Peter Turnbaugh, PhD
Professor
Microbiology and Immunology
School of Medicine

While we love sequencing and gnotobiotic mice, our work is question-driven not limited to a specific approach. Prior studies have ranged from the molecular (e.g., biochemistry, bacterial genetics, structural biology) to the organismal (e.g., gnotobiotic mice, conventional animals, and clinical trials) to the ecological (e.g., synthetic microbial communities and metagenomic sequencing). We embrace high-risk, high-reward projects and thrive on collaboration.

• Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states.
  bioRxiv : the preprint server for biology 2024 Babdor J, Patel RK, Davidson B, Noecker C, Rahim M, Bisanz JE, Tenvooren I, Marquez D, Calvo M, Johri V, McCarthy E, Shaheed A, Ekstrand C, Weakley AM, Yu FB, Fiehn O, Turnbaugh PJ, Combes AJ, …
• Human xenobiotic metabolism proteins have full-length and split homologs in the gut microbiome.
  bioRxiv : the preprint server for biology 2024 Rendina M, Turnbaugh PJ, Bradley PH
• Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme.
  Cell host & microbe 2024 Bae M, Le C, Mehta RS, Dong X, Pieper LM, Ramirez L, Alexander M, Kiamehr S, Turnbaugh PJ, Huttenhower C, Chan AT, Balskus EP
• A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.
  Cell reports 2024 Alexander M, Upadhyay V, Rock R, Ramirez L, Trepka K, Puchalska P, Orellana D, Ang QY, Whitty C, Turnbaugh JA, Tian Y, Dumlao D, Nayak R, Patterson A, Newman JC, Crawford PA, Turnbaugh PJ
• Expansion of a bacterial operon during cancer treatment ameliorates drug toxicity.
  bioRxiv : the preprint server for biology 2024 Trepka KR, Kidder WA, Kyaw TS, Halsey T, Olson CA, Ortega EF, Noecker C, Upadhyay V, Stanfield D, Steiding P, Guthrie BGH, Spanogiannopoulos P, Dumlao D, Turnbaugh JA, Stachler MD, Van Blarigan EL, …
• Metagenomic analysis during capecitabine therapy reveals microbial chemoprotective mechanisms and predicts drug toxicity in colorectal cancer patients.
  medRxiv : the preprint server for health sciences 2024 Hillege LE, Trepka KR, Ziemons J, Aarnoutse R, Guthrie BGH, de Vos-Geelen J, Iersel LV, van Hellemond IEG, Baars A, Vestjens JHMJ, Penders J, Deutschbauer A, Atreya CE, Kidder WA, Turnbaugh PJ, Smidt …
• Rationale and protocol for a safety, tolerability and feasibility randomized, parallel arm, double-blind, placebo-controlled, pilot study of a novel ketone ester targeting frailty via immunometabolic geroscience mechanisms.
  PloS one 2024 Stubbs BJ, Alvarez Azañedo G, Peralta S, Diaz SR, Gray W, Alexander L, Silverman-Martin W, Garcia TY, Blonquist TM, Upadhyay V, Turnbaugh PJ, Johnson JB, Newman JC
• Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice.
  Environmental health perspectives 2024 Tian Y, Rimal B, Bisanz JE, Gui W, Wolfe TM, Koo I, Murray IA, Nettleford SK, Yokoyama S, Dong F, Koshkin S, Prabhu KS, Turnbaugh PJ, Walk ST, Perdew GH, Patterson AD
• Pharma[e]cology: How the Gut Microbiome Contributes to Variations in Drug Response.
  Annual review of pharmacology and toxicology 2024 Trepka KR, Olson CA, Upadhyay V, Zhang C, Turnbaugh PJ
• Digesting the complex metabolic effects of diet on the host and microbiome.
  Cell 2024 Carmody RN, Varady K, Turnbaugh PJ
• Emerging tools and best practices for studying gut microbial community metabolism.
  Nature metabolism 2024 Noecker C, Turnbaugh PJ
• Short-Term Caloric Restriction Alters the Microbiome Modulating Resistance to Clostridioides difficile Infection.
  Current Developments in Nutrition 2024 Jingcheng Zhao, Arvid Sandforth, Shuchang Tian, Peter J Turnbaugh, Reiner Jumpertz Von Schwartzenberg, Jordan E Bisanz
• Effects of high dose aspartame-based sweetener on the gut microbiota and bone strength in young and aged mice.
