Peter Walter, PhD
Professor Emeritus
Biochemistry and Biophysics
School of Medicine

Additionally, we aim to understand how the rewiring of these processes leads to, or prevents the progression of disease. Our laboratory uses a diverse array of techniques, ranging from biochemical reconstitution to genetics, to fuel our search for fundamental discoveries in cell biology.

• A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling.
  Nature chemical biology 2023 Lawrence RE, Shoemaker SR, Deal A, Sangwan S, Anand AA, Wang L, Marqusee S, Walter P
• A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response.
  Nature cell biology 2023 Subramanian A, Wang L, Moss T, Voorhies M, Sangwan S, Stevenson E, Pulido EH, Kwok S, Chalkley RJ, Li KH, Krogan NJ, Swaney DL, Burlingame AL, Floor SN, Sil A, Walter P, Mukherjee S
• Early Alterations of RNA Binding Protein (RBP) Homeostasis and ER Stress-Mediated Autophagy Contributes to Progressive Retinal Degeneration in the rd10 Mouse Model of Retinitis Pigmentosa (RP).
  Cells 2023 Yamoah A, Tripathi P, Guo H, Scheve L, Walter P, Johnen S, Müller F, Weis J, Goswami A
• A central helical switch controls integrated stress response signaling via eIF2B conformation and assembly.
  Biophysical Journal 2023 Rosalie Lawrence, Sophie Shoemaker, Aniliese Deal, Lan Wang, Susan Marqusee, Peter Walter
• Observation of site-selective chemical bond changes via ultrafast chemical shifts.
  Nature communications 2022 Al-Haddad A, Oberli S, González-Vázquez J, Bucher M, Doumy G, Ho P, Krzywinski J, Lane TJ, Lutman A, Marinelli A, Maxwell TJ, Moeller S, Pratt ST, Ray D, Shepard R, Southworth SH, Vázquez-Mayagoitia Á…
• Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Frias ES, Hoseini MS, Krukowski K, Paladini MS, Grue K, Ureta G, Rienecker KDA, Walter P, Stryker MP, Rosi S
• Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers.
  eLife 2022 Belyy V, Zuazo-Gaztelu I, Alamban A, Ashkenazi A, Walter P
• Conserved structural elements specialize ATAD1 as a membrane protein extraction machine.
  eLife 2022 Wang L, Toutkoushian H, Belyy V, Kokontis CY, Walter P
• Systematic characterization of gene function in the photosynthetic alga Chlamydomonas reinhardtii.
  Nature genetics 2022 Fauser F, Vilarrasa-Blasi J, Onishi M, Ramundo S, Patena W, Millican M, Osaki J, Philp C, Nemeth M, Salomé PA, Li X, Wakao S, Kim RG, Kaye Y, Grossman AR, Niyogi KK, Merchant SS, Cutler SR, Walter P, …
• A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation.
  eLife 2022 Boone M, Wang L, Lawrence RE, Frost A, Walter P, Schoof M
• Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression.
  EMBO molecular medicine 2022 Yildirim Z, Baboo S, Hamid SM, Dogan AE, Tufanli O, Robichaud S, Emerton C, Diedrich JK, Vatandaslar H, Nikolos F, Gu Y, Iwawaki T, Tarling E, Ouimet M, Nelson DL, Yates JR, Walter P, Erbay E
• Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.
  Nature communications 2021 Le Thomas A, Ferri E, Marsters S, Harnoss JM, Lawrence DA, Zuazo-Gaztelu I, Modrusan Z, Chan S, Solon M, Chalouni C, Li W, Koeppen H, Rudolph J, Wang W, Wu TD, Walter P, Ashkenazi A
• Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B.
  Nature communications 2021 Schoof M, Wang L, Cogan JZ, Lawrence RE, Boone M, Wuerth JD, Frost A, Walter P
• BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.
  The EMBO journal 2021 Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C
• Small molecule cognitive enhancer reverses age-related memory decline in mice.
  Brain Behavior and Immunity 2021 K. Krukowski, Amber Nolan, Elma S. Frias, Morgane Boone, Gonzalo Ureta, Katherine Grue, Maria-Serena Paladini, Edward Elizarraras, Luz Delgado, Sebastian Bernales, Peter Walter, Susanna Rosi
• The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes.
  Science (New York, N.Y.) 2021 Tran NH, Carter SD, De Mazière A, Ashkenazi A, Klumperman J, Walter P, Jensen GJ
• Cristae-dependent quality control of the mitochondrial genome.
  Science advances 2021 Jakubke C, Roussou R, Maiser A, Schug C, Thoma F, Bunk D, Hörl D, Leonhardt H, Walter P, Klecker T, Osman C
• Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci.
  Nature communications 2021 Chang YC, Lamichhane AK, Cai H, Walter PJ, Bennett JE, Kwon-Chung KJ
• eIF2B Conformation and Assembly State Regulate the Integrated Stress Response.
  The FASEB Journal 2021 Michael Schoof, Morgane Boone, Lan Wang, Rosalie Lawrence, Adam Frost, Peter Walter
• Protomer alignment modulates specificity of RNA substrate recognition by Ire1.
  eLife 2021 Li W, Crotty K, Garrido Ruiz D, Voorhies M, Rivera C, Sil A, Mullins RD, Jacobson MP, Peschek J, Walter P
• Correction: Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response.
  The Journal of cell biology 2021 Schuck S, Prinz WA, Thorn KS, Voss C, Walter P
• eIF2B conformation and assembly state regulate the integrated stress response.
  eLife 2021 Schoof M, Boone M, Wang L, Lawrence R, Frost A, Walter P
• Coexpressed subunits of dual genetic origin define a conserved supercomplex mediating essential protein import into chloroplasts.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Ramundo S, Asakura Y, Salomé PA, Strenkert D, Boone M, Mackinder LCM, Takafuji K, Dinc E, Rahire M, Crèvecoeur M, Magneschi L, Schaad O, Hippler M, Jonikas MC, Merchant S, Nakai M, Rochaix JD, Walter …
• Small molecule cognitive enhancer reverses age-related memory decline in mice.
  eLife 2020 Krukowski K, Nolan A, Frias ES, Boone M, Ureta G, Grue K, Paladini MS, Elizarraras E, Delgado L, Bernales S, Walter P, Rosi S
• An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
  Science (New York, N.Y.) 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…
• Blockade of Retinal Oscillations by Benzodiazepines Improves Efficiency of Electrical Stimulation in the Mouse Model of RP, rd10.
  Investigative ophthalmology & visual science 2020 Gehlen J, Esser S, Schaffrath K, Johnen S, Walter P, Müller F
• Msp1/ATAD1 in Protein Quality Control and Regulation of Synaptic Activities.
  Annual review of cell and developmental biology 2020 Wang L, Walter P
• An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation.
  bioRxiv : the preprint server for biology 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…
• Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association.
  Nature microbiology 2020 Rabouw HH, Visser LJ, Passchier TC, Langereis MA, Liu F, Giansanti P, van Vliet ALW, Dekker JG, van der Grein SG, Saucedo JG, Anand AA, Trellet ME, Bonvin AMJJ, Walter P, Heck AJR, de Groot RJ, van …
• Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response.
  Nature communications 2020 Dufey E, Bravo-San Pedro JM, Eggers C, González-Quiroz M, Urra H, Sagredo AI, Sepulveda D, Pihán P, Carreras-Sureda A, Hazari Y, Sagredo EA, Gutierrez D, Valls C, Papaioannou A, Acosta-Alvear D, …
• The integrated stress response: From mechanism to disease.
  Science (New York, N.Y.) 2020 Costa-Mattioli M, Walter P
• IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment.
