Paul Simpson, MD
Professor Emeritus
Medicine
School of Medicine

The lab has pursued initial findings from the early 1980s to the present, identifying a subclass of receptors for adrenaline as potential targets for a heart failure drug. Efforts in the lab are directed to this new drug, as well as discovering novel aspects of the class of adrenaline receptors. The lab has been funded continuously by the NIH and the VA, with additional important contribution from the AHA.

• Reversal of right ventricular failure by chronic α1A-subtype adrenergic agonist therapy.
  American journal of physiology. Heart and circulatory physiology 2018 Cowley PM, Wang G, Swigart PM, Raghunathan A, Reddy N, Dulam P, Lovett DH, Simpson PC, Baker AJ
• Shift toward greater pathologic post-myocardial infarction remodeling with loss of the adaptive hypertrophic signaling of alpha1 adrenergic receptors in mice.
  PloS one 2017 Yeh CC, Fan Y, Xu Y, Yang YL, Simpson PC, Mann MJ
• A method to increase reproducibility in adult ventricular myocyte sizing and flow cytometry: Avoiding cell size bias in single cell preparations.
  PloS one 2017 López JE, Jaradeh K, Silva E, Aminololama-Shakeri S, Simpson PC
• α1A-Subtype adrenergic agonist therapy for the failing right ventricle.
  American journal of physiology. Heart and circulatory physiology 2017 Cowley PM, Wang G, Joshi S, Swigart PM, Lovett DH, Simpson PC, Baker AJ
• Novel large-particle FACS purification of adult ventricular myocytes reveals accumulation of myosin and actin disproportionate to cell size and proteome in normal post-weaning development.
  Journal of molecular and cellular cardiology 2017 López JE, Sharma J, Avila J, Wood TS, VanDyke JE, McLaughlin B, Abbey CK, Wong A, Myagmar BE, Swigart PM, Simpson PC, Chiamvimonvat N
• Response by Simpson et al to Letter Regarding Article, "Adrenergic Receptors in Individual Ventricular Myocytes: the Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent".
  Circulation research 2017 Simpson PC, Myagmar BE, Swigart PM, Melov S, Baker AJ
• Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent.
  Circulation research 2017 Myagmar BE, Flynn JM, Cowley PM, Swigart PM, Montgomery MD, Thai K, Nair D, Gupta R, Deng DX, Hosoda C, Melov S, Baker AJ, Simpson PC
• An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity.
  JACC. Basic to translational science 2017 Beak J, Huang W, Parker JS, Hicks ST, Patterson C, Simpson PC, Ma A, Jin J, Jensen BC
• An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice.
  PloS one 2017 Montgomery MD, Chan T, Swigart PM, Myagmar BE, Dash R, Simpson PC
• The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid and endocannabinoid metabolites associated with inflammation in vivo.
  Metabolomics : Official journal of the Metabolomic Society 2016 Willis MS, Ilaiwy A, Montgomery MD, Simpson PC, Jensen BC
• The Alpha-1A Adrenergic Receptor in the Rabbit Heart.
  PloS one 2016 Thomas RC, Cowley PM, Singh A, Myagmar BE, Swigart PM, Baker AJ, Simpson PC
• A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart.
  JACC. Basic to translational science 2016 Thomas RC, Singh A, Cowley P, Myagmar BE, Montgomery MD, Swigart PM, De Marco T, Baker AJ, Simpson PC
• A New Pathway for Sympathetic Cardioprotection in Heart Failure.
  Circulation research 2015 Simpson PC
• The α1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium.
  American journal of physiology. Heart and circulatory physiology 2015 Cowley PM, Wang G, Chang AN, Makwana O, Swigart PM, Lovett DH, Stull JT, Simpson PC, Baker AJ
• Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone.
  American journal of physiology. Heart and circulatory physiology 2014 Shimkunas R, Makwana O, Spaulding K, Bazargan M, Khazalpour M, Takaba K, Soleimani M, Myagmar BE, Lovett DH, Simpson PC, Ratcliffe MB, Baker AJ
• Alpha-1-adrenergic receptors in heart failure: the adaptive arm of the cardiac response to chronic catecholamine stimulation.
