Paul Wolters, MD
Professor
Medicine
School of Medicine

Research Interests The goal of my research program is to understand the molecular pathogenesis of fibrotic lung disease and to use this knowledge to develop novel therapies for treating these diseases. My research group investigates lung fibrosis by applying animal models and translational studies using patient samples to define the cellular and molecular mechanisms that promote lung fibrosis. To achieve this goal, we have established a large repository of biological specimens, obtained from generous patients with interstitial lung diseases, and methods for isolating pure populations of alveolar type II cells from fibrotic lungs that can be used to investigate mechanisms of disease pathogenesis. Our recent scientific focus has been on explaining the role epithelial cells play in promoting lung fibrosis with an emphasis on the roles of telomere dysfunction, senescence reprogramming and aging.

• Invasive mucinous adenocarcinoma of the lung with bronchorrhea - A marked reduction volume of sputum after SARS-CoV-2 infection.
  Respiratory medicine case reports 2024 Liu X, Zhou X, Zhang X, Sun L, Zhao G, Mao S, Li F, Gu X, Wolters PJ, Liu S
• Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease.
  The European respiratory journal 2023 Zhang D, Adegunsoye A, Oldham JM, Kozlitina J, Garcia N, Poonawalla M, Strykowski R, Linderholm AL, Ley B, Ma SF, Noth I, Strek ME, Wolters PJ, Garcia CK, Newton CA
• An interleukin 6 responsive plasma cell signature is associated with disease progression in systemic sclerosis interstitial lung disease.
  iScience 2023 Jia G, Ramalingam TR, Heiden JV, Gao X, DePianto D, Morshead KB, Modrusan Z, Ramamoorthi N, Wolters P, Lin C, Khanna D, Arron JR
• Short airway telomeres are associated with primary graft dysfunction and chronic lung allograft dysfunction.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023 Greenland JR, Guo R, Lee S, Tran L, Kapse B, Kukreja J, Hays SR, Golden JA, Calabrese DR, Singer JP, Wolters PJ
• Targeted alveolar regeneration with Frizzled-specific agonists.
  Cell 2023 Nabhan AN, Webster JD, Adams JJ, Blazer L, Everrett C, Eidenschenk C, Arlantico A, Fleming I, Brightbill HD, Wolters PJ, Modrusan Z, Seshagiri S, Angers S, Sidhu SS, Newton K, Arron JR, Dixit VM
• PCSK6 and Survival in Idiopathic Pulmonary Fibrosis.
  American journal of respiratory and critical care medicine 2023 Oldham JM, Allen RJ, Lorenzo-Salazar JM, Molyneaux PL, Ma SF, Joseph C, Kim JS, Guillen-Guio B, Hernández-Beeftink T, Kropski JA, Huang Y, Lee CT, Adegunsoye A, Pugashetti JV, Linderholm AL, Vo V, …
• Protein biomarkers of disease progression in patients with systemic sclerosis associated interstitial lung disease.
  Scientific reports 2023 Cerro-Chiang G, Ayres M, Rivas A, Romero T, Parker SJ, Mastali M, Elashoff D, Chen P, Van Eyk JE, Wolters PJ, Boin F, Zaman T
• Idiopathic Pulmonary Fibrosis Is Associated with Common Genetic Variants and Limited Rare Variants.
  American journal of respiratory and critical care medicine 2023 Peljto AL, Blumhagen RZ, Walts AD, Cardwell J, Powers J, Corte TJ, Dickinson JL, Glaspole I, Moodley YP, Vasakova MK, Bendstrup E, Davidsen JR, Borie R, Crestani B, Dieude P, Bonella F, Costabel U, …
• Inhibition of MRTF activation as a clinically achievable anti-fibrotic mechanism for pirfenidone.
  The European respiratory journal 2023 Ma HY, Vander Heiden JA, Uttarwar S, Xi Y, N'Diaye EN, LaCanna R, Caplazi P, Gierke S, Moffat J, Wolters PJ, Ding N
• Identification of a Genetic Susceptibility Locus for Idiopathic Pulmonary Fibrosis in the 16p Subtelomere Using Whole-Genome Sequencing.
  American journal of respiratory and critical care medicine 2023 Donoghue LJ, Stockwell AD, Neighbors M, Sheng RX, Prabhakaran R, Wolters PJ, Lancaster LH, Kropski JA, Blackwell TS, McCarthy MI, Yaspan BL
• Interstitial Lung Disease in Veterans: Leveraging Big Data to Bridge Evidence and Practice Gaps.
  Annals of the American Thoracic Society 2023 Kaul B, Petersen LA, Rosas IO, Lee JS, Martinez FJ, Bandi VD, Helmer DA, Wolters PJ, Collard HR, Whooley MA
• Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts.
  Nature communications 2023 Adegunsoye A, Newton CA, Oldham JM, Ley B, Lee CT, Linderholm AL, Chung JH, Garcia N, Zhang D, Vij R, Guzy R, Jablonski R, Bag R, Voogt RS, Ma SF, Sperling AI, Raghu G, Martinez FJ, Strek ME, Wolters …
• Evaluation of Pulmonary Fibrosis Outcomes by Race and Ethnicity in US Adults.
  JAMA network open 2023 Adegunsoye A, Freiheit E, White EN, Kaul B, Newton CA, Oldham JM, Lee CT, Chung J, Garcia N, Ghodrati S, Vij R, Jablonski R, Flaherty KR, Wolters PJ, Garcia CK, Strek ME
• Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir.
  Immunity 2023 Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB, Peng T
• Diffuse lung involvement in rheumatoid arthritis: a respiratory physician's perspective.
  Chinese medical journal 2023 Huang H, Chen R, Shao C, Xu Z, Wolters PJ
• Colocalization of Gene Expression and DNA Methylation with Genetic Risk Variants Supports Functional Roles of MUC5B and DSP in Idiopathic Pulmonary Fibrosis.
  American journal of respiratory and critical care medicine 2022 Borie R, Cardwell J, Konigsberg IR, Moore CM, Zhang W, Sasse SK, Gally F, Dobrinskikh E, Walts A, Powers J, Brancato J, Rojas M, Wolters PJ, Brown KK, Blackwell TS, Nakanishi T, Richards JB, Gerber AN…
• A WISP1 antibody inhibits MRTF signaling to prevent the progression of established liver fibrosis.
