic depressive symptomatology and CSF amyloid beta and tau levels in mild cognitive impairment.
  International journal of geriatric psychiatry 2018 Gonzales MM, Insel PS, Nelson C, Tosun D, Schöll M, Mattsson N, Sacuiu S, Bickford D, Weiner MW, Mackin RS, Alzheimer's Disease Neuroimaging Initiative
• Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2018 Mackin RS, Insel PS, Truran D, Finley S, Flenniken D, Nosheny R, Ulbright A, Comacho M, Bickford D, Harel B, Maruff P, Weiner MW
• The Brain Health Registry: An internet-based platform for recruitment, assessment, and longitudinal monitoring of participants for neuroscience studies.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2018 Weiner MW, Nosheny R, Camacho M, Truran-Sacrey D, Mackin RS, Flenniken D, Ulbricht A, Insel P, Finley S, Fockler J, Veitch D
• Comparing 18F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease.
  Neurology 2018 Mattsson N, Smith R, Strandberg O, Palmqvist S, Schöll M, Insel PS, Hägerström D, Ohlsson T, Zetterberg H, Blennow K, Jögi J, Hansson O
• Amyloid pathology in the progression to mild cognitive impairment.
  Neurobiology of aging 2017 Insel PS, Hansson O, Mackin RS, Weiner M, Mattsson N, Alzheimer's Disease Neuroimaging Initiative
• Serum tau and neurological outcome in cardiac arrest.
  Annals of neurology 2017 Mattsson N, Zetterberg H, Nielsen N, Blennow K, Dankiewicz J, Friberg H, Lilja G, Insel PS, Rylander C, Stammet P, Aneman A, Hassager C, Kjaergaard J, Kuiper M, Pellis T, Wetterslev J, Wise M, …
• Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations.
  Alzheimer's research & therapy 2017 Lautner R, Insel PS, Skillbäck T, Olsson B, Landén M, Frisoni GB, Herukka SK, Hampel H, Wallin A, Minthon L, Hansson O, Blennow K, Mattsson N, Zetterberg H
• 18F-AV-1451 and CSF T-tau and P-tau as biomarkers in Alzheimer's disease.
  EMBO molecular medicine 2017 Mattsson N, Schöll M, Strandberg O, Smith R, Palmqvist S, Insel PS, Hägerström D, Ohlsson T, Zetterberg H, Jögi J, Blennow K, Hansson O
• Time to Amyloid Positivity and Preclinical Changes in Brain Metabolism, Atrophy, and Cognition: Evidence for Emerging Amyloid Pathology in Alzheimer's Disease.
  Frontiers in neuroscience 2017 Insel PS, Ossenkoppele R, Gessert D, Jagust W, Landau S, Hansson O, Weiner MW, Mattsson N, Alzheimer's Disease Neuroimaging Initiative
• Cortical Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2017 Gonzales MM, Insel PS, Nelson C, Tosun D, Mattsson N, Mueller SG, Sacuiu S, Bickford D, Weiner MW, Mackin RS, Alzheimer's Disease Neuroimaging Initiative
• Cross-validation of optimized composites for preclinical Alzheimer's disease.
  Alzheimer's & dementia (New York, N. Y.) 2017 Donohue MC, Sun CK, Raman R, Insel PS, Aisen PS, AN-ADNI, AIBL, J-ADNI
• Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease.
  EMBO molecular medicine 2016 Mattsson N, Insel PS, Palmqvist S, Portelius E, Zetterberg H, Weiner M, Blennow K, Hansson O, Alzheimer's Disease Neuroimaging Initiative
• Plasma tau in Alzheimer disease.
  Neurology 2016 Mattsson N, Zetterberg H, Janelidze S, Insel PS, Andreasson U, Stomrud E, Palmqvist S, Baker D, Tan Hehir CA, Jeromin A, Hanlon D, Song L, Shaw LM, Trojanowski JQ, Weiner MW, Hansson O, Blennow K, …
• Cognitive and functional changes associated with Aβ pathology and the progression to mild cognitive impairment.
  Neurobiology of aging 2016 Insel PS, Donohue MC, Mackin RS, Aisen PS, Hansson O, Weiner MW, Mattsson N, Alzheimer's Disease Neuroimaging Initiative
• Assessing risk for preclinical β-amyloid pathology with APOE, cognitive, and demographic information.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2016 Insel PS, Palmqvist S, Mackin RS, Nosheny RL, Hansson O, Weiner MW, Mattsson N
• Accelerating rates of cognitive decline and imaging markers associated with β-amyloid pathology.