  Journal of cardiovascular pharmacology 2014 Jensen BC, O'Connell TD, Simpson PC
• Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance.
  Pharmacological reviews 2013 O'Connell TD, Jensen BC, Baker AJ, Simpson PC
• Intraventricular and interventricular cellular heterogeneity of inotropic responses to α(1)-adrenergic stimulation.
  American journal of physiology. Heart and circulatory physiology 2013 Chu C, Thai K, Park KW, Wang P, Makwana O, Lovett DH, Simpson PC, Baker AJ
• Synthesis of an in vivo MRI-detectable apoptosis probe.
  Journal of visualized experiments : JoVE 2012 Lam J, Simpson PC, Yang PC, Dash R
• Large-scale discovery of enhancers from human heart tissue.
  Nature genetics 2011 May D, Blow MJ, Kaplan T, McCulley DJ, Jensen BC, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Wright C, Afzal V, Simpson PC, Rubin EM, Black BL, Bristow J, Pennacchio LA, Visel A
• Where are the new drugs to treat heart failure? Introduction to the special issue on "key signaling molecules in hypertrophy and heart failure".
  Journal of molecular and cellular cardiology 2011 Simpson PC
• Long-term α1A-adrenergic receptor stimulation improves synaptic plasticity, cognitive function, mood, and longevity.
  Molecular pharmacology 2011 Doze VA, Papay RS, Goldenstein BL, Gupta MK, Collette KM, Nelson BW, Lyons MJ, Davis BA, Luger EJ, Wood SG, Haselton JR, Simpson PC, Perez DM
• β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes.
  Circulation research 2011 López JE, Myagmar BE, Swigart PM, Montgomery MD, Haynam S, Bigos M, Rodrigo MC, Simpson PC
• A molecular MRI probe to detect treatment of cardiac apoptosis in vivo.
  Magnetic resonance in medicine 2011 Dash R, Chung J, Chan T, Yamada M, Barral J, Nishimura D, Yang PC, Simpson PC
• Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure.
  Journal of molecular and cellular cardiology 2010 Jensen BC, O'Connell TD, Simpson PC
• Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells.
  Naunyn-Schmiedeberg's archives of pharmacology 2010 Jensen BC, Swigart PM, Montgomery MD, Simpson PC
• Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves.
  The Journal of heart valve disease 2010 Nigam V, Sievers HH, Jensen BC, Sier HA, Simpson PC, Srivastava D, Mohamed SA
• Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse.
  Journal of cellular biochemistry 2010 Yeh CC, Li H, Malhotra D, Turcato S, Nicholas S, Tu R, Zhu BQ, Cha J, Swigart PM, Myagmar BE, Baker AJ, Simpson PC, Mann MJ
• Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium.
  The Journal of clinical investigation 2009 Smyth JW, Hong TT, Gao D, Vogan JM, Jensen BC, Fong TS, Simpson PC, Stainier DY, Chi NC, Shaw RM
• Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive.
  American journal of physiology. Heart and circulatory physiology 2009 Wang GY, Yeh CC, Jensen BC, Mann MJ, Simpson PC, Baker AJ
• Alpha1A/B-knockout mice explain the native alpha1D-adrenoceptor's role in vasoconstriction and show that its location is independent of the other alpha1-subtypes.
  British journal of pharmacology 2009 Methven L, Simpson PC, McGrath JC
• The alpha-1D Is the predominant alpha-1-adrenergic receptor subtype in human epicardial coronary arteries.
  Journal of the American College of Cardiology 2009 Jensen BC, Swigart PM, Laden ME, DeMarco T, Hoopes C, Simpson PC
• {alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium.
  Circulation. Heart failure 2009 Jensen BC, Swigart PM, De Marco T, Hoopes C, Simpson PC
• Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific.
  Naunyn-Schmiedeberg's archives of pharmacology 2008 Jensen BC, Swigart PM, Simpson PC
• Identification of alpha 1L-adrenoceptor in mice and its abolition by alpha 1A-adrenoceptor gene knockout.
