Paul Green, PhD
Professor
Preventive & Restor Dent Sci
School of Dentistry
My recent research has focused on mechanisms underlying chronic muscle pain, a very common clinical complaint that is extremely difficult to treat, in large part due to the lack of understanding of underlying mechanisms.
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I have developed two new animals models of ergonomic muscle pain (vibration and eccentric exercise), which together with inflammatory mediator-induced muscle pain will facilitate our investigation into the cellular mechanisms underlying the critical transition from acute to chronic muscle pain. In collaboration with Drs. Dina, Alvarez and Levine, we have found that the inflammatory cytokine, interleukin-6, that is produced during acute muscle inflammation mediates the production of a chronic-latent hyperalgesic state in which a subsequent exposure to inflammatory mediators produce a markedly prolonged mechanical hyperalgesia (i.e. analogous to transition from acute to chronic muscle pain) (Dina et al., Neuroscience 152:521-25, 2008; Alvarez et al, Eur J Neurosci 32:819-25, 2010). Furthermore, we have discovered that chronic-latent hyperalgesia produced by the inflammogen, carrageenan, is dependent on protein kinase Ce, a second messenger implicated in long-lasting plasticity in cutaneous nociceptors (Dina et al., J Pain 9:457-62, 2008). We have also observed that exposure to vibration produces neuropathic-like changes in the nociceptor (Chen et al., Pain 151:460-6, 2010). Vibration or eccentric exercise induced muscle pain appears to be restricted to one nociceptor phenotype, the isolectin B4-positive nociceptor (Alvarez, et al., Exp Neurol 233:859-65, 2012). I have also helped develop animal models of fibromyalgia syndrome and other widespread pain conditions, in the rat. Firstly, rats exposed to unpredictable sound stress develop a delayed onset enhancement and prolongation of cytokine-induced mechanical hyperalgesia in muscle and skin. This unpredictable sound stress model in the rat demonstrates several features (cutaneous, musculoskeletal, and visceral hyperalgesia, as well as anxiety) that are found in patients with fibromyalgia syndrome. Thus, this model may be used to test hypotheses about the underlying mechanisms and response to therapy in patients with fibromyalgia (Green et al. J Pain 12:811-8, 2011). Secondly, we evaluated activity in nociceptors innervating the gastrocnemius muscle in rats exposed to water avoidance stress. This stressor, which produces mechanical hyperalgesia in skeletal muscle, decreased mechanical threshold of muscle nociceptors and markedly increased the number of action potentials and conduction velocity in nociceptor. Thirdly, we evaluated cutaneous and muscle nociception and activity in muscle nociceptors in an animal model of neonatal stress, limited bedding (NLB), in the rat. NLB treatment produced both mechanical muscle hyperalgesia (and prolonged hyperalgesia to prostaglandin), as well as lower threshold and increased conduction velocity in muscle nociceptors (Green et al., Pain 152:2549-56, 2011). As part of my Tobacco-Related Disease Program funded research, I investigated the sexually dimorphic effects of nicotine on key components of inflammation. I observed that in vivo administration of nicotine increases reactive oxygen species (ROS) production in neutrophils from both males and females. However, there is a sexually dimorphic adrenal medulla-dependence in this effect, since after adrenal medullectomy nicotine increases ROS generation in males but inhibits it in females. Chronic nicotine, inhibits ROS production in neutrophils from females, but has no effect in males. Chronic nicotine inhibited macrophage phagocytosis in females, but not males, an effect abolished by adrenal medullectomy, suggesting a dependence on an adrenal medulla factor. Chronic nicotine also markedly enhanced the ability of the inflammatory agent, bradykinin, to increase plasma extravasation component of inflammation, in females but not in males. These results (manuscripts in preparation) show that nicotine significantly affects several aspects of the inflammatory response, and some of these effects of nicotine exhibit sex differences, that may, at least in part, underlie the sex differences in the