Peter Ganz, MD
Professor
Medicine
School of Medicine

His laboratory was the first to describe vascular endothelial function in the state of health and endothelial dysfunction in atherosclerosis in humans (N Engl J Med 1986; 315:1046-1051). He identified risk factors associated with endothelial dysfunction (Circulation 1990; 81:491-497) and showed that endothelial dysfunction can be corrected with statin therapy (N Engl J Med 1995; 332:488-493). Currently, Dr. Ganz is making important discoveries in another field - precision medicine enabled by proteomics and machine learning. He is using modified aptamers as binding reagents to quantify the levels of thousands of proteins simultaneously in blood in order to elucidate the risk and biological basis of diseases (JAMA 2016;315:2532-2541; Circulation 2018;137:999-1010; Nature Medicine 2019;25:1851-1857). Dr. Ganz has authored over 250 peer-reviewed articles, many widely cited and published in the top tier medical journals. Numerous trainees who worked in Dr. Ganz’s laboratory have gone onto key leadership positions in academic medicine nationally and internationally. Dr. Ganz served as the Chief of the Cardiovascular Division at Zuckerberg San Francisco General Hospital and Maurice Eliaser Distinguished Professor of Medicine at University of California, San Francisco from 2008 to 2019. Dr. Ganz received his M.D. from Harvard Medical School, completed his residency at the Massachusetts General Hospital and cardiovascular fellowship at the Brigham and Women’s Hospital. He spent 25 years directing cardiovascular research in the Cardiac Catheterization Laboratories at the Brigham and Women’s Hospital and Harvard Medical School, prior to arriving to the University of California, San Francisco in 2008.

• Evaluation of Associations of Growth Differentiation Factor-11, Growth Differentiation Factor-8, and Their Binding Proteins, Follistatin and Follistatin-Like Protein-3, With Measures of Skeletal Muscle Mass, Muscle Strength, and Physical Function in Older Adults.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2023 Cawthon PM, Patel S, Newman AB, Bhasin S, Peng L, Tracy RP, Kizer JR, Lee SJ, Ferrucci L, Ganz P, LeBrasseur NK, Cummings SR
• Proteomics of CKD progression in the chronic renal insufficiency cohort.
  Nature communications 2023 Dubin RF, Deo R, Ren Y, Wang J, Zheng Z, Shou H, Go AS, Parsa A, Lash JP, Rahman M, Hsu CY, Weir MR, Chen J, Anderson A, Grams ME, Surapaneni A, Coresh J, Li H, Kimmel PL, Vasan RS, Feldman H, Segal …
• Efficacy of Continuous Transdermal Nitroglycerin for Treating Hot Flashes by Inducing Nitrate Cross-tolerance in Perimenopausal and Postmenopausal Women: A Randomized Clinical Trial.
  JAMA internal medicine 2023 Huang AJ, Cummings SR, Ganz P, Schembri M, Raghunathan H, Vittinghoff E, Gibson CJ, Grady D
• Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life.
  Science translational medicine 2023 Walker KA, Chen J, Shi L, Yang Y, Fornage M, Zhou L, Schlosser P, Surapaneni A, Grams ME, Duggan MR, Peng Z, Gomez GT, Tin A, Hoogeveen RC, Sullivan KJ, Ganz P, Lindbohm JV, Kivimaki M, Nevado-Holgado…
• Associations of circulating proteins with lipoprotein profiles: proteomic analyses from the OmniHeart randomized trial and the Atherosclerosis Risk in Communities (ARIC) Study.
  Clinical proteomics 2023 Kim H, Lichtenstein AH, Ganz P, Miller ER, Coresh J, Appel LJ, Rebholz CM
• Proteomic cardiovascular risk assessment in chronic kidney disease.
  European heart journal 2023 Deo R, Dubin RF, Ren Y, Murthy AC, Wang J, Zheng H, Zheng Z, Feldman H, Shou H, Coresh J, Grams M, Surapaneni AL, Bhat Z, Cohen JB, Rahman M, He J, Saraf SL, Go AS, Kimmel PL, Vasan RS, Segal MR, Li H…
• Analytical and Biological Variability of a Commercial Modified Aptamer Assay in Plasma Samples of Patients with Chronic Kidney Disease.
  The journal of applied laboratory medicine 2023 Dubin RF, Deo R, Ren Y, Lee H, Shou H, Feldman H, Kimmel P, Waikar SS, Rhee EP, Tin A, Chen J, Coresh J, Go AS, Kelly T, Rao PS, Chen TK, Segal MR, Ganz P
• Identification of Protein Biomarkers of the Dietary Approaches to Stop Hypertension Diet in Randomized Feeding Studies and Validation in an Observational Study.
  Journal of the American Heart Association 2023 Kim H, Lichtenstein AH, Ganz P, Du S, Tang O, Yu B, Chatterjee N, Appel LJ, Coresh J, Rebholz CM
• Alterations in the Circulating Proteome Associated with Albuminuria.
  Journal of the American Society of Nephrology : JASN 2023 Kiernan E, Surapaneni A, Zhou L, Schlosser P, Walker KA, Rhee EP, Ballantyne CM, Deo R, Dubin RF, Ganz P, Coresh J, Grams ME
• Plasma Protein Biomarkers of Healthy Dietary Patterns: Results from the Atherosclerosis Risk in Communities Study and the Framingham Heart Study.