  Cell metabolism 2022 Xi Y, LaCanna R, Ma HY, N'Diaye EN, Gierke S, Caplazi P, Sagolla M, Huang Z, Lucio L, Arlantico A, Jeet S, Brightbill H, Emson C, Wong A, Morshead KB, DePianto DJ, Roose-Girma M, Yu C, Tam L, Jia G, …
• A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange.
  Developmental cell 2022 Zhang K, Yao E, Wang SA, Chuang E, Wong J, Minichiello L, Schroeder A, Eckalbar W, Wolters PJ, Chuang PT
• Sine oculis homeobox homolog 1 plays a critical role in pulmonary fibrosis.
  JCI insight 2022 Wilson C, Mertens TC, Shivshankar P, Bi W, Collum SD, Wareing N, Ko J, Weng T, Naikawadi RP, Wolters PJ, Maire P, Jyothula SS, Thandavarayan RA, Ren D, Elrod ND, Wagner EJ, Huang HJ, Dickey BF, Ford …
• Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria.
  eLife 2022 Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT
• Impaired CD8+ T Cell Proliferation to Alloantigens in Lung Transplant Recipients with Idiopathic Pulmonary Fibrosis is Associated with P53 Upregulation.
  The Journal of Heart and Lung Transplantation 2022 P. Wang, J. Leung, A. Lam, S. Lee, D.R. Calabrese, S.R. Hays, J.A. Golden, J. Kukreja, J.P. Singer, P.J. Wolters, Q. Tang, J.R. Greenland
• Genetically increased circulating FUT3 level leads to reduced risk of idiopathic pulmonary fibrosis: a Mendelian randomisation study.
  The European respiratory journal 2022 Nakanishi T, Cerani A, Forgetta V, Zhou S, Allen RJ, Leavy OC, Koido M, Assayag D, Jenkins RG, Wain LV, Yang IV, Lathrop GM, Wolters PJ, Schwartz DA, Richards JB
• A simple method to generate human airway epithelial organoids with externally orientated apical membranes.
  American journal of physiology. Lung cellular and molecular physiology 2022 Boecking CA, Walentek P, Zlock LT, Sun DI, Wolters PJ, Ishikawa H, Jin BJ, Haggie PM, Marshall WF, Verkman AS, Finkbeiner WE
• Proteomic biomarkers of progressive fibrosing interstitial lung disease: a multicentre cohort analysis.
  The Lancet. Respiratory medicine 2022 Bowman WS, Newton CA, Linderholm AL, Neely ML, Pugashetti JV, Kaul B, Vo V, Echt GA, Leon W, Shah RJ, Huang Y, Garcia CK, Wolters PJ, Oldham JM
• Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma.
  Science translational medicine 2022 Headland SE, Dengler HS, Xu D, Teng G, Everett C, Ratsimandresy RA, Yan D, Kang J, Ganeshan K, Nazarova EV, Gierke S, Wedeles CJ, Guidi R, DePianto DJ, Morshead KB, Huynh A, Mills J, Flanagan S, …
• Common idiopathic pulmonary fibrosis risk variants are associated with hypersensitivity pneumonitis.
  Thorax 2022 Furusawa H, Peljto AL, Walts AD, Cardwell J, Molyneaux PL, Lee JS, Fernández Pérez ER, Wolters PJ, Yang IV, Schwartz DA
• Cut from the Same Cloth: Similarities between Hypersensitivity Pneumonitis and Idiopathic Pulmonary Fibrosis.
  American journal of respiratory and critical care medicine 2022 Yang MM, Wolters PJ
• Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.
  Nature cell biology 2021 Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T
• The prognostic role of matrix metalloproteinase-7 in scleroderma-associated interstitial lung disease.
  The European respiratory journal 2021 Matson SM, Lee SJ, Peterson RA, Achtar-Zadeh NA, Boin F, Wolters PJ, Lee JS
• Molecular programs of fibrotic change in aging human lung.
  Nature communications 2021 Lee S, Islam MN, Boostanpour K, Aran D, Jin G, Christenson S, Matthay MA, Eckalbar WL, DePianto DJ, Arron JR, Magee L, Bhattacharya S, Matsumoto R, Kubota M, Farber DL, Bhattacharya J, Wolters PJ, …
• Lung Transplant Recipients with Idiopathic Pulmonary Fibrosis Have Impaired Alloreactive Immune Responses.
  The Journal of Heart and Lung Transplantation 2021 Ping Wang, Joey Leung, Alice Lam, Seoyeon Lee, Daniel R Calabrese, Steven R Hays, Jeffery A Golden, Jasleen Kukreja, Jonathan P Singer, Paul J Wolters, Qizhi Tang, John R Greenland
• Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF.
  Respiratory research 2021 Decaris ML, Schaub JR, Chen C, Cha J, Lee GG, Rexhepaj M, Ho SS, Rao V, Marlow MM, Kotak P, Budi EH, Hooi L, Wu J, Fridlib M, Martin SP, Huang S, Chen M, Muñoz M, Hom TF, Wolters PJ, Desai TJ, Rock F,…
• Treatment of fibrotic interstitial lung disease: current approaches and future directions.
  Lancet (London, England) 2021 Johannson KA, Chaudhuri N, Adegunsoye A, Wolters PJ
• Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates.
  Annals of the American Thoracic Society 2021 Maheshwari JA, Kolaitis NA, Anderson MR, Benvenuto L, Gao Y, Katz PP, Greenland J, Wolters PJ, Covinsky K, Hays SR, Kukreja J, Calabrese DR, Venado A, Shah RJ, Leard LE, Trinh B, Huang CY, Glidden D, …
• TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis.
  Science translational medicine 2021 Sun T, Huang Z, Liang WC, Yin J, Lin WY, Wu J, Vernes JM, Lutman J, Caplazi P, Jeet S, Wong T, Wong M, DePianto DJ, Morshead KB, Sun KH, Modrusan Z, Vander Heiden JA, Abbas AR, Zhang H, Xu M, N'Diaye …
• Peripheral blood leucocyte telomere length is associated with progression of interstitial lung disease in systemic sclerosis.
  Thorax 2021 Liu S, Chung MP, Ley B, French S, Elicker BM, Fiorentino DF, Chung LS, Boin F, Wolters PJ
• MUC5B promoter variant rs35705950 and rheumatoid arthritis associated interstitial lung disease survival and progression.