  JBMR plus 2024 Cyphert EL, Liu C, Morales AL, Nixon JC, Blackford E, Garcia M, Cevallos N, Turnbaugh PJ, Brito IL, Booth SL, Hernandez CJ
• Human gut Actinobacteria boost drug absorption by secreting P-glycoprotein ATPase inhibitors.
  iScience 2024 Kyaw TS, Zhang C, Sandy M, Trepka K, Zhang S, Ramirez Hernandez LA, Ramirez L, Goh JJN, Yu K, Dimassa V, Bess EN, Brockert JG, Dumlao DS, Bisanz JE, Turnbaugh PJ
• Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas.
  Cell 2024 McCurry MD, D'Agostino GD, Walsh JT, Bisanz JE, Zalosnik I, Dong X, Morris DJ, Korzenik JR, Edlow AG, Balskus EP, Turnbaugh PJ, Huh JR, Devlin AS
• A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.
  bioRxiv : the preprint server for biology 2024 Alexander M, Upadhyay V, Rock R, Ramirez L, Trepka K, Puchalska P, Orellana D, Ang QY, Whitty C, Turnbaugh JA, Tian Y, Dumlao D, Nayak R, Patterson A, Newman JC, Crawford PA, Turnbaugh PJ
• Microbiome single cell atlases generated with a commercial instrument.
  bioRxiv : the preprint server for biology 2024 Li X, Xu L, Demaree B, Noecker C, Bisanz JE, Weisgerber DW, Modavi C, Turnbaugh PJ, Abate AR
• High fat intake sustains sorbitol intolerance after antibiotic-mediated Clostridia depletion from the gut microbiota.
  Cell 2024 Lee JY, Tiffany CR, Mahan SP, Kellom M, Rogers AWL, Nguyen H, Stevens ET, Masson HLP, Yamazaki K, Marco ML, Eloe-Fadrosh EA, Turnbaugh PJ, Bäumler AJ
• Effects of long-term high dose aspartame on body mass, bone strength, femoral geometry, and microbiota composition in a young and aged cohort of male and female mice.
  bioRxiv : the preprint server for biology 2024 Cyphert EL, Liu C, Morales AL, Nixon JC, Blackford E, Garcia M, Cevallos N, Turnbaugh PJ, Brito IL, Booth SL, Hernandez CJ
• Rationale and protocol for a safety, tolerability and feasibility randomized, parallel group, double-blind, placebo-controlled, pilot study of a novel ketone ester targeting frailty via immunometabolic geroscience mechanisms.
  medRxiv : the preprint server for health sciences 2023 Stubbs BJ, Alvarez-Azanedo G, Peralta S, Roa-Diaz S, Gray W, Alexander L, Silverman-Martin W, Garcia T, Blonquist TM, Upadhyay V, Turnbaugh PJ, Johnson JB, Newman JC
• Simvastatin induces human gut bacterial cell surface genes.
  Molecular microbiology 2023 Escalante V, Nayak RR, Noecker C, Babdor J, Spitzer M, Deutschbauer AM, Turnbaugh PJ
• Microbiome single cell atlases generated with a commercial instrument.
  Research square 2023 Abate A, Li X, Xu L, Demaree B, Noecker C, Bisanz J, Weisgerber D, Modavi C, Turnbaugh P
• Associations between the Gut Microbiota, Race, and Ethnicity of Patients with Colorectal Cancer: A Pilot and Feasibility Study.
  Cancers 2023 Piawah S, Kyaw TS, Trepka K, Stewart AL, Mora RV, Stanfield D, Levine K, Van Blarigan EL, Venook A, Turnbaugh PJ, Nguyen T, Atreya CE
• The global anaerobic metabolism regulator fnr is necessary for the degradation of food dyes and drugs by Escherichia coli.
  mBio 2023 Pieper LM, Spanogiannopoulos P, Volk RF, Miller CJ, Wright AT, Turnbaugh PJ
• Variety of Fruit and Vegetables and Alcohol Intake are Associated with Gut Microbial Species and Gene Abundance in Colorectal Cancer Survivors.
  The American journal of clinical nutrition 2023 Kyaw TS, Upadhyay V, Tolstykh I, Van Loon K, Laffan A, Stanfield D, Gempis D, Kenfield SA, Chan JM, Piawah S, Atreya CE, Ng K, Venook A, Kidder W, Turnbaugh PJ, Van Blarigan EL
• SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations.
  eLife 2023 Bustion AE, Nayak RR, Agrawal A, Turnbaugh PJ, Pollard KS
• Mild SARS-CoV-2 infection results in long-lasting microbiota instability.
  mBio 2023 Upadhyay V, Suryawanshi RK, Tasoff P, McCavitt-Malvido M, Kumar RG, Murray VW, Noecker C, Bisanz JE, Hswen Y, Ha CWY, Sreekumar B, Chen IP, Lynch SV, Ott M, Lee S, Turnbaugh PJ
• Systems biology elucidates the distinctive metabolic niche filled by the human gut microbe Eggerthella lenta.
