Peter Kotsonis, PhD
AVC Hlth Tech, Innov & P'ship
Innovation Ventures
Chancellor/EVC/FAS

Publications (12)

Top publication keywords:
Quantitative Structure-Activity RelationshipSplanchnic CirculationStructure-Activity RelationshipPteridinesTRPV Cation ChannelsVascular ResistanceNitric Oxide SynthaseCapsaicinVasoconstrictionReceptors, Formyl PeptideQuinazolinesEnzyme InhibitorsIsoenzymesNerve Fibers, UnmyelinatedMesenteric Arteries

• Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain.
  Journal of medicinal chemistry 2006 Culshaw AJ, Bevan S, Christiansen M, Copp P, Davis A, Davis C, Dyson A, Dziadulewicz EK, Edwards L, Eggelte H, Fox A, Gentry C, Groarke A, Hallett A, Hart TW, Hughes GA, Knights S, Kotsonis P, Lee W, …
• Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases.
  Journal of medicinal chemistry 2005 Matter H, Kumar HS, Fedorov R, Frey A, Kotsonis P, Hartmann E, Fröhlich LG, Reif A, Pfleiderer W, Scheurer P, Ghosh DK, Schlichting I, Schmidt HH
• Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction.
  Circulation research 2004 Scotland RS, Chauhan S, Davis C, De Felipe C, Hunt S, Kabir J, Kotsonis P, Oh U, Ahluwalia A
• Biology and Chemistry of the Inhibition of Nitric Oxide Synthases by Pteridine-Derivatives as Therapeutic Agents.
  ChemInform 2004 Hans Matter, Peter Kotsonis
• Biology and chemistry of the inhibition of nitric oxide synthases by pteridine-derivatives as therapeutic agents.
  Medicinal research reviews 2004 Matter H, Kotsonis P

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• N-Formyl peptide receptor subtypes in human neutrophils activate L-plastin phosphorylation through different signal transduction intermediates.
  The Biochemical journal 2004 Paclet MH, Davis C, Kotsonis P, Godovac-Zimmermann J, Segal AW, Dekker LV
• Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors.
  Journal of medicinal chemistry 2002 Matter H, Kotsonis P, Klingler O, Strobel H, Fröhlich LG, Frey A, Pfleiderer W, Schmidt HH
• Life Sci
  Modulation of acetylcholine release from mouse cortex by protein kinase C: dependence on stimulation intensity. 2000 Iannazzo L, Kotsonis P, Majewski H.
• Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide.
  Biochemical Journal 2000 Peter KOTSONIS, Lothar G. FRÖHLICH, Zhanna V. SHUTENKO, Renate HOREJSI, Wolfgang PFLEIDERER, Harald H. H. W. SCHMIDT
• Eur J Pharmacol
  Structural determinants of phorbol ester binding in synaptosomes: pharmacokinetics and pharmacodynamics. 1999 Murphy TV, Prountzos C, Kotsonis P, Iannazzo L, Majewski H.
• Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity.
  Biochemical Journal 1999 Peter KOTSONIS, FREY Armin, Lothar G. FRÖHLICH, Heinrich HOFMANN, REIF Andreas, David A. WINK, Martin FEELISCH, Harald H. H. W. SCHMIDT
• Br J Pharmacol
  The structural requirements for phorbol esters to enhance serotonin and acetylcholine release from rat brain cortex. 1999 Iannazzo L, Kotsonis P, Majewski H.