effects of smoking on chronic diseases. I am also continuing to investigate the influence of sexually dimorphic neuroendocrine pathways on the inflammatory response. Specifically, I have been investigating the effect of sex and sex steroids on role of the sympathoadrenal axis, which is activated by stress, on several components of inflammation viz. plasma protein extravasation, leukocyte recruitment, phagocytosis and reactive oxygen species generation. Since the adrenal medulla is a principal organ of the stress response, I have been assessing the effect of activation of stress axes by different forms of stress stimuli on the inflammatory response. This research has important implications since stress exacerbates signs and symptoms of inflammatory diseases in humans and in animal models. I have shown that both the duration and severity of stress differentially affects the inflammatory response, probably by differential activation of the stress axes. I have shown that there is a striking sexual dimorphism in the effect of stress on plasma extravasation in that non-habituating stress markedly enhances plasma protein extravasation in female rats (Green & Levine, Eur. J. Pharmacol, 2005). In my recent studies on leukocyte recruitment, I have shown that stress markedly enhanced neutrophil recruitment in male rats, but not in females (Barker et al., Br. J. Pharmcol. 2005). This effect is dependent on sex steroids and on an intact sympathoadrenal system. I have also studied the effect of sympathoadrenal modulation on human leukocyte function in has been investigated, in collaboration with colleagues. These studies have shown that there is a marked sexual dimorphism in ß2-adrenergic receptor binding (the receptor that binds the principal adrenal medulla-derived stress hormone, epinephrine) as well as in ß-adrenergic-stimulated non-directed locomotion (chemokinesis) (de Coupade et al., Br. J. Pharmacol. 2004). I have also shown the important role played by ß2-adrenergic receptors in leukocyte migration by employing ß2-adrenergic receptor knock-out mice (de Coupade et al., J. Neuroimmunol. 2005).
Publications (117)
Top publication keywords:
SoundHyaluronic AcidSex CharacteristicsStress, PsychologicalBradykininNociceptorsPain ThresholdRats, Sprague-DawleyRatsProbioticsNeuralgiaMyalgiaSympathetic Nervous SystemChronic PainHyperalgesia
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Role of pattern recognition receptors in chemotherapy-induced neuropathic pain.
Brain : a journal of neurology 2024 Araldi D, Khomula EV, Bonet IJM, Bogen O, Green PG, Levine JD -
Sensitization of human and rat nociceptors by low dose morphine is toll-like receptor 4-dependent.
Molecular pain 2024 Khomula EV, Araldi D, Green PG, Levine JD -
Topical coapplication of hyaluronan with transdermal drug delivery enhancers attenuates inflammatory and neuropathic pain.
Pain 2023 Bonet IJM, Araldi D, Green PG, Levine JD -
Neuroendocrine mechanisms in oxaliplatin-induced hyperalgesic priming.
Pain 2022 Staurengo-Ferrari L, Araldi D, Green PG, Levine JD -
Probiotics attenuate alcohol-induced muscle mechanical hyperalgesia: Preliminary observations.
Molecular pain 2022 Green PG, Alvarez P, Levine JD
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Contribution of G-Protein α-Subunits to Analgesia, Hyperalgesia, and Hyperalgesic Priming Induced by Subanalgesic and Analgesic Doses of Fentanyl and Morphine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Araldi D, Bonet IJM, Green PG, Levine JD -
Neuroendocrine Stress Axis-Dependence of Duloxetine Analgesia (Anti-Hyperalgesia) in Chemotherapy-Induced Peripheral Neuropathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Staurengo-Ferrari L, Bonet IJM, Araldi D, Green PG, Levine JD -
Second messengers mediating high-molecular-weight hyaluronan-induced antihyperalgesia in rats with chemotherapy-induced peripheral neuropathy.
Pain 2021 Bonet IJM, Staurengo-Ferrari L, Araldi D, Green PG, Levine JD -
PI3Kγ/AKT Signaling in High Molecular Weight Hyaluronan (HMWH)-Induced Anti-Hyperalgesia and Reversal of Nociceptor Sensitization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Bonet IJM, Khomula EV, Araldi D, Green PG, Levine JD -
Sexually Dimorphic Role of Toll-like Receptor 4 (TLR4) in High Molecular Weight Hyaluronan (HMWH)-induced Anti-hyperalgesia.
The journal of pain 2021 Bonet IJM, Araldi D, Green PG, Levine JD -
Sexual dimorphism in the nociceptive effects of hyaluronan.
Pain 2021 Bonet IJM, Green PG, Levine JD -
Sexual dimorphism in the contribution of neuroendocrine stress axes to oxaliplatin-induced painful peripheral neuropathy.
Pain 2021 Staurengo-Ferrari L, Green PG, Araldi D, Ferrari LF, Miaskowski C, Levine JD -
Nociceptor Overexpression of NaV1.7 Contributes to Chronic Muscle Pain Induced by Early-Life Stress.
The journal of pain 2021 Alvarez P, Bogen O, Green PG, Levine JD -
A role for gut microbiota in early-life stress-induced widespread muscle pain in the adult rat.
Molecular pain 2021 Green PG, Alvarez P, Levine JD -
Sexual dimorphic role of the glucocorticoid receptor in chronic muscle pain produced by early-life stress.
Molecular pain 2021 Green PG, Alvarez P, Levine JD -
Exogenous Application of Proteoglycan to the Cell Surface Microenvironment Facilitates to Chondrogenic Differentiation and Maintenance.
International journal of molecular sciences 2020 Masutani T, Yamada S, Hara A, Takahashi T, Green PG, Niwa M -
Mechanisms Mediating High-Molecular-Weight Hyaluronan-Induced Antihyperalgesia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Bonet IJM, Araldi D, Khomula EV, Bogen O, Green PG, Levine JD -
Marked sexual dimorphism in neuroendocrine mechanisms for the exacerbation of paclitaxel-induced painful peripheral neuropathy by stress.
Pain 2020 Ferrari LF, Araldi D, Green PG, Levine JD -
Unpredictable stress delays recovery from exercise-induced muscle pain: contribution of the sympathoadrenal axis.
Pain reports 2019 Alvarez P, Green PG, Levine JD -
Role of Nociceptor Toll-like Receptor 4 (TLR4) in Opioid-Induced Hyperalgesia and Hyperalgesic Priming.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Araldi D, Bogen O, Green PG, Levine JD -
Systemic Morphine Produces Dose-dependent Nociceptor-mediated Biphasic Changes in Nociceptive Threshold and Neuroplasticity.
Neuroscience 2018 Ferrari LF, Araldi D, Bogen O, Green PG, Levine JD -
Neonatal Handling Produces Sex Hormone-Dependent Resilience to Stress-Induced Muscle Hyperalgesia in Rats.
The journal of pain 2018 Alvarez P, Green PG, Levine JD -
Nociceptor interleukin 10 receptor 1 is critical for muscle analgesia induced by repeated bouts of eccentric exercise in the rat.
Pain 2017 Alvarez P, Bogen O, Green PG, Levine JD -
Age-Dependent Sexual Dimorphism in Susceptibility to Develop Chronic Pain in the Rat.
Neuroscience 2017 Ferrari LF, Araldi D, Green P, Levine JD -
Marked sexual dimorphism in 5-HT1 receptors mediating pronociceptive effects of sumatriptan.
Neuroscience 2016 Araldi D, Ferrari LF, Green P, Levine JD -
Retinal Cell Degeneration in Animal Models.
International journal of molecular sciences 2016 Niwa M, Aoki H, Hirata A, Tomita H, Green PG, Hara A -
Mechanisms mediating nitroglycerin-induced delayed-onset hyperalgesia in the rat.
Neuroscience 2016 Ferrari LF, Levine JD, Green PG -
Contribution of Piezo2 to endothelium-dependent pain.
Molecular pain 2015 Ferrari LF, Bogen O, Green P, Levine JD -
Topical Tetrodotoxin Attenuates Photophobia Induced by Corneal Injury in the Rat.
The journal of pain 2015 Green PG, Alvarez P, Levine JD -
Neonatal handling (resilience) attenuates water-avoidance stress induced enhancement of chronic mechanical hyperalgesia in the rat.