  PLoS biology 2023 Noecker C, Sanchez J, Bisanz JE, Escalante V, Alexander M, Trepka K, Heinken A, Liu Y, Dodd D, Thiele I, DeFelice BC, Turnbaugh PJ
• Forging the microbiome to help us live long and prosper.
  PLoS biology 2023 Rock RR, Turnbaugh PJ
• Early-life exposure to a potent Aryl hydrocarbon receptor ligand results in persistent changes to the microbiota and host glucose homeostasis.
  2023 Yuan Tian, Bipin Rimal, Jordan E Bisanz, Wei Gui, Trenton M Wolfe, Imhoi Koo, Iain M Murray, Shaneice K Nettleford, Shigetoshi Yokoyama, Fangcong Dong, K Sandeep Prabhu, Peter J Turnbaugh, Seth T Walk…
• Genetic manipulation of the human gut bacterium Eggerthella lenta reveals a widespread family of transcriptional regulators.
  Nature communications 2022 Dong X, Guthrie BGH, Alexander M, Noecker C, Ramirez L, Glasser NR, Turnbaugh PJ, Balskus EP
• Mild SARS-CoV-2 infection results in long-lasting microbiota instability.
  bioRxiv : the preprint server for biology 2022 Upadhyay V, Suryawanshi R, Tasoff P, McCavitt-Malvido M, Kumar GR, Murray VW, Noecker C, Bisanz JE, Hswen Y, Ha C, Sreekumar B, Chen IP, Lynch SV, Ott M, Lee S, Turnbaugh PJ
• nicX-ing bad habits with your microbial friends.
  Nature metabolism 2022 Upadhyay V, Turnbaugh PJ
• Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism.
  Nature microbiology 2022 Spanogiannopoulos P, Kyaw TS, Guthrie BGH, Bradley PH, Lee JV, Melamed J, Malig YNA, Lam KN, Gempis D, Sandy M, Kidder W, Van Blarigan EL, Atreya CE, Venook A, Gerona RR, Goga A, Pollard KS, Turnbaugh…
• Tiny Gatekeepers: Microbial Control of Host Drug Transporters.
  Clinical pharmacology and therapeutics 2022 Kyaw TS, Turnbaugh PJ
• Designed secretion deters microbiome depletion.
  Nature microbiology 2022 Olson CA, Turnbaugh PJ
• Fluoropyrimidine Bioactivation and Metabolism by the Gut Microbiome.
  The FASEB Journal 2022 Benjamin G. H. Guthrie, Peter J. Turnbaugh
• The tiny pharmacists within: How the microbiome impacts the treatment of human disease.
  The FASEB Journal 2022 Peter J. Turnbaugh
• Tu1517: MICROBIAL SIGNALS, MYD88, AND LYMPHOTOXIN DRIVE TNFINDEPENDENT DEATH OF A20 AND ABIN-1 DEFICIENT EPITHELIUM.
  Gastroenterology 2022 Iulia Rusu, Elvira Mennillo, Jared L. Bain, Zhongmei Li, Xiaofei Sun, Kimberly Ly, Yenny Y. Rosli, Mohammad Naser, Zunqiu Wang, Rommel Advincula, Philip Achacoso, Ling Shao, Bahram Razani, Ophir D. …
• Effects of caloric restriction on the gut microbiome are linked with immune senescence.
  Microbiome 2022 Sbierski-Kind J, Grenkowitz S, Schlickeiser S, Sandforth A, Friedrich M, Kunkel D, Glauben R, Brachs S, Mai K, Thürmer A, Radonic A, Drechsel O, Turnbaugh PJ, Bisanz JE, Volk HD, Spranger J, von …
• Human gut bacteria produce ΤΗ17-modulating bile acid metabolites.
  Nature 2022 Paik D, Yao L, Zhang Y, Bae S, D'Agostino GD, Zhang M, Kim E, Franzosa EA, Avila-Pacheco J, Bisanz JE, Rakowski CK, Vlamakis H, Xavier RJ, Turnbaugh PJ, Longman RS, Krout MR, Clish CB, Rastinejad F, …
• Synthetic glycans control gut microbiome structure and mitigate colitis in mice.