  The Journal of nutrition 2022 Du S, Chen J, Kim H, Walker ME, Lichtenstein AH, Chatterjee N, Ganz P, Yu B, Vasan RS, Coresh J, Rebholz CM
• Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels.
  Arteriosclerosis, thrombosis, and vascular biology 2022 Mohammadi L, Han DD, Xu F, Huang A, Derakhshandeh R, Rao P, Whitlatch A, Cheng J, Keith RJ, Hamburg NM, Ganz P, Hellman J, Schick SF, Springer ML
• Testican-2 Is Associated with Reduced Risk of Incident ESKD.
  Journal of the American Society of Nephrology : JASN 2022 Wen D, Zhou L, Zheng Z, Surapaneni A, Ballantyne CM, Hoogeveen RC, Shlipak MG, Waikar SS, Vasan RS, Kimmel PL, Dubin RF, Deo R, Feldman HI, Ganz P, Coresh J, Grams ME, Rhee EP, CKD Biomarkers …
• Response to comment on "A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk".
  Science translational medicine 2022 Williams SA, Ganz P
• Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls.
  Journal of the Endocrine Society 2022 Parikh NI, Arowolo F, Durstenfeld MS, Nah G, Njoroge J, Vittinghoff E, Long CS, Ganz P, Pearce D, Hsue P, Wu AHS, Hajizadeh N, Liu KD, Lynch KL
• A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk.
  Science translational medicine 2022 Williams SA, Ostroff R, Hinterberg MA, Coresh J, Ballantyne CM, Matsushita K, Mueller CE, Walter J, Jonasson C, Holman RR, Shah SH, Sattar N, Taylor R, Lean ME, Kato S, Shimokawa H, Sakata Y, Nochioka…
• Effect of HIV-1 Infection on Angiopoietin 1 and 2 Levels and Measures of Microvascular and Macrovascular Endothelial Dysfunction.
  Journal of the American Heart Association 2021 Thakkar AB, Ma Y, Dela Cruz M, Wu Y, Arechiga V, Swaminathan S, Ganz P, Wu AHB, Scherzer R, Deeks S, Hsue PY
• Proteins Associated with Risk of Kidney Function Decline in the General Population.
  Journal of the American Society of Nephrology : JASN 2021 Grams ME, Surapaneni A, Chen J, Zhou L, Yu Z, Dutta D, Welling PA, Chatterjee N, Zhang J, Arking DE, Chen TK, Rebholz CM, Yu B, Schlosser P, Rhee EP, Ballantyne CM, Boerwinkle E, Lutsey PL, Mosley T, …
• Comparison of proteomic methods in evaluating biomarker-AKI associations in cardiac surgery patients.
  Translational research : the journal of laboratory and clinical medicine 2021 Liu RX, Thiessen-Philbrook HR, Vasan RS, Coresh J, Ganz P, Bonventre JV, Kimmel PL, Parikh CR
• Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk.
  Nature aging 2021 Walker KA, Chen J, Zhang J, Fornage M, Yang Y, Zhou L, Grams ME, Tin A, Daya N, Hoogeveen RC, Wu A, Sullivan KJ, Ganz P, Zeger SL, Gudmundsson EF, Emilsson V, Launer LJ, Jennings LL, Gudnason V, …
• Proteomics for personalized cardiovascular risk assessment: in pursuit of the Holy Grail.
  European heart journal 2020 Ganz P, Deo R, Dubin RF
• Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease.
  Journal of the American Heart Association 2020 Yang J, Brody EN, Murthy AC, Mehler RE, Weiss SJ, DeLisle RK, Ostroff R, Williams SA, Ganz P
• Mechanisms of Sodium-Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics.
  Diabetes care 2020 Ferrannini E, Murthy AC, Lee YH, Muscelli E, Weiss S, Ostroff RM, Sattar N, Williams SA, Ganz P
• Do Ambient Ozone or Other Pollutants Modify Effects of Controlled Ozone Exposure on Pulmonary Function?
  Annals of the American Thoracic Society 2020 Rich DQ, Thurston SW, Balmes JR, Bromberg PA, Arjomandi M, Hazucha MJ, Alexis NE, Ganz P, Zareba W, Thevenet-Morrison K, Koutrakis P, Frampton MW
• Nonsurgical Periodontal Therapy in CKD: Findings of the Kidney and Periodontal Disease (KAPD) Pilot Randomized Controlled Trial.
  Kidney medicine 2019 Grubbs V, Garcia F, Vittinghoff E, Jue BL, Ryder M, Lovett DH, Offenbacher S, Taylor G, Ganz P, Bibbins-Domingo K, Powe NR
• Plasma protein patterns as comprehensive indicators of health.
  Nature medicine 2019 Williams SA, Kivimaki M, Langenberg C, Hingorani AD, Casas JP, Bouchard C, Jonasson C, Sarzynski MA, Shipley MJ, Alexander L, Ash J, Bauer T, Chadwick J, Datta G, DeLisle RK, Hagar Y, Hinterberg M, …
• Emerging Affinity Reagents for High Throughput Proteomics: Trust, but Verify.
  Circulation 2019 Benson MD, Ngo D, Ganz P, Gerszten RE
• William Ganz and His Legacy.
  Annals of internal medicine 2019 Ganz T, Ganz P
• Echocardiographic determination of pulmonary arterial capacitance.
