Paolo Rinaudo, MD, PhD
Professor
Ob/Gyn, Reproductive Sciences
School of Medicine

He is the recipient of numerous prestigious honors and awards, including the ASRM/Serono grant in reproductive biology and the President Presenter Award at the 50th annual meeting of the Society for Gynecological Investigation, Washington, DC. He is a member of professional societies, such as the American Society for Reproductive Medicine, American College of Obstetrics and Gynecology and Society for Reproductive Endocrinology and Infertility.

Rinaudo earned a medical degree at Torino Medical School and a doctorate at Torino University in Torino, Italy. He completed a residency in obstetrics and gynecology at Yale University, followed by a fellowship in reproductive endocrinology and infertility at the Hospital of the University of Pennsylvania. He is an Associate Professor in residence in the department of Obstetrics, Gynecology and Reproductive Sciences at UCSF.

• Fertility treatment increases the risk of preterm birth independent of multiple gestations.
  F&S reports 2023 Fineman DC, Keller RL, Maltepe E, Rinaudo PF, Steurer MA
• Study protocol for a Developmental Epidemiological Study of Children born through Reproductive Technologies (DESCRT).
  Human reproduction open 2023 Adeleye AJ, Zablotska L, Rinaudo P, Huang D, Lustig RH, Cedars MI
• Meiotic spindle transfer for infertility: Where should we go next?
  Fertility and sterility 2023 Rinaudo P, Coutifaris C
• Metabolomic Profile of Children Conceived With Medically Assisted Technologies.
  The Journal of clinical endocrinology and metabolism 2023 Tolani AT, Cedars MI, Zablotska LB, Rinaudo PF
• Murine blastocysts generated by in vitro fertilization show increased Warburg metabolism and altered lactate production.
  eLife 2022 Lee SH, Liu X, Jimenez-Morales D, Rinaudo PF
• Micro-scale probing of the Rat's oviduct detects its viscoelastic property needed for creating a biologically relevant substrate for In-Vitro- Fertilization.
  Progress in biophysics and molecular biology 2022 Jafarbeglou F, Nazari MA, Iravanimanesh S, Amanpour S, Keikha F, Rinaudo P, Azadi M
• Emulating a target trial of the comparative effectiveness of clomiphene citrate and letrozole for ovulation induction.
  Human reproduction (Oxford, England) 2022 Yland JJ, Chiu YH, Rinaudo P, Hsu J, Hernán MA, Hernández-Díaz S
• Effectiveness and safety of intrauterine insemination vs. assisted reproductive technology: emulating a target trial using an observational database of administrative claims.
  Fertility and sterility 2022 Chiu YH, Yland JJ, Rinaudo P, Hsu J, McGrath S, Hernández-Díaz S, Hernán MA
• DNA methylation profile of liver of mice conceived by in vitro fertilization.
  Journal of developmental origins of health and disease 2021 Lira-Albarrán S, Liu X, Lee SH, Rinaudo P
• Ovulation induction is associated with altered growth but with preservation of normal metabolic function in murine offspring.
  F&S science 2021 Harner R, Lira-Albarrán S, Chalas C, Lee SH, Liu X, Rinaudo P
• Outcomes of Very Preterm Infants Conceived with Assisted Reproductive Technologies.
  The Journal of pediatrics 2021 Fineman DC, Keller RL, Maltepe E, Rinaudo PF, Steurer MA
• Will PRP therapy find a niche in reproductive medicine? Not ready for prime time.
  Journal of assisted reproduction and genetics 2021 Rinaudo P, Albertini D
• Preimplantation embryo: the first physical exam.
  F&S science 2021 Rinaudo P
• Sex-specific epigenetic profile of inner cell mass of mice conceived in vivo or by IVF.
  Molecular human reproduction 2020 Ruggeri E, Lira-Albarrán S, Grow EJ, Liu X, Harner R, Maltepe E, Ramalho-Santos M, Donjacour A, Rinaudo P
• Effect of culture conditions and method of conception on mouse live birth rate.
  F&S science 2020 Xiao Z, Donjacour A, Harner R, Simbulan R, Kao CN, Ruggeri E, Liu X, Maltepe E, Rinaudo P
• The Effect of Prenatal Treatments on Offspring Events in the Presence of Competing Events: An Application to a Randomized Trial of Fertility Therapies.