  British journal of pharmacology 2008 Muramatsu I, Morishima S, Suzuki F, Yoshiki H, Anisuzzaman AS, Tanaka T, Rodrigo MC, Myagmar BE, Simpson PC
• Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse.
  Circulation 2007 Bao X, Lu CM, Liu F, Gu Y, Dalton ND, Zhu BQ, Foster E, Chen J, Karliner JS, Ross J, Simpson PC, Ziegler MG
• Blockade of both alpha1A- and alpha1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery.
  American journal of physiology. Heart and circulatory physiology 2007 Hosoda C, Hiroyama M, Sanbe A, Birumachi J, Kitamura T, Cotecchia S, Simpson PC, Tsujimoto G, Tanoue A
• An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes.
  Circulation 2007 Huang Y, Wright CD, Merkwan CL, Baye NL, Liang Q, Simpson PC, O'Connell TD
• Isolation and culture of adult mouse cardiac myocytes.
  Methods in molecular biology (Clifton, N.J.) 2007 O'Connell TD, Rodrigo MC, Simpson PC
• Left ventricular pressure-volume relationship in conscious mice.
  American journal of physiology. Heart and circulatory physiology 2006 Joho S, Ishizaka S, Sievers R, Foster E, Simpson PC, Grossman W
• Localization of the mouse alpha1A-adrenergic receptor (AR) in the brain: alpha1AAR is expressed in neurons, GABAergic interneurons, and NG2 oligodendrocyte progenitors.
  The Journal of comparative neurology 2006 Papay R, Gaivin R, Jha A, McCune DF, McGrath JC, Rodrigo MC, Simpson PC, Doze VA, Perez DM
• Contrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardium.
  American journal of physiology. Heart and circulatory physiology 2006 Wang GY, McCloskey DT, Turcato S, Swigart PM, Simpson PC, Baker AJ
• Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload.
  The Journal of clinical investigation 2006 O'Connell TD, Swigart PM, Rodrigo MC, Ishizaka S, Joho S, Turnbull L, Tecott LH, Baker AJ, Foster E, Grossman W, Simpson PC
• Ischemic preconditioning depends on age and gender.
  Basic research in cardiology 2006 Turcato S, Turnbull L, Wang GY, Honbo N, Simpson PC, Karliner JS, Baker AJ
• Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator.
  American journal of physiology. Heart and circulatory physiology 2005 Turnbull L, Zhou HZ, Swigart PM, Turcato S, Karliner JS, Conklin BR, Simpson PC, Baker AJ
• Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility.
  Cardiovascular research 2005 Wang GY, Bergman MR, Nguyen AP, Turcato S, Swigart PM, Rodrigo MC, Simpson PC, Karliner JS, Lovett DH, Baker AJ
• Both alpha(1A)- and alpha(1B)-adrenergic receptors crosstalk to down regulate beta(1)-ARs in mouse heart: coupling to differential PTX-sensitive pathways.
  Journal of molecular and cellular cardiology 2005 Rorabaugh BR, Gaivin RJ, Papay RS, Shi T, Simpson PC, Perez DM
• Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression.
  Physiological genomics 2005 McCloskey DT, Turnbull L, Swigart PM, Zambon AC, Turcato S, Joho S, Grossman W, Conklin BR, Simpson PC, Baker AJ
• alpha1A- but not alpha1B-adrenergic receptors precondition the ischemic heart by a staurosporine-sensitive, chelerythrine-insensitive mechanism.
  Cardiovascular research 2005 Rorabaugh BR, Ross SA, Gaivin RJ, Papay RS, McCune DF, Simpson PC, Perez DM
• Aldosterone directly stimulates cardiac myocyte hypertrophy.
  Journal of cardiac failure 2004 Okoshi MP, Yan X, Okoshi K, Nakayama M, Schuldt AJ, O'Connell TD, Simpson PC, Lorell BH
• New technique for measurement of left ventricular pressure in conscious mice.
  American journal of physiology. Heart and circulatory physiology 2003 Ishizaka S, Sievers RE, Zhu BQ, Rodrigo MC, Joho S, Foster E, Simpson PC, Grossman W
• Abnormal myocardial contraction in alpha(1A)- and alpha(1B)-adrenoceptor double-knockout mice.