  The international journal of cardiovascular imaging 2019 Papolos A, Fan E, Wagle RR, Foster E, Boyle AJ, Yeghiazarians Y, MacGregor JS, Grossman W, Schiller NB, Ganz P, Tison GH
• Vascular Aging Is Accelerated in Flight Attendants With Occupational Secondhand Smoke Exposure.
  Journal of occupational and environmental medicine 2019 Wei J, Shufelt C, Oestreicher Stock E, Mills C, Dhawan S, Jacob R, Torbati T, Cook-Wiens G, Benowitz N, Jacob P, Ganz P, Bairey Merz CN, Redberg R
• Associations of microvascular dysfunction with cardiovascular outcomes: The cardiac, endothelial function and arterial stiffness in ESRD (CERES) cohort.
  Hemodialysis international. International Symposium on Home Hemodialysis 2019 Ayer A, Mills C, Donovan C, Christenson RH, Ganz P, Dubin RF
• Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation.
  American journal of physiology. Heart and circulatory physiology 2019 Conklin DJ, Schick S, Blaha MJ, Carll A, DeFilippis A, Ganz P, Hall ME, Hamburg N, O'Toole T, Reynolds L, Srivastava S, Bhatnagar A
• Reproducibility and Variability of Protein Analytes Measured Using a Multiplexed Modified Aptamer Assay.
  The journal of applied laboratory medicine 2019 Tin A, Yu B, Ma J, Masushita K, Daya N, Hoogeveen RC, Ballantyne CM, Couper D, Rebholz CM, Grams ME, Alonso A, Mosley T, Heiss G, Ganz P, Selvin E, Boerwinkle E, Coresh J
• Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study.
  PloS one 2018 Dubin RF, Whooley M, Pico A, Ganz P, Schiller NB, Meyer C
• Unique Circulating MicroRNA Profiles in HIV Infection.
  Journal of acquired immune deficiency syndromes (1999) 2018 Narla V, Bhakta N, Freedman JE, Tanriverdi K, Maka K, Deeks SG, Ganz P, Hsue P
• IL-1β Inhibition Reduces Atherosclerotic Inflammation in HIV Infection.
  Journal of the American College of Cardiology 2018 Hsue PY, Li D, Ma Y, Ishai A, Manion M, Nahrendorf M, Ganz P, Ridker PM, Deeks SG, Tawakol A
• Higher incidence of vasodilator-induced left ventricular cavity dilation by PET when compared to treadmill exercise-ECHO in hypertrophic cardiomyopathy.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2018 Lu DY, Yalçin H, Sivalokanathan S, Greenland GV, Vasquez N, Yalçin F, Zhao M, Valenta I, Ganz P, Pampaloni MH, Zimmerman S, Schindler TH, Abraham TP, Abraham MR
• Cardiovascular function and ozone exposure: The Multicenter Ozone Study in oldEr Subjects (MOSES).
  Environment international 2018 Rich DQ, Balmes JR, Frampton MW, Zareba W, Stark P, Arjomandi M, Hazucha MJ, Costantini MG, Ganz P, Hollenbeck-Pringle D, Dagincourt N, Bromberg PA
• Association of Osteopontin, Neopterin, and Myeloperoxidase With Stroke Risk in Patients With Prior Stroke or Transient Ischemic Attacks: Results of an Analysis of 13 Biomarkers From the Stroke Prevention by Aggressive Reduction in Cholesterol Levels Trial.
  Stroke 2017 Ganz P, Amarenco P, Goldstein LB, Sillesen H, Bao W, Preston GM, Welch KMA, SPARCL Steering Committee
• Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib.
  Circulation 2017 Williams SA, Murthy AC, DeLisle RK, Hyde C, Malarstig A, Ostroff R, Weiss SJ, Segal MR, Ganz P
• Sex differences in vascular dysfunction and cardiovascular outcomes: The cardiac, endothelial function, and arterial stiffness in ESRD (CERES) study.
  Hemodialysis international. International Symposium on Home Hemodialysis 2017 Guajardo I, Ayer A, Johnson AD, Ganz P, Mills C, Donovan C, Scherzer R, Shah SJ, Peralta CA, Dubin RF
• Association of Arterial and Lymph Node Inflammation With Distinct Inflammatory Pathways in Human Immunodeficiency Virus Infection.
  JAMA cardiology 2017 Tawakol A, Ishai A, Li D, Takx RA, Hur S, Kaiser Y, Pampaloni M, Rupert A, Hsu D, Sereti I, Fromentin R, Chomont N, Ganz P, Deeks SG, Hsue PY
• In Reply.
  Menopause (New York, N.Y.) 2017 Huang AJ, Ganz P, Grady D, Cummings SR
• Role of T-Cell Dysfunction, Inflammation, and Coagulation in Microvascular Disease in HIV.
  Journal of the American Heart Association 2016 Sinha A, Ma Y, Scherzer R, Hur S, Li D, Ganz P, Deeks SG, Hsue PY
• The Kidney and Periodontal Disease (KAPD) study: A pilot randomized controlled trial testing the effect of non-surgical periodontal therapy on chronic kidney disease.
  Contemporary clinical trials 2016 Grubbs V, Garcia F, Jue BL, Vittinghoff E, Ryder M, Lovett D, Carrillo J, Offenbacher S, Ganz P, Bibbins-Domingo K, Powe NR
• Associations of Macro- and Microvascular Endothelial Dysfunction With Subclinical Ventricular Dysfunction in End-Stage Renal Disease.