  Seminars in arthritis and rheumatism 2021 Juge PA, Solomon JJ, van Moorsel CHM, Garofoli R, Lee JS, Louis-Sydney F, Rojas-Serrano J, González-Pérez MI, Mejia M, Buendia-Roldán I, Falfán-Valencia R, Ambrocio-Ortiz E, Manali E, Papiris SA, …
• Invariant Natural Killer T cells coordinate removal of senescent cells.
  Med (New York, N.Y.) 2021 Arora S, Thompson PJ, Wang Y, Bhattacharyya A, Apostolopoulou H, Hatano R, Naikawadi RP, Shah A, Wolters PJ, Koliwad S, Bhattacharya M, Bhushan A
• Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population.
  JCI insight 2021 DePianto DJ, Heiden JAV, Morshead KB, Sun KH, Modrusan Z, Teng G, Wolters PJ, Arron JR
• MAV(S)erick mitochondria: an unconventional role for mitochondrial antiviral signalling protein in pulmonary fibrosis.
  The European respiratory journal 2021 Naikawadi RP, Wolters PJ
• Molecular markers of telomere dysfunction and senescence are common findings in the usual interstitial pneumonia pattern of lung fibrosis.
  Histopathology 2021 Lee JS, La J, Aziz S, Dobrinskikh E, Brownell R, Jones KD, Achtar-Zadeh N, Green G, Elicker BM, Golden JA, Matthay MA, Kukreja J, Schwartz DA, Wolters PJ
• Leukocyte telomere length and mycophenolate therapy in chronic hypersensitivity pneumonitis.
  The European respiratory journal 2021 Adegunsoye A, Morisset J, Newton CA, Oldham JM, Vittinghoff E, Linderholm AL, Strek ME, Noth I, Garcia CK, Wolters PJ, Ley B
• Autoantibodies targeting telomere-associated proteins in systemic sclerosis.
  Annals of the rheumatic diseases 2021 Adler BL, Boin F, Wolters PJ, Bingham CO, Shah AA, Greider C, Casciola-Rosen L, Rosen A
• Blocking LOXL2 and TGFβ1 signalling induces collagen I turnover in precision-cut lung slices derived from patients with idiopathic pulmonary fibrosis.
  Thorax 2021 Wei Y, Dong W, Jackson J, Ho TC, Le Saux CJ, Brumwell A, Li X, Klesney-Tait J, Cohen ML, Wolters PJ, Chapman HA
• The Pulmonary Fibrosis Foundation Patient Registry. Rationale, Design, and Methods.
  Annals of the American Thoracic Society 2020 Wang BR, Edwards R, Freiheit EA, Ma Y, Burg C, de Andrade J, Lancaster L, Lindell K, Nathan SD, Raghu G, Gibson K, Gulati M, Mason W, Noth I, Schmidt B, Spino C, Staszak S, Stauffer J, Wolters PJ, …
• Extracellular BMP1 is the major proteinase for COOH-terminal proteolysis of type I procollagen in lung fibroblasts.
  American journal of physiology. Cell physiology 2020 N'Diaye EN, Cook R, Wang H, Wu P, LaCanna R, Wu C, Ye Z, Seshasayee D, Hazen M, Lin W, Tyagi T, Hotzel I, Tam L, Newman R, Roose-Girma M, Wolters PJ, Ding N
• Osteopontin Links Myeloid Activation and Disease Progression in Systemic Sclerosis.
  Cell reports. Medicine 2020 Gao X, Jia G, Guttman A, DePianto DJ, Morshead KB, Sun KH, Ramamoorthi N, Vander Heiden JA, Modrusan Z, Wolters PJ, Jahreis A, Arron JR, Khanna D, Ramalingam TR
• Chronic Hypersensitivity Pneumonitis, an Interstitial Lung Disease with Distinct Molecular Signatures.
  American journal of respiratory and critical care medicine 2020 Furusawa H, Cardwell JH, Okamoto T, Walts AD, Konigsberg IR, Kurche JS, Bang TJ, Schwarz MI, Brown KK, Kropski JA, Rojas M, Cool CD, Lee JS, Wolters PJ, Yang IV, Schwartz DA
• Osteopontin Links Myeloid Activation and Disease Progression in Systemic Sclerosis.
  2020 Xia Gao, Guiquan Jia, Anna Guttman, Daryle J. DePianto, Katrina B. Morshead, Kai-Hui Sun, Nandhini Ramamoorthi, Jason A. Vander Heiden, Zora Modrusan, Paul J. Wolters, Angelika Jahreis, Joseph R. …
• Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.
  Nature cell biology 2020 Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T
• Lymphatic Proliferation Ameliorates Pulmonary Fibrosis after Lung Injury.
  The American journal of pathology 2020 Baluk P, Naikawadi RP, Kim S, Rodriguez F, Choi D, Hong YK, Wolters PJ, McDonald DM
• Essential Components of an Interstitial Lung Disease Clinic: Results From a Delphi Survey and Patient Focus Group Analysis.
  Chest 2020 Graney BA, He C, Marll M, Matson S, Bianchi P, Cosgrove GP, Lee JS, PFF CCN Delphi Collaborators
• Airway Epithelial Telomere Dysfunction Drives Remodeling Similar to Chronic Lung Allograft Dysfunction.
  American journal of respiratory cell and molecular biology 2020 Naikawadi RP, Green G, Jones KD, Achtar-Zadeh N, Mieleszko JE, Arnould I, Kukreja J, Greenland JR, Wolters PJ
• Telomere length in patients with unclassifiable interstitial lung disease: a cohort study.
  The European respiratory journal 2020 Ley B, Liu S, Elicker BM, Henry TS, Vittinghoff E, Golden JA, Jones KD, Wolters PJ
• Age-dependent regulation of cell-mediated collagen turnover.
  JCI insight 2020 Podolsky MJ, Yang CD, Valenzuela CL, Datta R, Huang SK, Nishimura SL, Dallas SL, Wolters PJ, Le Saux CJ, Atabai K
• A mammalian Wnt5a-Ror2-Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis.
  eLife 2020 Zhang K, Yao E, Lin C, Chou YT, Wong J, Li J, Wolters PJ, Chuang PT
• Long-term ozone exposure is positively associated with telomere length in critically ill patients.
  Environment international 2020 Wang C, Wolters PJ, Calfee CS, Liu S, Balmes JR, Zhao Z, Koyama T, Ware LB
• Frailty after lung transplantation is associated with impaired health-related quality of life and mortality.