  Nature communications 2022 Tolonen AC, Beauchemin N, Bayne C, Li L, Tan J, Lee J, Meehan BM, Meisner J, Millet Y, LeBlanc G, Kottler R, Rapp E, Murphy C, Turnbaugh PJ, von Maltzahn G, Liu CM, van Hylckama Vlieg JET
• Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage.
  The Journal of clinical investigation 2022 Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG
• Human gut bacterial metabolism drives Th17 activation and colitis.
  Cell host & microbe 2021 Alexander M, Ang QY, Nayak RR, Bustion AE, Sandy M, Zhang B, Upadhyay V, Pollard KS, Lynch SV, Turnbaugh PJ
• Reporting guidelines for human microbiome research: the STORMS checklist.
  Nature medicine 2021 Mirzayi C, Renson A, Genomic Standards Consortium, Massive Analysis and Quality Control Society, Zohra F, Elsafoury S, Geistlinger L, Kasselman LJ, Eckenrode K, van de Wijgert J, Loughman A, Marques …
• Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome.
  Cell reports 2021 Lam KN, Spanogiannopoulos P, Soto-Perez P, Alexander M, Nalley MJ, Bisanz JE, Nayak RR, Weakley AM, Yu FB, Turnbaugh PJ
• The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health.
  eLife 2021 Ang QY, Alba DL, Upadhyay V, Bisanz JE, Cai J, Lee HL, Barajas E, Wei G, Noecker C, Patterson AD, Koliwad SK, Turnbaugh PJ
• Caloric restriction disrupts the microbiota and colonization resistance.
  Nature 2021 von Schwartzenberg RJ, Bisanz JE, Lyalina S, Spanogiannopoulos P, Ang QY, Cai J, Dickmann S, Friedrich M, Liu SY, Collins SL, Ingebrigtsen D, Miller S, Turnbaugh JA, Patterson AD, Pollard KS, Mai K, …
• The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis.
  Arthritis & rheumatology (Hoboken, N.J.) 2021 Artacho A, Isaac S, Nayak R, Flor-Duro A, Alexander M, Koo I, Manasson J, Smith PB, Rosenthal P, Homsi Y, Gulko P, Pons J, Puchades-Carrasco L, Izmirly P, Patterson A, Abramson SB, Pineda-Lucena A, …
• Dissecting the contribution of host genetics and the microbiome in complex behaviors.
  Cell 2021 Buffington SA, Dooling SW, Sgritta M, Noecker C, Murillo OD, Felice DF, Turnbaugh PJ, Costa-Mattioli M
• Functional genetics of human gut commensal Bacteroides thetaiotaomicron reveals metabolic requirements for growth across environments.
  Cell reports 2021 Liu H, Shiver AL, Price MN, Carlson HK, Trotter VV, Chen Y, Escalante V, Ray J, Hern KE, Petzold CJ, Turnbaugh PJ, Huang KC, Arkin AP, Deutschbauer AM
• A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Man K, Bowman C, Braverman KN, Escalante V, Tian Y, Bisanz JE, Ganeshan K, Wang B, Patterson A, Bayrer JR, Turnbaugh PJ, Chawla A
• Gut microbiota-specific IgA+ B cells traffic to the CNS in active multiple sclerosis.
  Science immunology 2020 Pröbstel AK, Zhou X, Baumann R, Wischnewski S, Kutza M, Rojas OL, Sellrie K, Bischof A, Kim K, Ramesh A, Dandekar R, Greenfield AL, Schubert RD, Bisanz JE, Vistnes S, Khaleghi K, Landefeld J, Kirkish …
• Stressed-out gut bacteria are pterin up gut inflammation.
  Nature microbiology 2020 Alexander M, Turnbaugh PJ
• Deconstructing Mechanisms of Diet-Microbiome-Immune Interactions.
  Immunity 2020 Alexander M, Turnbaugh PJ
• Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections.
  Med (New York, N.Y.) 2020 Stubbs BJ, Koutnik AP, Goldberg EL, Upadhyay V, Turnbaugh PJ, Verdin E, Newman JC
• Probing the tumor micro(b)environment.
  Science (New York, N.Y.) 2020 Atreya CE, Turnbaugh PJ
• A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria.
  Cell host & microbe 2020 Bisanz JE, Soto-Perez P, Noecker C, Aksenov AA, Lam KN, Kenney GE, Bess EN, Haiser HJ, Kyaw TS, Yu FB, Rekdal VM, Ha CWY, Devkota S, Balskus EP, Dorrestein PC, Allen-Vercoe E, Turnbaugh PJ
• Effects of underfeeding and oral vancomycin on gut microbiome and nutrient absorption in humans.