Neuroscience letters 2015 Alvarez P, Levine JD, Green PG -
Homocysteine-induced attenuation of vascular endothelium-dependent hyperalgesia in the rat.
Neuroscience 2014 Joseph EK, Green PG, Ferrari LF, Levine JD -
ATP release mechanisms of endothelial cell-mediated stimulus-dependent hyperalgesia.
The journal of pain 2014 Joseph EK, Green PG, Levine JD -
Does the antihyperalgesic disruptor of endothelial cells, octoxynol-9, alter nociceptor function?
Journal of neurophysiology 2014 Chen X, Green PG, Levine JD -
Role for monocyte chemoattractant protein-1 in the induction of chronic muscle pain in the rat.
Pain 2014 Alvarez P, Green PG, Levine JD -
Acute inflammation in the joint: its control by the sympathetic nervous system and by neuroendocrine systems.
Autonomic neuroscience : basic & clinical 2014 Jänig W, Green PG -
NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids.
Neuroscience 2013 Gear RW, Bogen O, Ferrari LF, Green PG, Levine JD -
The fundamental unit of pain is the cell.
Pain 2013 Reichling DB, Green PG, Levine JD -
Stress in the adult rat exacerbates muscle pain induced by early-life stress.
Biological psychiatry 2013 Alvarez P, Green PG, Levine JD -
Vascular endothelial cells mediate mechanical stimulation-induced enhancement of endothelin hyperalgesia via activation of P2X2/3 receptors on nociceptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Joseph EK, Green PG, Bogen O, Alvarez P, Levine JD -
Ectopic uterine tissue as a chronic pain generator.
Neuroscience 2012 Alvarez P, Chen X, Hendrich J, Irwin JC, Green PG, Giudice LC, Levine JD -
IB4(+) nociceptors mediate persistent muscle pain induced by GDNF.
Journal of neurophysiology 2012 Alvarez P, Chen X, Bogen O, Green PG, Levine JD -
Primary afferent nociceptor as a target for the relief of pain.
Pain research and treatment 2012 Parada CA, Tambeli CH, Green PG, Cairns BE -
IB4-saporin attenuates acute and eliminates chronic muscle pain in the rat.
Experimental neurology 2011 Alvarez P, Gear RW, Green PG, Levine JD -
Early-life stress produces muscle hyperalgesia and nociceptor sensitization in the adult rat.
Pain 2011 Green PG, Chen X, Alvarez P, Ferrari LF, Levine JD -
Abnormal muscle afferent function in a model of Taxol chemotherapy-induced painful neuropathy.
Journal of neurophysiology 2011 Chen X, Green PG, Levine JD -
Stress enhances muscle nociceptor activity in the rat.
Neuroscience 2011 Chen X, Green PG, Levine JD -
Further validation of a model of fibromyalgia syndrome in the rat.
The journal of pain 2011 Green PG, Alvarez P, Gear RW, Mendoza D, Levine JD -
Enhanced cytokine-induced mechanical hyperalgesia in skeletal muscle produced by a novel mechanism in rats exposed to unpredictable sound stress.
European journal of pain (London, England) 2011 Dina OA, Levine JD, Green PG -
Neuropathic pain-like alterations in muscle nociceptor function associated with vibration-induced muscle pain.
Pain 2010 Chen X, Green PG, Levine JD -
Eccentric exercise induces chronic alterations in musculoskeletal nociception in the rat.
The European journal of neuroscience 2010 Alvarez P, Levine JD, Green PG -
Mechanisms mediating vibration-induced chronic musculoskeletal pain analyzed in the rat.
The journal of pain 2009 Dina OA, Joseph EK, Levine JD, Green PG -
Sound stress-induced long-term enhancement of mechanical hyperalgesia in rats is maintained by sympathoadrenal catecholamines.
The journal of pain 2009 Khasar SG, Dina OA, Green PG, Levine JD -
Sexual dimorphism in the effect of sound stress on neutrophil function.
Journal of neuroimmunology 2008 Brown AS, Levine JD, Green PG -
Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy.