  Cancer research 2020 Harnoss JM, Le Thomas A, Reichelt M, Guttman O, Wu TD, Marsters SA, Shemorry A, Lawrence DA, Kan D, Segal E, Merchant M, Totpal K, Crocker LM, Mesh K, Dohse M, Solon M, Modrusan Z, Rudolph J, Koeppen …
• Regulating ER protein homeostasis by differentially processing mRNAs.
  The FASEB Journal 2020 Weihan Li, Kelly Crotty, Diego Garrido Ruiz, Jirka Peschek, Peter Walter
• Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells.
  Science advances 2020 Carter SD, Hampton CM, Langlois R, Melero R, Farino ZJ, Calderon MJ, Li W, Wallace CT, Tran NH, Grassucci RA, Siegmund SE, Pemberton J, Morgenstern TJ, Eisenman L, Aguilar JI, Greenberg NL, Levy ES, …
• Integrated Stress Response Inhibitor Reverses Sex-Dependent Behavioral and Cell-Specific Deficits after Mild Repetitive Head Trauma.
  Journal of neurotrauma 2020 Krukowski K, Nolan A, Frias ES, Grue K, Becker M, Ureta G, Delgado L, Bernales S, Sohal VS, Walter P, Rosi S
• Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction.
  eLife 2020 Wang L, Myasnikov A, Pan X, Walter P
• The role of transient resonances for ultra-fast imaging of single sucrose nanoclusters.
  Nature communications 2020 Ho PJ, Daurer BJ, Hantke MF, Bielecki J, Al Haddad A, Bucher M, Doumy G, Ferguson KR, Flückiger L, Gorkhover T, Iwan B, Knight C, Moeller S, Osipov T, Ray D, Southworth SH, Svenda M, Timneanu N, Ulmer…
• Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress.
  eLife 2020 Lam M, Marsters SA, Ashkenazi A, Walter P
• Quantitative microscopy reveals dynamics and fate of clustered IRE1α.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Belyy V, Tran NH, Walter P
• Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome.
  Science (New York, N.Y.) 2019 Zhu PJ, Khatiwada S, Cui Y, Reineke LC, Dooling SW, Kim JJ, Li W, Walter P, Costa-Mattioli M
• Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response.
  The FEBS journal 2019 Anand AA, Walter P
• The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response.
  eLife 2019 Perlaza K, Toutkoushian H, Boone M, Lam M, Iwai M, Jonikas MC, Walter P, Ramundo S
• Mrx6 regulates mitochondrial DNA copy number in Saccharomyces cerevisiae by engaging the evolutionarily conserved Lon protease Pim1.
  Molecular biology of the cell 2019 Göke A, Schrott S, Mizrak A, Belyy V, Osman C, Walter P
• From symbiont to parasite: the evolution of for-profit science publishing.
  Molecular biology of the cell 2019 Walter P, Mullins D
• The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum.
  Cold Spring Harbor perspectives in biology 2019 Karagöz GE, Acosta-Alvear D, Walter P
• A Novel Role of Fungal Type I Myosin in Regulating Membrane Properties and Its Association with d-Amino Acid Utilization in Cryptococcus gattii.
  mBio 2019 Khanal Lamichhane A, Garraffo HM, Cai H, Walter PJ, Kwon-Chung KJ, Chang YC
• Withdrawal: Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum.
  The Journal of biological chemistry 2019 Doolittle MH, Neher SB, Ben-Zeev O, Ling-Liao J, Gallagher CM, Hosseini M, Yin F, Wong H, Walter P, Péterfy M
• Disruption of IRE1α through its kinase domain attenuates multiple myeloma.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, …
• In vitro RNA Cleavage Assays to Characterize IRE1-dependent RNA Decay.
  Bio-protocol 2019 Karagöz GE, Peschek J, Walter P, Acosta-Alvear D
• tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay.
  eLife 2019 Peschek J, Walter P
• Pulmonary Iron Limitation Induced by Exogenous Type I IFN Protects Mice from Cryptococcus gattii Independently of T Cells.
  mBio 2019 Davis MJ, Moyer S, Hoke ES, Sionov E, Mayer-Barber KD, Barber DL, Cai H, Jenkins L, Walter PJ, Chang YC, Kwon-Chung KJ
• Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.
  eLife 2019 Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P
• Electrospray sample injection for single-particle imaging with x-ray lasers.
  Science advances 2019 Bielecki J, Hantke MF, Daurer BJ, Reddy HKN, Hasse D, Larsson DSD, Gunn LH, Svenda M, Munke A, Sellberg JA, Flueckiger L, Pietrini A, Nettelblad C, Lundholm I, Carlsson G, Okamoto K, Timneanu N, …
• eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.
  Science (New York, N.Y.) 2019 Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A
• Abstract # 2056 Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury.
  Brain Behavior and Immunity 2019 K. Krukowski, A. Chou, T. Jopson, P. Jun Zhu, M. Costa-Mattioli, P. Walter, S. Rosi
• Small molecule ISRIB suppresses the integrated stress response within a defined window of activation.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Rabouw HH, Langereis MA, Anand AA, Visser LJ, de Groot RJ, Walter P, van Kuppeveld FJM
• The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1.
  eLife 2018 Acosta-Alvear D, Karagöz GE, Fröhlich F, Li H, Walther TC, Walter P
• Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress.
  Cell death and differentiation 2018 Lam M, Lawrence DA, Ashkenazi A, Walter P
• Engineering ER-stress dependent non-conventional mRNA splicing.
  eLife 2018 Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M, Weissman JS, Walter P
• Leonardo Gallery: Scientific Delirium Madness 4.0.
  Leonardo 2018 Margot H. Knight, Marco Buongiorno Nardelli, Anna M. Davidson, Ken Eklund, Katharine Hawthorne, GinaRae LaCerva, Adria C. LeBoeuf, Patrice Le Gal, Ainissa Ramirez, Heather Spence, Javiera Tejerina-…
• Development of a stress response therapy targeting aggressive prostate cancer.
  Science translational medicine 2018 Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D
• Günter Blobel (1936-2018).
  Science (New York, N.Y.) 2018 Walter P, Anderson D
• Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.
  Cell host & microbe 2018 Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI
• Regulating ER Protein Folding Homeostasis By Distinctively Processing mRNAs.
  The FASEB Journal 2018 Weihan Li, Voytek Okreglak, Jirka Peschek, Philipp Kimmig, Peter Walter
• Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
  Science (New York, N.Y.) 2018 Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P
• An unfolded protein-induced conformational switch activates mammalian IRE1.
  eLife 2017 Karagöz GE, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter P
• Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe.
  eLife 2017 Guydosh NR, Kimmig P, Walter P, Green R
• Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling.
  Journal of cell science 2017 Cohen N, Breker M, Bakunts A, Pesek K, Chas A, Argemí J, Orsi A, Gal L, Chuartzman S, Wigelman Y, Jonas F, Walter P, Ernst R, Aragón T, van Anken E, Schuldiner M
• Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Chou A, Krukowski K, Jopson T, Zhu PJ, Costa-Mattioli M, Walter P, Rosi S
• BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.
  The EMBO journal 2017 Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C
• Targeting IRE1 with small molecules counteracts progression of atherosclerosis.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Tufanli O, Telkoparan Akillilar P, Acosta-Alvear D, Kocaturk B, Onat UI, Hamid SM, Çimen I, Walter P, Weber C, Erbay E
• eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons.
  eLife 2016 Placzek AN, Prisco GV, Khatiwada S, Sgritta M, Huang W, Krnjevic K, Kaufman RJ, Dani JA, Walter P, Costa-Mattioli M
• Multiple selection filters ensure accurate tail-anchored membrane protein targeting.
  eLife 2016 Rao M, Okreglak V, Chio US, Cho H, Walter P, Shan SO
• CD46 Is Amplified in High-Risk Myeloma with Gain of Chromosome 1q and Selectively Targeted By a Novel Anti-CD46 Antibody-Drug Conjugate.