  Neurology 2016 Insel PS, Mattsson N, Mackin RS, Schöll M, Nosheny RL, Tosun D, Donohue MC, Aisen PS, Jagust WJ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis.
  Nature communications 2016 Mattsson N, Insel PS, Palmqvist S, Stomrud E, van Westen D, Minthon L, Zetterberg H, Blennow K, Hansson O
• PATTERNS OF CLINICALLY SIGNIFICANT COGNITIVE IMPAIRMENT IN HOARDING DISORDER.
  Depression and anxiety 2015 Mackin RS, Vigil O, Insel P, Kivowitz A, Kupferman E, Hough CM, Fekri S, Crothers R, Bickford D, Delucchi KL, Mathews CA
• Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2015 Jack CR, Barnes J, Bernstein MA, Borowski BJ, Brewer J, Clegg S, Dale AM, Carmichael O, Ching C, DeCarli C, Desikan RS, Fennema-Notestine C, Fjell AM, Fletcher E, Fox NC, Gunter J, Gutman BA, Holland …
• Evidence for age-associated cognitive decline from Internet game scores.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2015 Geyer J, Insel P, Farzin F, Sternberg D, Hardy JL, Scanlon M, Mungas D, Kramer J, Mackin RS, Weiner MW
• Predicting Reduction of Cerebrospinal Fluid β-Amyloid 42 in Cognitively Healthy Controls.
  JAMA neurology 2015 Mattsson N, Insel PS, Donohue M, Jagust W, Sperling R, Aisen P, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative
• Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2015 Sacuiu S, Insel PS, Mueller S, Tosun D, Mattsson N, Jack CR, DeCarli C, Petersen R, Aisen PS, Weiner MW, Mackin RS, Alzheimer's Disease Neuroimaging Initiative
• Biomarkers and cognitive endpoints to optimize trials in Alzheimer's disease.
  Annals of clinical and translational neurology 2015 Insel PS, Mattsson N, Mackin RS, Kornak J, Nosheny R, Tosun-Turgut D, Donohue MC, Aisen PS, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Brain amyloid-β burden is associated with disruption of intrinsic functional connectivity within the medial temporal lobe in cognitively normal elderly.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Song Z, Insel PS, Buckley S, Yohannes S, Mezher A, Simonson A, Wilkins S, Tosun D, Mueller S, Kramer JH, Miller BL, Weiner MW
• Brain structure and function as mediators of the effects of amyloid on memory.
  Neurology 2015 Mattsson N, Insel PS, Aisen PS, Jagust W, Mackin S, Weiner M, Alzheimer's Disease Neuroimaging Initiative
• Cerebrospinal fluid α-synuclein and Lewy body-like symptoms in normal controls, mild cognitive impairment, and Alzheimer's disease.
  Journal of Alzheimer's disease : JAD 2015 Mackin RS, Insel P, Zhang J, Mohlenhoff B, Galasko D, Weiner M, Mattsson N
• Independent information from cerebrospinal fluid amyloid-β and florbetapir imaging in Alzheimer's disease.
  Brain : a journal of neurology 2014 Mattsson N, Insel PS, Donohue M, Landau S, Jagust WJ, Shaw LM, Trojanowski JQ, Zetterberg H, Blennow K, Weiner MW, Alzheimer's Disease Neuroimaging Initiative*
• The transitional association between β-amyloid pathology and regional brain atrophy.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2014 Insel PS, Mattsson N, Donohue MC, Mackin RS, Aisen PS, Jack CR, Shaw LM, Trojanowski JQ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment.
  Neurobiology of aging 2014 Nosheny RL, Insel PS, Truran D, Schuff N, Jack CR, Aisen PS, Shaw LM, Trojanowski JQ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Diagnostic accuracy of CSF Ab42 and florbetapir PET for Alzheimer's disease.
  Annals of clinical and translational neurology 2014 Mattsson N, Insel PS, Landau S, Jagust W, Donohue M, Shaw LM, Trojanowski JQ, Zetterberg H, Blennow K, Weiner M, Alzheimer's Disease Neuroimaging Initiativea
• Emerging β-amyloid pathology and accelerated cortical atrophy.
  JAMA neurology 2014 Mattsson N, Insel PS, Nosheny R, Tosun D, Trojanowski JQ, Shaw LM, Jack CR, Donohue MC, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative
• Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment.
  Brain : a journal of neurology 2014 Mattsson N, Tosun D, Insel PS, Simonson A, Jack CR, Beckett LA, Donohue M, Jagust W, Schuff N, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Neuroimaging abnormalities in adults with sickle cell anemia: associations with cognition.
