Pauline Marangoni, PhD
Research Manager
Orofacial Sciences
School of Dentistry

Publications (28)

Top publication keywords:
Stem CellsMouth MucosaEpithelial CellsSingle-Cell AnalysisArvicolinaeEctodermIncisorHedgehog ProteinsToothExtracellular Signal-Regulated MAP KinasesMAP Kinase Signaling SystemRibosomal Protein S6 Kinases, 90-kDaOdontogenesisCell PlasticityCell Differentiation

• Asymmetry of sonic hedgehog expression is necessary for early incisor tooth morphogenesis.
  Development (Cambridge, England) 2026 Haque AS, Hata M, Marchuk K, Marangoni P, Green JBA, Klein OD
• Decoding epithelial regeneration in the cornea: multi-omic analysis reveals cellular plasticity as central mechanism.
  Cellular & molecular biology letters 2025 Feret N, Megido AC, Kuony A, Marangoni P, Fichter L, Garcia Llorens S, Attina A, Nhiri N, Jacquet E, Vialaret J, Daien V, David A, Hirtz C, Loulier K, Klein OD, Michon F
• YAP-driven malignant reprogramming of oral epithelial stem cells at single cell resolution.
  Nature communications 2025 Faraji F, Ramirez SI, Clubb LM, Sato K, Burghi V, Hoang TS, Officer A, Anguiano Quiroz PY, Galloway WMG, Mikulski Z, Medetgul-Ernar K, Marangoni P, Jones KB, Cao Y, Molinolo AA, Kim K, Sakaguchi K, …
• Bank vole genomics links determinate and indeterminate growth of teeth.
  BMC genomics 2024 Calamari ZT, Song A, Cohen E, Akter M, Das Roy R, Hallikas O, Christensen MM, Li P, Marangoni P, Jernvall J, Klein OD
• Loss of transcriptional heterogeneity in aged human muscle stem cells.
  PloS one 2023 Barruet E, Striedinger K, Marangoni P, Pomerantz JH

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• CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids.
  Nature communications 2022 Lo M, Sharir A, Paul MD, Torosyan H, Agnew C, Li A, Neben C, Marangoni P, Xu L, Raleigh DR, Jura N, Klein OD
• Parallels in signaling between development and regeneration in ectodermal organs.
  Current topics in developmental biology 2022 Pincha N, Marangoni P, Haque A, Klein OD
• From Bite to Byte: Dental Structures Resolved at a Single-Cell Resolution.
  Journal of dental research 2021 Fresia R, Marangoni P, Burstyn-Cohen T, Sharir A
• Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth.
  Nature communications 2020 Krivanek J, Soldatov RA, Kastriti ME, Chontorotzea T, Herdina AN, Petersen J, Szarowska B, Landova M, Matejova VK, Holla LI, Kuchler U, Zdrilic IV, Vijaykumar A, Balic A, Marangoni P, Klein OD, Neves …
• Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress.
  Cell stem cell 2019 Byrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ, Williams SE
• A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage.
  Nature cell biology 2019 Sharir A, Marangoni P, Zilionis R, Wan M, Wald T, Hu JK, Kawaguchi K, Castillo-Azofeifa D, Epstein L, Harrington K, Pagella P, Mitsiadis T, Siebel CW, Klein AM, Klein OD
• Downregulation of FGF Signaling by Spry4 Overexpression Leads to Shape Impairment, Enamel Irregularities, and Delayed Signaling Center Formation in the Mouse Molar.
  JBMR plus 2019 Marangoni P, Charles C, Ahn Y, Seidel K, Jheon A, Ganss B, Krumlauf R, Viriot L, Klein OD
• Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development.
  International journal of molecular sciences 2019 El Shahawy M, Reibring CG, Hallberg K, Neben CL, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A
• Prominin-1 controls stem cell activation by orchestrating ciliary dynamics.
  The EMBO journal 2018 Singer D, Thamm K, Zhuang H, Karbanová J, Gao Y, Walker JV, Jin H, Wu X, Coveney CR, Marangoni P, Lu D, Grayson PRC, Gulsen T, Liu KJ, Ardu S, Wann AK, Luo S, Zambon AC, Jetten AM, Tredwin C, Klein OD…
• Quantitative Clonal Analysis and Single-Cell Transcriptomics Reveal Division Kinetics, Hierarchy, and Fate of Oral Epithelial Progenitor Cells.
  Cell stem cell 2018 Jones KB, Furukawa S, Marangoni P, Ma H, Pinkard H, D'Urso R, Zilionis R, Klein AM, Klein OD
• Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development.
  Frontiers in genetics 2018 Prochazkova M, Prochazka J, Marangoni P, Klein OD
• Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.
  Nature 2018 Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD
• Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.
  Nature 2018 Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD
• FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells.
  Nature communications 2018 Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E
• Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2017 Naveau A, Zhang B, Meng B, Sutherland MT, Prochazkova M, Wen T, Marangoni P, Jones KB, Cox TC, Ganss B, Jheon AH, Klein OD
• IRF6 and SPRY4 Signaling Interact in Periderm Development.
  Journal of dental research 2017 Kousa YA, Roushangar R, Patel N, Walter A, Marangoni P, Krumlauf R, Klein OD, Schutte BC
• Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid.
  PLoS genetics 2017 El Shahawy M, Reibring CG, Neben CL, Hallberg K, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A
• Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis.
  eLife 2017 Seidel K, Marangoni P, Tang C, Houshmand B, Du W, Maas RL, Murray S, Oldham MC, Klein OD
• The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape.
  G3 (Bethesda, Md.) 2017 Percival CJ, Marangoni P, Tapaltsyan V, Klein O, Hallgrímsson B
• Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model.
  Scientific reports 2015 Marangoni P, Charles C, Tafforeau P, Laugel-Haushalter V, Joo A, Bloch-Zupan A, Klein OD, Viriot L
• RSK2 is a modulator of craniofacial development.
  PloS one 2014 Laugel-Haushalter V, Paschaki M, Marangoni P, Pilgram C, Langer A, Kuntz T, Demassue J, Morkmued S, Choquet P, Constantinesco A, Bornert F, Schmittbuhl M, Pannetier S, Viriot L, Hanauer A, Dollé P, …
• Continuous dental replacement in a hyper-chisel tooth digging rodent.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Rodrigues HG, Marangoni P, Šumbera R, Tafforeau P, Wendelen W, Viriot L
• Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling.
  Development (Cambridge, England) 2011 Charles C, Hovorakova M, Ahn Y, Lyons DB, Marangoni P, Churava S, Biehs B, Jheon A, Lesot H, Balooch G, Krumlauf R, Viriot L, Peterkova R, Klein OD