  Epidemiology (Cambridge, Mass.) 2020 Chiu YH, Stensrud MJ, Dahabreh IJ, Rinaudo P, Diamond MP, Hsu J, Hernández-Díaz S, Hernán MA
• Oxygen concentration alters mitochondrial structure and function in in vitro fertilized preimplantation mouse embryos.
  Human reproduction (Oxford, England) 2020 Belli M, Zhang L, Liu X, Donjacour A, Ruggeri E, Palmerini MG, Nottola SA, Macchiarelli G, Rinaudo P
• Pre-Implantation Mouse Embryos Cultured In Vitro under Different Oxygen Concentrations Show Altered Ultrastructures.
  International journal of environmental research and public health 2020 Belli M, Rinaudo P, Palmerini MG, Ruggeri E, Antonouli S, Nottola SA, Macchiarelli G
• Outcomes of pulmonary vascular disease in infants conceived with non-IVF fertility treatment and assisted reproductive technologies at 1 year of age.
  Pediatric pulmonology 2019 Fineman DC, Baer RJ, Chambers CD, Rajagopal S, Maltepe E, Rinaudo PF, Fineman JR, Jelliffe-Pawlowski LL, Steurer MA
• Oxygen concentration alters mitochondrial structure and function in in vitro fertilized preimplantation mouse embryos.
  Human reproduction (Oxford, England) 2019 Belli M, Zhang L, Liu X, Donjacour A, Ruggeri E, Palmerini MG, Nottola SA, Macchiarelli G, Rinaudo P
• Transitioning from Infertility-Based (ART 1.0) to Elective (ART 2.0) Use of Assisted Reproductive Technologies and the DOHaD Hypothesis: Do We Need to Change Consenting?
  Seminars in reproductive medicine 2019 Rinaudo P, Adeleye A
• Promising noninvasive microscopy imaging technique evaluates metabolic markers in mouse oocytes.
  Fertility and sterility 2018 Rinaudo P, Albertini D
• Paternal developmental toxicant exposure is associated with epigenetic modulation of sperm and placental Pgr and Igf2 in a mouse model.
  Biology of reproduction 2018 Ding T, Mokshagundam S, Rinaudo PF, Osteen KG, Bruner-Tran KL
• Advanced Paternal Age Affects Sperm Count and Anogenital Distance in Mouse Offspring.
  Reproductive sciences (Thousand Oaks, Calif.) 2018 Caballero-Campo P, Lin W, Simbulan R, Liu X, Feuer S, Donjacour A, Rinaudo PF
• Report from the 2016 University of California, San Francisco, Center for Reproductive Sciences retreat.
  Molecular reproduction and development 2017 Rinaudo PF, Conti M
• An initial step in examining long-term outcomes for children born after IVF.
  Reproductive biomedicine online 2017 Hsu J, Velasco JAG, Rinaudo P
• Physiological, metabolic and transcriptional postnatal phenotypes of in vitro fertilization (IVF) in the mouse.
  Journal of developmental origins of health and disease 2017 Feuer SK, Rinaudo PF
• To freeze or not to freeze: heating the debate but cooling the practice?
  Journal of assisted reproduction and genetics 2017 Rinaudo PF, Hsu J
• Common and specific transcriptional signatures in mouse embryos and adult tissues induced by in vitro procedures.
  Reproduction (Cambridge, England) 2016 Feuer S, Liu X, Donjacour A, Simbulan R, Maltepe E, Rinaudo P
• From Embryos to Adults: A DOHaD Perspective on In Vitro Fertilization and Other Assisted Reproductive Technologies.
  Healthcare (Basel, Switzerland) 2016 Feuer S, Rinaudo P
• Adult male mice conceived by in vitro fertilization exhibit increased glucocorticoid receptor expression in fat tissue.
  Journal of developmental origins of health and disease 2015 Simbulan RK, Liu X, Feuer SK, Maltepe E, Donjacour A, Rinaudo P
• Unwind and transcribe: chromatin reprogramming in the early mammalian embryo.
  Current opinion in genetics & development 2015 Biechele S, Lin CJ, Rinaudo PF, Ramalho-Santos M
• Embryonic stem cells derived from in vivo or in vitro-generated murine blastocysts display similar transcriptome and differentiation potential.
  PloS one 2015 Simbulan RK, Di Santo M, Liu X, Lin W, Donjacour A, Maltepe E, Shenoy A, Borini A, Rinaudo P
• HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth.
  Cell reports 2015 Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo PF, Costello JF, Aghi MK, Maltepe E
• 150 years of congenital adrenal hyperplasia: translation and commentary of De Crecchio's classic paper from 1865.