  Neurology 2014 Mackin RS, Insel P, Truran D, Vichinsky EP, Neumayr LD, Armstrong FD, Gold JI, Kesler K, Brewer J, Weiner MW, Neuropsychological Dysfunction and Neuroimaging Adult Sickle Cell Anemia Study Group
• Differences in prefrontal, limbic, and white matter lesion volumes according to cognitive status in elderly patients with first-onset subsyndromal depression.
  PloS one 2014 Lee JY, Park S, Mackin S, Ewers M, Chui H, Jagust W, Insel PS, Weiner MW
• Effects of baseline CSF α-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease.
  PloS one 2013 Mattsson N, Insel P, Tosun D, Zhang J, Jack CR, Galasko D, Weiner M, Alzheimer’s Disease Neuroimaging Initiative
• Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults.
  Neurobiology of aging 2013 Mattsson N, Insel P, Nosheny R, Trojanowski JQ, Shaw LM, Jack CR, Tosun D, Weiner M, Alzheimer's Disease Neuroimaging Initiative
• Early indications of future cognitive decline: stable versus declining controls.
  PloS one 2013 Rizk-Jackson A, Insel P, Petersen R, Aisen P, Jack C, Weiner M
• Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease.
  Neurology 2013 Ewers M, Insel PS, Stern Y, Weiner MW, Alzheimer's Disease Neuroimaging Initiative (ADNI)
• Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2013 Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW
• The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2013 Mackin RS, Insel P, Tosun D, Mueller SG, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Lee JY, Jack CR, Aisen PS, Petersen RC, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• A composite score for executive functioning, validated in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment.
  Brain imaging and behavior 2012 Gibbons LE, Carle AC, Mackin RS, Harvey D, Mukherjee S, Insel P, Curtis SM, Mungas D, Crane PK, Alzheimer’s Disease Neuroimaging Initiative
• Development and assessment of a composite score for memory in the Alzheimer's Disease Neuroimaging Initiative (ADNI).
  Brain imaging and behavior 2012 Crane PK, Carle A, Gibbons LE, Insel P, Mackin RS, Gross A, Jones RN, Mukherjee S, Curtis SM, Harvey D, Weiner M, Mungas D, Alzheimer’s Disease Neuroimaging Initiative
• Greater regional brain atrophy rate in healthy elderly subjects with a history of cigarette smoking.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2012 Durazzo TC, Insel PS, Weiner MW, Alzheimer Disease Neuroimaging Initiative
• Different associations of white matter lesions with depression and cognition.
  BMC neurology 2012 Lee JY, Insel P, Mackin RS, Schuff N, Chui H, DeCarli C, Park KH, Mueller SG, Weiner MW
• CSF biomarker and PIB-PET-derived beta-amyloid signature predicts metabolic, gray matter, and cognitive changes in nondemented subjects.
  Cerebral cortex (New York, N.Y. : 1991) 2011 Ewers M, Insel P, Jagust WJ, Shaw L, Trojanowski JQ, Aisen P, Petersen RC, Schuff N, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative (ADNI)
• Impact of apolipoprotein E4-cerebrospinal fluid β-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2011 Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Thompson PM, Reiman EM, Jack CR, Fox NC, Jagust WJ, Harvey DJ, Beckett LA, Gamst A, Aisen PS, Petersen RC, Weiner MW, …
• Longitudinal stability of subsyndromal symptoms of depression in individuals with mild cognitive impairment: relationship to conversion to dementia after 3 years.
  International journal of geriatric psychiatry 2011 Mackin RS, Insel P, Aisen PS, Geda YE, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes.
  Radiology 2011 Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang S, Jack CR, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Treatment with cholinesterase inhibitors and memantine of patients in the Alzheimer's Disease Neuroimaging Initiative.
  Archives of neurology 2011 Schneider LS, Insel PS, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Nonlinear time course of brain volume loss in cognitively normal and impaired elders.
  Neurobiology of aging 2010 Schuff N, Tosun D, Insel PS, Chiang GC, Truran D, Aisen PS, Jack CR, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Characteristics and performance of a modified version of the ADCS-CGIC CIBIC+ for mild cognitive impairment clinical trials.
  Alzheimer disease and associated disorders 2009 Schneider LS, Raman R, Schmitt FA, Doody RS, Insel P, Clark CM, Morris JC, Reisberg B, Petersen RC, Ferris SH
• Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2006 Schneider LS, Dagerman K, Insel PS
• Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials.
  JAMA 2005 Schneider LS, Dagerman KS, Insel P