Paul Larson, MD
Professor
Neurological Surgery
School of Medicine
Dr. Paul Larson is Professor and Vice Chair of Neurological Surgery at the University of California San Francisco, Chief of Neurosurgery at the San Francisco VA Medical Center and Surgical Director of the Parkinson’s Disease Research, Education and Clinical Center. He specializes in functional neurosurgery, specifically deep brain stimulation for movement disorders and MR-guided procedures.
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The Surgical Movement Disorders program at UCSF and the SFVA is one of the largest and most active centers in the world.
Dr. Larson’s research program is built around three core areas of interest. He has 20 years of experience in interventional MRI-guided surgery, and was one of three researchers at UCSF that started and developed the field of iMRI-guided stereotactic surgery for DBS placement and drug delivery. He has had continuous funding for device development and clinical trials in interventional MRI procedures since 2003. Secondly, his group at UCSF has been at the forefront of gene therapy for Parkinson’s disease. They have had a leadership role in 4 of the 7 human trials completed worldwide to date, and have performed more than 1/3 of all Parkinson’s gene therapy procedures ever performed. He is currently the PI for a fifth gene therapy trial using convection enhanced, iMRI-guided delivery of AAV2-AADC into the putamen of patients with Parkinson’s disease. Finally, Dr. Larson has a significant interest in the neurobiology and underlying brain circuitry of phantom auditory disorders including tinnitus. His work in this area with Dr. Steven Cheung has led to the discovery of a new region of brain involved in auditory perception, as well as a new proposed model of the basal ganglia for chronic tinnitus. They have a U01 grant from the NIDCD to study the use of DBS in the caudate nucleus in patients with severe, medically refractory tinnitus.
Education & Training
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- Neurosurgery Residency University of Louisville 2001
- MD University of Arizona 1995
Interests
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- Deep brain stimulation
- Tinnitus
- Gene therapy
- Essential tremor
- MRI-guided surgery
- Parkinson's disease
Websites
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- Profile at UCSF Neurosurgery (neurosurgery.ucsf.edu)
- Larson Lab (neurosurgery.ucsf.edu)
- Clinical Profile at UCSF Medical Center (ucsfhealth.org)
Publications (117)
Top publication keywords:
DystoniaAromatic-L-Amino-Acid DecarboxylasesParkinson DiseaseNeurosurgical ProceduresPutamenStereotaxic TechniquesDeep Brain StimulationCaudate NucleusGlobus PallidusElectrodes, ImplantedGenetic TherapyMovement DisordersSubthalamic NucleusMagnetic Resonance Imaging, InterventionalTinnitus
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Tractography-based DBS lead repositioning improves outcome in refractory OCD and depression.
Frontiers in human neuroscience 2024 Basich-Pease G, Slepneva N, Frank AC, Norbu T, Morrison MA, Sugrue LP, Larson PS, Starr PA, Lee AM -
Procedure-Related Complications in Sham Surgeries for Parkinson's Clinical Trials: A Meta-analysis.
Movement disorders : official journal of the Movement Disorder Society 2023 Mamaril-Davis JC, Gelb AW, Larson PS -
Targeting Accuracy and Clinical Outcomes of Awake versus Asleep Interventional Magnetic Resonance Imaging-Guided Deep Brain Stimulation for Parkinson's Disease: The University of California, San Francisco Experience.
Neurosurgery 2022 Lee AT, Han KJ, Nichols N, Sudhakar VR, Burke JF, Wozny TA, Chung JE, Volz MM, Ostrem JL, Martin AJ, Larson PS, Starr PA, Wang DD -
Author Response: Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease: Three-Year Outcomes From the PD-1101 Trial.
Neurology 2022 Christine CW, Richardson RM, Fine EM, Khwaja OS, Liang GS, Meier A, Roberts EW, Bankiewicz K, Larson PS -
Author Response: Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease: Three-Year Outcomes From the PD-1101 Trial.
Neurology 2022 Christine CW, Richardson RM, Van Laar A, Fine EM, Khwaja OS, Liang GS, Bankiewicz K, Larson PS
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Benefits and Risks of a Staged-Bilateral VIM Versus Unilateral VIM DBS for Essential Tremor.