  Thorax 2020 Venado A, Kolaitis NA, Huang CY, Gao Y, Glidden DV, Soong A, Sutter N, Katz PP, Greenland JR, Calabrese DR, Hays SR, Golden JA, Shah RJ, Leard LE, Kukreja J, Deuse T, Wolters PJ, Covinsky K, Blanc PD,…
• Diaphragmatic Atrophy May Limit Progression of Idiopathic Pulmonary Fibrosis.
  American journal of respiratory and critical care medicine 2020 Venado A, Witt LJ, Kallianos K, Wolters PJ
• Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis.
  Nature communications 2020 Tsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, Adams TS, Schupp JC, Poli SD, Rosas IO, Kaminski N, Matthay MA, Wolters PJ, Sheppard D
• Reversal of TGFβ1-Driven Profibrotic State in Patients with Pulmonary Fibrosis.
  The New England journal of medicine 2020 Chapman HA, Wei Y, Montas G, Leong D, Golden JA, Trinh BN, Wolters PJ, Le Saux CJ, Jones KD, Hills NK, Foster E, Oldham JM, Linderholm AL, Kotak P, Decaris M, Turner S, Song JW
• A Systematically Derived Exposure Assessment Instrument for Chronic Hypersensitivity Pneumonitis.
  Chest 2020 Barnes H, Morisset J, Molyneaux P, Westall G, Glaspole I, Collard HR, CHP Exposure Assessment Collaborators
• Peripheral blood leukocyte telomere length is associated with survival of sepsis patients.
  The European respiratory journal 2020 Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ
• Interaction Between Epithelial and Mesenchymal Cells in Interstitial Lung Disease.
  2020 Max L. Cohen, Paul J. Wolters
• Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis.
  American journal of respiratory and critical care medicine 2019 Ley B, Torgerson DG, Oldham JM, Adegunsoye A, Liu S, Li J, Elicker BM, Henry TS, Golden JA, Jones KD, Dressen A, Yaspan BL, Arron JR, Noth I, Hoffmann TJ, Wolters PJ
• Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses.
  Science immunology 2019 Kalekar LA, Cohen JN, Prevel N, Sandoval PM, Mathur AN, Moreau JM, Lowe MM, Nosbaum A, Wolters PJ, Haemel A, Boin F, Rosenblum MD
• Oxygen in patients with fibrotic interstitial lung disease: an international Delphi survey.
  The European respiratory journal 2019 Lim RK, Humphreys C, Morisset J, Holland AE, Johannson KA, O2 Delphi Collaborators
• A nonlinear relationship between visceral adipose tissue and frailty in adult lung transplant candidates.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2019 Anderson MR, Kolaitis NA, Gao Y, Kukreja J, Greenland J, Hays S, Wolters P, Golden J, Diamond J, Palmer S, Arcasoy S, Udupa J, Christie JD, Lederer DJ, Singer JP
• Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.
  American journal of respiratory and critical care medicine 2019 Moore C, Blumhagen RZ, Yang IV, Walts A, Powers J, Walker T, Bishop M, Russell P, Vestal B, Cardwell J, Markin CR, Mathai SK, Schwarz MI, Steele MP, Lee J, Brown KK, Loyd JE, Crapo JD, Silverman EK, …
• Prevalence and Clinical Significance of Antineutrophil Cytoplasmic Antibodies in North American Patients With Idiopathic Pulmonary Fibrosis.
  Chest 2019 Liu GY, Ventura IB, Achtar-Zadeh N, Elicker BM, Jones KD, Wolters PJ, Collard HR, Adegunsoye A, Strek ME, Ley B
• Pulmonary physiology is poorly associated with radiological extent of disease in systemic sclerosis-associated interstitial lung disease.
  The European respiratory journal 2019 Jhajj A, Gill HP, Hague CJ, Murphy D, Elicker B, Soon J, Sulaiman N, Castillo-Saldana D, Wilcox PG, Dunne J, Lee JS, Wolters PJ, Ley B, Jones KD, Morisset J, Ryerson CJ
• Significance of bronchiolocentric fibrosis in patients with histopathological usual interstitial pneumonia.
  Histopathology 2019 Tanizawa K, Ley B, Vittinghoff E, Elicker BM, Henry TS, Wolters PJ, Brownell R, Liu S, Collard HR, Jones KD
• Telomere length and genetic variant associations with interstitial lung disease progression and survival.
  The European respiratory journal 2019 Newton CA, Oldham JM, Ley B, Anand V, Adegunsoye A, Liu G, Batra K, Torrealba J, Kozlitina J, Glazer C, Strek ME, Wolters PJ, Noth I, Garcia CK
• Molecular endpoints for establishing target engagement by novel idiopathic pulmonary fibrosis therapies.
  The European respiratory journal 2019 Wolters PJ, Cottin V
• Association between greenhouse working exposure and bronchial asthma: A pilot, cross-sectional survey of 5,420 greenhouse farmers from northeast China.
  Journal of occupational and environmental hygiene 2019 Liu S, Wolters PJ, Zhang Y, Zhao M, Liu D, Wang L, Zhao G, Mao S, Wu L, Zhao H, Wang X
• Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage.
  Nature immunology 2019 Aran D, Looney AP, Liu L, Wu E, Fong V, Hsu A, Chak S, Naikawadi RP, Wolters PJ, Abate AR, Butte AJ, Bhattacharya M
• Increased Extracellular Vesicles Mediate WNT5A Signaling in Idiopathic Pulmonary Fibrosis.
  American journal of respiratory and critical care medicine 2018 Martin-Medina A, Lehmann M, Burgy O, Hermann S, Baarsma HA, Wagner DE, De Santis MM, Ciolek F, Hofer TP, Frankenberger M, Aichler M, Lindner M, Gesierich W, Guenther A, Walch A, Coughlan C, Wolters P,…
• Pirfenidone in the kaleidoscope: reflecting mechanisms through different angles.
  The European respiratory journal 2018 Tzouvelekis A, Wolters PJ
• Histopathological and molecular analysis of idiopathic pulmonary fibrosis lungs from patients treated with pirfenidone or nintedanib.
  Histopathology 2018 Zhang Y, Jones KD, Achtar-Zadeh N, Green G, Kukreja J, Xu B, Wolters PJ
• MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease.
  The New England journal of medicine 2018 Juge PA, Lee JS, Ebstein E, Furukawa H, Dobrinskikh E, Gazal S, Kannengiesser C, Ottaviani S, Oka S, Tohma S, Tsuchiya N, Rojas-Serrano J, González-Pérez MI, Mejía M, Buendía-Roldán I, Falfán-Valencia…
• Response.
  Chest 2018 Johannson KA, Vittinghoff E, Morisset J, Wolters PJ, Noth EM, Balmes JR, Collard HR
• Laparoscopic anti-reflux surgery for the treatment of idiopathic pulmonary fibrosis (WRAP-IPF): a multicentre, randomised, controlled phase 2 trial.
  The Lancet. Respiratory medicine 2018 Raghu G, Pellegrini CA, Yow E, Flaherty KR, Meyer K, Noth I, Scholand MB, Cello J, Ho LA, Pipavath S, Lee JS, Lin J, Maloney J, Martinez FJ, Morrow E, Patti MG, Rogers S, Wolters PJ, Yates R, Anstrom …
• Prognostic and predictive biomarkers for patients with idiopathic pulmonary fibrosis treated with pirfenidone: post-hoc assessment of the CAPACITY and ASCEND trials.
  The Lancet. Respiratory medicine 2018 Neighbors M, Cabanski CR, Ramalingam TR, Sheng XR, Tew GW, Gu C, Jia G, Peng K, Ray JM, Ley B, Wolters PJ, Collard HR, Arron JR
• Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study.
  The Lancet. Respiratory medicine 2018 Dressen A, Abbas AR, Cabanski C, Reeder J, Ramalingam TR, Neighbors M, Bhangale TR, Brauer MJ, Hunkapiller J, Reeder J, Mukhyala K, Cuenco K, Tom J, Cowgill A, Vogel J, Forrest WF, Collard HR, Wolters…
• Air Pollution Exposure Is Associated With Lower Lung Function, but Not Changes in Lung Function, in Patients With Idiopathic Pulmonary Fibrosis.
  Chest 2018 Johannson KA, Vittinghoff E, Morisset J, Wolters PJ, Noth EM, Balmes JR, Collard HR
• Time for a change: is idiopathic pulmonary fibrosis still idiopathic and only fibrotic?
  The Lancet. Respiratory medicine 2018 Wolters PJ, Blackwell TS, Eickelberg O, Loyd JE, Kaminski N, Jenkins G, Maher TM, Molina-Molina M, Noble PW, Raghu G, Richeldi L, Schwarz MI, Selman M, Wuyts WA, Schwartz DA
• Identification of Diagnostic Criteria for Chronic Hypersensitivity Pneumonitis: An International Modified Delphi Survey.
  American journal of respiratory and critical care medicine 2017 Morisset J, Johannson KA, Jones KD, Wolters PJ, Collard HR, Walsh SLF, Ley B, HP Delphi Collaborators
• The MUC5B promoter polymorphism and telomere length in patients with chronic hypersensitivity pneumonitis: an observational cohort-control study.
  The Lancet. Respiratory medicine 2017 Ley B, Newton CA, Arnould I, Elicker BM, Henry TS, Vittinghoff E, Golden JA, Jones KD, Batra K, Torrealba J, Garcia CK, Wolters PJ
• Mortality Risk Prediction in Scleroderma-Related Interstitial Lung Disease: The SADL Model.
  Chest 2017 Morisset J, Vittinghoff E, Elicker BM, Hu X, Le S, Ryu JH, Jones KD, Haemel A, Golden JA, Boin F, Ley B, Wolters PJ, King TE, Collard HR, Lee JS
• A recurring theme in pulmonary fibrosis genetics.
  The European respiratory journal 2017 Wolters PJ
• Short lung transplant donor telomere length is associated with decreased CLAD-free survival.
  Thorax 2017 Faust HE, Golden JA, Rajalingam R, Wang AS, Green G, Hays SR, Kukreja J, Singer JP, Wolters PJ, Greenland JR
• The performance of the GAP model in patients with rheumatoid arthritis associated interstitial lung disease.
  Respiratory medicine 2017 Morisset J, Vittinghoff E, Lee BY, Tonelli R, Hu X, Elicker BM, Ryu JH, Jones KD, Cerri S, Manfredi A, Sebastiani M, Gross AJ, Ley B, Wolters PJ, King TE, Kim DS, Collard HR, Lee JS
• Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.
  Cell 2017 Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM
• CXCL14 is a candidate biomarker for Hedgehog signalling in idiopathic pulmonary fibrosis.
  Thorax 2017 Jia G, Chandriani S, Abbas AR, DePianto DJ, N'Diaye EN, Yaylaoglu MB, Moore HM, Peng I, DeVoss J, Collard HR, Wolters PJ, Egen JG, Arron JR
• Pathologic Findings and Prognosis in a Large Prospective Cohort of Chronic Hypersensitivity Pneumonitis.
  Chest 2017 Wang P, Jones KD, Urisman A, Elicker BM, Urbania T, Johannson KA, Assayag D, Lee J, Wolters PJ, Collard HR, Koth LL
• The use of pretest probability increases the value of high-resolution CT in diagnosing usual interstitial pneumonia.
  Thorax 2017 Brownell R, Moua T, Henry TS, Elicker BM, White D, Vittinghoff E, Jones KD, Urisman A, Aravena C, Johannson KA, Golden JA, King TE, Wolters PJ, Collard HR, Ley B
• Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity.
  JCI insight 2016 Lofgren S, Hinchcliff M, Carns M, Wood T, Aren K, Arroyo E, Cheung P, Kuo A, Valenzuela A, Haemel A, Wolters PJ, Gordon J, Spiera R, Assassi S, Boin F, Chung L, Fiorentino D, Utz PJ, Whitfield ML, …
• Use of Mycophenolate Mofetil or Azathioprine for the Management of Chronic Hypersensitivity Pneumonitis.
  Chest 2016 Morisset J, Johannson KA, Vittinghoff E, Aravena C, Elicker BM, Jones KD, Fell CD, Manganas H, Dubé BP, Wolters PJ, Collard HR, Ryerson CJ, Ley B
• Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts.
  Transplantation 2016 Greenland JR, Wong CM, Ahuja R, Wang AS, Uchida C, Golden JA, Hays SR, Leard LE, Rajalingam R, Singer JP, Kukreja J, Wolters PJ, Caughey GH, Tang Q
• Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis.
  JCI insight 2016 Naikawadi RP, Disayabutr S, Mallavia B, Donne ML, Green G, La JL, Rock JR, Looney MR, Wolters PJ
• Brief Report: Whole-Exome Sequencing for Identification of Potential Causal Variants for Diffuse Cutaneous Systemic Sclerosis.
  Arthritis & rheumatology (Hoboken, N.J.) 2016 Mak AC, Tang PL, Cleveland C, Smith MH, Kari Connolly M, Katsumoto TR, Wolters PJ, Kwok PY, Criswell LA
• Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis.
  PloS one 2016 Tatler AL, Goodwin AT, Gbolahan O, Saini G, Porte J, John AE, Clifford RL, Violette SM, Weinreb PH, Parfrey H, Wolters PJ, Gauldie J, Kolb M, Jenkins G
• miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis.
  PloS one 2016 Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay MA, Kukreja J, Erle DJ, Collard HR, Wolters PJ
• Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia.
  BMC genetics 2016 Fingerlin TE, Zhang W, Yang IV, Ainsworth HC, Russell PH, Blumhagen RZ, Schwarz MI, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch DA, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, …
• A diagnostic model for chronic hypersensitivity pneumonitis.
  Thorax 2016 Johannson KA, Elicker BM, Vittinghoff E, Assayag D, de Boer K, Golden JA, Jones KD, King TE, Koth LL, Lee JS, Ley B, Wolters PJ, Collard HR
• Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression.
  The Journal of biological chemistry 2016 Tatler AL, Habgood A, Porte J, John AE, Stavrou A, Hodge E, Kerama-Likoko C, Violette SM, Weinreb PH, Knox AJ, Laurent G, Parfrey H, Wolters PJ, Wallace W, Alberti S, Nordheim A, Jenkins G
• Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes.
  Scientific reports 2016 Withana NP, Ma X, McGuire HM, Verdoes M, van der Linden WA, Ofori LO, Zhang R, Li H, Sanman LE, Wei K, Yao S, Wu P, Li F, Huang H, Xu Z, Wolters PJ, Rosen GD, Collard HR, Zhu Z, Cheng Z, Bogyo M
• Frailty Phenotypes, Disability, and Outcomes in Adult Candidates for Lung Transplantation.
  American journal of respiratory and critical care medicine 2015 Singer JP, Diamond JM, Gries CJ, McDonnough J, Blanc PD, Shah R, Dean MY, Hersh B, Wolters PJ, Tokman S, Arcasoy SM, Ramphal K, Greenland JR, Smith N, Heffernan P, Shah L, Shrestha P, Golden JA, …
• Interstitial lung diseases in the hospitalized patient.
  BMC medicine 2015 Disayabutr S, Calfee CS, Collard HR, Wolters PJ
• Survival in interstitial pneumonia with features of autoimmune disease: a comparison of proposed criteria.
  Respiratory medicine 2015 Assayag D, Kim EJ, Elicker BM, Jones KD, Golden JA, King TE, Koth LL, Shum AK, Wolters PJ, Collard HR, Lee JS
• The effect of bronchodilators on forced vital capacity measurement in patients with idiopathic pulmonary fibrosis.
  Respiratory medicine 2015 Assayag D, Vittinghoff E, Ryerson CJ, Cocconcelli E, Tonelli R, Hu X, Elicker BM, Golden JA, Jones KD, King TE, Koth LL, Lee JS, Ley B, Shum AK, Wolters PJ, Ryu JH, Collard HR
• Lung transplantation for hypersensitivity pneumonitis.
  Chest 2015 Kern RM, Singer JP, Koth L, Mooney J, Golden J, Hays S, Greenland J, Wolters P, Ghio E, Jones KD, Leard L, Kukreja J, Blanc PD
• Classification of usual interstitial pneumonia in patients with interstitial lung disease: assessment of a machine learning approach using high-dimensional transcriptional data.
  The Lancet. Respiratory medicine 2015 Kim SY, Diggans J, Pankratz D, Huang J, Pagan M, Sindy N, Tom E, Anderson J, Choi Y, Lynch DA, Steele MP, Flaherty KR, Brown KK, Farah H, Bukstein MJ, Pardo A, Selman M, Wolters PJ, Nathan SD, Colby …
• Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter.
  The Journal of biological chemistry 2015 Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL
• Overexpression of inhibitor of DNA-binding 2 attenuates pulmonary fibrosis through regulation of c-Abl and Twist.
  The American journal of pathology 2015 Yang J, Velikoff M, Agarwal M, Disayabutr S, Wolters PJ, Kim KK
• Subacute onset of pulmonary langerhans cell histiocytosis with resolution after smoking cessation.
  American journal of respiratory and critical care medicine 2014 Wolters PJ, Elicker BM
• Fibulin-1 predicts disease progression in patients with idiopathic pulmonary fibrosis.
  Chest 2014 Jaffar J, Unger S, Corte TJ, Keller M, Wolters PJ, Richeldi L, Cerri S, Prêle CM, Hansbro PM, Argraves WS, Oliver RA, Oliver BG, Black JL, Burgess JK
• Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis.
  Thorax 2014 DePianto DJ, Chandriani S, Abbas AR, Jia G, N'Diaye EN, Caplazi P, Kauder SE, Biswas S, Karnik SK, Ha C, Modrusan Z, Matthay MA, Kukreja J, Collard HR, Egen JG, Wolters PJ, Arron JR
• Dipeptidyl peptidase I controls survival from Klebsiella pneumoniae lung infection by processing surfactant protein D.
  Biochemical and biophysical research communications 2014 Sutherland RE, Barry SS, Olsen JS, Salantes DB, Caughey GH, Wolters PJ
• Selective targeting of TGF-β activation to treat fibroinflammatory airway disease.
  Science translational medicine 2014 Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ…
• Effect of telomere length on survival in patients with idiopathic pulmonary fibrosis: an observational cohort study with independent validation.
  The Lancet. Respiratory medicine 2014 Stuart BD, Lee JS, Kozlitina J, Noth I, Devine MS, Glazer CS, Torres F, Kaza V, Girod CE, Jones KD, Elicker BM, Ma SF, Vij R, Collard HR, Wolters PJ, Garcia CK
• Accumulation of BDCA1⁺ dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma.
  PloS one 2014 Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS
• Endogenously expressed IL-13Rα2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Chandriani S, DePianto DJ, N'Diaye EN, Abbas AR, Jackman J, Bevers J, Ramirez-Carrozzi V, Pappu R, Kauder SE, Toy K, Ha C, Modrusan Z, Wu LC, Collard HR, Wolters PJ, Egen JG, Arron JR
• Predicting survival across chronic interstitial lung disease: the ILD-GAP model.