  Hypertension (Dallas, Tex. : 1979) 2016 Dubin RF, Guajardo I, Ayer A, Mills C, Donovan C, Beussink L, Scherzer R, Ganz P, Shah SJ
• Development and Validation of a Protein-Based Risk Score for Cardiovascular Outcomes Among Patients With Stable Coronary Heart Disease.
  JAMA 2016 Ganz P, Heidecker B, Hveem K, Jonasson C, Kato S, Segal MR, Sterling DG, Williams SA
• HIV and Hepatitis C-Coinfected Patients Have Lower Low-Density Lipoprotein Cholesterol Despite Higher Proprotein Convertase Subtilisin Kexin 9 (PCSK9): An Apparent "PCSK9-Lipid Paradox".
  Journal of the American Heart Association 2016 Kohli P, Ganz P, Ma Y, Scherzer R, Hur S, Weigel B, Grunfeld C, Deeks S, Wasserman S, Scott R, Hsue PY
• Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation.
  Circulation research 2016 Walker RG, Poggioli T, Katsimpardi L, Buchanan SM, Oh J, Wattrus S, Heidecker B, Fong YW, Rubin LL, Ganz P, Thompson TB, Wagers AJ, Lee RT
• Continuous transdermal nitroglycerin therapy for menopausal hot flashes: a single-arm, dose-escalation trial.
  Menopause (New York, N.Y.) 2016 Huang AJ, Cummings SR, Schembri M, Vittinghoff E, Ganz P, Grady D
• Endothelin-1 Predicts Hemodynamically Assessed Pulmonary Arterial Hypertension in HIV Infection.
  PloS one 2016 Parikh RV, Ma Y, Scherzer R, Heringer AS, Macgregor JS, Martin JN, Deeks SG, Ganz P, Hsue PY
• Behavioral Cardiovascular Risk Factors　- Effect of Physical Activity and Cardiorespiratory Fitness on Cardiovascular Outcomes.
  Circulation journal : official journal of the Japanese Circulation Society 2015 Spencer RM, Heidecker B, Ganz P
• Soluble endothelial cell selective adhesion molecule and cardiovascular outcomes in patients with stable coronary disease: A report from the Heart and Soul Study.
  Atherosclerosis 2015 Park M, Kulkarni A, Beatty A, Ganz P, Regan M, Vittinghoff E, Whooley M
• Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts.
  European heart journal 2015 Olson KA, Beatty AL, Heidecker B, Regan MC, Brody EN, Foreman T, Kato S, Mehler RE, Singer BS, Hveem K, Dalen H, Sterling DG, Lawn RM, Schiller NB, Williams SA, Whooley MA, Ganz P
• Novel Biomarkers of Cardiac Stress, Cardiovascular Dysfunction, and Outcomes in HIV-Infected Individuals.
  JACC. Heart failure 2015 Secemsky EA, Scherzer R, Nitta E, Wu AH, Lange DC, Deeks SG, Martin JN, Snider J, Ganz P, Hsue PY
• Traditional Risk Factors Versus Biomarkers for Prediction of Secondary Events in Patients With Stable Coronary Heart Disease: From the Heart and Soul Study.
  Journal of the American Heart Association 2015 Beatty AL, Ku IA, Bibbins-Domingo K, Christenson RH, DeFilippi CR, Ganz P, Ix JH, Lloyd-Jones D, Omland T, Sabatine MS, Schiller NB, Shlipak MG, Skali H, Takeuchi M, Vittinghoff E, Whooley MA
• Correction: A novel minimally-invasive method to sample human endothelial cells for molecular profiling.
  PloS one 2015 Waldo SW, Brenner DA, McCabe JM, De la Cruz M, Long B, Narla VA, Park J, Kulkarni A, Sinclair E, Chan SY, Schick SF, Malik N, Ganz P, Hsue PY
• Utility of both carotid intima-media thickness and endothelial function for cardiovascular risk stratification in patients with angina-like symptoms.
  International journal of cardiology 2015 Matsuzawa Y, Svedlund S, Aoki T, Guddeti RR, Kwon TG, Cilluffo R, Widmer RJ, Nelson RE, Lennon RJ, Lerman LO, Gao S, Ganz P, Gan LM, Lerman A
• A novel minimally-invasive method to sample human endothelial cells for molecular profiling.
  PloS one 2015 Waldo SW, Brenner DA, McCabe JM, Dela Cruz M, Long B, Narla VA, Park J, Kulkarni A, Sinclair E, Chan SY, Schick SF, Malik N, Ganz P, Hsue PY
• Depletion of B-cells with rituximab improves endothelial function and reduces inflammation among individuals with rheumatoid arthritis.
  Journal of the American Heart Association 2014 Hsue PY, Scherzer R, Grunfeld C, Imboden J, Wu Y, Del Puerto G, Nitta E, Shigenaga J, Schnell Heringer A, Ganz P, Graf J
• Changes in erectile dysfunction over time in relation to Framingham cardiovascular risk in the Boston Area Community Health (BACH) Survey.
  The journal of sexual medicine 2014 Fang SC, Rosen RC, Vita JA, Ganz P, Kupelian V
• Association of peripheral microvascular dysfunction and erectile dysfunction.