The European journal of neuroscience 2008 Dina OA, Khasar SG, Alessandri-Haber N, Bogen O, Chen X, Green PG, Reichling DB, Messing RO, Levine JD -
Stress induces a switch of intracellular signaling in sensory neurons in a model of generalized pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Khasar SG, Burkham J, Dina OA, Brown AS, Bogen O, Alessandri-Haber N, Green PG, Reichling DB, Levine JD -
Muscle inflammation induces a protein kinase Cepsilon-dependent chronic-latent muscle pain.
The journal of pain 2008 Dina OA, Levine JD, Green PG -
Role of interleukin-6 in chronic muscle hyperalgesic priming.
Neuroscience 2008 Dina OA, Green PG, Levine JD -
Alcohol-induced stress in painful alcoholic neuropathy.
The European journal of neuroscience 2007 Dina OA, Khasar SG, Alessandri-Haber N, Green PG, Messing RO, Levine JD -
beta(2)-Adrenergic receptor-dependent sexual dimorphism for murine leukocyte migration.
Journal of neuroimmunology 2007 de Coupade C, Brown AS, Dazin PF, Levine JD, Green PG -
Burn injury pain: the continuing challenge.
The journal of pain 2007 Summer GJ, Puntillo KA, Miaskowski C, Green PG, Levine JD -
TrkA and PKC-epsilon in thermal burn-induced mechanical hyperalgesia in the rat.
The journal of pain 2006 Summer GJ, Puntillo KA, Miaskowski C, Dina OA, Green PG, Levine JD -
Neurogenic inflammation and arthritis.
Annals of the New York Academy of Sciences 2006 Levine JD, Khasar SG, Green PG -
Sympathoadrenal-dependent sexually dimorphic effect of nonhabituating stress on in vivo neutrophil recruitment in the rat.
British journal of pharmacology 2005 Barker LA, Dazin PF, Levine JD, Green PG -
Repeated sound stress enhances inflammatory pain in the rat.
Pain 2005 Khasar SG, Green PG, Levine JD -
Estrogen regulates adrenal medullary function producing sexual dimorphism in nociceptive threshold and beta-adrenergic receptor-mediated hyperalgesia in the rat.
The European journal of neuroscience 2005 Khasar SG, Dina OA, Green PG, Levine JD -
Gastrin-releasing peptide, substance P and cytokines in rheumatoid arthritis.
Arthritis research & therapy 2005 Green PG -
Sexual dimorphism in the effect of nonhabituating stress on neurogenic plasma extravasation.
The European journal of neuroscience 2005 Green PG, Levine JD -
Beta 2-adrenergic receptor regulation of human neutrophil function is sexually dimorphic.
British journal of pharmacology 2004 de Coupade C, Gear RW, Dazin PF, Sroussi HY, Green PG, Levine JD -
Central terminals of nociceptors are targets for nicotine suppression of inflammation.
Neuroscience 2004 Miao FJ, Green PG, Benowitz N, Levine JD -
Mechanosensitive duodenal afferents contribute to vagal modulation of inflammation in the rat.
The Journal of physiology 2004 Miao FJ, Green PG, Levine JD -
Vagal modulation of spinal nicotine-induced inhibition of the inflammatory response mediated by descending antinociceptive controls.
Neuropharmacology 2003 Miao FJ, Green P, Benowitz N, Levine JD -
Vagal modulation of bradykinin-induced mechanical hyperalgesia in the female rat.
The journal of pain 2003 Khasar SG, Miao FJ, Gear RW, Green PG, Levine JD -
Gonadal hormones do not account for sexual dimorphism in vagal modulation of nociception in the rat.
The journal of pain 2003 Khasar SG, Green PG, Gear RW, Isenberg W, Levine JD -
Repeated, non-habituating stress suppresses inflammatory plasma extravasation by a novel, sympathoadrenal dependent mechanism.
The European journal of neuroscience 2003 Strausbaugh HJ, Green PG, Dallman MF, Levine JD -
Vagal modulation of nociception is mediated by adrenomedullary epinephrine in the rat.