  Blood 2016 Daniel W. Sherbenou, Blake T. Aftab, Yang Su, Christopher R. Behrens, Arun P. Wiita, Aaron C. Logan, Diego Acosta-Alvear, Byron C. Hann, Peter Walter, Xiaobo Wu, John P. Atkinson, Jeffrey L. Wolf, …
• Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells.
  The Journal of clinical investigation 2016 Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B
• Science as a Way of Knowing: From Protein Machines to Evidence-Based Decisions.
  Cell 2016 Walter P, Yamamoto KR
• Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG
• Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch.
  eLife 2016 Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P
• Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress.
  eLife 2016 Gallagher CM, Walter P
• Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.
  eLife 2016 Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, Hodder P, Wiseman RL, Kelly JW
• Evaluation of Retinal Function and Morphology of the Pink-Eyed Royal College of Surgeons (RCS) Rat: A Comparative Study of in Vivo and in Vitro Methods.
  Current eye research 2016 Rösch S, Aretzweiler C, Müller F, Walter P
• Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine.
  eLife 2016 Huang W, Placzek AN, Viana Di Prisco G, Khatiwada S, Sidrauski C, Krnjevic K, Walter P, Dani JA, Costa-Mattioli M
• Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α.
  eLife 2016 Placzek AN, Molfese DL, Khatiwada S, Viana Di Prisco G, Huang W, Sidrauski C, Krnjevic K, Amos CL, Ray R, Dani JA, Walter P, Salas R, Costa-Mattioli M
• Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response.
  ChemMedChem 2016 Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR
• Dynamics of co-translational protein targeting.
  Current opinion in chemical biology 2015 Elvekrog MM, Walter P
• A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing.
  EMBO reports 2015 Peschek J, Acosta-Alvear D, Mendez AS, Walter P
• ER-mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13.
  The Journal of cell biology 2015 Lang AB, John Peter AT, Walter P, Kornmann B
• Abstract A43: Opposing roles of the 19S regulatory- and 20S core-proteasomal subunits in controlling sensitivity of multiple myeloma cells to proteasome inhibition.
  Myeloma 2015 Diego Acosta-Alvear, Martin Kampmann, Min Y. Cho, Thomas Wild, Chunaram Choudhary, Marc A. Shuman, Jonathan S. Weissman, Peter Walter
• Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits.
  eLife 2015 Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M
• Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic.
  eLife 2015 Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P
• Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.
  eLife 2015 Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P
• The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly.
  eLife 2015 Sidrauski C, McGeachy AM, Ingolia NT, Walter P
• Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Osman C, Noriega TR, Okreglak V, Fung JC, Walter P
• Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer.
  Molecular cancer therapeutics 2015 Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE
• Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1.
  eLife 2014 van Anken E, Pincus D, Coyle S, Aragón T, Osman C, Lari F, Gómez Puerta S, Korennykh AV, Walter P
• Real-time observation of signal recognition particle binding to actively translating ribosomes.
  eLife 2014 Noriega TR, Chen J, Walter P, Puglisi JD
• Delayed Ras/PKA signaling augments the unfolded protein response.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Pincus D, Aranda-Díaz A, Zuleta IA, Walter P, El-Samad H
• Lasker Award winner Peter Walter.
  Nature medicine 2014 Walter P
• ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery.
  Journal of cell science 2014 Schuck S, Gallagher CM, Walter P
• Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis.
  Science (New York, N.Y.) 2014 Lu M, Lawrence DA, Marsters S, Acosta-Alvear D, Kimmig P, Mendez AS, Paton AW, Paton JC, Walter P, Ashkenazi A
• Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α.
  Nature neuroscience 2014 Di Prisco GV, Huang W, Buffington SA, Hsu CC, Bonnen PE, Placzek AN, Sidrauski C, Krnjevic K, Kaufman RJ, Walter P, Costa-Mattioli M
• The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Okreglak V, Walter P
• Signal recognition particle-ribosome binding is sensitive to nascent chain length.
  The Journal of biological chemistry 2014 Noriega TR, Tsai A, Elvekrog MM, Petrov A, Neher SB, Chen J, Bradshaw N, Puglisi JD, Walter P
• Molecular mechanisms of hypoxic responses via unique roles of Ras1, Cdc24 and Ptp3 in a human fungal pathogen Cryptococcus neoformans.
  PLoS genetics 2014 Chang YC, Khanal Lamichhane A, Garraffo HM, Walter PJ, Leerkes M, Kwon-Chung KJ
• Identification of key components involved in mtDNA inheritance during cell division (965.1).
  The FASEB Journal 2014 Beatriz Camacho, Christof Osman, Peter Walter
• Heat shock transcription factor σ32 co-opts the signal recognition particle to regulate protein homeostasis in E. coli.
  PLoS biology 2013 Lim B, Miyazaki R, Neher S, Siegele DA, Ito K, Walter P, Akiyama Y, Yura T, Gross CA
• Abstract C01: Systematic blueprinting of genetic vulnerabilities using ultra-complex shRNA libraries identifies genes synergizing with proteasome inhibition or blockade of IRE1 in multiple myeloma cells.
  Signaling and Drug Resistance 2013 Diego Acosta-Alvear, Martin Kampmann, Michael C. Bassik, Crystal P. Lee, Min Y. Cho, Blake T. Aftab, Xiaokai Li, Jason E. Gestwicki, Marc A. Shuman, Jonathan S. Weissman, Peter Walter
• Abstract PR07: Systematic genetic interaction maps reveal rewiring of the stress response network and resulting vulnerabilities in leukemia and multiple myeloma cells.
  Interpreting the Cancer Genome 2013 Martin Kampmann, Diego Acosta-Alvear, Min Cho, Yuwen Chen, Xiaokai Li, Luke Gilbert, Blake T. Aftab, Jason Gestwicki, Peter Walter, Jonathan S. Weissman
• The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling.
  Cell host & microbe 2013 Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI
• ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast.
  eLife 2013 Murley A, Lackner LL, Osman C, West M, Voeltz GK, Walter P, Nunnari J
• Abstract A08: Systematic identification of genetic vulnerabilities synergizing with proteasome and IRE1 inhibition in multiple myeloma cells using ultra-complex shRNA libraries.
  Genome Scale Synthetic Lethal Screens in Model Organisms 2013 Diego Acosta-Alvear, Martin Kampmann, Michael C. Bassik, Crystal P. Lee, Marc A. Shuman, Jonathan S. Weissman, Peter Walter
• Abstract PR06: Systematic genetic interaction maps reveal synthetic-lethal vulnerabilities in leukemia and multiple myeloma.
  Systemic Functional Genomics 2013 Martin Kampmann, Diego Acosta-Alvear, Michael C. Bassik, Yuwen Chen, Peter Walter, Jonathan S. Weissman
• Two structure papers, a call from Frankfurt airport, and how to escape from reviewer delays: an interview with Peter Walter by Miranda Robertson.
  BMC biology 2013 Walter P
• Predicting where small molecules bind at protein-protein interfaces.
  PloS one 2013 Walter P, Metzger J, Thiel C, Helms V
• Endoplasmic reticulum stress sensing in the unfolded protein response.
  Cold Spring Harbor perspectives in biology 2013 Gardner BM, Pincus D, Gotthardt K, Gallagher CM, Walter P
• The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis.
  eLife 2012 Kimmig P, Diaz M, Zheng J, Williams CC, Lang A, Aragón T, Li H, Walter P
• Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Fordyce PM, Pincus D, Kimmig P, Nelson CS, El-Samad H, Walter P, DeRisi JL
• A quaternary equation for interdisciplinary medical research (IMR).
