Paul Brakeman, MD, PhD
Professor
Pediatrics
School of Medicine

Awards

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• Top Doctor, Marin Magazine, 2019
• Top Doctor, San Francisco Magazine, 2019
• Designated Nephrotic Syndrome Expert, Nephcure Kidney International, 2018
• Excellence in Teaching Award, Haile T. Debas Academy of Medical Educators, 2016

Education & Training

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• M.D. School of Medicine John Hopkins University 1997
• Residency School of Medicine University of California, San Francisco

Websites

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• Clinical Profile at UCSF Benioff Children's Hospital (ucsfbenioffchildrens.org)

Grants and Projects

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• The Role of Nectin in Congenital Obstructive Nephropathy, NIH, 2004-2010

Publications (44)

Top publication keywords:
Epidermal Growth FactorSiliconKidney Failure, ChronicTight JunctionsKidney TubulesVesico-Ureteral RefluxKidneyCell TransdifferentiationArteriovenous Shunt, SurgicalReceptors, Metabotropic GlutamateEpithelial CellsCell Adhesion MoleculesMicrofilament ProteinsCell PolarityNanopores

• Voices of Hope: Leveraging Think-Aloud Cognitive Interviews to Develop a Hope Assessment Tool for Young People Living with Chronic Health Conditions.
  Children (Basel, Switzerland) 2024 von Scheven E, Braun M, Nahal B, Perito ER, Brakeman P, Soulsby WD, Quill L, Cuneo A, Franck LS
• Healthcare Utilization Among Youth with Chronic Illness Receiving Care at a Large Urban Academic Healthcare System.
  Healthcare (Basel, Switzerland) 2024 Soulsby WD, Franck LS, Perito E, Brakeman P, Cuneo A, Quill L, Boscardin J, von Scheven E
• Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes.
  Nature communications 2023 Kim EJ, Chen C, Gologorsky R, Santandreu A, Torres A, Wright N, Goodin MS, Moyer J, Chui BW, Blaha C, Brakeman P, Vartanian S, Tang Q, David Humes H, Fissell WH, Roy S
• Persistent Increase in Serum Ferritin Levels despite Converting to Permanent Vascular Access in Pediatric Hemodialysis Patients: Pediatric Nephrology Research Consortium Study.
  Journal of clinical medicine 2023 Onder AM, Ansari MAY, Deng F, Grinsell MM, Patterson L, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chadha V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Marsenic O, …
• COVID-19 in pediatric kidney transplantation: a follow-up report of the Improving Renal Outcomes Collaborative.
  Pediatric nephrology (Berlin, Germany) 2022 Varnell C, Harshman LA, Liu C, Smith L, Al-Akash S, Barletta GM, Brakeman P, Chaudhuri A, Fadakar P, Galea L, Garro R, Gluck C, Kershaw DB, Matossian D, Patel HP, Peterson C, Pruette C, Ranabothu S, …

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• Urologic Considerations in Pediatric Chronic Kidney Disease.
  Advances in chronic kidney disease 2022 Lombel RM, Brakeman PR, Sack BS, Butani L
• Conversion to permanent vascular access is associated with improved markers of hemodialysis efficacy in children: Pediatric nephrology research consortium study.
  Clinical nephrology 2021 Onder AM, Flynn JT, Ansari MAY, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson L, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chadha V, Elmaghrabi A, Lin JJ, …
• Association of Plasma Uremic Solute Levels with Residual Kidney Function in Children on Peritoneal Dialysis.
  Clinical journal of the American Society of Nephrology : CJASN 2021 Ganesan LL, O'Brien FJ, Sirich TL, Plummer NS, Sheth R, Fajardo C, Brakeman P, Sutherland SM, Meyer TW
• COVID-19 in pediatric kidney transplantation: The Improving Renal Outcomes Collaborative.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2021 Varnell C, Harshman LA, Smith L, Liu C, Chen S, Al-Akash S, Barletta GM, Belsha C, Brakeman P, Chaudhuri A, Fadakar P, Garro R, Gluck C, Goebel J, Kershaw D, Matossian D, Nailescu C, Patel HP, Pruette…
• Plasma pseudouridine levels reflect body size in children on hemodialysis.
  Pediatric nephrology (Berlin, Germany) 2019 O'Brien FJ, Sirich TL, Taussig A, Fung E, Ganesan LL, Plummer NS, Brakeman P, Sutherland SM, Meyer TW
• Predictors of time to first cannulation for arteriovenous fistula in pediatric hemodialysis patients: Midwest Pediatric Nephrology Consortium study.
  Pediatric nephrology (Berlin, Germany) 2019 Onder AM, Flynn JT, Billings AA, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson L, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chadha V, Elmaghrabi A, Lin JJ, …
• Simple Rules Determine Distinct Patterns of Branching Morphogenesis.
  Cell systems 2019 Yu W, Marshall WF, Metzger RJ, Brakeman PR, Morsut L, Lim W, Mostov KE
• Correction to: Predictors of patency for arteriovenous fistulae and grafts in pediatric hemodialysis patients.
  Pediatric nephrology (Berlin, Germany) 2019 Onder AM, Flynn JT, Billings AA, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson LT, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chadha V, Elmaghrabi A, Lin JJ, …
• Application of physiological shear stress to renal tubular epithelial cells.
  Methods in cell biology 2019 Ferrell N, Sandoval RM, Molitoris BA, Brakeman P, Roy S, Fissell WH
• Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2019 Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A
• Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing.
  The Journal of pharmacology and experimental therapeutics 2019 Jayagopal A, Brakeman PR, Soler P, Ferrell N, Fissell W, Kroetz DL, Roy S
• Outcome of participants with nephrotic syndrome in combined clinical trials of lupus nephritis.
  Lupus science & medicine 2019 Gomez Mendez LM, Cascino MD, Katsumoto TR, Brakeman P, Brunetta P, Jayne D, Dall'Era M, Rovin B, Garg J
• Predictors of patency for arteriovenous fistulae and grafts in pediatric hemodialysis patients.
  Pediatric nephrology (Berlin, Germany) 2018 Onder AM, Flynn JT, Billings AA, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson LT, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chanda V, Elmaghrabi A, Lin JJ, …
• Peripheral Blood B Cell Depletion after Rituximab and Complete Response in Lupus Nephritis.
  Clinical journal of the American Society of Nephrology : CJASN 2018 Gomez Mendez LM, Cascino MD, Garg J, Katsumoto TR, Brakeman P, Dall'Era M, Looney RJ, Rovin B, Dragone L, Brunetta P
• Renal function outcomes in pediatric patients with symptomatic reflux into the transplanted kidney treated with redo ureteroneocystostomy.
  Journal of pediatric urology 2018 Wang MK, Chuang KW, Li Y, Gaither T, Brakeman P, Gonzalez L, Brennan J, Baskin LS
• Afadin orients cell division to position the tubule lumen in developing renal tubules.
  Development (Cambridge, England) 2017 Gao L, Yang Z, Hiremath C, Zimmerman SE, Long B, Brakeman PR, Mostov KE, Bryant DM, Luby-Phelps K, Marciano DK
• Laser acupuncture reduces pain in pediatric kidney biopsies: a randomized controlled trial.
  Pain 2017 Oates A, Benedict KA, Sun K, Brakeman PR, Lim J, Kim C
• A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells.
  Biomicrofluidics 2016 Brakeman P, Miao S, Cheng J, Lee CZ, Roy S, Fissell WH, Ferrell N
• Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy.
  ASAIO journal (American Society for Artificial Internal Organs : 1992) 2016 Kim S, Heller J, Iqbal Z, Kant R, Kim EJ, Durack J, Saeed M, Do L, Hetts S, Wilson M, Brakeman P, Fissell WH, Roy S
• Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection.
  Cell host & microbe 2014 Tran CS, Eran Y, Ruch TR, Bryant DM, Datta A, Brakeman P, Kierbel A, Wittmann T, Metzger RJ, Mostov KE, Engel JN
• Acute changes in blood pressure in patients with neuroblastoma treated with ¹³¹I-metaiodobenzylguanidine (MIBG).
  Pediatric blood & cancer 2013 Wong T, Matthay KK, Boscardin WJ, Hawkins RA, Brakeman PR, DuBois SG
• De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity.
  Development (Cambridge, England) 2013 Yang Z, Zimmerman S, Brakeman PR, Beaudoin GM, Reichardt LF, Marciano DK
• Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells.
  Nature cell biology 2012 Gálvez-Santisteban M, Rodriguez-Fraticelli AE, Bryant DM, Vergarajauregui S, Yasuda T, Bañón-Rodríguez I, Bernascone I, Datta A, Spivak N, Young K, Slim CL, Brakeman PR, Fukuda M, Mostov KE, Martín-…
• Preso1 dynamically regulates group I metabotropic glutamate receptors.
  Nature neuroscience 2012 Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF
• p120 catenin is required for normal renal tubulogenesis and glomerulogenesis.
  Development (Cambridge, England) 2011 Marciano DK, Brakeman PR, Lee CZ, Spivak N, Eastburn DJ, Bryant DM, Beaudoin GM, Hofmann I, Mostov KE, Reichardt LF
• Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis.
  American journal of physiology. Renal physiology 2008 Brakeman PR, Liu KD, Shimizu K, Takai Y, Mostov KE
• Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity.
  EMBO reports 2008 Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, Bryant DM, Fan QW, Weiss WA, Zegers MM, Mostov KE
• Renal repair and recovery.
  Critical care medicine 2008 Liu KD, Brakeman PR
• Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats.
  Anesthesiology 2008 Hirose R, Xu F, Dang K, Liu T, Behrends M, Brakeman PR, Wiener-Kronish J, Niemann CU
• Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents.
  Pediatrics 2008 Nguyen S, McCulloch C, Brakeman P, Portale A, Hsu CY
• Vesicoureteral reflux, reflux nephropathy, and end-stage renal disease.
  Advances in urology 2008 Brakeman P
• Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway.
  American journal of physiology. Renal physiology 2007 Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE
• Polarity proteins PAR6 and aPKC regulate cell death through GSK-3beta in 3D epithelial morphogenesis.
  Journal of cell science 2007 Kim M, Datta A, Brakeman P, Yu W, Mostov KE
• Formation of multicellular epithelial structures.
  Novartis Foundation symposium 2005 Mostov K, Brakeman P, Datta A, Gassama A, Katz L, Kim M, Leroy P, Levin M, Liu K, Martin F, O'Brien LE, Verges M, Su T, Tang K, Tanimizu N, Yamaji T, Yu W
• The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo.
  Nature neuroscience 2001 Foa L, Rajan I, Haas K, Wu GY, Brakeman P, Worley P, Cline H
• Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.
  Neuron 1999 Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Aakalu VK, Lanahan AA, Sheng M, Worley PF
• Homer: a protein that selectively binds metabotropic glutamate receptors.
  Nature 1997 Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF
• MR-based correction of brain PET measurements for heterogeneous gray matter radioactivity distribution.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1996 Meltzer CC, Zubieta JK, Links JM, Brakeman P, Stumpf MJ, Frost JJ
• Magnetohydrodynamics of blood flow.
  Magnetic resonance in medicine 1990 Keltner JR, Roos MS, Brakeman PR, Budinger TF