  Chest 2014 Ryerson CJ, Vittinghoff E, Ley B, Lee JS, Mooney JJ, Jones KD, Elicker BM, Wolters PJ, Koth LL, King TE, Collard HR
• Serum IgE clearance is facilitated by human FcεRI internalization.
  The Journal of clinical investigation 2014 Greer AM, Wu N, Putnam AL, Woodruff PG, Wolters P, Kinet JP, Shin JS
• Increased susceptibility to Klebsiella pneumonia and mortality in GSNOR-deficient mice.
  Biochemical and biophysical research communications 2013 Tang CH, Seeley EJ, Huang X, Wolters PJ, Liu L
• BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease.
  Science translational medicine 2013 Shum AK, Alimohammadi M, Tan CL, Cheng MH, Metzger TC, Law CS, Lwin W, Perheentupa J, Bour-Jordan H, Carel JC, Husebye ES, De Luca F, Janson C, Sargur R, Dubois N, Kajosaari M, Wolters PJ, Chapman HA,…
• Pathogenesis of idiopathic pulmonary fibrosis.
  Annual review of pathology 2013 Wolters PJ, Collard HR, Jones KD
• Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
  Nature genetics 2013 Fingerlin TE, Murphy E, Zhang W, Peljto AL, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch D, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS,…
• Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice.
  Journal of immunology (Baltimore, Md. : 1950) 2013 Seeley EJ, Barry SS, Narala S, Matthay MA, Wolters PJ
• Prevalence and prognosis of unclassifiable interstitial lung disease.
  The European respiratory journal 2012 Ryerson CJ, Urbania TH, Richeldi L, Mooney JJ, Lee JS, Jones KD, Elicker BM, Koth LL, King TE, Wolters PJ, Collard HR
• Prevalence and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis.
  Respiratory medicine 2012 Lee JS, Kim EJ, Lynch KL, Elicker B, Ryerson CJ, Katsumoto TR, Shum AK, Wolters PJ, Cerri S, Richeldi L, Jones KD, King TE, Collard HR
• Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis.
  Respiratory research 2012 Cha SI, Ryerson CJ, Lee JS, Kukreja J, Barry SS, Jones KD, Elicker BM, Kim DS, Papa FR, Collard HR, Wolters PJ
• Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR
• Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.
  The Journal of clinical investigation 2012 Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters PJ, Shokat KM, Huang X, Sheppard D
• Inflection points in sepsis biology: from local defense to systemic organ injury.
  American journal of physiology. Lung cellular and molecular physiology 2012 Seeley EJ, Matthay MA, Wolters PJ
• Noradrenergic neurons regulate the egress and trafficking of splenic monocytes and influence mortality during Gram-negative infection in mice.
  Critical Care 2012 EJ Seeley, S Barry, M Matthay, PJ Wolters
• Relative versus absolute change in forced vital capacity in idiopathic pulmonary fibrosis.
  Thorax 2012 Richeldi L, Ryerson CJ, Lee JS, Wolters PJ, Koth LL, Ley B, Elicker BM, Jones KD, King TE, Ryu JH, Collard HR
• Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis.
  Histopathology 2012 Cha SI, Chang CS, Kim EK, Lee JW, Matthay MA, Golden JA, Elicker BM, Jones K, Collard HR, Wolters PJ
• Bronchoalveolar lavage pepsin in acute exacerbation of idiopathic pulmonary fibrosis.
  The European respiratory journal 2011 Lee JS, Song JW, Wolters PJ, Elicker BM, King TE, Kim DS, Collard HR
• Parasitic infection improves survival from septic peritonitis by enhancing mast cell responses to bacteria in mice.
  PloS one 2011 Sutherland RE, Xu X, Kim SS, Seeley EJ, Caughey GH, Wolters PJ
• Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture.
  The Journal of biological chemistry 2011 Markovics JA, Araya J, Cambier S, Somanath S, Gline S, Jablons D, Hill A, Wolters PJ, Nishimura SL
• Gastroesophageal reflux therapy is associated with longer survival in patients with idiopathic pulmonary fibrosis.
  American journal of respiratory and critical care medicine 2011 Lee JS, Ryu JH, Elicker BM, Lydell CP, Jones KD, Wolters PJ, King TE, Collard HR
• In search of the fibrotic epithelial cell: opportunities for a collaborative network.
  Thorax 2011 Jenkins G, Blanchard A, Borok Z, Bradding P, Ehrhardt C, Fisher A, Hirani N, Johnson S, Königshoff M, Maher TM, Millar A, Parfrey H, Scotton C, Tetley T, Thickett D, Wolters P, ECIPF workshop
• Systemic mast cell degranulation increases mortality during polymicrobial septic peritonitis in mice.
  Journal of leukocyte biology 2011 Seeley EJ, Sutherland RE, Kim SS, Wolters PJ
• Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.
  The Journal of clinical investigation 2011 Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL
• Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis.
  American journal of physiology. Lung cellular and molecular physiology 2011 Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ
• Viral infection in acute exacerbation of idiopathic pulmonary fibrosis.
  American journal of respiratory and critical care medicine 2011 Wootton SC, Kim DS, Kondoh Y, Chen E, Lee JS, Song JW, Huh JW, Taniguchi H, Chiu C, Boushey H, Lancaster LH, Wolters PJ, DeRisi J, Ganem D, Collard HR
• Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway.
  The Journal of biological chemistry 2010 Markovics JA, Araya J, Cambier S, Jablons D, Hill A, Wolters PJ, Nishimura SL
• Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis.
  American journal of physiology. Lung cellular and molecular physiology 2010 Collard HR, Calfee CS, Wolters PJ, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay MA, Kim DS
• Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function.
  Lung 2010 Kinder BW, Shariat C, Collard HR, Koth LL, Wolters PJ, Golden JA, Panos RJ, King TE
• Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages.
  The Journal of clinical investigation 2009 Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D
• Could N-acetylcysteine slow progression of idiopathic pulmonary fibrosis by inhibiting EMT?
  American journal of physiology. Lung cellular and molecular physiology 2009 Wolters PJ
• Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice.
  Nature medicine 2009 Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP
• Neutrophil-derived IL-6 limits alveolar barrier disruption in experimental ventilator-induced lung injury.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Wolters PJ, Wray C, Sutherland RE, Kim SS, Koff J, Mao Y, Frank JA
• Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis.
