Pekka Talke, MD
Professor Emeritus
Anesthesia
School of Medicine

For more than three decades, Talke has conducted research that focuses on noninvasive physiological monitoring (using devices outside the body to continuously assess a patient's status) and blood vessel function.

Talke earned his medical degree at the University of Texas Medical Branch at Galveston, where he also completed a residency in anesthesiology. He is a member of the Society for Neuroscience in Anesthesiology and Critical Care, and has served on its board of directors.

Talke is a native of Finland.

• Republished: Society for Neuroscience in Anesthesiology and Critical Care expert consensus statement: Anesthetic management of endovascular treatment for acute ischemic stroke.
  Stroke 2014 Talke PO, Sharma D, Heyer EJ, Bergese SD, Blackham KA, Stevens RD
• Enzyme-inducing anticonvulsants increase plasma clearance of dexmedetomidine: a pharmacokinetic and pharmacodynamic study.
  Anesthesiology 2014 Flexman AM, Wong H, Riggs KW, Shih T, Garcia PA, Vacas S, Talke PO
• Society for Neuroscience in Anesthesiology and Critical Care Expert consensus statement: anesthetic management of endovascular treatment for acute ischemic stroke*: endorsed by the Society of NeuroInterventional Surgery and the Neurocritical Care Society.
  Journal of neurosurgical anesthesiology 2014 Talke PO, Sharma D, Heyer EJ, Bergese SD, Blackham KA, Stevens RD
• The time when hypotension occurs may be important in the management of intraarterial thrombolysis for stroke.
  Anesthesiology 2012 Gelb AW, Talke PO
• Hemodynamic stability after intraarterial injection of verapamil for cerebral vasospasm.
  Anesthesia and analgesia 2012 Flexman AM, Ryerson CJ, Talke PO
• Effect of pain on autonomic nervous system indices derived from photoplethysmography in healthy volunteers.
  British journal of anaesthesia 2012 Hamunen K, Kontinen V, Hakala E, Talke P, Paloheimo M, Kalso E
• The effects of sympathectomy on finger photoplethysmography and temperature measurements in healthy subjects.
  Anesthesia and analgesia 2011 Talke P, Snapir A, Huiku M
• Photoplethysmographic waveform: what do the numbers mean?
  Acta anaesthesiologica Scandinavica 2010 Talke P
• Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracy.
  Journal of neurosurgery 2010 Starr PA, Martin AJ, Ostrem JL, Talke P, Levesque N, Larson PS
• Recent advances in pulse oximetry.
  F1000 medicine reports 2009 Cannesson M, Talke P
• It's hot to be cool.
  Anesthesiology 2009 Talke PO
• Effects of nitric oxide synthase inhibition on dexmedetomidine-induced vasoconstriction in healthy human volunteers.
  British journal of anaesthesia 2008 Snapir A, Talke P, Posti J, Huiku M, Kentala E, Scheinin M
• Expecting the unexpected.
  Anesthesia and analgesia 2008 Talke PO, Maze M
• Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsy.
  Journal of neurosurgical anesthesiology 2007 Talke P, Stapelfeldt C, Garcia P
• Effect of peripheral vasoconstriction on pulse oximetry.
  Journal of clinical monitoring and computing 2006 Talke P, Stapelfeldt C
• Positive end-expiratory pressure ventilation increases extravascular lung water due to a decrease in lung lymph flow.
  Anaesthesia and intensive care 2006 Maybauer DM, Talke PO, Westphal M, Maybauer MO, Traber LD, Enkhbaatar P, Morita N, Traber DL
• Placement of deep brain stimulator electrodes using real-time high-field interventional magnetic resonance imaging.
  Magnetic resonance in medicine 2005 Martin AJ, Larson PS, Ostrem JL, Keith Sootsman W, Talke P, Weber OM, Levesque N, Myers J, Starr PA
• Intraoperative clonidine administration to neurosurgical patients.
  Anesthesia and analgesia 2005 Talke PO, Lobo EP, Stapelfeldt C, Brown R
• Alpha-2B adrenoceptor polymorphism and peripheral vasoconstriction.
  Pharmacogenetics and genomics 2005 Talke P, Stapelfeldt C, Lobo E, Brown R, Scheinin M, Snapir A
• Postcraniotomy pain remains a real headache!
  European journal of anaesthesiology 2005 Talke PO, Gelb AW
• Effect of alpha2B-adrenoceptor polymorphism on peripheral vasoconstriction in healthy volunteers.
  Anesthesiology 2005 Talke P, Stapelfeldt C, Lobo E, Brown R, Scheinin M, Snapir A
• Intraoperative clonidine administration to neurosurgical patients.
  Anesthesia and analgesia 2005 Stapelfeldt C, Lobo EP, Brown R, Talke PO
• Intracranial vascular surgery.
  Current opinion in anaesthesiology 2004 Talke P
• Systemically administered alpha2-agonist-induced peripheral vasoconstriction in humans.
  Anesthesiology 2003 Talke P, Lobo E, Brown R
• Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats.
  Acta anaesthesiologica Scandinavica 2003 Talke P, Xu M, Paloheimo M, Kalso E
• Autonomic nervous system responses during sedative infusions of dexmedetomidine.
  Anesthesiology 2002 Hogue CW, Talke P, Stein PK, Richardson C, Domitrovich PP, Sessler DI
• A comparison of three anesthetic techniques in patients undergoing craniotomy for supratentorial intracranial surgery.
  Anesthesia and analgesia 2002 Talke P, Caldwell JE, Brown R, Dodson B, Howley J, Richardson CA
• Effect of dexmedetomidine, an alpha2-adrenoceptor agonist, on human pupillary reflexes during general anaesthesia.
  British journal of clinical pharmacology 2001 Larson MD, Talke PO
• The effects of clonidine on human digital vasculature.
  Anesthesia and analgesia 2000 Talke PO, Caldwell JE, Richardson CA, Heier T
• The effect of alpha(2) agonist-induced sedation and its reversal with an alpha(2) antagonist on organ blood flow in sheep.
  Anesthesia and analgesia 2000 Talke PO, Traber DL, Richardson CA, Harper DD, Traber LD
• The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery.
  Anesthesia and analgesia 2000 Talke P, Chen R, Thomas B, Aggarwall A, Gottlieb A, Thorborg P, Heard S, Cheung A, Son SL, Kallio A
• Sevoflurane increases lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy.
  Anesthesiology 1999 Talke P, Caldwell JE, Richardson CA
• Amount of air infused to patient increases as fluid flow rates decrease when using the Hotline HL-90 fluid warmer.
  Journal of clinical monitoring and computing 1999 Woon S, Talke P
• The effects of dexmedetomidine on neuromuscular blockade in human volunteers.
  Anesthesia and analgesia 1999 Talke PO, Caldwell JE, Richardson CA, Kirkegaard-Nielsen H, Stafford M
• Concept for easy fiberoptic intubation via a laryngeal airway mask.
  Anesthesia and analgesia 1999 Talke PO, Nguyen H
• Receptor-specific reversible sedation: beginning of new era of anesthesia?
  Anesthesiology 1998 Talke P
• Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine.
  Anesthesia and analgesia 1997 Talke P, Richardson CA, Scheinin M, Fisher DM
• Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholds.
  Anesthesiology 1997 Talke P, Tayefeh F, Sessler DI, Jeffrey R, Noursalehi M, Richardson C
• The effect of clonidine on cerebral blood flow velocity, carbon dioxide cerebral vasoreactivity, and response to increased arterial pressure in human volunteers.
  Anesthesiology 1997 Lee HW, Caldwell JE, Dodson B, Talke P, Howley J
• Effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in humans.
  Anesthesia and analgesia 1997 Talke P, Tong C, Lee HW, Caldwell J, Eisenach JC, Richardson CA
• Desflurane and isoflurane increase lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy.
  Anesthesiology 1996 Talke P, Caldwell J, Dodsont B, Richardson CA
• Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices.
  Anesthesiology 1996 Talke P, Bickler PE
• Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group.
  Anesthesiology 1995 Talke P, Li J, Jain U, Leung J, Drasner K, Hollenberg M, Mangano DT
• Dose-response study of oral famotidine for reduction of gastric acidity and volume in outpatients and inpatients.
  Anesthesia and analgesia 1993 Talke PO, Solanki DR
• Treatment of postoperative nausea and vomiting after outpatient surgery with the 5-HT3 antagonist ondansetron.
  Anesthesiology 1993 Scuderi P, Wetchler B, Sung YF, Mingus M, DuPen S, Claybon L, Leslie J, Talke P, Apfelbaum J, Sharifi-Azad S
• Ondansetron in the treatment of postoperative nausea and vomiting in ambulatory outpatients: a dose-comparative, stratified, multicentre study.
  European journal of anaesthesiology. Supplement 1992 Du Pen S, Scuderi P, Wetchler B, Sung YF, Mingus M, Clayborn L, Leslie J, Talke P, Apfelbaum J, Sharifi-Azad S
• Measurement of systolic blood pressure using pulse oximetry during helicopter flight.
  Critical care medicine 1991 Talke PO
• Monitoring patients during helicopter flight.
  Journal of clinical monitoring 1990 Talke P, Nichols RJ, Traber DL
• Does measurement of systolic blood pressure with a pulse oximeter correlate with conventional methods?
  Journal of clinical monitoring 1990 Talke P, Nichols RJ, Traber DL
• Effects of allopurinol on smoke inhalation in the ovine model.
  Journal of applied physiology (Bethesda, Md. : 1985) 1990 Ahn SY, Sugi K, Talke P, Theissen JL, Linares HA, Traber LD, Herndon DN, Traber DL
• A model of ovine endotoxemia characterized by an increased cardiac output.
  Circulatory shock 1985 Talke P, Dunn A, Lawlis L, Sziebert L, White A, Herndon D, Flynn JT, Traber D
• Transcutaneous PO2 measurements in health and peripheral arterial occlusive disease.
  Surgery 1982 Franzeck UK, Talke P, Bernstein EF, Golbranson FL, Fronek A