Paul Ogongo, PhD
Assistant Researcher
Medicine
School of Medicine

Awards

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• ARI/CFAR Diversity Scholar, University of California San Francisco, 2024-2026
• TB RAMP Scholar, University of California San Francisco, 2023-2025
• TBVI Young Scientist, TuBerculosis Vaccine Initiative, 2023-2024
• Postdoctoral Fellow, Helen Hay Whitney Foundation, 2021-2024
• Rising Star, Bill and Melinda Gates Foundation, 2019

Education & Training

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• Postdoc Human Immunology University of California San Francisco 06/2024
• PhD Medical Microbiology University of KwaZulu Natal 07/2019
• MSc Molecular Medicine Jomo Kenyatta University of Agriculture and Technology 11/2014
• BSc Zoology University of Nairobi 09/2007

Interests

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• T cells
• Tuberculosis
• Immunology
• Infectious Diseases
• Vaccines

Publications (27)

Top publication keywords:
Schistosomiasis mansoniTuberculosis VaccinesReceptors, Antigen, T-Cell, gamma-deltaLungSchistosomiasisTh17 CellsTuberculosis, PulmonaryT-Lymphocyte SubsetsSchistosoma mansoniInterleukin-17Mycobacterium tuberculosisLatent TuberculosisVaccinesAntigens, BacterialParasitology

• A broader evaluation of vaccine-induced T cell immunity against tuberculosis.
  Frontiers in Tuberculosis 2024 Paul Ogongo
• B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles.
  Communications biology 2024 Krause R, Ogongo P, Tezera L, Ahmed M, Mbano I, Chambers M, Ngoepe A, Magnoumba M, Muema D, Karim F, Khan K, Lumamba K, Nargan K, Madansein R, Steyn A, Shalek AK, Elkington P, Leslie A
• High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL-17 against M. tuberculosis antigen.
  Frontiers in immunology 2024 Ogongo P, Tran A, Marzan F, Gingrich D, Krone M, Aweeka F, Lindestam Arlehamn CS, Martin JN, Deeks SG, Hunt PW, Ernst JD
• Rare Variable M. tuberculosis Antigens induce predominant Th17 responses in human infection.
  bioRxiv : the preprint server for biology 2024 Ogongo P, Wassie L, Tran A, Columbus D, Sharling L, Ouma G, Ouma SG, Bobosha K, Lindestam Arlehamn CS, Gandhi NR, Auld SC, Rengarajan J, Day CL, Altman JD, Blumberg HM, Ernst JD, TBRU ASTRa Study …
• Recognition and control of Mycobacterium tuberculosis-infected cells: from basics to the clinic: a NIAID/WGNV workshop report 2023
  Recognition and control of Mycobacterium tuberculosis-infected cells: from basics to the clinic: a NIAID/WGNV workshop report 2023 2023 Carly C Young, Mbali N. Mkhonza, Paul Ogongo