  Journal of molecular and cellular cardiology 2003 McCloskey DT, Turnbull L, Swigart P, O'Connell TD, Simpson PC, Baker AJ
• Cerebral ischemia and infarction from atheroemboli <100 microm in Size.
  Stroke 2003 Rapp JH, Pan XM, Yu B, Swanson RA, Higashida RT, Simpson P, Saloner D
• The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse.
  The Journal of clinical investigation 2003 O'Connell TD, Ishizaka S, Nakamura A, Swigart PM, Rodrigo MC, Simpson GL, Cotecchia S, Rokosh DG, Grossman W, Foster E, Simpson PC
• Basal and alpha1-adrenergic-induced activity of minimal rat betaMHC promoters in cardiac myocytes requires multiple TEF-1 but not NFAT binding sites.
  Journal of molecular and cellular cardiology 2003 McLean BG, Lee KS, Simpson PC, Farrance IK
• Overview of the Alliance for Cellular Signaling.
  Nature 2002 Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, …
• Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR.
  American journal of physiology. Heart and circulatory physiology 2002 Turnbull L, McCloskey DT, O'Connell TD, Simpson PC, Baker AJ
• Alpha(1)-adrenoceptor subtypes mediate negative inotropy in myocardium from alpha(1A/C)-knockout and wild type mice.
  Journal of molecular and cellular cardiology 2002 McCloskey DT, Rokosh DG, O'Connell TD, Keung EC, Simpson PC, Baker AJ
• Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Rokosh DG, Simpson PC
• Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy.
  Circulation research 2001 Kinugawa K, Yonekura K, Ribeiro RC, Eto Y, Aoyagi T, Baxter JD, Camacho SA, Bristow MR, Long CS, Simpson PC
• LV systolic performance improves with development of hypertrophy after transverse aortic constriction in mice.
  American journal of physiology. Heart and circulatory physiology 2001 Nakamura A, Rokosh DG, Paccanaro M, Yee RR, Simpson PC, Grossman W, Foster E
• Cloning and characterization of the mouse alpha1C/A-adrenergic receptor gene and analysis of an alpha1C promoter in cardiac myocytes: role of an MCAT element that binds transcriptional enhancer factor-1 (TEF-1).
  Molecular pharmacology 2001 O'Connell TD, Rokosh DG, Simpson PC
• Abnormal contraction caused by expression of G(i)-coupled receptor in transgenic model of dilated cardiomyopathy.
  American journal of physiology. Heart and circulatory physiology 2001 Baker AJ, Redfern CH, Harwood MD, Simpson PC, Conklin BR
• Tumor cell splice variants of the transcription factor TEF-1 induced by SV40 T-antigen transformation.
  Biochimica et biophysica acta 2000 Zuzarte PC, Farrance IK, Simpson PC, Wildeman AG
• Autonomous and growth factor-induced hypertrophy in cultured neonatal mouse cardiac myocytes. Comparison with rat.
  Circulation research 2000 Deng XF, Rokosh DG, Simpson PC
• Beta-protein kinase C and hypertrophic signaling in human heart failure.
  Circulation 1999 Simpson PC
• Post-infarction heart failure in the rat is associated with distinct alterations in cardiac myocyte molecular phenotype.
  Journal of molecular and cellular cardiology 1998 Yue P, Long CS, Austin R, Chang KC, Simpson PC, Massie BM
• Cytokine expression increases in nonmyocytes from rats with postinfarction heart failure.
  The American journal of physiology 1998 Yue P, Massie BM, Simpson PC, Long CS
• Thyroid hormone improves function and Ca2+ handling in pressure overload hypertrophy. Association with increased sarcoplasmic reticulum Ca2+-ATPase and alpha-myosin heavy chain in rat hearts.
  The Journal of clinical investigation 1997 Chang KC, Figueredo VM, Schreur JH, Kariya K, Weiner MW, Simpson PC, Camacho SA
• Alpha1-adrenergic receptor subtype mRNAs are differentially regulated by alpha1-adrenergic and other hypertrophic stimuli in cardiac myocytes in culture and in vivo. Repression of alpha1B and alpha1D but induction of alpha1C.