  Nature medicine 2020 Basolo A, Hohenadel M, Ang QY, Piaggi P, Heinitz S, Walter M, Walter P, Parrington S, Trinidad DD, von Schwartzenberg RJ, Turnbaugh PJ, Krakoff J
• Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis-like disease and inflammation.
  Nature immunology 2020 Razani B, Whang MI, Kim FS, Nakamura MC, Sun X, Advincula R, Turnbaugh JA, Pendse M, Tanbun P, Achacoso P, Turnbaugh PJ, Malynn BA, Ma A
• Pharmacomicrobiomics in inflammatory arthritis: gut microbiome as modulator of therapeutic response.
  Nature reviews. Rheumatology 2020 Scher JU, Nayak RR, Ubeda C, Turnbaugh PJ, Abramson SB
• A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols.
  eLife 2020 Maini Rekdal V, Nol Bernadino P, Luescher MU, Kiamehr S, Le C, Bisanz JE, Turnbaugh PJ, Bess EN, Balskus EP
• Sensing Living Bacteria in Vivo Using d-Alanine-Derived 11C Radiotracers.
  ACS central science 2020 Parker MFL, Luu JM, Schulte B, Huynh TL, Stewart MN, Sriram R, Yu MA, Jivan S, Turnbaugh PJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM
• Diet should be a tool for researchers, not a treatment.
  Nature 2020 Turnbaugh PJ
• S4.3 - Impact of the human gut microbiome on drug disposition.
  Drug Metabolism and Pharmacokinetics 2020 Peter Turnbaugh
• Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria.
  Nature microbiology 2019 Bess EN, Bisanz JE, Yarza F, Bustion A, Rich BE, Li X, Kitamura S, Waligurski E, Ang QY, Alba DL, Spanogiannopoulos P, Nayfach S, Koliwad SK, Wolan DW, Franke AA, Turnbaugh PJ
• Using DNA Metabarcoding To Evaluate the Plant Component of Human Diets: a Proof of Concept.
  mSystems 2019 Reese AT, Kartzinel TR, Petrone BL, Turnbaugh PJ, Pringle RM, David LA
• Cooking shapes the structure and function of the gut microbiome.
  Nature microbiology 2019 Carmody RN, Bisanz JE, Bowen BP, Maurice CF, Lyalina S, Louie KB, Treen D, Chadaideh KS, Maini Rekdal V, Bess EN, Spanogiannopoulos P, Ang QY, Bauer KC, Balon TW, Pollard KS, Northen TR, Turnbaugh PJ
• CRISPR-Cas System of a Prevalent Human Gut Bacterium Reveals Hyper-targeting against Phages in a Human Virome Catalog.
  Cell host & microbe 2019 Soto-Perez P, Bisanz JE, Berry JD, Lam KN, Bondy-Denomy J, Turnbaugh PJ
• Author Correction: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2.
  Nature biotechnology 2019 Bolyen E, Rideout JR, Dillon MR, Bokulich NA, Abnet CC, Al-Ghalith GA, Alexander H, Alm EJ, Arumugam M, Asnicar F, Bai Y, Bisanz JE, Bittinger K, Brejnrod A, Brislawn CJ, Brown CT, Callahan BJ, …
• Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2.
  Nature biotechnology 2019 Bolyen E, Rideout JR, Dillon MR, Bokulich NA, Abnet CC, Al-Ghalith GA, Alexander H, Alm EJ, Arumugam M, Asnicar F, Bai Y, Bisanz JE, Bittinger K, Brejnrod A, Brislawn CJ, Brown CT, Callahan BJ, …
• Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet.
  Cell host & microbe 2019 Bisanz JE, Upadhyay V, Turnbaugh JA, Ly K, Turnbaugh PJ
• Precision Medicine Goes Microscopic: Engineering the Microbiome to Improve Drug Outcomes.
  Cell host & microbe 2019 Lam KN, Alexander M, Turnbaugh PJ
• Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism.
  Science (New York, N.Y.) 2019 Maini Rekdal V, Bess EN, Bisanz JE, Turnbaugh PJ, Balskus EP
• Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass.
  Cell metabolism 2019 Chagwedera DN, Ang QY, Bisanz JE, Leong YA, Ganeshan K, Cai J, Patterson AD, Turnbaugh PJ, Chawla A
• Megaphages infect Prevotella and variants are widespread in gut microbiomes.
  Nature microbiology 2019 Devoto AE, Santini JM, Olm MR, Anantharaman K, Munk P, Tung J, Archie EA, Turnbaugh PJ, Seed KD, Blekhman R, Aarestrup FM, Thomas BC, Banfield JF
• Predicting and preventing the inactivation of drugs by human gut bacteria.