Movement disorders clinical practice 2022 Prakash P, Deuschl G, Ozinga S, Mitchell KT, Cheeran B, Larson PS, Merola A, Groppa S, Tomlinson T, Ostrem JL -
Reduced Risk of Reoperations With Modern Deep Brain Stimulator Systems: Big Data Analysis From a United States Claims Database.
Frontiers in neurology 2021 Wu C, Nagel SJ, Agarwal R, Pötter-Nerger M, Hamel W, Sharan AD, Connolly AT, Cheeran B, Larson PS -
Identification of a Personalized Intracranial Biomarker of Depression and Response to DBS Therapy.
Brain Stimulation 2021 Adam Frank, Katherine Scangos, Paul Larson, Tenzin Norbu, Anthony Lee, Moses Lee -
Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease: Three-Year Outcomes From the PD-1101 Trial.
Neurology 2021 Christine CW, Richardson RM, Van Laar AD, Thompson ME, Fine EM, Khwaja OS, Li C, Liang GS, Meier A, Roberts EW, Pfau ML, Rodman JR, Bankiewicz KS, Larson PS -
Striatal networks for tinnitus treatment targeting.
Human brain mapping 2021 Hinkley LBN, Larson PS, Henderson Sabes J, Mizuiri D, Demopoulos C, Adams ME, Neylan TC, Hess CP, Nagarajan SS, Cheung SW -
Identification of a personalized intracranial biomarker of depression and response to DBS therapy.
Brain stimulation 2021 Frank AC, Scangos KW, Larson PS, Norbu T, Lee AT, Lee AM -
Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson's disease.
Nature biotechnology 2021 Gilron R, Little S, Perrone R, Wilt R, de Hemptinne C, Yaroshinsky MS, Racine CA, Wang SS, Ostrem JL, Larson PS, Wang DD, Galifianakis NB, Bledsoe IO, San Luciano M, Dawes HE, Worrell GA, Kremen V, … -
Are preoperative chlorhexidine gluconate showers associated with a reduction in surgical site infection following craniotomy? A retrospective cohort analysis of 3126 surgical procedures.
Journal of neurosurgery 2021 Ammanuel SG, Edwards CS, Chan AK, Mummaneni PV, Kidane J, Vargas E, D'Souza S, Nichols AD, Sankaran S, Abla AA, Aghi MK, Chang EF, Hervey-Jumper SL, Kunwar S, Larson PS, Lawton MT, Starr PA, … -
Impact of brain shift on neural pathways in deep brain stimulation: a preliminary analysis via multi-physics finite element models.
Journal of neural engineering 2021 Luo M, Narasimhan S, Larson PS, Martin AJ, Konrad PE, Miga MI -
CT and MRI Image Fusion Error: An Analysis of Co-Registration Error Using Commercially Available Deep Brain Stimulation Surgical Planning Software.
Stereotactic and functional neurosurgery 2021 Burke JF, Tanzillo D, Starr PA, Lim DA, Larson PS -
Improved Delivery Methods for Gene Therapy and Cell Transplantation in Parkinson's Disease.
Journal of Parkinson's disease 2021 Larson PS -
Preoperative Chlorhexidine Showers Are Not Associated With a Reduction in Surgical Site Infection Following Craniotomy.
Neurosurgery 2020 Simon G Ammanuel, Caleb S Edwards, Andrew K.H Chan, Praveen V Mummaneni, Joseph Kidane, Enrique Vargas, Sarah D’Souza, Amy D Nichols, Sujatha Sankaran, Adib A Abla, Manish K Aghi, Edward F Chang, … -
Data-driven evolution of neurosurgical gene therapy delivery in Parkinson's disease.
Journal of neurology, neurosurgery, and psychiatry 2020 Richardson RM, Bankiewicz KS, Christine CW, Van Laar AD, Gross RE, Lonser R, Factor SA, Kostyk SK, Kells AP, Ravina B, Larson PS -
Rescue Ventral Intermediate Thalamus Deep Brain Stimulation to Address Refractory Tremor Following Subthalamic Nucleus Deep Brain Stimulation With Brittle Dyskinesia.
2020 Mitra Afshari, Jill L. Ostrem, Marta San Luciano, Paul S. Larson -
Aromatic L-Amino Acid Decarboxylase Gene Therapy Enhances Levodopa Response in Parkinson's Disease.
Movement disorders : official journal of the Movement Disorder Society 2020 Nutt JG, Curtze C, Hiller A, Anderson S, Larson PS, Van Laar AD, Richardson RM, Thompson ME, Sedkov A, Leinonen M, Ravina B, Bankiewicz KS, Christine CW -
Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans.
Neuron 2020 Chen W, de Hemptinne C, Miller AM, Leibbrand M, Little SJ, Lim DA, Larson PS, Starr PA -
Accounting for Deformation in Deep Brain Stimulation Surgery With Models: Comparison to Interventional Magnetic Resonance Imaging.
IEEE transactions on bio-medical engineering 2020 Luo M, Larson PS, Martin AJ, Miga MI -
Phase I trial of caudate deep brain stimulation for treatment-resistant tinnitus.
Journal of neurosurgery 2019 Cheung SW, Racine CA, Henderson-Sabes J, Demopoulos C, Molinaro AM, Heath S, Nagarajan SS, Bourne AL, Rietcheck JE, Wang SS, Larson PS -
Altered Prefrontal Theta and Gamma Activity during an Emotional Face Processing Task in Parkinson Disease.
Journal of cognitive neuroscience 2019 Chen W, de Hemptinne C, Leibbrand M, Miller AM, Larson PS, Starr PA -
PD-1102: A Phase 1 study of VY-AADC01 Administered Using a Posterior Approach in Patients with Parkinson’s Disease and Motor Fluctuations (P1.8-017).
Neurology 2019 Amber Van Laar, Mark Richardson, Chadwick Christine, Stewart Factor, Robert Gross, Sandra Kostyk, Russell Lonser, Marc de Somer, Alex Sedkov, Bernard Ravina, Adrian Kells, Krystof Bankiewicz, Paul … -
Magnetic resonance imaging-guided phase 1 trial of putaminal AADC gene therapy for Parkinson's disease.
Annals of neurology 2019 Christine CW, Bankiewicz KS, Van Laar AD, Richardson RM, Ravina B, Kells AP, Boot B, Martin AJ, Nutt J, Thompson ME, Larson PS -
Human caudate nucleus subdivisions in tinnitus modulation.
Journal of neurosurgery 2019 Perez PL, Wang SS, Heath S, Henderson-Sabes J, Mizuiri D, Hinkley LB, Nagarajan SS, Larson PS, Cheung SW -
An Integrated Multi-physics Finite Element Modeling Framework for Deep Brain Stimulation: Preliminary Study on Impact of Brain Shift on Neuronal Pathways.
2019 Ma Luo, Paul S. Larson, Alastair J. Martin, Peter E. Konrad, Michael I. Miga -
Chapter 23 Direct Convective Nervous System Drug Delivery for Patients with Neurodegenerative Disorders.
Nervous System Drug Delivery 2019 R. Mark Richardson, Paul Larson -
Surgical management of camptocormia in Parkinson's disease: systematic review and meta-analysis.
Journal of neurosurgery 2018 Chan AK, Chan AY, Lau D, Durcanova B, Miller CA, Larson PS, Starr PA, Mummaneni PV -
Accuracy of image-guided percutaneous injection into a phantom spinal cord utilizing flat panel detector CT with MR fusion and integrated navigational software.
Journal of neurointerventional surgery 2018 Talbott JF, Cooke DL, Mabray MC, Larson PS, Amans MR, Hetts SW, Wilson MW, Moore T, Salegio EA -
Unilateral Versus Bilateral Ventral Intermediate Nucleus Deep Brain Stimulation for Axial Essential Tremor Symptoms (S18.003).
Neurology 2018 Kyle Mitchell, Delea Peichel, Robert Wharen, Michael Okun, Barton Guthrie, Ryan Uitti, Paul Larson, Harrison Walker, Rajesh Pahwa, Khashayar Dashtipour, Joseph Jankovic, Kelly Foote, Jason Schwalb, … -
Venous Thromboembolism during Interventional MRI-Guided Stereotactic Surgery.
Stereotactic and functional neurosurgery 2018 Kundishora AJ, Englot DJ, Starr PA, Martin AJ, Larson PS -
Laser ablative therapy of sessile hypothalamic hamartomas in children using interventional MRI: report of 5 cases.
Journal of neurosurgery. Pediatrics 2018 Southwell DG, Birk HS, Larson PS, Starr PA, Sugrue LP, Auguste KI -
Deep Brain Stimulation: Interventional and Intraoperative MRI Approaches.
Progress in neurological surgery 2018 Larson PS, Starr PA, Martin AJ -
Before and after the veterans affairs cooperative program 468 study: Deep brain stimulator target selection for treatment of Parkinson's disease.
Parkinsonism & related disorders 2017 Southwell DG, Rutkowski MJ, San Luciano M, Racine C, Ostrem J, Starr PA, Larson PS -
Hemorrhage Detection and Incidence during Magnetic Resonance-Guided Deep Brain Stimulator Implantations.
Stereotactic and functional neurosurgery 2017 Martin AJ, Starr PA, Ostrem JL, Larson PS -
Little Black Boxes: Noncardiac Implantable Electronic Medical Devices and Their Anesthetic and Surgical Implications.
Anesthesia and analgesia 2017 Srejic U, Larson P, Bickler PE -
MRI-guided stereotactic neurosurgical procedures in a diagnostic MRI suite: Background and safe practice recommendations.
Journal of healthcare risk management : the journal of the American Society for Healthcare Risk Management 2017 Larson PS, Willie JT, Vadivelu S, Azmi-Ghadimi H, Nichols A, Fauerbach LL, Johnson HB, Graham D -
Parkinson's disease patient preference and experience with various methods of DBS lead placement.
Parkinsonism & related disorders 2017 LaHue SC, Ostrem JL, Galifianakis NB, San Luciano M, Ziman N, Wang S, Racine CA, Starr PA, Larson PS, Katz M -
Neurosurgical laser ablation and MR thermometry: Risks of multisite workflow pattern.
Journal of healthcare risk management : the journal of the American Society for Healthcare Risk Management 2017 Larson PS, Vadivelu S, Azmi-Ghadimi H, Nichols A, Fauerbach L, Johnson HB -
Thalamic DBS with a constant-current device in essential tremor: A controlled clinical trial.
Parkinsonism & related disorders 2017 Wharen RE, Okun MS, Guthrie BL, Uitti RJ, Larson P, Foote K, Walker H, Marshall FJ, Schwalb J, Ford B, Jankovic J, Simpson R, Dashtipour K, Phibbs F, Neimat JS, Stewart RM, Peichel D, Pahwa R, Ostrem … -
Little Black Boxes.
Survey of Anesthesiology 2017 U. Srejic, P. Larson, P. E. Bickler -
An unexpectedly high rate of revisions and removals in deep brain stimulation surgery: Analysis of multiple databases.
Parkinsonism & related disorders 2016 Rolston JD, Englot DJ, Starr PA, Larson PS -
Spinal Subdural Abscess Following Laminectomy for Symptomatic Stenosis: A Report of 2 Cases and Review of the Literature.
The American journal of case reports 2016 Ramos AD, Rolston JD, Gauger GE, Larson PS -
Comparison of Deep Brain Stimulation Lead Targeting Accuracy and Procedure Duration between 1.5- and 3-Tesla Interventional Magnetic Resonance Imaging Systems: An Initial 12-Month Experience.
Stereotactic and functional neurosurgery 2016 Southwell DG, Narvid JA, Martin AJ, Qasim SE, Starr PA, Larson PS -
Interventional MRI-guided catheter placement and real time drug delivery to the central nervous system.
Expert review of neurotherapeutics 2016 Han SJ, Bankiewicz K, Butowski NA, Larson PS, Aghi MK -
Deep brain stimulator implantation in a diagnostic MRI suite: infection history over a 10-year period.
Journal of neurosurgery 2016 Martin AJ, Larson PS, Ziman N, Levesque N, Volz M, Ostrem JL, Starr PA -
Long-Term Safety of Patients with Parkinson's Disease Receiving rAAV2-Neurturin (CERE-120) Gene Transfer.
Human gene therapy 2016 Marks WJ, Baumann TL, Bartus RT -
Merging DBS with viral vector or stem cell implantation: "hybrid" stereotactic surgery as an evolution in the surgical treatment of Parkinson's disease.
Molecular therapy. Methods & clinical development 2016 Rowland NC, Kalia SK, Kalia LV, Larson PS, Lim DA, Bankiewicz KS -
Clinical outcomes using ClearPoint interventional MRI for deep brain stimulation lead placement in Parkinson's disease.
Journal of neurosurgery 2015 Ostrem JL, Ziman N, Galifianakis NB, Starr PA, Luciano MS, Katz M, Racine CA, Martin AJ, Markun LC, Larson PS -
E-053 accuracy of flat panel detector ct with integrated navigational software with and without mr fusion for single pass needle placement in a deep brain stimulator phantom in the interventional suite.
Journal of NeuroInterventional Surgery 2015 M Mabray, S Datta, P Lillaney, T Moore, S Gehrisch, J Talbott, P Larson, D Cooke -
Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double-blind, randomized, controlled trial.
Annals of neurology 2015 Warren Olanow C, Bartus RT, Baumann TL, Factor S, Boulis N, Stacy M, Turner DA, Marks W, Larson P, Starr PA, Jankovic J, Simpson R, Watts R, Guthrie B, Poston K, Henderson JM, Stern M, Baltuch G, … -
Accuracy of flat panel detector CT with integrated navigational software with and without MR fusion for single-pass needle placement.
Journal of neurointerventional surgery 2015 Mabray MC, Datta S, Lillaney PV, Moore T, Gehrisch S, Talbott JF, Levitt MR, Ghodke BV, Larson PS, Cooke DL -
Parkinson’s Disease (PD) Patient Experience with the ClearPoint(TM) Interventional MRI (iMRI)-Guided Method for Placement of Deep Brain Stimulation (DBS) Leads (P6.085).
Neurology 2015 Sara LaHue, Maya Katz, Nicholas Galifianakis, Marta San Luciano, Nathan Ziman, Sarah Wang, Caroline Racine, Philip Starr, Paul Larson, Jill Ostrem -
Differential effects of deep brain stimulation target on motor subtypes in Parkinson's disease.
Annals of neurology 2015 Katz M, Luciano MS, Carlson K, Luo P, Marks WJ, Larson PS, Starr PA, Follett KA, Weaver FM, Stern MB, Reda DJ, Ostrem JL, CSP 468 study group -
Surgical implantation of STN-DBS leads using intraoperative MRI guidance: technique, accuracy, and clinical benefit at 1-year follow-up.
Acta neurochirurgica 2015 Chabardes S, Isnard S, Castrioto A, Oddoux M, Fraix V, Carlucci L, Payen JF, Krainik A, Krack P, Larson P, Le Bas JF -
Combining cell transplants or gene therapy with deep brain stimulation for Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2014 Rowland NC, Starr PA, Larson PS, Ostrem JL, Marks WJ, Lim DA -
Delay Period Activity of the Substantia Nigra during Proactive Control of Response Selection as Determined by a Novel fMRI Localization Method.
Journal of cognitive neuroscience 2014 Yoon JH, Larson P, Grandelis A, La C, Cui E, Carter CS, Minzenberg MJ -
Neuropsychological changes following deep brain stimulation surgery for Parkinson's disease: comparisons of treatment at pallidal and subthalamic targets versus best medical therapy.
Journal of neurology, neurosurgery, and psychiatry 2014 Rothlind JC, York MK, Carlson K, Luo P, Marks WJ, Weaver FM, Stern M, Follett K, Reda D, CSP-468 Study Group -
Interventional magnetic resonance imaging-guided cell transplantation into the brain with radially branched deployment.
Molecular therapy : the journal of the American Society of Gene Therapy 2014 Silvestrini MT, Yin D, Martin AJ, Coppes VG, Mann P, Larson PS, Starr PA, Zeng X, Gupta N, Panter SS, Desai TA, Lim DA -
Interventional MRI-guided deep brain stimulation in pediatric dystonia: first experience with the ClearPoint system.
Journal of neurosurgery. Pediatrics 2014 Starr PA, Markun LC, Larson PS, Volz MM, Martin AJ, Ostrem JL -
Deep brain stimulation for movement disorders.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2014 Larson PS -
Brain shift during bur hole-based procedures using interventional MRI.
Journal of neurosurgery 2014 Ivan ME, Yarlagadda J, Saxena AP, Martin AJ, Starr PA, Sootsman WK, Larson PS -
Image-guided deep brain stimulation.
Neurosurgery clinics of North America 2013 Vega RA, Holloway KL, Larson PS -
203 Application Accuracy of a Second Generation Interventional MRI Stereotactic Platform.
Neurosurgery 2013 Paul Larson, Philip A. Starr, Jill L. Ostrem, Nicholas Galifianakis, Marta San Luciano Palenzuela, Alastair Martin -
Suicide ideation and behaviours after STN and GPi DBS surgery for Parkinson's disease: results from a randomised, controlled trial.
Journal of neurology, neurosurgery, and psychiatry 2013 Weintraub D, Duda JE, Carlson K, Luo P, Sagher O, Stern M, Follett KA, Reda D, Weaver FM, CSP 468 Study Group -
Responsiveness of Parkinson's Disease Motor Subtypes to Subthalamic Nucleus (STN) Versus Globus Pallidus Internus (GPi) Deep Brain Stimulation (DBS): An Additional Analysis of the VA CSP #468 Study (S23.006).
Neurology 2013 Maya Katz, Marta San Luciano, Ping Luo, Kimberly Carlson, William Marks, Paul Larson, Philip Starr, Kenneth Follett, Frances Weaver, Matthew Stern, Domenic Reda, Jill Ostrem -
Radially branched deployment for more efficient cell transplantation at the scale of the human brain.
Stereotactic and functional neurosurgery 2013 Silvestrini MT, Yin D, Coppes VG, Mann P, Martin AJ, Larson PS, Starr PA, Gupta N, Panter SS, Desai TA, Lim DA -
A stroke of silence: tinnitus suppression following placement of a deep brain stimulation electrode with infarction in area LC.
Journal of neurosurgery 2012 Larson PS, Cheung SW -
Clinical outcomes of PD patients having bilateral STN DBS using high-field interventional MR-imaging for lead placement.
Clinical neurology and neurosurgery 2012 Ostrem JL, Galifianakis NB, Markun LC, Grace JK, Martin AJ, Starr PA, Larson PS -
Securing dual ipsilateral leads through a single burr hole in deep brain stimulation surgery: technical note.
Stereotactic and functional neurosurgery 2012 Potts MB, Larson PS -
Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes.
Neurology 2012 Weaver FM, Follett KA, Stern M, Luo P, Harris CL, Hur K, Marks WJ, Rothlind J, Sagher O, Moy C, Pahwa R, Burchiel K, Hogarth P, Lai EC, Duda JE, Holloway K, Samii A, Horn S, Bronstein JM, Stoner G, … -
Acute effects of thalamic deep brain stimulation and thalamotomy on sensorimotor cortex local field potentials in essential tremor.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2012 Air EL, Ryapolova-Webb E, de Hemptinne C, Ostrem JL, Galifianakis NB, Larson PS, Chang EF, Starr PA -
Long-term evaluation of a phase 1 study of AADC gene therapy for Parkinson's disease.
Human gene therapy 2012 Mittermeyer G, Christine CW, Rosenbluth KH, Baker SL, Starr P, Larson P, Kaplan PL, Forsayeth J, Aminoff MJ, Bankiewicz KS -
An optimized system for interventional magnetic resonance imaging-guided stereotactic surgery: preliminary evaluation of targeting accuracy.
Neurosurgery 2012 Larson PS, Starr PA, Bates G, Tansey L, Richardson RM, Martin AJ -
Deep brain stimulation in area LC controllably triggers auditory phantom percepts.
Neurosurgery 2012 Larson PS, Cheung SW -
Abnormal T2-weighted MRI signal surrounding leads in a subset of deep brain stimulation patients.
Stereotactic and functional neurosurgery 2011 Englot DJ, Glastonbury CM, Larson PS -
Lead cap localization using ultrasound in deep brain stimulation surgery: technical note.
Minimally invasive neurosurgery : MIN 2011 Englot DJ, Chang EF, Larson PS -
Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain.
Stereotactic and functional neurosurgery 2011 Richardson RM, Kells AP, Martin AJ, Larson PS, Starr PA, Piferi PG, Bates G, Tansey L, Rosenbluth KH, Bringas JR, Berger MS, Bankiewicz KS -
Intraoperative computed tomography for deep brain stimulation surgery: technique and accuracy assessment.
Neurosurgery 2011 Shahlaie K, Larson PS, Starr PA -
Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2011 Richardson RM, Kells AP, Rosenbluth KH, Salegio EA, Fiandaca MS, Larson PS, Starr PA, Martin AJ, Lonser RR, Federoff HJ, Forsayeth JR, Bankiewicz KS -
Incidence and management of venous air embolisms during awake deep brain stimulation surgery in a large clinical series.
Stereotactic and functional neurosurgery 2011 Chang EF, Cheng JS, Richardson RM, Lee C, Starr PA, Larson PS -
Chapter 18 Safety Concerns and Limitations.
Essential Neuromodulation 2011 Paul S. Larson, Alastair J. Martin, Ali Rezai, Jeffrey E. Arle -
Human/nonhuman primate AC-PC ratio--considerations for translational brain measurements.
Journal of neuroscience methods 2010 Fiandaca MS, Salegio EA, Yin D, Richardson RM, Valles FE, Larson PS, Starr PA, Lonser RR, Bankiewicz KS -
Qualitative imaging of adeno-associated virus serotype 2-human aromatic L-amino acid decarboxylase gene therapy in a phase I study for the treatment of Parkinson disease.
Neurosurgery 2010 Valles F, Fiandaca MS, Eberling JL, Starr PA, Larson PS, Christine CW, Forsayeth J, Richardson RM, Su X, Aminoff MJ, Bankiewicz KS -
Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial.
The Lancet. Neurology 2010 Marks WJ, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis N, Vitek J, Stacy M, Turner D, Verhagen L, Bakay R, Watts R, Guthrie B, Jankovic J, Simpson R, Tagliati M, Alterman R, Stern M, Baltuch G, … -
Minimally invasive surgery for movement disorders.
Neurosurgery clinics of North America 2010 Larson PS -
Tinnitus modulation by deep brain stimulation in locus of caudate neurons (area LC).
Neuroscience 2010 Cheung SW, Larson PS -
Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease.
The New England journal of medicine 2010 Follett KA, Weaver FM, Stern M, Hur K, Harris CL, Luo P, Marks WJ, Rothlind J, Sagher O, Moy C, Pahwa R, Burchiel K, Hogarth P, Lai EC, Duda JE, Holloway K, Samii A, Horn S, Bronstein JM, Stoner G, … -
Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracy.
Journal of neurosurgery 2010 Starr PA, Martin AJ, Ostrem JL, Talke P, Levesque N, Larson PS -
Physiological identification of the human pedunculopontine nucleus.
Journal of neurology, neurosurgery, and psychiatry 2009 Shimamoto SA, Larson PS, Ostrem JL, Glass GA, Turner RS, Starr PA -
Safety and tolerability of putaminal AADC gene therapy for Parkinson disease.
Neurology 2009 Christine CW, Starr PA, Larson PS, Eberling JL, Jagust WJ, Hawkins RA, VanBrocklin HF, Wright JF, Bankiewicz KS, Aminoff MJ -
Implantation of deep brain stimulator electrodes using interventional MRI.
Neurosurgery clinics of North America 2009 Starr PA, Martin AJ, Larson PS -
Intraoperative MRI in functional neurosurgery. Preface.
Neurosurgery clinics of North America 2009 Lim DA, Larson PS -
Software requirements for interventional MR in restorative and functional neurosurgery.
Neurosurgery clinics of North America 2009 Martin AJ, Starr PA, Larson PS -
Fluoroscopic, EMG-guided injection of botulinum toxin into the longus colli for the treatment of anterocollis.