The European journal of neuroscience 2003 Khasar SG, Green PG, Miao FJ, Levine JD -
Fasting is a physiological stimulus of vagus-mediated enhancement of nociception in the female rat.
Neuroscience 2003 Khasar SG, Reichling DB, Green PG, Isenberg WM, Levine JD -
Sympathetic-independent bradykinin mechanical hyperalgesia induced by subdiaphragmatic vagotomy in the rat.
The journal of pain 2002 Khasar SG, Miao FJ, Gear RW, Green PG, Isenberg WM, Levine JD -
Altered nucleus accumbens circuitry mediates pain-induced antinociception in morphine-tolerant rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Schmidt BL, Tambeli CH, Barletta J, Luo L, Green P, Levine JD, Gear RW -
The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline.
Proceedings of the National Academy of Sciences of the United States of America 2002 Jasmin L, Tien D, Weinshenker D, Palmiter RD, Green PG, Janni G, Ohara PT -
Role of adrenal medulla in development of sexual dimorphism in inflammation.
The European journal of neuroscience 2001 Green PG, Dahlqvist SR, Isenberg WM, Miao FJ, Levine JD -
Gender and gonadal hormone effects on vagal modulation of tonic nociception.
The journal of pain 2001 Khasar SG, Isenberg WM, Miao FJ, Gear RW, Green PG, Levine JD -
Opioid inhibition of formalin-induced changes in plasma extravasation and local blood flow in rats.
Pain 2000 Taylor BK, Peterson MA, Roderick RE, Tate J, Green PG, Levine JO, Basbaum AI -
Bradykinin-induced neurogenic migration of neutrophils into the rat knee joint.
Neuroreport 1999 Lo EJ, Green PG, Miao FJ, Relchling DB, Levine JD -
A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice.
Neuron 1999 Khasar SG, Lin YH, Martin A, Dadgar J, McMahon T, Wang D, Hundle B, Aley KO, Isenberg W, McCarter G, Green PG, Hodge CW, Levine JD, Messing RO -
Painful stimulation suppresses joint inflammation by inducing shedding of L-selectin from neutrophils.
Nature medicine 1999 Strausbaugh HJ, Green PG, Lo E, Tangemann K, Reichling DB, Rosen SD, Levine JD -
Sex steroid regulation of the inflammatory response: sympathoadrenal dependence in the female rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 Green PG, Dahlqvist SR, Isenberg WM, Strausbaugh HJ, Miao FJ, Levine JD -
Annexin I is a local mediator in neural-endocrine feedback control of inflammation.
Journal of neurophysiology 1998 Green PG, Strausbaugh HJ, Levine JD -
Endocrine and vagal controls of sympathetically dependent neurogenic inflammation.
Annals of the New York Academy of Sciences 1998 Green PG, Miao FJ, Strausbaugh H, Heller P, Janig W, Levine JD -
Inhibition of bradykinin-induced plasma extravasation produced by noxious cutaneous and visceral stimuli and its modulation by vagal activity.
Journal of neurophysiology 1997 Miao FJ, Jänig W, Green PG, Levine JD -
Negative feedback neuroendocrine control of inflammatory response in the rat is dependent on the sympathetic postganglionic neuron.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997 Green PG, Jänig W, Levine JD -
Inhibition of bradykinin-induced synovial plasma extravasation produced by intrathecal nicotine is mediated by the hypothalamopituitary adrenal axis.
Journal of neurophysiology 1996 Miao FJ, Jänig W, Green PG, Levine JD -
Tachyphylaxis develops to bradykinin-induced plasma extravasation in the rat.
Neuroscience letters 1996 Miao FJ, Khasar SG, Green PG, Levine JD -
Sympathetic-dependence in bradykinin-induced synovial plasma extravasation is dose-related.
Neuroscience letters 1996 Miao FJ, Green PG, Coderre TJ, Jänig W, Levine JD -
Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995 Aley KO, Green PG, Levine JD -
5-Hydroxytryptamine-induced synovial plasma extravasation is mediated via 5-hydroxytryptamine2A receptors on sympathetic efferent terminals.