  Endocrinology 2015 Delle Piane L, Rinaudo PF, Miller WL
• A critical review of bi-dimensional and three-dimensional ultrasound techniques to monitor follicle growth: do they help improving IVF outcome?
  Reproductive biology and endocrinology : RB&E 2014 Revelli A, Martiny G, Delle Piane L, Benedetto C, Rinaudo P, Tur-Kaspa I
• Behavior and brain gene expression changes in mice exposed to preimplantation and prenatal stress.
  Reproductive sciences (Thousand Oaks, Calif.) 2014 Strata F, Giritharan G, Sebastiano FD, Piane LD, Kao CN, Donjacour A, Rinaudo P
• LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia.
  The American journal of pathology 2014 Zhou Y, Yuge A, Rajah AM, Unek G, Rinaudo PF, Maltepe E
• Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes.
  Endocrinology 2014 Feuer SK, Donjacour A, Simbulan RK, Lin W, Liu X, Maltepe E, Rinaudo PF
• Comparative intrauterine development and placental function of ART concepti: implications for human reproductive medicine and animal breeding.
  Human reproduction update 2014 Bloise E, Feuer SK, Rinaudo PF
• In vitro fertilization affects growth and glucose metabolism in a sex-specific manner in an outbred mouse model.
  Biology of reproduction 2014 Donjacour A, Liu X, Lin W, Simbulan R, Rinaudo PF
• Use of a mouse in vitro fertilization model to understand the developmental origins of health and disease hypothesis.
  Endocrinology 2014 Feuer SK, Liu X, Donjacour A, Lin W, Simbulan RK, Giritharan G, Piane LD, Kolahi K, Ameri K, Maltepe E, Rinaudo PF
• A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis.
  Journal of cellular physiology 2014 Caballero-Campo P, Buffone MG, Benencia F, Conejo-García JR, Rinaudo PF, Gerton GL
• Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress.
  PloS one 2013 Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, Delay M, Donne M, Choi HJ, Tormos KV, Yeghiazarians Y, Jeffrey SS, Rinaudo PF, Rowitch DH, Aghi M, Maltepe E
• ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.
  PloS one 2013 Choi HJ, Sanders TA, Tormos KV, Ameri K, Tsai JD, Park AM, Gonzalez J, Rajah AM, Liu X, Quinonez DM, Rinaudo PF, Maltepe E
• Bovine preimplantation embryo development is affected by the stiffness of the culture substrate.
  Molecular reproduction and development 2013 Rivera RM, Rinaudo P
• ART and health: clinical outcomes and insights on molecular mechanisms from rodent studies.
  Molecular human reproduction 2012 Feuer SK, Camarano L, Rinaudo PF
• Preimplantation stress and development.
  Birth defects research. Part C, Embryo today : reviews 2012 Feuer S, Rinaudo P
• (1)H NMR based profiling of spent culture media cannot predict success of implantation for day 3 human embryos.
  Journal of assisted reproduction and genetics 2012 Rinaudo P, Shen S, Hua J, Qian S, Prabhu U, Garcia E, Cedars M, Sukumaran D, Szyperski T, Andrews C
• Metaphase II (MII) oocytes obtained at different time points in the same in vitro fertilization cycle.
  Journal of assisted reproduction and genetics 2012 Cakmak H, Fujimoto VY, Zamah AM, Rosen MP, Tran ND, Cedars MI, Rinaudo PF
• Effect of substrate stiffness on early mouse embryo development.
  PloS one 2012 Kolahi KS, Donjacour A, Liu X, Lin W, Simbulan RK, Bloise E, Maltepe E, Rinaudo P
• Impaired placental nutrient transport in mice generated by in vitro fertilization.
  Endocrinology 2012 Bloise E, Lin W, Liu X, Simbulan R, Kolahi KS, Petraglia F, Maltepe E, Donjacour A, Rinaudo P
• In vitro culture of mouse embryos reduces differential gene expression between inner cell mass and trophectoderm.
  Reproductive sciences (Thousand Oaks, Calif.) 2012 Giritharan G, Delle Piane L, Donjacour A, Esteban FJ, Horcajadas JA, Maltepe E, Rinaudo P
• Fetal programming and metabolic syndrome.
  Annual review of physiology 2011 Rinaudo P, Wang E
• Effect of ICSI on gene expression and development of mouse preimplantation embryos.
  Human reproduction (Oxford, England) 2010 Giritharan G, Li MW, Di Sebastiano F, De Sebastiano F, Esteban FJ, