Petros Giannikopoulos, MD
Assistant Professor
Laboratory Medicine
School of Medicine

Education & Training

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• Residency Anatomic Pathology UCSF 06/2012
• Fellowship Molecular Genetic Pathology Harvard Medical School 06/2011
• Fellowship Pediatric Pathology Texas Children's Hospital 06/2010
• Internship Pediatrics UCSF 06/2007
• M.D. Medicine Harvard Medical School 06/2006
• B.S. Biochemistry UCLA 06/2001

Publications (26)

Top publication keywords:
Genetic TherapyHyperammonemiaLab-On-A-Chip DevicesPneumococcal InfectionsNoonan SyndromeRhabdomyosarcomaGenetic Predisposition to DiseaseRare DiseasesPulmonary Valve StenosisCoronary AneurysmCarbamoyl-Phosphate Synthase I Deficiency DiseaseGene EditingRibonuclease PBiomarkers, TumorSoft Tissue Neoplasms

• Development of a Fully Non-Viral 1XX-enhanced BCMA CAR-T Cell Therapy for Multiple Myeloma.
  bioRxiv : the preprint server for biology 2026 Talbot A, Li K, Lee JHJ, Lang S, Liu C, Kalter N, Li Z, Mortazavi Y, Almudhfar N, Muldoon JJ, Allain V, Nyberg W, Chung JJ, Wang C, Qi Z, Krishnappa N, Ha AS, Kong D, Houser D, Paruthiyil S, Ahmadi M,…
• Microfluidic capillary transit velocity as a functional measure for sickle cell disease and in vitro-derived red blood cells.
  Lab on a chip 2026 Oshabaheebwa S, Goreke U, Du Y, Wirth CL, Sekyonda Z, Benson BL, Fadaei P, Ley YB, Perez NM, Giannikopoulos P, Nguyen DN, Suster MA, Mohseni P, Gurkan UA
• Interventional genomics: Bridging germline diagnosis and therapeutic action.
  Genetics in medicine : official journal of the American College of Medical Genetics 2026 Giannikopoulos P, Lauffer MC, Marshall CR, Costain G, Niu Z, Bick D, Shen W, Hiemenz MC, Bhatt S, Grody W, Jobanputra V, Medical Genome Initiative
• Measurement and clinical interpretation of CRISPR off-targets.
  Nature genetics 2025 Angelini Stewart A, Ahrens-Nicklas RC, Tsai SQ, Musunuru K, Giannikopoulos P, Clelland CD
• Developmental Plasticity and Stromal Co-option Shape a Pituitary Neuroendocrine Tumor Transcriptional Continuum.
  bioRxiv : the preprint server for biology 2025 Osorio RC, Oh JY, Jung J, Ehrenberg AJ, Saha A, Lad M, Khela H, Brennick N, Giannikopoulos P, Seeley WW, Grinberg LT, Diaz A, Aghi MK