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• Finding antigens for TB vaccines: the good, the bad and the useless.
  Nature medicine 2023 Ogongo P, Ernst JD
• Do vaginal microbicides reduce the risk of HIV acquisition in women?
  The Pan African medical journal 2022 Obiero JA, Ogongo P, Mwethera PG, Wiysonge CS
• The Road to Elimination: Current State of Schistosomiasis Research and Progress Towards the End Game.
  Frontiers in immunology 2022 Ogongo P, Nyakundi RK, Chege GK, Ochola L
• Acquired Clinical Immunity to Malaria in Nonhuman Primates Coinfected with Schistosoma and Plasmodium Parasites.
  Infection and immunity 2021 Nyakundi RK, Hau J, Ogongo P, Nyamongo O, Jeneby M, Akinyi M, Mulei I, Nyundo F, Farah I, Malhotra I, Ozwara H, King CL, Kariuki T
• Repeated Plasmodium falciparum infection in humans drives the clonal expansion of an adaptive γδ T cell repertoire.
  Science translational medicine 2021 von Borstel A, Chevour P, Arsovski D, Krol JMM, Howson LJ, Berry AA, Day CL, Ogongo P, Ernst JD, Nomicos EYH, Boddey JA, Giles EM, Rossjohn J, Traore B, Lyke KE, Williamson KC, Crompton PD, Davey MS
• A Framework to Identify Antigen-Expanded T Cell Receptor Clusters Within Complex Repertoires.
  Frontiers in immunology 2021 Ceglia V, Kelley EJ, Boyle AS, Zurawski S, Mead HL, Harms CE, Blanck JP, Flamar AL, Kirschman JH, Ogongo P, Ernst JD, Levy Y, Zurawski G, Altin JA
• Performance Evaluation of Lateral Flow Assays for Coronavirus Disease-19 Serology.
  Clinics in laboratory medicine 2021 Ochola L, Ogongo P, Mungai S, Gitaka J, Suliman S
• Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung.
  The Journal of clinical investigation 2021 Ogongo P, Tezera LB, Ardain A, Nhamoyebonde S, Ramsuran D, Singh A, Ng'oepe A, Karim F, Naidoo T, Khan K, Dullabh KJ, Fehlings M, Lee BH, Nardin A, Lindestam Arlehamn CS, Sette A, Behar SM, Steyn AJ, …
• Topical microbicides for preventing sexually transmitted infections.
  The Cochrane database of systematic reviews 2021 Obiero J, Ogongo P, Mwethera PG, Wiysonge CS
• Unbiased Profiling Reveals Compartmentalization of Unconventional T-Cells Within the Intestinal Mucosa Irrespective of HIV Infection.
  Frontiers in immunology 2020 Magnoumba M, Singh A, Ogongo P, Roider J, Asowata O, Fehlings M, Karim F, Ndung'u T, Anderson F, Leslie A, Kløverpris H
• Single cell transcriptomics of the T cell response to Mycobacterium Tuberculosis reveals phenotypic diversity within and between infected individuals
  Single cell transcriptomics of the T cell response to Mycobacterium Tuberculosis reveals phenotypic diversity within and between infected individuals 2020 Junghwa Choi Kirschman; Paul Ogongo; Joel Ernst; John Altin
• Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α.
  eLife 2020 Tezera LB, Bielecka MK, Ogongo P, Walker NF, Ellis M, Garay-Baquero DJ, Thomas K, Reichmann MT, Johnston DA, Wilkinson KA, Ahmed M, Jogai S, Jayasinghe SN, Wilkinson RJ, Mansour S, Thomas GJ, …
• Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs.
  The Journal of clinical investigation 2020 Ogongo P, Steyn AJ, Karim F, Dullabh KJ, Awala I, Madansein R, Leslie A, Behar SM
• Publisher Correction: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis.
  Nature 2019 Ardain A, Domingo-Gonzalez R, Das S, Kazer SW, Howard NC, Singh A, Ahmed M, Nhamoyebonde S, Rangel-Moreno J, Ogongo P, Lu L, Ramsuran D, de la Luz Garcia-Hernandez M, Ulland TK, Darby M, Park E, Karim…
• Plasma IL-5 but Not CXCL13 Correlates With Neutralization Breadth in HIV-Infected Children.
  Frontiers in immunology 2019 Roider J, Porterfield JZ, Ogongo P, Muenchhoff M, Adland E, Groll A, Morris L, Moore PL, Ndung'u T, Kløverpris H, Goulder PJR, Leslie A
• Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis.
  Nature 2019 Ardain A, Domingo-Gonzalez R, Das S, Kazer SW, Howard NC, Singh A, Ahmed M, Nhamoyebonde S, Rangel-Moreno J, Ogongo P, Lu L, Ramsuran D, de la Luz Garcia-Hernandez M, K Ulland T, Darby M, Park E, …
• Lung Tissue Resident Memory T-Cells in the Immune Response to Mycobacterium tuberculosis.
  Frontiers in immunology 2019 Ogongo P, Porterfield JZ, Leslie A
• Major TCR Repertoire Perturbation by Immunodominant HLA-B*44:03-Restricted CMV-Specific T Cells.
  Frontiers in immunology 2018 Attaf M, Malik A, Severinsen MC, Roider J, Ogongo P, Buus S, Ndung'u T, Leslie A, Kløverpris HN, Matthews PC, Sewell AK, Goulder P
• Nifuratel‐Nystatin combination for the treatment of mixed infections of bacterial vaginosis, vulvovaginal candidiasis, and trichomonal vaginitis
  Cochrane Database Systematic Reviews 2018 Jael Obrero, Stephen Rulisa, Paul Ogongo and Charles S Wiysonge
• Diagnosis of schistosomiasis mansoni: an evaluation of existing methods and research towards single worm pair detection.
  Parasitology 2018 Ogongo P, Kariuki TM, Wilson RA
• Protective Potential of Antioxidant Enzymes as Vaccines for Schistosomiasis in a Non-Human Primate Model.
  Frontiers in immunology 2015 Carvalho-Queiroz C, Nyakundi R, Ogongo P, Rikoi H, Egilmez NK, Farah IO, Kariuki TM, LoVerde PT
• International Journal of Infectious Diseases
  Identification and evaluation of Schistosoma mansoni proteins as diagnostic targets for schistosomiasis 2014 Paul Ogongo