  The Journal of clinical investigation 2008 Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA
• Mast cell IL-6 improves survival from Klebsiella pneumonia and sepsis by enhancing neutrophil killing.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Sutherland RE, Olsen JS, McKinstry A, Villalta SA, Wolters PJ
• Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice.
  The Journal of clinical investigation 2007 Sun J, Sukhova GK, Yang M, Wolters PJ, MacFarlane LA, Libby P, Sun C, Zhang Y, Liu J, Ennis TL, Knispel R, Xiong W, Thompson RW, Baxter BT, Shi GP
• Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients.
  The Journal of clinical investigation 2007 Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL
• Use of mycophenolate mofetil to treat scleroderma-associated interstitial lung disease.
  Respiratory medicine 2007 Zamora AC, Wolters PJ, Collard HR, Connolly MK, Elicker BM, Webb WR, King TE, Golden JA
• Relationships between early inflammatory response to bleomycin and sensitivity to lung fibrosis: a role for dipeptidyl-peptidase I and tissue inhibitor of metalloproteinase-3?
  American journal of respiratory and critical care medicine 2007 Pottier N, Chupin C, Defamie V, Cardinaud B, Sutherland R, Rios G, Gauthier F, Wolters PJ, Berthiaume Y, Barbry P, Mari B
• Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease?
  American journal of respiratory and critical care medicine 2007 Kinder BW, Collard HR, Koth L, Daikh DI, Wolters PJ, Elicker B, Jones KD, King TE
• Mast cells promote atherosclerosis by releasing proinflammatory cytokines.
  Nature medicine 2007 Sun J, Sukhova GK, Wolters PJ, Yang M, Kitamoto S, Libby P, MacFarlane LA, Mallen-St Clair J, Shi GP
• Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.
  Gastroenterology 2007 Cottrell GS, Amadesi S, Pikios S, Camerer E, Willardsen JA, Murphy BR, Caughey GH, Wolters PJ, Coughlin SR, Peterson A, Knecht W, Pothoulakis C, Bunnett NW, Grady EF
• Clinical problem-solving. Anchors away.
  The New England journal of medicine 2007 Calfee CS, Shah SJ, Wolters PJ, Saint S, King TE
• Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.
  The Journal of experimental medicine 2006 Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH
• Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses.
  Journal of immunology (Baltimore, Md. : 1950) 2006 Wang B, Huang X, Wolters PJ, Sun J, Kitamoto S, Yang M, Riese R, Leng L, Chapman HA, Finn PW, David JR, Bucala R, Shi GP
• Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA
• Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice.
  Biological chemistry 2006 Mallen-St Clair J, Shi GP, Sutherland RE, Chapman HA, Caughey GH, Wolters PJ
• Neurofibromatosis-associated lung disease: a case series and literature review.
  The European respiratory journal 2006 Zamora AC, Collard HR, Wolters PJ, Webb WR, King TE
• Mast cells protect mice from Mycoplasma pneumonia.
  American journal of respiratory and critical care medicine 2005 Xu X, Zhang D, Lyubynska N, Wolters PJ, Killeen NP, Baluk P, McDonald DM, Hawgood S, Caughey GH
• c-Kit immunophenotyping and metalloproteinase expression profiles of mast cells in interstitial lung diseases.
  The Journal of pathology 2005 Edwards ST, Cruz AC, Donnelly S, Dazin PF, Schulman ES, Jones KD, Wolters PJ, Hoopes C, Dolganov GM, Fang KC
• Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice.
  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005 Wolters PJ, Mallen-St Clair J, Lewis CC, Villalta SA, Baluk P, Erle DJ, Caughey GH
• Mast cell dipeptidyl peptidase I mediates survival from sepsis.
  The Journal of clinical investigation 2004 Mallen-St Clair J, Pham CT, Villalta SA, Caughey GH, Wolters PJ
• Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5.
  Biological chemistry 2003 Henningsson F, Wolters P, Chapman HA, Caughey GH, Pejler G
• Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas.
  The Journal of biological chemistry 2002 Bhagwandin VJ, Hau LW, Mallen-St Clair J, Wolters PJ, Caughey GH
• Lys40 but not Arg143 influences selectivity of angiotensin conversion by human alpha-chymase.
  Biochimica et biophysica acta 2002 Muilenburg DJ, Raymond WW, Wolters PJ, Caughey GH
• Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice.
  The Journal of biological chemistry 2001 Wolters PJ, Pham CT, Muilenburg DJ, Ley TJ, Caughey GH
• Importance of lysosomal cysteine proteases in lung disease.
  Respiratory research 2000 Wolters PJ, Chapman HA
• Angiotensin II generation by mast cell alpha- and beta-chymases.
  Biochimica et biophysica acta 2000 Caughey GH, Raymond WW, Wolters PJ
• Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families.
  Journal of immunology (Baltimore, Md. : 1950) 2000 Caughey GH, Raymond WW, Blount JL, Hau LW, Pallaoro M, Wolters PJ, Verghese GM
• Dipeptidyl peptidase I cleaves matrix-associated proteins and is expressed mainly by mast cells in normal dog airways.
  American journal of respiratory cell and molecular biology 2000 Wolters PJ, Laig-Webster M, Caughey GH
• Mast cell expression of gelatinases A and B is regulated by kit ligand and TGF-beta.
  Journal of immunology (Baltimore, Md. : 1950) 1999 Fang KC, Wolters PJ, Steinhoff M, Bidgol A, Blount JL, Caughey GH
• Regulated expression, processing, and secretion of dog mast cell dipeptidyl peptidase I.
  The Journal of biological chemistry 1998 Wolters PJ, Raymond WW, Blount JL, Caughey GH
• Polymer length of teichuronic acid released from cell walls of Micrococcus luteus.
  Journal of bacteriology 1990 Wolters PJ, Hildebrandt KM, Dickie JP, Anderson JS
• Evidence for chloride secretion in the intestine of the winter flounder.
  The American journal of physiology 1990 O'Grady SM, Wolters PJ
• Cardiac antisecretory peptide inhibits intestinal chloride secretion.
  The American journal of physiology 1989 O'Grady SM, Wolters PJ
• Regulation of ion transport in porcine gallbladder: effects of VIP and norepinephrine.
  The American journal of physiology 1989 O'Grady SM, Wolters PJ, Hildebrand K, Brown DR
• Sodium and chloride transport across the isolated porcine gallbladder.
  The American journal of physiology 1989 O'Grady SM, Wolters PJ