  The Journal of urology 2014 Gerber RE, Vita JA, Ganz P, Wager CG, Araujo AB, Rosen RC, Kupelian V
• Increased levels of asymmetric dimethylarginine are associated with pulmonary arterial hypertension in HIV infection.
  AIDS (London, England) 2014 Parikh RV, Scherzer R, Nitta EM, Leone A, Hur S, Mistry V, Macgregor JS, Martin JN, Deeks SG, Ganz P, Hsue PY
• Reperfusion times and in-hospital outcomes among patients with an isolated posterior myocardial infarction: insights from the National Cardiovascular Data Registry (NCDR).
  American heart journal 2013 Waldo SW, Brenner DA, Li S, Alexander K, Ganz P
• All men with vasculogenic erectile dysfunction require a cardiovascular workup.
  The American journal of medicine 2013 Miner M, Nehra A, Jackson G, Bhasin S, Billups K, Burnett AL, Buvat J, Carson C, Cunningham G, Ganz P, Goldstein I, Guay A, Hackett G, Kloner RA, Kostis JB, LaFlamme KE, Montorsi P, Ramsey M, Rosen R,…
• Role of soluble endothelial cell-selective adhesion molecule biomarker in albuminuria and kidney function changes in patients with coronary artery disease: the Heart and Soul Study.
  Arteriosclerosis, thrombosis, and vascular biology 2013 Park M, Vittinghoff E, Ganz P, Peralta CA, Whooley M, Shlipak MG
• Physician accuracy in interpreting potential ST-segment elevation myocardial infarction electrocardiograms.
  Journal of the American Heart Association 2013 McCabe JM, Armstrong EJ, Ku I, Kulkarni A, Hoffmayer KS, Bhave PD, Waldo SW, Hsue P, Stein JC, Marcus GM, Kinlay S, Ganz P
• Long-term outcomes of patients sent emergently to the catheterization laboratory for possible primary percutaneous coronary intervention.
  The American journal of cardiology 2013 Turner TE, Waldo SW, Kulkarni A, Armstrong EJ, Hoffmayer KS, Kinlay S, Hsue P, Ganz P, McCabe JM
• Clinical characteristics and reperfusion times among patients with an isolated posterior myocardial infarction.
  The Journal of invasive cardiology 2013 Waldo SW, Armstrong EJ, Kulkarni A, Hoffmayer KS, Hsue P, Ganz P, McCabe JM
• Emergency medical service utilization and door-to-balloon time for HIV-infected individuals with ST-elevation myocardial infarction.
  International journal of cardiology 2013 Brenner DA, Dela Cruz M, Thomas K, McCabe JM, Ganz P, Hsue PY, Waldo SW
• Endothelial dysfunction in coronary heart disease is more than a systemic process.
  European heart journal 2013 Ganz P, Hsue PY
• Elevated levels of asymmetric dimethylarginine are associated with lower CD4+ count and higher viral load in HIV-infected individuals.
  Atherosclerosis 2013 Parikh RV, Scherzer R, Grunfeld C, Nitta EM, Leone A, Martin JN, Deeks SG, Ganz P, Hsue PY
• Glycemic associations with endothelial function and biomarkers among 5 ethnic groups: the Multi-Ethnic Study of Atherosclerosis and the Mediators of Atherosclerosis in South Asians Living in America studies.
  Journal of the American Heart Association 2013 Kanaya AM, Dobrosielski DA, Ganz P, Creasman J, Gupta R, Nelacanti V, Vogel-Claussen J, Herrington D
• Comparison of clinical characteristics and outcomes of cardiac arrest survivors having versus not having coronary angiography.
  The American journal of cardiology 2013 Waldo SW, Armstrong EJ, Kulkarni A, Hoffmayer K, Kinlay S, Hsue P, Ganz P, McCabe JM
• Inflammatory biomarkers, death, and recurrent nonfatal coronary events after an acute coronary syndrome in the MIRACL study.
  Journal of the American Heart Association 2013 Zamani P, Schwartz GG, Olsson AG, Rifai N, Bao W, Libby P, Ganz P, Kinlay S, Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators
• Impact of door-to-activation time on door-to-balloon time in primary percutaneous coronary intervention for ST-segment elevation myocardial infarctions: a report from the Activate-SF registry.
  Circulation. Cardiovascular quality and outcomes 2012 McCabe JM, Armstrong EJ, Hoffmayer KS, Bhave PD, MacGregor JS, Hsue P, Stein JC, Kinlay S, Ganz P
• The assessment of endothelial function: from research into clinical practice.
  Circulation 2012 Flammer AJ, Anderson T, Celermajer DS, Creager MA, Deanfield J, Ganz P, Hamburg NM, Lüscher TF, Shechter M, Taddei S, Vita JA, Lerman A
• Electrocardiographic criteria for ST-elevation myocardial infarction in patients with left ventricular hypertrophy.
  The American journal of cardiology 2012 Armstrong EJ, Kulkarni AR, Bhave PD, Hoffmayer KS, Macgregor JS, Stein JC, Kinlay S, Ganz P, McCabe JM
• Prevalence and factors associated with false-positive ST-segment elevation myocardial infarction diagnoses at primary percutaneous coronary intervention–capable centers: a report from the Activate-SF registry.