  Journal of Translational Medicine 2012 Marc Shuman, Jim Wells, K Shokat, S Bernales, P Walter, Leonard Shultz, Neal Goodwin
• A first line of defense against ER stress.
  The Journal of cell biology 2012 Pincus D, Walter P
• Seg1 controls eisosome assembly and shape.
  The Journal of cell biology 2012 Moreira KE, Schuck S, Schrul B, Fröhlich F, Moseley JB, Walther TC, Walter P
• Structural basis of the unfolded protein response.
  Annual review of cell and developmental biology 2012 Korennykh A, Walter P
• The unfolded protein response: from stress pathway to homeostatic regulation.
  Science (New York, N.Y.) 2011 Walter P, Ron D
• Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101.
  Journal of oncology 2011 Braunstein MJ, Scott SS, Scott CM, Behrman S, Walter P, Wipf P, Coplan JD, Chrico W, Joseph D, Brodsky JL, Batuman O
• BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.
  The EMBO journal 2011 Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C
• The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Kornmann B, Osman C, Walter P
• Concerted complex assembly and GTPase activation in the chloroplast signal recognition particle.
  Biochemistry 2011 Nguyen TX, Chandrasekar S, Neher S, Walter P, Shan SO
• Endogenic regulation of proliferation and zinc transporters by pigment epithelial cells nonvirally transfected with PEDF.
  Investigative ophthalmology & visual science 2011 Johnen S, Kazanskaya O, Armogan N, Stickelmann C, Stöcker M, Walter P, Thumann G
• Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1.
  BMC biology 2011 Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P
• Structural and functional basis for RNA cleavage by Ire1.
  BMC biology 2011 Korennykh AV, Korostelev AA, Egea PF, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P
• Presence of xenogenic mouse RNA in RPE and IPE cells cultured on mitotically inhibited 3T3 fibroblasts.
  Investigative ophthalmology & visual science 2011 Johnen S, Wickert L, Meier M, Salz AK, Walter P, Thumann G
• Peter Walter: investigating how the ER handles secretory proteins. Interview by Sedwick Caitlin.
  The Journal of cell biology 2011 Walter P
• Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity.
  The Journal of cell biology 2011 Rubio C, Pincus D, Korennykh A, Schuck S, El-Samad H, Walter P
• A CHOP-regulated microRNA controls rhodopsin expression.
  The Journal of cell biology 2011 Behrman S, Acosta-Alvear D, Walter P
• Prediction of the exposure status of transmembrane beta barrel residues from protein sequence.
  Journal of bioinformatics and computational biology 2011 Hayat S, Walter P, Park Y, Helms V
• Multi-Modality Imaging of Multiple Myeloma Bone Disease In Orthotopic Xenograft Models.
  Blood 2010 Diego Acosta-Alvear, Byron C Hann, Brian A Rabinovich, Marc A Shuman, Peter Walter
• Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Li H, Korennykh AV, Behrman SL, Walter P
• BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response.
  PLoS biology 2010 Pincus D, Chevalier MW, Aragón T, van Anken E, Vidal SE, El-Samad H, Walter P
• Automated identification of pathways from quantitative genetic interaction data.
  Molecular systems biology 2010 Battle A, Jonikas MC, Walter P, Weissman JS, Koller D
• A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking.
  Nature structural & molecular biology 2010 Aguilar PS, Fröhlich F, Rehman M, Shales M, Ulitsky I, Olivera-Couto A, Braberg H, Shamir R, Walter P, Mann M, Ejsing CS, Krogan NJ, Walther TC
• The yeast cell fusion protein Prm1p requires covalent dimerization to promote membrane fusion.
  PloS one 2010 Engel A, Aguilar PS, Walter P
• ERMES-mediated ER-mitochondria contacts: molecular hubs for the regulation of mitochondrial biology.
  Journal of cell science 2010 Kornmann B, Walter P
• Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Aguilar PS, Heiman MG, Walther TC, Engel A, Schwudke D, Gushwa N, Kurzchalia T, Walter P
• Walking along the serendipitous path of discovery.
  Molecular biology of the cell 2010 Walter P
• Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response.
  The Journal of cell biology 2009 Schuck S, Prinz WA, Thorn KS, Voss C, Walter P
• Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum.
  The Journal of biological chemistry 2009 Doolittle MH, Neher SB, Ben-Zeev O, Ling-Liao J, Gallagher CM, Hosseini M, Yin F, Wong H, Walter P, Péterfy M
• Regulated Ire1-dependent decay of messenger RNAs in mammalian cells.
  The Journal of cell biology 2009 Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman JS
• A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling.
  The Journal of cell biology 2009 Fröhlich F, Moreira K, Aguilar PS, Hubner NC, Mann M, Walter P, Walther TC
• The unfolded protein response during prostate cancer development.
  Cancer metastasis reviews 2009 So AY, de la Fuente E, Walter P, Shuman M, Bernales S
• BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha.
  Molecular cell 2009 Lisbona F, Rojas-Rivera D, Thielen P, Zamorano S, Todd D, Martinon F, Glavic A, Kress C, Lin JH, Walter P, Reed JC, Glimcher LH, Hetz C
• Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.
  Science (New York, N.Y.) 2009 Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, Schuldiner M
• Divergent effects of PERK and IRE1 signaling on cell viability.
  PloS one 2009 Lin JH, Li H, Zhang Y, Ron D, Walter P
• Signal sequences activate the catalytic switch of SRP RNA.
  Science (New York, N.Y.) 2009 Bradshaw N, Neher SB, Booth DS, Walter P
• Messenger RNA targeting to endoplasmic reticulum stress signalling sites.
  Nature 2008 Aragón T, van Anken E, Pincus D, Serafimova IM, Korennykh AV, Rubio CA, Walter P
• Pil1 controls eisosome biogenesis.
  Molecular biology of the cell 2008 Moreira KE, Walther TC, Aguilar PS, Walter P
• Targeting Hsp70 in Multiple Myeloma Induces Synergistic Cytotoxicity with Inhibitors of the Proteasome and of Hsp90.
  Blood 2008 Marc J Braunstein, Craig M Scott, Shannon Behrman, Peter Walter, Peter Wipf, Eric LP Smith, Sadeaqua S Scott, H. Uwe Klueppelberg, Jeffrey L Brodsky, Olcay Batuman
• Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membrane.
  PloS one 2008 Egea PF, Tsuruta H, de Leon GP, Napetschnig J, Walter P, Stroud RM
• Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus.
  PloS one 2008 Egea PF, Napetschnig J, Walter P, Stroud RM
• The in vitro and in vivo behaviour of retinal pigment epithelial cells cultured on ultrathin collagen membranes.
  Biomaterials 2008 Thumann G, Viethen A, Gaebler A, Walter P, Kaempf S, Johnen S, Salz AK
• Membrane lysis during biological membrane fusion: collateral damage by misregulated fusion machines.
  The Journal of cell biology 2008 Engel A, Walter P
• SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction.
  Nature structural & molecular biology 2008 Neher SB, Bradshaw N, Floor SN, Gross JD, Walter P
• Helenius et al. reply.
  Nature 2008 Jonne Helenius, Davis T. W. Ng, Cristina L. Marolda, Peter Walter, Miguel A. Valvano, Markus Aebi
• Functional genomic screen reveals genes involved in lipid-droplet formation and utilization.
  Nature 2008 Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV
• Endoplasmic reticulum stress in disease pathogenesis.
  Annual review of pathology 2008 Lin JH, Walter P, Yen TS
• Pkh-kinases control eisosome assembly and organization.
