Peter Sargent, PhD
Professor Emeritus
Cell and Tissue Biology
School of Dentistry

Education & Training

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• postdoctoral Neurobiology/School of Medicine Stanford University 1979
• postdoctoral Physiology/School of Medicine UC San Francisco 1978
• PhD Neurobiology Harvard University 1975
• AB Amherst College 1969

Grants and Projects

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• Nicotinic Synaptic Mechanisms in Chick Ciliary Ganglion, NIH, 2007-2012
• Neuronal Nicotinic Acetylcholine Receptors, NIH, 1986-2001
• Pre &Postsynaptic Nicotinic Achrs--Structure &Function, NIH, 1996-2001
• Postsynaptic Proteins at the Neuromuscular Junction, NIH, 1977-2000
• Synapse Formation and Growth in an Autonomic Ganglion, NIH, 1986-1989
• Neuronal Nicotinic Acetylcholine Receptors, NIH, 1985-1986

Publications (40)

Top publication keywords:
Synaptic TransmissionAcetylcholinePresynaptic TerminalsGanglia, AutonomicProtein SubunitsReceptors, CholinergicReceptors, NicotinicDenervationSynapsesChick EmbryoGangliaNeuronsRana pipiensParasympathetic Nervous SystemGanglia, Parasympathetic

• α7-Containing and non-α7-containing nicotinic receptors respond differently to spillover of acetylcholine.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Stanchev D, Sargent PB
• Nicotinic receptors concentrated in the subsynaptic membrane do not contribute significantly to synaptic currents at an embryonic synapse in the chicken ciliary ganglion.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Sargent PB
• Evolution and revolution: the curriculum reform process at UCSF.
  Journal of dental education 2008 Ryder MI, Sargent P, Perry D
• Rapid vesicular release, quantal variability, and spillover contribute to the precision and reliability of transmission at a glomerular synapse.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Sargent PB, Saviane C, Nielsen TA, DiGregorio DA, Silver RA
• Rapid activation of presynaptic nicotinic acetylcholine receptors by nerve-released transmitter.
  The European journal of neuroscience 2003 Rogers M, Sargent PB