  The Journal of biological chemistry 1996 Rokosh DG, Stewart AF, Chang KC, Bailey BA, Karliner JS, Camacho SA, Long CS, Simpson PC
• M-CAT, CArG, and Sp1 elements are required for alpha 1-adrenergic induction of the skeletal alpha-actin promoter during cardiac myocyte hypertrophy. Transcriptional enhancer factor-1 and protein kinase C as conserved transducers of the fetal program in cardiac growth.
  The Journal of biological chemistry 1995 Karns LR, Kariya K, Simpson PC
• Cloning of the rat alpha 1C-adrenergic receptor from cardiac myocytes. alpha 1C, alpha 1B, and alpha 1D mRNAs are present in cardiac myocytes but not in cardiac fibroblasts.
  Circulation research 1994 Stewart AF, Rokosh DG, Bailey BA, Karns LR, Chang KC, Long CS, Kariya K, Simpson PC
• Distribution of alpha 1C-adrenergic receptor mRNA in adult rat tissues by RNase protection assay and comparison with alpha 1B and alpha 1D.
  Biochemical and biophysical research communications 1994 Rokosh DG, Bailey BA, Stewart AF, Karns LR, Long CS, Simpson PC
• An enhancer core element mediates stimulation of the rat beta-myosin heavy chain promoter by an alpha 1-adrenergic agonist and activated beta-protein kinase C in hypertrophy of cardiac myocytes.
  The Journal of biological chemistry 1994 Kariya K, Karns LR, Simpson PC
• Transcriptional enhancer factor-1 in cardiac myocytes interacts with an alpha 1-adrenergic- and beta-protein kinase C-inducible element in the rat beta-myosin heavy chain promoter.
  The Journal of biological chemistry 1993 Kariya K, Farrance IK, Simpson PC
• Beta-adrenergic stimulation of cardiac non-myocytes augments the growth-promoting activity of non-myocyte conditioned medium.
  Journal of molecular and cellular cardiology 1993 Long CS, Hartogensis WE, Simpson PC
• Sympathetic modulation of the cardiac myocyte phenotype: studies with a cell-culture model of myocardial hypertrophy.
  Basic research in cardiology 1992 Long CS, Kariya K, Karns L, Simpson PC
• A growth factor for cardiac myocytes is produced by cardiac nonmyocytes.
  Cell regulation 1991 Long CS, Henrich CJ, Simpson PC
• Expression of a constitutively activated mutant of the beta-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the beta-myosin heavy chain isogene.
  The Journal of biological chemistry 1991 Kariya K, Karns LR, Simpson PC
• Adrenergic hormones and control of cardiac myocyte growth.
  Molecular and cellular biochemistry 1991 Simpson PC, Kariya K, Karns LR, Long CS, Karliner JS
• Sympathetic activity: modulator of myocardial hypertrophy.
  Journal of cardiovascular pharmacology 1991 Long CS, Kariya K, Karns L, Simpson PC
• Trophic factors for cardiac myocytes.
  Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1990 Long CS, Kariya K, Karns L, Simpson PC
• A protein kinase C isozyme is translocated to cytoskeletal elements on activation.
  Cell regulation 1990 Mochly-Rosen D, Henrich CJ, Cheever L, Khaner H, Simpson PC
• The cardiac beta-myosin heavy chain isogene is induced selectively in alpha 1-adrenergic receptor-stimulated hypertrophy of cultured rat heart myocytes.
  The Journal of clinical investigation 1990 Waspe LE, Ordahl CP, Simpson PC
• Effects of pertussis toxin on alpha 1-agonist-mediated phosphatidylinositide turnover and myocardial cell hypertrophy in neonatal rat ventricular myocytes.
  Experientia 1990 Karliner JS, Kagiya T, Simpson PC
• Transcription of early developmental isogenes in cardiac myocyte hypertrophy.
  Journal of molecular and cellular cardiology 1989 Simpson PC, Long CS, Waspe LE, Henrich CJ, Ordahl CP
• Alpha 1-adrenergic receptor stimulation of sarcomeric actin isogene transcription in hypertrophy of cultured rat heart muscle cells.