  Drug Metabolism and Pharmacokinetics 2019 Peter Turnbaugh
• How to Determine the Role of the Microbiome in Drug Disposition.
  Drug metabolism and disposition: the biological fate of chemicals 2018 Bisanz JE, Spanogiannopoulos P, Pieper LM, Bustion AE, Turnbaugh PJ
• Broad collateral damage of drugs against the gut microbiome.
  Nature reviews. Gastroenterology & hepatology 2018 Spanogiannopoulos P, Turnbaugh PJ
• Announcement of 2019 Keystone Symposia Conference: "Microbiome: Chemical Mechanisms and Biological Consequences".
  mSystems 2018 Balskus EP, Turnbaugh PJ, Wolan DW
• A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling.
  Cell 2018 Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM
• Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins.
  eLife 2018 Koppel N, Bisanz JE, Pandelia ME, Turnbaugh PJ, Balskus EP
• Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories.
  Obesity reviews : an official journal of the International Association for the Study of Obesity 2018 Stanhope KL, Goran MI, Bosy-Westphal A, King JC, Schmidt LA, Schwarz JM, Stice E, Sylvetsky AC, Turnbaugh PJ, Bray GA, Gardner CD, Havel PJ, Malik V, Mason AE, Ravussin E, Rosenbaum M, Welsh JA, …
• The Metabolism of Fluoropyrimidine Anticancer Drugs by the Human Gut Microbiome.
  The FASEB Journal 2018 Peter Spanogiannopoulos, Andrew D. Patteron, Peter J. Turnbaugh
• Making Millennial Medicine More Meta.
  mSystems 2018 Turnbaugh PJ
• Grape proanthocyanidin-induced intestinal bloom of Akkermansia muciniphila is dependent on its baseline abundance and precedes activation of host genes related to metabolic health.
  The Journal of nutritional biochemistry 2018 Zhang L, Carmody RN, Kalariya HM, Duran RM, Moskal K, Poulev A, Kuhn P, Tveter KM, Turnbaugh PJ, Raskin I, Roopchand DE
• Combining 16S rRNA gene variable regions enables high-resolution microbial community profiling.
  Microbiome 2018 Fuks G, Elgart M, Amir A, Zeisel A, Turnbaugh PJ, Soen Y, Shental N
• Chemical reaction vector embeddings: towards predicting drug metabolism in the human gut microbiome.
  Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2018 Mallory EK, Acharya A, Rensi SE, Turnbaugh PJ, Bright RA, Altman RB
• Characterization of a cardiac drug-inactivating enzyme from the prominent human gut microbe, Eggerthella lenta.
  The FASEB Journal 2017 Nitzan Koppel, Jordan Bisanz, Peter Turnbaugh, Emily P Balskus
• Microbes and Diet-Induced Obesity: Fast, Cheap, and Out of Control.
  Cell host & microbe 2017 Turnbaugh PJ
• Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO).
  Acta pharmaceutica Sinica. B 2017 Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan ET, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, Zhong XB
• mockrobiota: a Public Resource for Microbiome Bioinformatics Benchmarking.
  mSystems 2016 Bokulich NA, Rideout JR, Mercurio WG, Shiffer A, Wolfe B, Maurice CF, Dutton RJ, Turnbaugh PJ, Knight R, Caporaso JG
• Metabolism of anticancer drugs by the human gut microbiome.
  Toxicology Letters 2016 P. Spanogiannopoulos, P.J. Turnbaugh
• Mirror, mirror on the wall: which microbiomes will help heal them all?
  BMC medicine 2016 Nayak RR, Turnbaugh PJ
• The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism.
  Nature reviews. Microbiology 2016 Spanogiannopoulos P, Bess EN, Carmody RN, Turnbaugh PJ
• Siri, What Should I Eat?
  Cell 2015 Jumpertz von Schwartzenberg R, Turnbaugh PJ
• Marked seasonal variation in the wild mouse gut microbiota.
  The ISME journal 2015 Maurice CF, Knowles SC, Ladau J, Pollard KS, Fenton A, Pedersen AB, Turnbaugh PJ
• Gut microbial succession follows acute secretory diarrhea in humans.
  mBio 2015 David LA, Weil A, Ryan ET, Calderwood SB, Harris JB, Chowdhury F, Begum Y, Qadri F, LaRocque RC, Turnbaugh PJ
• Characterization and detection of a widely distributed gene cluster that predicts anaerobic choline utilization by human gut bacteria.
  mBio 2015 Martínez-del Campo A, Bodea S, Hamer HA, Marks JA, Haiser HJ, Turnbaugh PJ, Balskus EP
• Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet-Induced Metabolic Syndrome.