The Journal of pharmacology and experimental therapeutics 1995 Pierce PA, Xie GX, Peroutka SJ, Green PG, Levine JD -
Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: a G-protein beta gamma subunit-mediated effect?
Neuroscience 1995 Khasar SG, Wang JF, Taiwo YO, Heller PH, Green PG, Levine JD -
Negative feedback neuroendocrine control of the inflammatory response in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995 Green PG, Miao FJ, Jänig W, Levine JD -
Peripheral nociceptive effects of alpha 2-adrenergic receptor agonists in the rat.
Neuroscience 1995 Khasar SG, Green PG, Chou B, Levine JD -
Is there more than one prostaglandin E receptor subtype mediating hyperalgesia in the rat hindpaw?
Neuroscience 1995 Khasar SG, Ouseph AK, Chou B, Ho T, Green PG, Levine JD -
Comparison of prostaglandin E1- and prostaglandin E2-induced hyperalgesia in the rat.
Neuroscience 1994 Khasar SG, Ho T, Green PG, Levine JD -
Effect of E-type prostaglandins on bradykinin-induced plasma extravasation in the knee joint of the rat.
European journal of pharmacology 1994 Green PG, Luo J, Heller PH, Levine JD -
Trypsin enhances sympathetic neuron-dependent plasma extravasation in the rat knee joint.
Neuroscience letters 1993 Green PG, Luo J, Hammond ER, Levine JD -
Further substantiation of a significant role for the sympathetic nervous system in inflammation.
Neuroscience 1993 Green PG, Luo J, Heller PH, Levine JD -
Comparison of intradermal and subcutaneous hyperalgesic effects of inflammatory mediators in the rat.
Neuroscience letters 1993 Khasar SG, Green PG, Levine JD -
Neurogenic and non-neurogenic mechanisms of plasma extravasation in the rat.
Neuroscience 1993 Green PG, Luo J, Heller PH, Levine JD -
Modulation of bradykinin-induced plasma extravasation in the rat knee joint by sympathetic co-transmitters.
Neuroscience 1993 Green PG, Luo J, Heller P, Levine JD -
Sensory neuropeptide interactions in the production of plasma extravasation in the rat.
Neuroscience 1992 Green PG, Basbaum AI, Levine JD -
Delta- and kappa-opioid agonists inhibit plasma extravasation induced by bradykinin in the knee joint of the rat.
Neuroscience 1992 Green PG, Levine JD -
Purinergic regulation of bradykinin-induced plasma extravasation and adjuvant-induced arthritis in the rat.
Proceedings of the National Academy of Sciences of the United States of America 1991 Green PG, Basbaum AI, Helms C, Levine JD -
Neutrophils contribute to sympathetic nerve terminal-dependent plasma extravasation in the knee joint of the rat.
Neuroscience 1991 Bjerknes L, Coderre TJ, Green PG, Basbaum AI, Levine JD -
Interactions between anticholinesterase poisoning and opioid analgesia and locomotion in mice.
Neurotoxicology and teratology 1988 Green PG, Kitchen I, Crowder M -
Differential displacement of opioids from plasma protein binding sites by di-isopropylfluorophosphate in the mouse.
The Journal of pharmacy and pharmacology 1988 Green PG, Kitchen I -
Dynorphin A-(1-13) attenuates withdrawal in morphine-dependent rats: effect of route of administration.
European journal of pharmacology 1988 Green PG, Lee NM -
Di-isopropylfluorophosphate induced antinociception and its interactions with opioid drugs in the rat.
Toxicology 1986 Green PG, Kitchen I -
Antinociception opioids and the cholinergic system.
Progress in neurobiology 1986 Green PG, Kitchen I -
Different effects of di-isopropylfluorophosphate on the entry of opioids into mouse brain.
British journal of pharmacology 1985 Green PG, Kitchen I -
Differential effects of di-isopropylfluorophosphate poisoning and its treatment on opioid antinociception in the mouse.
Life sciences 1983 Kitchen I, Green PG