  Archives of internal medicine 2012 McCabe JM, Armstrong EJ, Kulkarni A, Hoffmayer KS, Bhave PD, Garg S, Patel A, MacGregor JS, Hsue P, Stein JC, Kinlay S, Ganz P
• Prognostic utility of erectile dysfunction for cardiovascular disease in younger men and those with diabetes.
  American heart journal 2012 Miner M, Seftel AD, Nehra A, Ganz P, Kloner RA, Montorsi P, Vlachopoulos C, Ramsey M, Sigman M, Tilkemeier P, Jackson G
• The association of CD4+ T-cell counts and cardiovascular risk in treated HIV disease.
  AIDS (London, England) 2012 Ho JE, Scherzer R, Hecht FM, Maka K, Selby V, Martin JN, Ganz P, Deeks SG, Hsue PY
• The exposure-dependent effects of aged secondhand smoke on endothelial function.
  Journal of the American College of Cardiology 2012 Frey PF, Ganz P, Hsue PY, Benowitz NL, Glantz SA, Balmes JR, Schick SF
• Carotid Intima-Media Thickness Progression in HIV-Infected Adults Occurs Preferentially at the Carotid Bifurcation and Is Predicted by Inflammation.
  Journal of the American Heart Association 2012 Hsue PY, Scherzer R, Hunt PW, Schnell A, Bolger AF, Kalapus SC, Maka K, Martin JN, Ganz P, Deeks SG
• Delaying primary percutaneous coronary intervention for computed tomographic scans in the emergency department.
  The American journal of cardiology 2012 Armstrong EJ, Kulkarni AR, Hoffmayer KS, Bhave PD, MacGregor JS, Hsue P, Stein JC, Kinlay S, Ganz P, McCabe JM
• Relationship of antihypertensive treatment to plasma markers of vascular inflammation and remodeling in the Comparison of Amlodipine versus Enalapril to Limit Occurrences of Thrombosis study.
  American heart journal 2012 Zamani P, Ganz P, Libby P, Sutradhar SC, Rifai N, Nicholls SJ, Nissen SE, Kinlay S
• Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy.
  Heart rhythm 2012 Hong TT, Cogswell R, James CA, Kang G, Pullinger CR, Malloy MJ, Kane JP, Wojciak J, Calkins H, Scheinman MM, Tseng ZH, Ganz P, De Marco T, Judge DP, Shaw RM
• Carotid intima-media thickness among human immunodeficiency virus-infected patients without coronary calcium.
  The American journal of cardiology 2011 Hsue PY, Ordovas K, Lee T, Reddy G, Gotway M, Schnell A, Ho JE, Selby V, Madden E, Martin JN, Deeks SG, Ganz P, Waters DD
• Improvement in revascularization time after creation of a coronary catheterization laboratory at a public hospital.
  Archives of internal medicine 2011 Secemsky EA, Lange D, Ho JE, Brayton K, Ganz PA, Farr G, Macgregor JS, Hsue PY
• Predictors of depressed left ventricular function in patients presenting with ST-elevation myocardial infarction.
  The American journal of cardiology 2011 Bhave PD, Hoffmayer KS, Armstrong EJ, Garg S, Patel A, Macgregor JS, Stein JC, Kinlay S, Ganz P, McCabe JM
• Coronary circulatory function in patients with the metabolic syndrome.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011 Di Carli MF, Charytan D, McMahon GT, Ganz P, Dorbala S, Schelbert HR
• The CHADS2 score predicts ischemic stroke in the absence of atrial fibrillation among subjects with coronary heart disease: data from the Heart and Soul Study.
  American heart journal 2011 Welles CC, Whooley MA, Na B, Ganz P, Schiller NB, Turakhia MP
• Associations of endothelial dysfunction and arterial stiffness with intradialytic hypotension and hypertension.
  Hemodialysis international. International Symposium on Home Hemodialysis 2011 Dubin R, Owens C, Gasper W, Ganz P, Johansen K
• High-resolution magnetic resonance imaging enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis.
  Circulation 2010 Morishige K, Kacher DF, Libby P, Josephson L, Ganz P, Weissleder R, Aikawa M
• AJC editor's consensus: rheumatoid arthritis and atherosclerotic cardiovascular disease.
  The American journal of cardiology 2010 Friedewald VE, Ganz P, Kremer JM, Mease PJ, O'Dell JR, Pearson TA, Ram CV, Ridker PM, Salmon JE, Roberts WC
• Initiation of antiretroviral therapy at higher nadir CD4+ T-cell counts is associated with reduced arterial stiffness in HIV-infected individuals.
  AIDS (London, England) 2010 Ho JE, Deeks SG, Hecht FM, Xie Y, Schnell A, Martin JN, Ganz P, Hsue PY
• Effect of vascular endothelial growth factor and its receptor KDR on the transendothelial migration and local trafficking of human T cells in vitro and in vivo.
  Blood 2010 Edelbauer M, Datta D, Vos IH, Basu A, Stack MP, Reinders ME, Sho M, Calzadilla K, Ganz P, Briscoe DM
• Does erectile dysfunction contribute to cardiovascular disease risk prediction beyond the Framingham risk score?
  Journal of the American College of Cardiology 2010 Araujo AB, Hall SA, Ganz P, Chiu GR, Rosen RC, Kupelian V, Travison TG, McKinlay JB
• Assessment of structural disease in the coronary microvasculature.