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• Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease.
  The New England journal of medicine 2025 Musunuru K, Grandinette SA, Wang X, Hudson TR, Briseno K, Berry AM, Hacker JL, Hsu A, Silverstein RA, Hille LT, Ogul AN, Robinson-Garvin NA, Small JC, McCague S, Burke SM, Wright CM, Bick S, Indurthi …
• A Primer on Gene Editing: What Does It Mean for Pathologists?
  Archives of pathology & laboratory medicine 2023 Cushman-Vokoun A, Schmidt RJ, Hiemenz MC, Fung M, Zhang BM, Bradshaw G, Gandhi M, Yao J, Yohe S, Beckman A, Grody WW, Giannikopoulos P
• Association of Upper Respiratory Streptococcus pneumoniae Colonization With Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Adults.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2023 Parker AM, Jackson N, Awasthi S, Kim H, Alwan T, Wyllie AL, Baldwin AB, Brennick NB, Moehle EA, Giannikopoulos P, Kogut K, Holland N, Mora-Wyrobek A, Eskenazi B, Riley LW, Lewnard JA
• Association of upper respiratory Streptococcus pneumoniae colonization with SARS-CoV-2 infection among adults.
  medRxiv : the preprint server for health sciences 2022 Parker AM, Jackson N, Awasthi S, Kim H, Alwan T, Wyllie AL, Baldwin AB, Brennick NB, Moehle EA, Giannikopoulos P, Kogut K, Holland N, Mora-Wyrobek A, Eskenazi B, Riley LW, Lewnard JA
• Pediatric Sarcomas: The Next Generation of Molecular Studies.
  Cancers 2022 Giannikopoulos P, Parham DM
• LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples.
  PloS one 2021 Stahl EC, Gopez AR, Tsuchida CA, Fan VB, Moehle EA, Witkowsky LB, Hamilton JR, Lin-Shiao E, McElroy M, McDevitt SL, Ciling A, Tsui CK, Pestal K, Gildea HK, Keller A, Sylvain IA, Williams C, Hirsh A, …
• Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples.
  PloS one 2021 Hamilton JR, Stahl EC, Tsuchida CA, Lin-Shiao E, Tsui CK, Pestal K, Gildea HK, Witkowsky LB, Moehle EA, McDevitt SL, McElroy M, Keller A, Sylvain I, Hirsh A, Ciling A, Ehrenberg AJ, Ringeisen BR, …
• Rhabdomyosarcoma: How Advanced Molecular Methods Are Shaping the Diagnostic and Therapeutic Paradigm.
  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2021 Giannikopoulos P, Parham DM
• Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus.
  PloS one 2021 Ehrenberg AJ, Moehle EA, Brook CE, Doudna Cate AH, Witkowsky LB, Sachdeva R, Hirsh A, Barry K, Hamilton JR, Lin-Shiao E, McDevitt S, Valentin-Alvarado L, Letourneau KN, Hunter L, Keller A, Pestal K, …
• Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples.
  medRxiv : the preprint server for health sciences 2021 Hamilton JR, Stahl EC, Tsuchida CA, Lin-Shiao E, Tsui CK, Pestal K, Gildea HK, Witkowsky LB, Moehle EA, McDevitt SL, McElroy M, Keller A, Sylvain I, Hirsh A, Ciling A, Ehrenberg AJ, IGI SARS-CoV-2 …
• Rhabdomyosarcoma: From Obscurity to Clarity in Diagnosis … But With Ongoing Challenges in Management: The Farber-Landing Lecture of 2020.
  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2021 Parham DM, Giannikopoulos P
• IGI-LuNER: single-well multiplexed RT-qPCR test for SARS-CoV-2.
  medRxiv : the preprint server for health sciences 2020 Stahl EC, Tsuchida CA, Hamilton JR, Lin-Shiao E, McDevitt SL, Moehle EA, Witkowsky LB, Tsui CK, Pestal K, Gildea HK, McElroy M, Keller A, Sylvain I, Williams C, Hirsh A, Ciling A, Ehrenberg AJ, IGI …
• Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers.
  Nature genetics 2017 Blakely CM, Watkins TBK, Wu W, Gini B, Chabon JJ, McCoach CE, McGranahan N, Wilson GA, Birkbak NJ, Olivas VR, Rotow J, Maynard A, Wang V, Gubens MA, Banks KC, Lanman RB, Caulin AF, St John J, Cordero …
• Oncogenic activation of the PI3-kinase p110β isoform via the tumor-derived PIK3Cβ(D1067V) kinase domain mutation.
  Oncogene 2015 Pazarentzos E, Giannikopoulos P, Hrustanovic G, St John J, Olivas VR, Gubens MA, Balassanian R, Weissman J, Polkinghorn W, Bivona TG
• Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences.
  Oncogene 2014 Pugh TJ, Yu W, Yang J, Field AL, Ambrogio L, Carter SL, Cibulskis K, Giannikopoulos P, Kiezun A, Kim J, McKenna A, Nickerson E, Getz G, Hoffher S, Messinger YH, Dehner LP, Roberts CW, Rodriguez-…
• The impact of EGFR T790M mutations and BIM mRNA expression on outcome in patients with EGFR-mutant NSCLC treated with erlotinib or chemotherapy in the randomized phase III EURTAC trial.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Costa C, Molina MA, Drozdowskyj A, Giménez-Capitán A, Bertran-Alamillo J, Karachaliou N, Gervais R, Massuti B, Wei J, Moran T, Majem M, Felip E, Carcereny E, Garcia-Campelo R, Viteri S, Taron M, Ono M…
• The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism.
  Nature medicine 2011 Lee JH, Giannikopoulos P, Duncan SA, Wang J, Johansen CT, Brown JD, Plutzky J, Hegele RA, Glimcher LH, Lee AH
• Prenatal diagnosis of primary pulmonary hypoplasia in fraternal twins.
  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 2010 Chen S, Ursell PC, Adatia I, Hislop AA, Giannikopoulos P, Hornberger LK
• A case report of Noonan's syndrome with pulmonary valvar stenosis and coronary aneurysms.
  Medical science monitor : international medical journal of experimental and clinical research 2004 Loukas M, Dabrowski M, Kantoch M, Ruzyllo W, Waltenberger J, Giannikopoulos P
• A retroesophageal right subclavian artery originating from the left aortic arch -- a case report and review of the literature.
  Folia morphologica 2004 Loukas M, Giannikopoulos P, Fudalej M, Dimopoulos C, Wagner T
• Binding to cisplatin-modified DNA by the Saccharomyces cerevisiae HMGB protein Nhp6A.
  Biochemistry 2002 Wong B, Masse JE, Yen YM, Giannikopoulos P, Feigon J, Johnson RC, Giannikoupolous P