  The EMBO journal 2007 Walther TC, Aguilar PS, Fröhlich F, Chu F, Moreira K, Burlingame AL, Walter P
• In Vitro Antimyeloma Effects of Inhibitors of the Heat Shock Protein 70 (Hsp70) Molecular Chaperone.
  Blood 2007 M.J. Braunstein, C.M. Scott, S. Berman, P. Walter, P. Wipf, J.L. Brodsky, O. Batuman
• Identification of yeast proteins necessary for cell-surface function of a potassium channel.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Haass FA, Jonikas M, Walter P, Weissman JS, Jan YN, Jan LY, Schuldiner M
• Conformational changes in the GTPase modules of the signal reception particle and its receptor drive initiation of protein translocation.
  The Journal of cell biology 2007 Shan SO, Chandrasekar S, Walter P
• X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates.
  PloS one 2007 Reyes CL, Rutenber E, Walter P, Stroud RM
• Signal integration in the endoplasmic reticulum unfolded protein response.
  Nature reviews. Molecular cell biology 2007 Ron D, Walter P
• The signal recognition particle (SRP) RNA links conformational changes in the SRP to protein targeting.
  Molecular biology of the cell 2007 Bradshaw N, Walter P
• ER-phagy: selective autophagy of the endoplasmic reticulum.
  Autophagy 2007 Bernales S, Schuck S, Walter P
• The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating.
  The Journal of cell biology 2007 Heiman MG, Engel A, Walter P
• The plasma membrane proteins Prm1 and Fig1 ascertain fidelity of membrane fusion during yeast mating.
  Molecular biology of the cell 2006 Aguilar PS, Engel A, Walter P
• Differential Effects of Hsp70 Inhibition within the Tumor and Microenvironment in Multiple Myeloma.
  Blood 2006 Marc J. Braunstein, Na Liu, Uwe Klueppelberg, Craig Scott, Shannon Behrman, Can Tamucin, Peter Walter, Peter Wipf, Jeffrey Brodsky, Olcay Batuman
• Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response.
  PLoS biology 2006 Bernales S, McDonald KL, Walter P
• Eisosomes mark static sites of endocytosis.
  Nature 2006 Walther TC, Brickner JH, Aguilar PS, Bernales S, Pantoja C, Walter P
• Intracellular signaling by the unfolded protein response.
  Annual review of cell and developmental biology 2006 Bernales S, Papa FR, Walter P
• On the mechanism of sensing unfolded protein in the endoplasmic reticulum.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P
• Structural basis of FFAT motif-mediated ER targeting.
  Structure (London, England : 1993) 2005 Kaiser SE, Brickner JH, Reilein AR, Fenn TD, Walter P, Brunger AT
• Molecular Crosstalk between the Nucleotide Specificity Determinant of the SRP GTPase and the SRP Receptor.
  Biochemistry 2005 Shu-ou Shan, Peter Walter
• Molecular crosstalk between the nucleotide specificity determinant of the SRP GTPase and the SRP receptor.
  Biochemistry 2005 Shan SO, Walter P
• Targeting proteins to membranes: structure of the signal recognition particle.
  Current opinion in structural biology 2005 Egea PF, Stroud RM, Walter P
• Co-translational protein targeting by the signal recognition particle.
  FEBS letters 2005 Shan SO, Walter P
• Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease.
  Genome biology 2004 Niwa M, Patil CK, DeRisi J, Walter P
• Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Chu F, Shan SO, Moustakas DT, Alber F, Egea PF, Stroud RM, Walter P, Burlingame AL
• Gene recruitment of the activated INO1 locus to the nuclear membrane.
  PLoS biology 2004 Brickner JH, Walter P
• Mechanism of association and reciprocal activation of two GTPases.
  PLoS biology 2004 Shan SO, Stroud RM, Walter P
• Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response.
  PLoS biology 2004 Patil CK, Li H, Walter P
• IRE1-independent gain control of the unfolded protein response.
  PLoS biology 2004 Leber JH, Bernales S, Walter P
• Induced nucleotide specificity in a GTPase.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Shan SO, Walter P
• Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh.
  Journal of molecular biology 2002 Ramirez UD, Minasov G, Focia PJ, Stroud RM, Walter P, Kuhn P, Freymann DM
• Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein.
  Nature 2002 Helenius J, Ng DT, Marolda CL, Walter P, Valvano MA, Aebi M
• 8 The Unfolded Protein Response.
  Protein Targeting, Transport, and Translocation 2002 Carmela Sidrauski, Jason H. Brickner, Peter Walter
• Role of SRP RNA in the GTPase cycles of Ffh and FtsY.
  Biochemistry 2001 Peluso P, Shan SO, Nock S, Herschlag D, Walter P
• Crystal structures of coaxially stacked kissing complexes of the HIV-1 RNA dimerization initiation site.
  Nature structural biology 2001 Ennifar E, Walter P, Ehresmann B, Ehresmann C, Dumas P
• Yeast cytoplasmic and mitochondrial methionyl-tRNA synthetases: two structural frameworks for identical functions.
  Journal of molecular biology 2001 Senger B, Despons L, Walter P, Jakubowski H, Fasiolo F
• Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals.
  Current opinion in cell biology 2001 Patil C, Walter P
• Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p.
  RNA (New York, N.Y.) 2001 Dong B, Niwa M, Walter P, Silverman RH
• Multifaceted physiological response allows yeast to adapt to the loss of the signal recognition particle-dependent protein-targeting pathway.
  Molecular biology of the cell 2001 Mutka SC, Walter P
• Ire1p: a kinase and site-specific endoribonuclease.
  Methods in molecular biology (Clifton, N.J.) 2001 Gonzalez TN, Walter P
• Pausing to decide.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Niwa M, Walter P
• Prm1p, a pheromone-regulated multispanning membrane protein, facilitates plasma membrane fusion during yeast mating.
  The Journal of cell biology 2000 Heiman MG, Walter P
• The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control.
  The Journal of cell biology 2000 Ng DT, Spear ED, Walter P
• Role of 4.5S RNA in assembly of the bacterial signal recognition particle with its receptor.
  Science (New York, N.Y.) 2000 Peluso P, Herschlag D, Nock S, Freymann DM, Johnson AE, Walter P
• Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation.
  Cell 2000 Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weissman JS, Walter P
• Perspectives: structural biology. SRP--where the RNA and membrane worlds meet.
  Science (New York, N.Y.) 2000 Walter P, Keenan R, Schmitz U
• A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response.
  Cell 1999 Niwa M, Sidrauski C, Kaufman RJ, Walter P
• Blobel's nobel: a vision validated.
  Cell 1999 Anderson D, Walter P
• Signal sequence recognition and protein targeting.
  Current opinion in structural biology 1999 Stroud RM, Walter P
• The crystal structure of the dimerization initiation site of genomic HIV-1 RNA reveals an extended duplex with two adenine bulges.
  Structure (London, England : 1993) 1999 Ennifar E, Yusupov M, Walter P, Marquet R, Ehresmann B, Ehresmann C, Dumas P
• Structure of the phylogenetically most conserved domain of SRP RNA.
  RNA (New York, N.Y.) 1999 Schmitz U, Behrens S, Freymann DM, Keenan RJ, Lukavsky P, Walter P, James TL
• Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP.
  Nature structural biology 1999 Freymann DM, Keenan RJ, Stroud RM, Walter P
• Structure of the most conserved internal loop in SRP RNA.
  Nature structural biology 1999 Schmitz U, James TL, Lukavsky P, Walter P
• Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway.
  The EMBO journal 1999 Gonzalez TN, Sidrauski C, Dörfler S, Walter P
• Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae.
  Molecular biology of the cell 1999 Powers T, Walter P
• Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins.
  Molecular biology of the cell 1999 Barz WP, Walter P
• Neisseria gonorrhoeae PilA is an FtsY homolog.