  Circulation 2009 Ganz P, Hsue PY
• Association of abacavir and impaired endothelial function in treated and suppressed HIV-infected patients.
  AIDS (London, England) 2009 Hsue PY, Hunt PW, Wu Y, Schnell A, Ho JE, Hatano H, Xie Y, Martin JN, Ganz P, Deeks SG
• Evaluating patients with persistent chest pain and no obstructive coronary artery disease.
  JAMA 2009 Beltrame JF, Ganz P
• Endothelin-1 is a key mediator of coronary vasoconstriction in patients with transplant coronary arteriosclerosis.
  Circulation. Heart failure 2009 Larose E, Behrendt D, Kinlay S, Selwyn AP, Ganz P, Fang JC
• Erectile dysfunction and mortality.
  The journal of sexual medicine 2009 Araujo AB, Travison TG, Ganz P, Chiu GR, Kupelian V, Rosen RC, Hall SA, McKinlay JB
• Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial.
  Journal of the American College of Cardiology 2009 Fraley AE, Schwartz GG, Olsson AG, Kinlay S, Szarek M, Rifai N, Libby P, Ganz P, Witztum JL, Tsimikas S, MIRACL Study Investigators
• Structural and functional manifestations of human atherosclerosis: do they run in parallel?
  European heart journal 2009 Ganz P, Ho JE, Hsue PY
• Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis.
  AIDS (London, England) 2009 Hsue PY, Hunt PW, Schnell A, Kalapus SC, Hoh R, Ganz P, Martin JN, Deeks SG
• Rheumatoid arthritis: model of systemic inflammation driving atherosclerosis.
  Circulation journal : official journal of the Japanese Circulation Society 2009 Ku IA, Imboden JB, Hsue PY, Ganz P
• Endogenous tissue plasminogen activator and risk of recurrent cardiac events after an acute coronary syndrome in the MIRACL study.
  Atherosclerosis 2009 Kinlay S, Schwartz GG, Olsson AG, Rifai N, Bao W, Libby P, Ganz P, Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators
• Individualized approach to the management of coronary heart disease: identifying the nonresponders before it is too late.
  Journal of the American College of Cardiology 2009 Ganz P, Hsue PY
• Comparison of effects of rosuvastatin (10 mg) versus atorvastatin (40 mg) on rho kinase activity in caucasian men with a previous atherosclerotic event.
  The American journal of cardiology 2008 Rawlings R, Nohria A, Liu PY, Donnelly J, Creager MA, Ganz P, Selwyn A, Liao JK
• Statins inhibit Rho kinase activity in patients with atherosclerosis.
  Atherosclerosis 2008 Nohria A, Prsic A, Liu PY, Okamoto R, Creager MA, Selwyn A, Liao JK, Ganz P
• Effects of the direct lipoprotein-associated phospholipase A(2) inhibitor darapladib on human coronary atherosclerotic plaque.
  Circulation 2008 Serruys PW, García-García HM, Buszman P, Erne P, Verheye S, Aschermann M, Duckers H, Bleie O, Dudek D, Bøtker HE, von Birgelen C, D'Amico D, Hutchinson T, Zambanini A, Mastik F, van Es GA, van der …
• Inflammation, statin therapy, and risk of stroke after an acute coronary syndrome in the MIRACL study.
  Arteriosclerosis, thrombosis, and vascular biology 2007 Kinlay S, Schwartz GG, Olsson AG, Rifai N, Szarek M, Waters DD, Libby P, Ganz P, Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators
• Improved characterization of atherosclerotic plaques by gadolinium contrast during intravascular magnetic resonance imaging of human arteries.
  Atherosclerosis 2007 Larose E, Kinlay S, Selwyn AP, Yeghiazarians Y, Yucel EK, Kacher DF, Libby P, Ganz P
• Right ventricular dysfunction assessed by cardiovascular magnetic resonance imaging predicts poor prognosis late after myocardial infarction.
  Journal of the American College of Cardiology 2007 Larose E, Ganz P, Reynolds HG, Dorbala S, Di Carli MF, Brown KA, Kwong RY
• Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease.
  Circulation research 2006 Nohria A, Grunert ME, Rikitake Y, Noma K, Prsic A, Ganz P, Liao JK, Creager MA
• Beyond lipid lowering: What have we learned about the benefits of statins from the acute coronary syndromes trials?
  The American journal of cardiology 2006 Ray KK, Cannon CP, Ganz P
• Role of nitric oxide in the regulation of digital pulse volume amplitude in humans.
  Journal of applied physiology (Bethesda, Md. : 1985) 2006 Nohria A, Gerhard-Herman M, Creager MA, Hurley S, Mitra D, Ganz P
• Impact of coronary endothelial function on the progression of cardiac transplant-associated arteriosclerosis: effect of anti-oxidant vitamins C and E.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2006 Behrendt D, Beltrame J, Hikiti H, Wainstein M, Kinlay S, Selwyn AP, Ganz P, Fang JC
• Effect of ACAT inhibition on the progression of coronary atherosclerosis.
  The New England journal of medicine 2006 Nissen SE, Tuzcu EM, Brewer HB, Sipahi I, Nicholls SJ, Ganz P, Schoenhagen P, Waters DD, Pepine CJ, Crowe TD, Davidson MH, Deanfield JE, Wisniewski LM, Hanyok JJ, Kassalow LM, ACAT Intravascular …
• Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference).