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• Synaptic vesicle recycling at two classes of release sites in giant nerve terminals of the embryonic chicken ciliary ganglion.
  The Journal of comparative neurology 2002 Nguyen D, Sargent PB
• Properties of nicotinic receptors underlying Renshaw cell excitation by alpha-motor neurons in neonatal rat spinal cord.
  Journal of neurophysiology 2002 Dourado M, Sargent PB
• Efficient construction of a large nonimmune phage antibody library: the production of high-affinity human single-chain antibodies to protein antigens.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Sheets MD, Amersdorfer P, Finnern R, Sargent P, Lindquist E, Schier R, Hemingsen G, Wong C, Gerhart JC, Marks JD, Lindqvist E
• Rapid synaptic transmission in the avian ciliary ganglion is mediated by two distinct classes of nicotinic receptors.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1997 Ullian EM, McIntosh JM, Sargent PB
• Effects of denervation on acetylcholine receptor clusters on frog cardiac ganglion neurons as revealed by quantitative laser scanning confocal microscopy.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1996 Horch HL, Sargent PB
• Synaptic and extrasynaptic distribution of two distinct populations of nicotinic acetylcholine receptor clusters in the frog cardiac ganglion.
  Journal of neurocytology 1996 Wilson Horch HL, Sargent PB
• Perisynaptic surface distribution of multiple classes of nicotinic acetylcholine receptors on neurons in the chicken ciliary ganglion.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1995 Horch HL, Sargent PB
• Pronounced cellular diversity and extrasynaptic location of nicotinic acetylcholine receptor subunit immunoreactivities in the chicken pretectum.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1995 Ullian EM, Sargent PB
• The characterization of alpha-bungarotoxin receptors on the surface of parasympathetic neurons in the frog heart.
  Brain research 1995 Sargent PB, Garrett EN
• Double-label immunofluorescence with the laser scanning confocal microscope using cyanine dyes.
  NeuroImage 1994 Sargent PB
• The diversity of neuronal nicotinic acetylcholine receptors.
  Annual review of neuroscience 1993 Sargent PB
• The role of acetylcholinesterase in denervation supersensitivity in the frog cardiac ganglion.
  The Journal of physiology 1992 Streichert LC, Sargent PB
• Denervation does not alter the number of neuronal bungarotoxin binding sites on autonomic neurons in the frog cardiac ganglion.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1991 Sargent PB, Bryan GK, Streichert LC, Garrett EN
• Differential effects of denervation on acetylcholinesterase activity in parasympathetic and sympathetic ganglia of the frog, Rana pipiens.
  Journal of neurobiology 1990 Streichert LC, Sargent PB
• Acetylcholine receptor-like molecules are found in both synaptic and extrasynaptic clusters on the surface of neurons in the frog cardiac ganglion.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1989 Sargent PB, Pang DZ
• Bouton ultrastructure and synaptic growth in a frog autonomic ganglion.
  The Journal of comparative neurology 1989 Streichert LC, Sargent PB
• Nicotinic acetylcholine receptor-like molecules in the retina, retinotectal pathway, and optic tectum of the frog.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1989 Sargent PB, Pike SH, Nadel DB, Lindstrom JM
• Denervation alters the size, number, and distribution of clusters of acetylcholine receptor-like molecules on frog cardiac ganglion neurons.
  Neuron 1988 Sargent PB, Pang DZ
• Growth and morphogenesis of an autonomic ganglion. I. Matching neurons with target.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1987 Heathcote RD, Sargent PB
• Growth and morphogenesis of an autonomic ganglion. II. Establishment of neuron position.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1987 Heathcote RD, Sargent PB
• Using monoclonal antibodies to determine the structures of acetylcholine receptors from electric organs, muscles, and neurons.
  Annals of the New York Academy of Sciences 1987 Lindstrom J, Criado M, Ratnam M, Whiting P, Ralston S, Rivier J, Sarin V, Sargent P
• Location of antigenic determinants on primary sequences of subunits of nicotinic acetylcholine receptor by peptide mapping.
  Biochemistry 1986 Ratnam M, Sargent PB, Sarin V, Fox JL, Nguyen DL, Rivier J, Criado M, Lindstrom J
• Transmembrane topography of nicotinic acetylcholine receptor: immunochemical tests contradict theoretical predictions based on hydrophobicity profiles.
  Biochemistry 1986 Ratnam M, Nguyen DL, Rivier J, Sargent PB, Lindstrom J
• Loss of supernumerary axons during neuronal morphogenesis.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1985 Heathcote RD, Sargent PB
• The genesis and differentiation of neurons in a frog parasympathetic ganglion.
  Developmental biology 1984 Heathcote RD, Sargent PB
• Structure and transmembrane nature of the acetylcholine receptor in amphibian skeletal muscle as revealed by cross-reacting monoclonal antibodies.
  The Journal of cell biology 1984 Sargent PB, Hedges BE, Tsavaler L, Clemmons L, Tzartos S, Lindstrom JM
• The number of synaptic boutons terminating on Xenopus cardiac ganglion cells is directly correlated with cell size.
  The Journal of physiology 1983 Sargent PB
• The influence of normal innervation upon abnormal synaptic connections between frog parasympathetic neurons.
  Developmental biology 1981 Sargent PB, Dennis MJ
• Acetylcholine receptors in regenerating muscle accumulate at original synaptic sites in the absence of the nerve.
  The Journal of cell biology 1979 Burden SJ, Sargent PB, McMahan UJ
• Loss of extrasynaptic acetylcholine sensitivity upon reinnervation of parasympathetic ganglion cells.
  The Journal of physiology 1979 Dennis MJ, Sargent PB
• Multiple innervation of normal and re-innervated parasympathetic neurones in the frog cardiac ganglion.
  The Journal of physiology 1978 Dennis MJ, Sargent PB
• Formation of synapses between parasympathetic neurones deprived of preganglionic innervation.
  Nature 1977 Sargent PB, Dennis MJ
• Extrasynaptic receptors on cell bodies of neurons in central nervous system of the leech.
  Journal of neurophysiology 1977 Sargent PB, Yau KW, Nicholls JG
• Synthesis of acetylcholine by excitatory motoneurons in central nervous system of the leech.
  Journal of neurophysiology 1977 Sargent PB
• Binding of -bungarotoxin to acetylcholine receptors in mammalian muscle (snake venom-denervated muscle-neonatal muscle-rat diaphragm-SDS-polyacrylamide gel electrophoresis).
  Proceedings of the National Academy of Sciences of the United States of America 1972 Berg DK, Kelly RB, Sargent PB, Williamson P, Hall ZW