  The Journal of clinical investigation 1989 Long CS, Ordahl CP, Simpson PC
• Proto-oncogenes and cardiac hypertrophy.
  Annual review of physiology 1989 Simpson PC
• Differential acute and chronic response of protein kinase C in cultured neonatal rat heart myocytes to alpha 1-adrenergic and phorbol ester stimulation.
  Journal of molecular and cellular cardiology 1988 Henrich CJ, Simpson PC
• Beta-adrenoceptor and adenylate cyclase regulation in cardiac myocyte growth.
  Basic research in cardiology 1988 Karliner JS, Simpson PC
• Role of proto-oncogenes in myocardial hypertrophy.
  The American journal of cardiology 1988 Simpson PC
• Comments on "Load regulation of the properties of adult feline cardiocytes: the role of substrate adhesion."Circ Res 1986;58:692-705.
  Circulation research 1988 Simpson PC
• Induction of the skeletal alpha-actin gene in alpha 1-adrenoceptor-mediated hypertrophy of rat cardiac myocytes.
  The Journal of clinical investigation 1987 Bishopric NH, Simpson PC, Ordahl CP
• Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression.
  Proceedings of the National Academy of Sciences of the United States of America 1986 Starksen NF, Simpson PC, Bishopric N, Coughlin SR, Lee WM, Escobedo JA, Williams LT
• Mechanisms and time course of beta 1 adrenoceptor desensitisation in mammalian cardiac myocytes.
  Cardiovascular research 1986 Karliner JS, Simpson PC, Honbo N, Woloszyn W
• Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating.
  Circulation research 1985 Simpson P
• Adrenergic receptor characteristics of cardiac myocytes cultured in serum-free medium: comparison with serum-supplemented medium.
  Biochemical and biophysical research communications 1985 Karliner JS, Simpson PC, Taylor JE, Honbo N, Woloszyn W
• Antihypertensive therapy with diltiazem and comparison with hydrochlorothiazide.
  The American journal of cardiology 1984 Inouye IK, Massie BM, Benowitz N, Simpson P, Loge D
• Failure of antihypertensive therapy with diuretic, beta-blocking and calcium channel-blocking drugs to consistently reverse left ventricular diastolic filling abnormalities.
  The American journal of cardiology 1984 Inouye IK, Massie BM, Loge D, Simpson P, Tubau JF
• Monotherapy in mild to moderate hypertension: comparison of hydrochlorothiazide, propranolol and prazosin.
  The American journal of cardiology 1984 Inouye I, Massie B, Benowitz N, Simpson P, Loge D, Topic N
• Abnormal left ventricular filling: an early finding in mild to moderate systemic hypertension.
  The American journal of cardiology 1984 Inouye I, Massie B, Loge D, Topic N, Silverstein D, Simpson P, Tubau J
• Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.
  The Journal of clinical investigation 1983 Simpson P
• Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines.
  Circulation research 1982 Simpson P, McGrath A, Savion S
• Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol.
  Circulation research 1982 Simpson P, Savion S
• Computed tomography: a new method for diagnosing tumor of the heart.
  Circulation 1981 Godwin JD, Axel L, Adams JR, Schiller NB, Simpson PC, Gertz EW
• Regulation of acetylcholine release from neuroblastoma x glioma hybrid cells.
  Proceedings of the National Academy of Sciences of the United States of America 1978 McGee R, Simpson P, Christian C, Mata M, Nelson P, Nirenberg M
• scyllo-inositol and myo-inositol levels in tissues of the skate Raja erinacea.
  Comparative biochemistry and physiology. B, Comparative biochemistry 1978 Sherman WR, Simpson PC, Goodwin SL
• Effect of cyanide and electrical stimulation on phosphoinositide metabolism in lobster nerves.
  Journal of neurochemistry 1971 Birnberger AC, Birnberger KL, Eliasson SG, Simpson PC
• The identification of myo-inosose-2 and scyllo-inositol in mammalian tissues.
  Biochemistry 1968 Sherman WR, Stewart MA, Simpson PC, Goodwin SL