  The American journal of cardiology 2005 Kostis JB, Jackson G, Rosen R, Barrett-Connor E, Billups K, Burnett AL, Carson C, Cheitlin M, Debusk R, Fonseca V, Ganz P, Goldstein I, Guay A, Hatzichristou D, Hollander JE, Hutter A, Katz S, Kloner …
• Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging.
  Circulation 2005 Larose E, Yeghiazarians Y, Libby P, Yucel EK, Aikawa M, Kacher DF, Aikawa E, Kinlay S, Schoen FJ, Selwyn AP, Ganz P
• Erectile dysfunction: pathophysiologic mechanisms pointing to underlying cardiovascular disease.
  The American journal of cardiology 2005 Ganz P
• Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference).
  The American journal of cardiology 2005 Kostis JB, Jackson G, Rosen R, Barrett-Connor E, Billups K, Burnett AL, Carson C, Cheitlin M, Debusk R, Fonseca V, Ganz P, Goldstein I, Guay A, Hatzichristou D, Hollander JE, Hutter A, Katz S, Kloner …
• High-density lipoprotein, but not low-density lipoprotein cholesterol levels influence short-term prognosis after acute coronary syndrome: results from the MIRACL trial.
  European heart journal 2005 Olsson AG, Schwartz GG, Szarek M, Sasiela WJ, Ezekowitz MD, Ganz P, Oliver MF, Waters D, Zeiher A
• Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease.
  The New England journal of medicine 2005 Nissen SE, Tuzcu EM, Schoenhagen P, Crowe T, Sasiela WJ, Tsai J, Orazem J, Magorien RD, O'Shaughnessy C, Ganz P, Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) Investigators
• Statins and endothelial dysfunction.
  Seminars in vascular medicine 2004 Larose E, Ganz P
• Comparison of endothelial function in young men and women with a family history of premature coronary artery disease.
  The American journal of cardiology 2004 Hamburg NM, Charbonneau F, Gerhard-Herman M, Ganz P, Creager MA
• Effect of atorvastatin on risk of recurrent cardiovascular events after an acute coronary syndrome associated with high soluble CD40 ligand in the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study.
  Circulation 2004 Kinlay S, Schwartz GG, Olsson AG, Rifai N, Sasiela WJ, Szarek M, Ganz P, Libby P, Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators
• Role of endothelial dysfunction in atherosclerosis.
  Circulation 2004 Davignon J, Ganz P
• Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial.
  JAMA 2004 Nissen SE, Tuzcu EM, Schoenhagen P, Brown BG, Ganz P, Vogel RA, Crowe T, Howard G, Cooper CJ, Brodie B, Grines CL, DeMaria AN, REVERSAL Investigators
• Long-term effect of combined vitamins E and C on coronary and peripheral endothelial function.
  Journal of the American College of Cardiology 2004 Kinlay S, Behrendt D, Fang JC, Delagrange D, Morrow J, Witztum JL, Rifai N, Selwyn AP, Creager MA, Ganz P
• Early statin therapy in acute coronary syndromes.
  Seminars in vascular medicine 2003 Kinlay S, Ganz P
• Pharmacoeconomic evaluation of the effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes.
  The American journal of cardiology 2003 Schwartz GG, Ganz P, Waters D, Arikian S
• Testing endothelial vasomotor function: nitric oxide, a multipotent molecule.
  Circulation 2003 Ganz P, Vita JA
• High-dose atorvastatin enhances the decline in inflammatory markers in patients with acute coronary syndromes in the MIRACL study.
  Circulation 2003 Kinlay S, Schwartz GG, Olsson AG, Rifai N, Leslie SJ, Sasiela WJ, Szarek M, Libby P, Ganz P, Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering Study Investigators
• Expression patterns of vascular endothelial growth factor in human cardiac allografts: association with rejection.
  Transplantation 2003 Reinders ME, Fang JC, Wong W, Ganz P, Briscoe DM
• Endothelin-1 and vascular tone in subjects with atherogenic risk factors.
  Hypertension (Dallas, Tex. : 1979) 2003 Nohria A, Garrett L, Johnson W, Kinlay S, Ganz P, Creager MA
• Circulating autoantibodies to oxidized LDL correlate with impaired coronary endothelial function after cardiac transplantation.
  Arteriosclerosis, thrombosis, and vascular biology 2002 Fang JC, Kinlay S, Behrendt D, Hikita H, Witztum JL, Selwyn AP, Ganz P
• Contribution of endothelin to pulmonary vascular tone under normoxic and hypoxic conditions.
  American journal of physiology. Heart and circulatory physiology 2002 Johnson W, Nohria A, Garrett L, Fang JC, Igo J, Katai M, Ganz P, Creager MA
• Coronary flow velocity and disturbed flow predict adverse clinical outcome after coronary angioplasty.
  Arteriosclerosis, thrombosis, and vascular biology 2002 Kinlay S, Grewal J, Manuelin D, Fang JC, Selwyn AP, Bittl JA, Ganz P
• Vasomotor and vascular effects of hormone replacement therapy.
  The American journal of cardiology 2002 Ganz P
• Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial.
  Lancet (London, England) 2002 Fang JC, Kinlay S, Beltrame J, Hikiti H, Wainstein M, Behrendt D, Suh J, Frei B, Mudge GH, Selwyn AP, Ganz P