  Journal of bacteriology 1999 Arvidson CG, Powers T, Walter P, So M
• Crystallization of the dimerization-initiation site of genomic HIV-1 RNA: preliminary crystallographic results.
  Acta crystallographica. Section D, Biological crystallography 1999 Yusupov M, Walter P, Marquet R, Ehresmann C, Ehresmann B, Dumas P
• A functional GTPase domain, but not its transmembrane domain, is required for function of the SRP receptor beta-subunit.
  The Journal of cell biology 1998 Ogg SC, Barz WP, Walter P
• Crystal structure of the signal sequence binding subunit of the signal recognition particle.
  Cell 1998 Keenan RJ, Freymann DM, Walter P, Stroud RM
• The unfolded protein response: an intracellular signalling pathway with many surprising features.
  Trends in cell biology 1998 Sidrauski C, Chapman R, Walter P
• Heterodimer SRP9/14 is an integral part of the neural BC200 RNP in primate brain.
  Neuroscience letters 1998 Kremerskothen J, Zopf D, Walter P, Cheng JG, Nettermann M, Niewerth U, Maraia RJ, Brosius J
• Intracellular signaling from the endoplasmic reticulum to the nucleus.
  Annual review of cell and developmental biology 1998 Chapman R, Sidrauski C, Walter P
• A ribosome at the end of the tunnel.
  Science (New York, N.Y.) 1997 Powers T, Walter P
• Translational attenuation mediated by an mRNA intron.
  Current biology : CB 1997 Chapman RE, Walter P
• The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane.
  Molecular biology of the cell 1997 Cox JS, Chapman RE, Walter P
• Co-translational protein targeting catalyzed by the Escherichia coli signal recognition particle and its receptor.
  The EMBO journal 1997 Powers T, Walter P
• Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA.
  Molecular biology of the cell 1997 Nunnari J, Marshall WF, Straight A, Murray A, Sedat JW, Walter P
• Structure of the conserved GTPase domain of the signal recognition particle.
  Nature 1997 Freymann DM, Keenan RJ, Stroud RM, Walter P
• NMR studies of the most conserved RNA domain of the mammalian signal recognition particle (SRP).
  RNA (New York, N.Y.) 1996 Schmitz U, Freymann DM, James TL, Keenan RJ, Vinayak R, Walter P
• A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response.
  Cell 1996 Cox JS, Walter P
• tRNA ligase is required for regulated mRNA splicing in the unfolded protein response.
  Cell 1996 Sidrauski C, Cox JS, Walter P
• Progress torwards the crystal structure of Ffh, the bacterial homolog of SRP54.
  Acta Crystallographica Section A: Foundations and advances 1996 D. Freymann, R. Keenan, R. Stroud, P. Walter
• Signal sequences specify the targeting route to the endoplasmic reticulum membrane.
  The Journal of cell biology 1996 Ng DT, Brown JD, Walter P
• Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.
  The EMBO journal 1996 Shamu CE, Walter P
• Protein targeting. The ribosome talks back.
  Nature 1996 Powers T, Walter P
• The nascent polypeptide-associated complex modulates interactions between the signal recognition particle and the ribosome.
  Current biology : CB 1996 Powers T, Walter P
• Regulation of organelle biogenesis.
  Cell 1996 Nunnari J, Walter P
• ER membrane protein complex required for nuclear fusion.
  The Journal of cell biology 1996 Ng DT, Walter P
• Conservation in evolution for a small monomeric phenylalanyl-tRNA synthetase of the tRNA(Phe) recognition nucleotides and initial aminoacylation site.
  Biochemistry 1996 Aphasizhev R, Senger B, Rengers JU, Sprinzl M, Walter P, Nussbaum G, Fasiolo F
• Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases.
  Science (New York, N.Y.) 1995 Powers T, Walter P
• An amino-terminal domain containing hydrophobic and hydrophilic sequences binds the signal recognition particle receptor alpha subunit to the beta subunit on the endoplasmic reticulum membrane.
  The Journal of biological chemistry 1995 Young JC, Ursini J, Legate KR, Miller JD, Walter P, Andrews DW
• SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation.
  Cell 1995 Ogg SC, Walter P
• The 70 carboxyl-terminal amino acids of nascent secretory proteins are protected from proteolysis by the ribosome and the protein translocation apparatus of the endoplasmic reticulum membrane.
  The Journal of biological chemistry 1995 Matlack KE, Walter P
• The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane.
  The Journal of cell biology 1995 Miller JD, Tajima S, Lauffer L, Walter P
• Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane.
  Harvey lectures 1995 Walter P
• Targeting pathways to the endoplasmic reticulum membrane.
  Cold Spring Harbor symposia on quantitative biology 1995 Brown JD, NG DT, Ogg SC, Walter P
• Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression.
  The EMBO journal 1994 Brown JD, Hann BC, Medzihradszky KF, Niwa M, Burlingame AL, Walter P
• Protein translocation across the endoplasmic reticulum.
  Current opinion in cell biology 1994 Ng DT, Walter P
• Genetic and biochemical analysis of the fission yeast ribonucleoprotein particle containing a homolog of Srp54p.
  Nucleic acids research 1994 Selinger D, Brennwald P, Althoff S, Reich C, Hann B, Walter P, Wise JA
• Interaction of E. coli Ffh/4.5S ribonucleoprotein and FtsY mimics that of mammalian signal recognition particle and its receptor.
  Nature 1994 Miller JD, Bernstein HD, Walter P
• Role of the histone amino termini in facilitated binding of a transcription factor, GAL4-AH, to nucleosome cores.
  Molecular and cellular biology 1994 Vettese-Dadey M, Walter P, Chen H, Juan LJ, Workman JL
• The unfolded-protein-response pathway in yeast.
  Trends in cell biology 1994 Shamu CE, Cox JS, Walter P
• Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane.
  Annual review of cell biology 1994 Walter P, Johnson AE
• [Noninvasive studies of macro- and microcirculation in follow-up of femoropopliteal bypass operation in IIb peripheral arterial occlusive disease].
  VASA. Zeitschrift fur Gefasskrankheiten 1994 Scheffler P, Gross J, Dabringhaus S, de la Hamette D, Walter P
• A mitochondrial protease with two catalytic subunits of nonoverlapping specificities.
  Science (New York, N.Y.) 1993 Nunnari J, Fox TD, Walter P
• GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation.
  Nature 1993 Miller JD, Wilhelm H, Gierasch L, Gilmore R, Walter P
• Shedding light on the translocation pore.
  Current biology : CB 1993 Matlack KE, Walter P
• Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase.
  Cell 1993 Cox JS, Shamu CE, Walter P
• Discrete nascent chain lengths are required for the insertion of presecretory proteins into microsomal membranes.
  The Journal of cell biology 1993 Wolin SL, Walter P
• Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog.
  Proceedings of the National Academy of Sciences of the United States of America 1993 Bernstein HD, Zopf D, Freymann DM, Walter P
• GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding.
  The Journal of cell biology 1993 Zopf D, Bernstein HD, Walter P
• A GTPase cycle in initiation of protein translocation across the endoplasmic reticulum membrane.
  Ciba Foundation symposium 1993 Miller JD, Walter P
• The SRP-Dependent Protein Targeting Pathway in Saccharomyces Cerevisiae.
  Protein Synthesis and Targeting in Yeast 1993 Peter Walter, Stephen C. Ogg, Byron C. Hann
• Protein targeting to and translocation across the membrane of the endoplasmic reticulum.
  Current opinion in cell biology 1992 Nunnari J, Walter P
• Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae.
  Molecular biology of the cell 1992 Ogg SC, Poritz MA, Walter P
• Fluorescence-detected assembly of the signal recognition particle: binding of the two SRP protein heterodimers to SRP RNA is noncooperative.