  Diabetes 2015 Roopchand DE, Carmody RN, Kuhn P, Moskal K, Rojas-Silva P, Turnbaugh PJ, Raskin I
• Functional characterization of bacteria isolated from ancient arctic soil exposes diverse resistance mechanisms to modern antibiotics.
  PloS one 2015 Perron GG, Whyte L, Turnbaugh PJ, Goordial J, Hanage WP, Dantas G, Desai MM
• Diet dominates host genotype in shaping the murine gut microbiota.
  Cell host & microbe 2014 Carmody RN, Gerber GK, Luevano JM, Gatti DM, Somes L, Svenson KL, Turnbaugh PJ
• Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013.
  Microbiome 2014 Jacques Ravel, Martin J Blaser, Jonathan Braun, Eric Brown, Frederic D Bushman, Eugene B Chang, Julian Davies, Kathryn G Dewey, Timothy Dinan, Maria Dominguez-Bello, Susan E Erdman, B Brett Finlay, …
• Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness.
  Nature 2014 Pickard JM, Maurice CF, Kinnebrew MA, Abt MC, Schenten D, Golovkina TV, Bogatyrev SR, Ismagilov RF, Pamer EG, Turnbaugh PJ, Chervonsky AV
• Microbial determinants of biochemical individuality and their impact on toxicology and pharmacology.
  Cell metabolism 2014 Patterson AD, Turnbaugh PJ
• Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics.
  The Journal of clinical investigation 2014 Carmody RN, Turnbaugh PJ
• The intestinal metabolome: an intersection between microbiota and host.
  Gastroenterology 2014 Ursell LK, Haiser HJ, Van Treuren W, Garg N, Reddivari L, Vanamala J, Dorrestein PC, Turnbaugh PJ, Knight R
• Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics.
  Gut microbes 2014 Haiser HJ, Seim KL, Balskus EP, Turnbaugh PJ
• High-resolution microbial community reconstruction by integrating short reads from multiple 16S rRNA regions.
  Nucleic acids research 2013 Amir A, Zeisel A, Zuk O, Elgart M, Stern S, Shamir O, Turnbaugh PJ, Soen Y, Shental N
• Cancer: An acidic link.
  Nature 2013 Devkota S, Turnbaugh PJ
• Quantifying the metabolic activities of human-associated microbial communities across multiple ecological scales.
  FEMS microbiology reviews 2013 Maurice CF, Turnbaugh PJ
• Translating the human microbiome.
  Nature biotechnology 2013 Brown J, de Vos WM, DiStefano PS, Doré J, Huttenhower C, Knight R, Lawley TD, Raes J, Turnbaugh P
• Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity.
  Science translational medicine 2013 Liou AP, Paziuk M, Luevano JM, Machineni S, Turnbaugh PJ, Kaplan LM
• Quantifying and identifying the active and damaged subsets of indigenous microbial communities.
  Methods in enzymology 2013 Maurice CF, Turnbaugh PJ
• Antibiotic exposure promotes fat gain.
  Cell metabolism 2012 Liou AP, Turnbaugh PJ
• Gut microbes make for fattier fish.
  Cell host & microbe 2012 Carmody RN, Turnbaugh PJ
• Taking a metagenomic view of human nutrition.
  Current opinion in clinical nutrition and metabolic care 2012 Dutton RJ, Turnbaugh PJ
• Developing a metagenomic view of xenobiotic metabolism.
  Pharmacological research 2012 Haiser HJ, Turnbaugh PJ
• Microbiology: fat, bile and gut microbes.
  Nature 2012 Turnbaugh PJ
• Is it time for a metagenomic basis of therapeutics?
  Science (New York, N.Y.) 2012 Haiser HJ, Turnbaugh PJ
• 515 Weight-Independent Changes in Gut Microbial Ecology Regulate Adiposity Following Roux-en-Y Gastric Bypass Surgery in Mice.
  Gastroenterology 2012 Alice P. Liou, Jesus M. Luevano, Peter J. Turnbaugh, Lee M. Kaplan
• Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Greenblum S, Turnbaugh PJ, Borenstein E
• Detecting novel associations in large data sets.
  Science (New York, N.Y.) 2011 Reshef DN, Reshef YA, Finucane HK, Grossman SR, McVean G, Turnbaugh PJ, Lander ES, Mitzenmacher M, Sabeti PC
• Wild immunology: converging on the real world.
