Paraskevi Tsiolaki, PhD
Specialist
Biochemistry and Biophysics
School of Medicine

Awards

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• EMBO long-term Fellowship, University of California, San Francisco, 2020-2022
• Fellowships of Excellence for Postgraduate Studies in Greece – Siemens Programme, Greek State Scholarships Foundation, 2015-2017

Education & Training

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• PhD Molecular Biophysics University of Athens 2018
• MSc Structural Bioinformatics University of Athens 2014

Websites

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• Agard Lab, UCSF (msg.ucsf.edu)

Publications (21)

Top publication keywords:
Cystatin CClusterinProtein Aggregation, PathologicalAmyloidogenic ProteinsOligopeptidesProtein AggregatesC-PeptideChorionAmyloidosisTandem Repeat SequencesAmyloidCalcitonin Gene-Related PeptideProtein ConformationData MiningBombyx

• Bacterial Lectin FimH and Its Aggregation Hot-Spots: An Alternative Strategy against Uropathogenic Escherichia coli.
  Pharmaceutics 2023 Nasi GI, Georgakopoulou KI, Theodoropoulou MK, Papandreou NC, Chrysina ED, Tsiolaki PL, Iconomidou VA
• Clusterin in Alzheimer's disease: An amyloidogenic inhibitor of amyloid formation?
  Biochimica et biophysica acta. Molecular basis of disease 2022 Spatharas PM, Nasi GI, Tsiolaki PL, Theodoropoulou MK, Papandreou NC, Hoenger A, Trougakos IP, Iconomidou VA
• Arabidopsis thaliana Plant Natriuretic Peptide Active Domain Forms Amyloid-like Fibrils in a pH-Dependent Manner.
  Plants (Basel, Switzerland) 2021 Nasi GI, Aktypi FD, Spatharas PM, Louros NN, Tsiolaki PL, Magafa V, Trougakos IP, Iconomidou VA
• Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism.
  The Journal of biological chemistry 2021 Tao J, Berthet A, Citron YR, Tsiolaki PL, Stanley R, Gestwicki JE, Agard DA, McConlogue L
• Delving into the amyloidogenic core of human leukocyte chemotactic factor 2.
  Journal of structural biology 2019 Tsiolaki PL, Nasi GI, Baltoumas FA, Fishman S, Tu HC, Iconomidou VA

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• AmyCo: the amyloidoses collection.
  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2019 Nastou KC, Nasi GI, Tsiolaki PL, Litou ZI, Iconomidou VA
• Hidden Aggregation Hot-Spots on Human Apolipoprotein E: A Structural Study.
  International journal of molecular sciences 2019 Tsiolaki PL, Katsafana AD, Baltoumas FA, Louros NN, Iconomidou VA
• The amyloid interactome: mapping protein aggregation.
  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2019 Nastou KC, Tsiolaki PL, Iconomidou VA
• Hexapeptide Tandem Repeats Dictate the Formation of Silkmoth Chorion, a Natural Protective Amyloid.
  Journal of molecular biology 2018 Tsiolaki PL, Louros NN, Iconomidou VA
• αCGRP, another amyloidogenic member of the CGRP family.
  Journal of structural biology 2018 Tsiolaki PL, Nasi GI, Baltoumas FA, Louros NN, Magafa V, Hamodrakas SJ, Iconomidou VA
• Mining databases for protein aggregation: a review.
  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2017 Tsiolaki PL, Nastou KC, Hamodrakas SJ, Iconomidou VA
• Tracking the amyloidogenic core of IAPP amyloid fibrils: Insights from micro-Raman spectroscopy.
  Journal of structural biology 2017 Louros NN, Tsiolaki PL, Baltoumas FA, Chryssikos GD, Gionis V, Hamodrakas SJ, Iconomidou VA
• The amyloid interactome: Exploring protein aggregation.
  PloS one 2017 Biza KV, Nastou KC, Tsiolaki PL, Mastrokalou CV, Hamodrakas SJ, Iconomidou VA
• Unraveling the aggregation propensity of human insulin C-peptide.
  Biopolymers 2017 Tsiolaki PL, Louros NN, Zompra AA, Hamodrakas SJ, Iconomidou VA
• Exploring Amyloidogenicity of Clusterin: A Structural and Bioinformatics Analysis.
  Advances in experimental medicine and biology 2017 Tsiolaki PL, Nastou KC, Louros NN, Hamodrakas SJ, Iconomidou VA
• Intrinsic aggregation propensity of the CsgB nucleator protein is crucial for curli fiber formation.
  Journal of structural biology 2016 Louros NN, Bolas GMP, Tsiolaki PL, Hamodrakas SJ, Iconomidou VA
• Exploring the 'aggregation-prone' core of human Cystatin C: A structural study.
  Journal of structural biology 2015 Tsiolaki PL, Louros NN, Hamodrakas SJ, Iconomidou VA
• Chameleon 'aggregation-prone' segments of apoA-I: A model of amyloid fibrils formed in apoA-I amyloidosis.
  International journal of biological macromolecules 2015 Louros NN, Tsiolaki PL, Griffin MD, Howlett GJ, Hamodrakas SJ, Iconomidou VA
• Structural studies and cytotoxicity assays of "aggregation-prone" IAPP(8-16) and its non-amyloidogenic variants suggest its important role in fibrillogenesis and cytotoxicity of human amylin.
  Biopolymers 2015 Louros NN, Tsiolaki PL, Zompra AA, Pappa EV, Magafa V, Pairas G, Cordopatis P, Cheimonidou C, Trougakos IP, Iconomidou VA, Hamodrakas SJ
• The pentapeptide LQVVR plays a pivotal role in human cystatin C fibrillization.
  FEBS letters 2014 Tsiolaki PL, Hamodrakas SJ, Iconomidou VA
• An N-terminal pro-atrial natriuretic peptide (NT-proANP) 'aggregation-prone' segment involved in isolated atrial amyloidosis.
  FEBS letters 2013 Louros NN, Iconomidou VA, Tsiolaki PL, Chrysina ED, Baltatzis GE, Patsouris ES, Hamodrakas SJ