  Biochemistry 1992 Janiak F, Walter P, Johnson AE
• Binding of the yeast tRNA(Met) anticodon by the cognate methionyl-tRNA synthetase involves at least two independent peptide regions.
  Journal of molecular biology 1992 Despons L, Senger B, Fasiolo F, Walter P
• Protein translocation. Travelling by TRAM.
  Nature 1992 Walter P
• SEC65 gene product is a subunit of the yeast signal recognition particle required for its integrity.
  Nature 1992 Hann BC, Stirling CJ, Walter P
• Mutants in three novel complementation groups inhibit membrane protein insertion into and soluble protein translocation across the endoplasmic reticulum membrane of Saccharomyces cerevisiae.
  The Journal of cell biology 1992 Green N, Fang H, Walter P
• C-Terminal Sequences Can Inhibit the Insertion of Membrane Proteins into the Endoplasmic Reticulum of Saccharomyces cerevisiae.
  Molecular and Cellular Biology 1992 Neil Green, Peter Walter
• C-terminal sequences can inhibit the insertion of membrane proteins into the endoplasmic reticulum of Saccharomyces cerevisiae.
  Molecular and cellular biology 1992 Green N, Walter P
• C-terminal sequences can inhibit the insertion of membrane proteins into the endoplasmic reticulum of Saccharomyces cerevisiae.
  Molecular and Cellular Biology 1992 N Green, P Walter
• Chapter 11 The role of GTP in protein targeting to the endoplasmic reticulum.
  Membrane Biogenesis and Protein Targeting 1992 Stephen C. Ogg, Jodi M. Nunnari, Joshua D. Miller, Peter Walter
• Characterization of the rough endoplasmic reticulum ribosome-binding activity.
  Trends in Cell Biology 1991 J.M. Nunnari, D.L. Zimmerman, S.C. Ogg, P. Walter
• The signal recognition particle in S. cerevisiae.
  Cell 1991 Hann BC, Walter P
• An ATP-binding membrane protein is required for protein translocation across the endoplasmic reticulum membrane.
  Cell regulation 1991 Zimmerman DL, Walter P
• Evolution of aminoacyl-tRNA synthetase quaternary structure and activity: Saccharomyces cerevisiae mitochondrial phenylalanyl-tRNA synthetase.
  Proceedings of the National Academy of Sciences of the United States of America 1991 Sanni A, Walter P, Boulanger Y, Ebel JP, Fasiolo F
• Identification of potential amino acid residues supporting anticodon recognition in yeast methionyl-tRNA synthetase.
  FEBS letters 1991 Despons L, Walter P, Senger B, Ebel JP, Fasiolo F
• Characterization of the rough endoplasmic reticulum ribosome-binding activity.
  Nature 1991 Nunnari JM, Zimmerman DL, Ogg SC, Walter P
• Binding Sites of the 9- and 14-Kilodalton Heterodimeric Protein Subunit of the Signal Recognition Particle (SRP) Are Contained Exclusively in the Alu Domain of SRP RNA and Contain a Sequence Motif That Is Conserved in Evolution.
  Molecular and Cellular Biology 1991 Katharina Strub, Jennifer Moss, Peter Walter
• Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution.
  Molecular and Cellular Biology 1991 K Strub, J Moss, P Walter
• Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution.
  Molecular and cellular biology 1991 Strub K, Moss J, Walter P
• Small ribonucleoproteins.
  Current Opinion in Structural Biology 1991 Sandra L. Wolin, Peter Walter
• Response: "Sequence-Gazing?".
  Science 1991 Mark A. Poritz, Harris D. Bernstein, Peter Walter
• Response: "Sequence-Gazing?".
  Science 1991 Mark A. Poritz, Harris D. Bernstein, Peter Walter
• A nascent membrane protein is located adjacent to ER membrane proteins throughout its integration and translation.
  The Journal of cell biology 1991 Thrift RN, Andrews DW, Walter P, Johnson AE
• The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence.
  The EMBO journal 1990 Zopf D, Bernstein HD, Johnson AE, Walter P
• An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle.
  Science (New York, N.Y.) 1990 Poritz MA, Bernstein HD, Strub K, Zopf D, Wilhelm H, Walter P
• Yeast methionyl-tRNA synthetase: analysis of the N-terminal extension and the putative tRNA anticodon binding region by site-directed mutagenesis.
  Biochimie 1990 Walter P, Despons L, Laforet M, Ebel JP, Fasiolo F
• Reconstitution of protein translocation activity from partially solubilized microsomal vesicles.
  The Journal of biological chemistry 1990 Zimmerman DL, Walter P
• Assembly of the Alu Domain of the Signal Recognition Particle (SRP): Dimerization of the Two Protein Components Is Required for Efficient Binding to SRP RNA.
  Molecular and Cellular Biology 1990 Katharina Strub, Peter Walter
• Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA.
  Molecular and Cellular Biology 1990 K Strub, P Walter
• Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA.
  Molecular and cellular biology 1990 Strub K, Walter P
• Isolation of a cDNA clone of the 14-kDa subunit of the signal recognition particle by cross-hybridization of differently primed polymerase chain reactions.
  Proceedings of the National Academy of Sciences of the United States of America 1989 Strub K, Walter P
• Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth.
  The Journal of cell biology 1989 Hann BC, Poritz MA, Walter P
• Signal recognition particle mediates a transient elongation arrest of preprolactin in reticulocyte lysate.
  The Journal of cell biology 1989 Wolin SL, Walter P
• Protein translocation across the endoplasmic reticulum membrane: identification by photocross-linking of a 39-kD integral membrane glycoprotein as part of a putative translocation tunnel.
  The Journal of cell biology 1989 Krieg UC, Johnson AE, Walter P
• Deletion analysis in the amino-terminal extension of methionyl-tRNA synthetase from Saccharomyces cerevisiae shows that a small region is important for the activity and stability of the enzyme.
  The Journal of biological chemistry 1989 Walter P, Weygand-Durasevic I, Sanni A, Ebel JP, Fasiolo F
• Cytosolic protein translocation factors. Is SRP still unique?
  Cell 1989 Bernstein HD, Rapoport TA, Walter P
• Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle.
  Nature 1989 Bernstein HD, Poritz MA, Strub K, Hoben PJ, Brenner S, Walter P
• Assembly of proteins in the endoplasmic reticulum.
  Current opinion in cell biology 1989 Siegel V, Walter P
• Cassette Mutagenic Analysis of the Yeast Invertase Signal Peptide: Effects on Protein Translocation.
  Molecular and Cellular Biology 1989 Johnny K. Ngsee, William Hansen, Peter Walter, Michael Smith
• Cassette mutagenic analysis of the yeast invertase signal peptide: effects on protein translocation.
  Molecular and Cellular Biology 1989 J K Ngsee, W Hansen, P Walter, M Smith
• Cassette mutagenic analysis of the yeast invertase signal peptide: effects on protein translocation.
  Molecular and cellular biology 1989 Ngsee JK, Hansen W, Walter P, Smith M
• Evidence for a two-step mechanism involved in assembly of functional signal recognition particle receptor.
  The Journal of cell biology 1989 Andrews DW, Lauffer L, Walter P, Lingappa VR
• The use of gene-fusions to determine membrane protein topology in Saccharomyces cerevisiae.
  Journal of cell science. Supplement 1989 Green GN, Hansen W, Walter P
• Ribosome pausing and stacking during translation of a eukaryotic mRNA.
  The EMBO journal 1988 Wolin SL, Walter P
• Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA.
  Nucleic acids research 1988 Lingelbach K, Zwieb C, Webb JR, Marshallsay C, Hoben PJ, Walter P, Dobberstein B
• Human SRP RNA and E. coli 4.5S RNA contain a highly homologous structural domain.
  Cell 1988 Poritz MA, Strub K, Walter P
• Functional dissection of the signal recognition particle.
  Trends in biochemical sciences 1988 Siegel V, Walter P
• Small ribonucleoproteins in Schizosaccharomyces pombe and Yarrowia lipolytica homologous to signal recognition particle.
  Proceedings of the National Academy of Sciences of the United States of America 1988 Poritz MA, Siegel V, Hansen W, Walter P
• The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length.
  The EMBO journal 1988 Siegel V, Walter P
• Heavy-chain binding protein recognizes aberrant polypeptides translocated in vitro.
  Nature 1988 Kassenbrock CK, Garcia PD, Walter P, Kelly RB
• Full-length prepro-alpha-factor can be translocated across the mammalian microsomal membrane only if translation has not terminated.
  The Journal of cell biology 1988 Garcia PD, Walter P
• Prepro-carboxypeptidase Y and a truncated form of pre-invertase, but not full-length pre-invertase, can be posttranslationally translocated across microsomal vesicle membranes from Saccharomyces cerevisiae.
  The Journal of cell biology 1988 Hansen W, Walter P
• Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm.
  The Journal of cell biology 1988 Garcia PD, Ou JH, Rutter WJ, Walter P
• Binding sites of the 19-kDa and 68/72-kDa signal recognition particle (SRP) proteins on SRP RNA as determined in protein-RNA "footprinting".
  Proceedings of the National Academy of Sciences of the United States of America 1988 Siegel V, Walter P
• Each of the activities of signal recognition particle (SRP) is contained within a distinct domain: analysis of biochemical mutants of SRP.
  Cell 1988 Siegel V, Walter P
• Evidence for an extended 7SL RNA structure in the signal recognition particle.
  The EMBO journal 1987 Andrews DW, Walter P, Ottensmeyer FP
• Functional dissection of the signal recognition particle.
  Molecular Biology Reports 1987 V. Siegel, M. Poritz, P. Walter
• Substrate requirements for SRP-mediated targeting to the ER membrane.
  Molecular Biology Reports 1987 V. Siegel, P. D. Garcia, P. Walter
• Signal recognition. Two receptors act sequentially.
  Nature 1987 Walter P
• Wild type and mutant signal peptides of Escherichia coli outer membrane lipoprotein interact with equal efficiency with mammalian signal recognition particle.
  The Journal of biological chemistry 1987 Garcia PD, Ghrayeb J, Inouye M, Walter P
• Mathematical modeling of the effects of the signal recognition particle on translation and translocation of proteins across the endoplasmic reticulum membrane.
  Journal of molecular biology 1987 Rapoport TA, Heinrich R, Walter P, Schulmeister T
• Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle.
  Proceedings of the National Academy of Sciences of the United States of America 1986 Krieg UC, Walter P, Johnson AE
• The signal recognition particle receptor is a complex that contains two distinct polypeptide chains.
  The Journal of cell biology 1986 Tajima S, Lauffer L, Rath VL, Walter P
• In vitro protein translocation across the yeast endoplasmic reticulum: ATP-dependent posttranslational translocation of the prepro-alpha-factor.
  Cell 1986 Hansen W, Garcia PD, Walter P
• Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.
  Nature 1986 Green S, Walter P, Kumar V, Krust A, Bornert JM, Argos P, Chambon P
• Removal of the Alu structural domain from signal recognition particle leaves its protein translocation activity intact.
  Nature 1986 Siegel V, Walter P
• Intracellular Protein Topogenesis.
  New Insights into Cell and Membrane Transport Processes 1986 Günter Blobel, Peter Walter, Reid Gilmore
• Mechanism of protein translocation across the endoplasmic reticulum membrane.
  Annual review of cell biology 1986 Walter P, Lingappa VR
• Structure and Function of the Signal Recognition Particle.
  Genetic Engineering 1986 Vivian Siegel, Peter Walter
• The Protein Translocation Machinery of the Endoplasmic Reticulum: The Signal Hypothesis Ten Years Later.
  Protein Compartmentalization 1986 Peter Walter, Vivian Siegel, Leander Lauffer, Pablo D. Garcia
• Topology of signal recognition particle receptor in endoplasmic reticulum membrane.
  Nature 1985 Lauffer L, Garcia PD, Harkins RN, Coussens L, Ullrich A, Walter P
• Elongation arrest is not a prerequisite for secretory protein translocation across the microsomal membrane.
  The Journal of cell biology 1985 Siegel V, Walter P
• Structure of the signal recognition particle by electron microscopy.
  Proceedings of the National Academy of Sciences of the United States of America 1985 Andrews DW, Walter P, Ottensmeyer FP
• Protein translocation across the endoplasmic reticulum.
  Cell 1984 Walter P, Gilmore R, Blobel G
• Role of signal recognition particle in the membrane assembly of Sindbis viral glycoproteins.
  European journal of biochemistry 1984 Bonatti S, Migliaccio G, Blobel G, Walter P
• Subcellular distribution of signal recognition particle and 7SL-RNA determined with polypeptide-specific antibodies and complementary DNA probe.
  The Journal of cell biology 1983 Walter P, Blobel G
• Disassembly and reconstitution of signal recognition particle.
  Cell 1983 Walter P, Blobel G
• Translocation of a lysosomal enzyme across the microsomal membrane requires signal recognition particle.
  Biochemical and biophysical research communications 1983 Erickson AH, Walter P, Blobel G
• Signal recognition particle: a ribonucleoprotein required for cotranslational translocation of proteins, isolation and properties.
  Methods in enzymology 1983 Walter P, Blobel G
• The protein translocation machinery of the endoplasmic reticulum.
  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1982 Walter P, Gilmore R, Müller M, Blobel G
• Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle.
  The Journal of cell biology 1982 Gilmore R, Blobel G, Walter P
• Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.
  The Journal of cell biology 1982 Gilmore R, Walter P, Blobel G
• A bacterial secretory protein requires signal recognition particle for translocation across mammalian endoplasmic reticulum.
  The Journal of biological chemistry 1982 Müller M, Ibrahimi I, Chang CN, Walter P, Blobel G
• Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum.
  Nature 1982 Walter P, Blobel G
• Signal recognition protein is required for the integration of acetylcholine receptor delta subunit, a transmembrane glycoprotein, into the endoplasmic reticulum membrane.
  The Journal of cell biology 1982 Anderson DJ, Walter P, Blobel G
• Mechanism of protein translocation across the endoplasmic reticulum.
  Biochemical Society symposium 1982 Walter P, Blobel G
• THE PROTEIN TRANSLOCATION MACHINERY OF THE ENDOPLASMIC RETICULUM.
  Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression 1982 PETER WALTER, REID GILMORE, MATTHIAS MULLER, GUNTER BLOBEL
• Translocation of proteins across the endoplasmic reticulum.
  Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine 1982 Walter P, Blobel G
• Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.
  The Journal of cell biology 1981 Walter P, Blobel G
• Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein.
  The Journal of cell biology 1981 Walter P, Ibrahimi I, Blobel G
• Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein.
  The Journal of cell biology 1981 Walter P, Blobel G
• Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum.
  Proceedings of the National Academy of Sciences of the United States of America 1980 Walter P, Blobel G
• Secretion requires a cytoplasmically disposed sulphydryl of the RER membrane.
  Nature 1980 Jackson RC, Walter P, Blobel G
• Translocation of proteins across membranes: the signal hypothesis and beyond.
  Symposia of the Society for Experimental Biology 1979 Blobel G, Walter P, Chang CN, Goldman BM, Erickson AH, Lingappa VR