  Annals of the New York Academy of Sciences 2011 Babayan SA, Allen JE, Bradley JE, Geuking MB, Graham AL, Grencis RK, Kaufman J, McCoy KD, Paterson S, Smith KG, Turnbaugh PJ, Viney ME, Maizels RM, Pedersen AB
• Human health and disease in a microbial world.
  Frontiers in microbiology 2011 Turnbaugh PJ, Stintzi A
• Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans.
  The American journal of clinical nutrition 2011 Jumpertz R, Le DS, Turnbaugh PJ, Trinidad C, Bogardus C, Gordon JI, Krakoff J
• Companion animals symposium: microbes and health.
  Journal of animal science 2011 Swanson KS, Suchodolski JS, Turnbaugh PJ
• Taxonomic metagenome sequence assignment with structured output models.
  Nature methods 2011 Patil KR, Haider P, Pope PB, Turnbaugh PJ, Morrison M, Scheffer T, McHardy AC
• Removing noise from pyrosequenced amplicons.
  BMC bioinformatics 2011 Quince C, Lanzen A, Davenport RJ, Turnbaugh PJ
• The mind-body-microbial continuum.
  Dialogues in clinical neuroscience 2011 Gonzalez A, Stombaugh J, Lozupone C, Turnbaugh PJ, Gordon JI, Knight R
• Companion animals symposium: humanized animal models of the microbiome.
  Journal of animal science 2010 Gootenberg DB, Turnbaugh PJ
• A microbe-dependent viral key to Crohn's box.
  Science translational medicine 2010 Peterson DA, Turnbaugh PJ
• Viewing the human microbiome through three-dimensional glasses: integrating structural and functional studies to better define the properties of myriad carbohydrate-active enzymes.
  Acta crystallographica. Section F, Structural biology and crystallization communications 2010 Turnbaugh PJ, Henrissat B, Gordon JI
• Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Caporaso JG, Lauber CL, Walters WA, Berg-Lyons D, Lozupone CA, Turnbaugh PJ, Fierer N, Knight R
• QIIME allows analysis of high-throughput community sequencing data.
  Nature methods 2010 Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, Fierer N, Peña AG, Goodrich JK, Gordon JI, Huttley GA, Kelley ST, Knights D, Koenig JE, Ley RE, Lozupone CA, McDonald D, …
• Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Turnbaugh PJ, Quince C, Faith JJ, McHardy AC, Yatsunenko T, Niazi F, Affourtit J, Egholm M, Henrissat B, Knight R, Gordon JI
• The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice.
  Science translational medicine 2009 Turnbaugh PJ, Ridaura VK, Faith JJ, Rey FE, Knight R, Gordon JI
• The core gut microbiome, energy balance and obesity.
  The Journal of physiology 2009 Turnbaugh PJ, Gordon JI
• Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Mahowald MA, Rey FE, Seedorf H, Turnbaugh PJ, Fulton RS, Wollam A, Shah N, Wang C, Magrini V, Wilson RK, Cantarel BL, Coutinho PM, Henrissat B, Crock LW, Russell A, Verberkmoes NC, Hettich RL, Gordon …
• A core gut microbiome in obese and lean twins.
  Nature 2008 Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, Egholm M, Henrissat B, Heath AC, Knight R, Gordon JI
• An invitation to the marriage of metagenomics and metabolomics.
  Cell 2008 Turnbaugh PJ, Gordon JI
• Evolution of mammals and their gut microbes.
  Science (New York, N.Y.) 2008 Ley RE, Hamady M, Lozupone C, Turnbaugh PJ, Ramey RR, Bircher JS, Schlegel ML, Tucker TA, Schrenzel MD, Knight R, Gordon JI
• Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome.
  Cell host & microbe 2008 Turnbaugh PJ, Bäckhed F, Fulton L, Gordon JI
• Host-bacterial coevolution and the search for new drug targets.
  Current opinion in chemical biology 2008 Zaneveld J, Turnbaugh PJ, Lozupone C, Ley RE, Hamady M, Gordon JI, Knight R
• The human microbiome project.
  Nature 2007 Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI
• Microbial ecology: human gut microbes associated with obesity.
  Nature 2006 Ley RE, Turnbaugh PJ, Klein S, Gordon JI
• Metagenomic analysis of the human distal gut microbiome.
  Science (New York, N.Y.) 2006 Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, Gordon JI, Relman DA, Fraser-Liggett CM, Nelson KE
• Discovery, validation, and genetic dissection of transcription factor binding sites by comparative and functional genomics.
  Genome research 2005 Gertz J, Riles L, Turnbaugh P, Ho SW, Cohen BA
• Obesity alters gut microbial ecology.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Ley RE, Bäckhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI