Param Priya Singh, PhD
Assistant Professor
Anatomy
School of Medicine

Together, diapause and the compressed lifespan make killifish an ideal model to identify new mechanisms for long-term protection and to study vertebrate aging at a rapid and high-throughput scale. We aim to utilize unbiased, comparative, and multidisciplinary approaches by integrating computational genomics and CRISPR-based perturbations to decode the complexity of gene regulation during diapause and aging in vertebrates and to leverage this knowledge to improve human health.

• Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate
  bioRxiv [Preprint] 2022 Chen YR, Harel I, Singh PP , Ziv I, Moses E, Goshtchevsky U, Machado BE, Brunet A, Jarosz DF
• Evolution of diapause in the African turquoise killifish by remodeling ancient gene regulatory landscape
  bioRxiv [Preprint] 2021 Singh PP, Reeves GA, Contrepois K, Ellenberger M, Hu CK, Snyder MP, Brunet A
• Mutations in calmodulin-binding domains of TRPV4/6 channels confer invasive properties to colon adenocarcinoma cells.
  Channels (Austin, Tex.) 2020 Arbabian A, Iftinca M, Altier C, Singh PP, Isambert H, Coscoy S
• OHNOLOGS v2: a comprehensive resource for the genes retained from whole genome duplication in vertebrates.
  Nucleic acids research 2020 Singh PP, Isambert H
• Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses.
  Genome research 2019 Benayoun BA, Pollina EA, Singh PP, Mahmoudi S, Harel I, Casey KM, Dulken BW, Kundaje A, Brunet A
• The genome of Austrofundulus limnaeus offers insights into extreme vertebrate stress tolerance and embryonic development.
  BMC genomics 2018 Wagner JT, Singh PP, Romney AL, Riggs CL, Minx P, Woll SC, Roush J, Warren WC, Brunet A, Podrabsky JE
• Learning causal networks with latent variables from multivariate information in genomic data.
  PLoS computational biology 2017 Verny L, Sella N, Affeldt S, Singh PP, Isambert H
• Progranulin, lysosomal regulation and neurodegenerative disease.
  Nature reviews. Neuroscience 2017 Kao AW, McKay A, Singh PP, Brunet A, Huang EJ
• The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan.
  Cell 2015 Valenzano DR, Benayoun BA, Singh PP, Zhang E, Etter PD, Hu CK, Clément-Ziza M, Willemsen D, Cui R, Harel I, Machado BE, Yee MC, Sharp SC, Bustamante CD, Beyer A, Johnson EA, Brunet A
• Identification of Ohnolog Genes Originating from Whole Genome Duplication in Early Vertebrates, Based on Synteny Comparison across Multiple Genomes.
  PLoS computational biology 2015 Singh PP, Arora J, Isambert H
• Human dominant disease genes are enriched in paralogs originating from whole genome duplication.
  PLoS computational biology 2014 Singh PP, Affeldt S, Malaguti G, Isambert H
• On the retention of gene duplicates prone to dominant deleterious mutations.
  Theoretical population biology 2014 Malaguti G, Singh PP, Isambert H
• [Evolution and cancer: expansion of dangerous gene repertoire by whole genome duplications].
  Medecine sciences : M/S 2013 Affeldt S, Singh PP, Cascone I, Selimoglu R, Camonis J, Isambert H
• On the expansion of "dangerous" gene repertoires by whole-genome duplications in early vertebrates.
  Cell reports 2012 Singh PP, Affeldt S, Cascone I, Selimoglu R, Camonis J, Isambert H
• Case for an RNA-prion world: a hypothesis based on conformational diversity.
  Journal of biological physics 2011 Singh PP, Banerji A