Parkinsonism & related disorders 2009 Glass GA, Ku S, Ostrem JL, Heath S, Larson PS -
Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial.
JAMA 2009 Weaver FM, Follett K, Stern M, Hur K, Harris C, Marks WJ, Rothlind J, Sagher O, Reda D, Moy CS, Pahwa R, Burchiel K, Hogarth P, Lai EC, Duda JE, Holloway K, Samii A, Horn S, Bronstein J, Stoner G, … -
Interventional magnetic resonance guidance of deep brain stimulator implantation for Parkinson disease.
Topics in magnetic resonance imaging : TMRI 2009 Martin AJ, Larson PS, Ostrem JL, Starr PA -
Gene and cell delivery to the degenerated striatum: status of preclinical efforts in primate models.
Neurosurgery 2008 Richardson RM, Larson PS, Bankiewicz KS -
Results from a phase I safety trial of hAADC gene therapy for Parkinson disease.
Neurology 2008 Eberling JL, Jagust WJ, Christine CW, Starr P, Larson P, Bankiewicz KS, Aminoff MJ -
Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial.
The Lancet. Neurology 2008 Marks WJ, Ostrem JL, Verhagen L, Starr PA, Larson PS, Bakay RA, Taylor R, Cahn-Weiner DA, Stoessl AJ, Olanow CW, Bartus RT -
Minimally invasive precision brain access using prospective stereotaxy and a trajectory guide.
Journal of magnetic resonance imaging : JMRI 2008 Martin AJ, Hall WA, Roark C, Starr PA, Larson PS, Truwit CL -
Deep brain stimulator hardware-related infections: incidence and management in a large series.
Neurosurgery 2008 Sillay KA, Larson PS, Starr PA -
Thalamic deep brain stimulation for essential tremor: relation of lead location to outcome.
Neurosurgery 2008 Papavassiliou E, Rau G, Heath S, Abosch A, Barbaro NM, Larson PS, Lamborn K, Starr PA -
Deep brain stimulation for psychiatric disorders.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2008 Larson PS -
Technical Alternatives in Performing Deep Brain Stimulator Implantation.
Deep Brain Stimulation in Neurological and Psychiatric Disorders 2008 Paul S. Larson -
Magnetic resonance imaging of implanted deep brain stimulators: experience in a large series.
Stereotactic and functional neurosurgery 2007 Larson PS, Richardson RM, Starr PA, Martin AJ -
Placement of Subthalamic DBS Electrodes in a Radiology Suite Using Interventional MRI.
Proceedings of the Medtronic Forum for Neuroscience and Neuro-Technology 2005 2007 P. A. Starr, A. J. Martin, P. Talke, J. Ostrem, W. K. Sootsman, N. Levesque, J. Meyers, P. S. Larson -
Placement of deep brain stimulator electrodes using real-time high-field interventional magnetic resonance imaging.
Magnetic resonance in medicine 2005 Martin AJ, Larson PS, Ostrem JL, Keith Sootsman W, Talke P, Weber OM, Levesque N, Myers J, Starr PA -
Thalamic deep brain stimulation for essential tremor: relation of lead location to outcome.
Neurosurgery 2004 Papavassiliou E, Rau G, Heath S, Abosch A, Barbaro NM, Larson PS, Lamborn K, Starr PA -
Frameless stereotactic neurosurgery using intraoperative magnetic resonance imaging: stereotactic brain biopsy.
Neurosurgery 2000 Moriarty TM, Quinones-Hinojosa A, Larson PS, Alexander E, Gleason PL, Schwartz RB, Jolesz FA, Black PM -
Traumatic intracranial aneurysms.
Neurosurgical focus 2000 Larson PS, Reisner A, Morassutti DJ, Abdulhadi B, Harpring JE -
Emergency magnetic resonance imaging of cervical spinal cord injuries: clinical correlation and prognosis.
Neurosurgery 1999 Larson PS, Christiano JA, Raque GH, Shields CB -
Loss of heterozygosity at 11q23 in squamous cell carcinoma of the head and neck is associated with recurrent disease.
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Visuomotor learning in cerebellar patients.
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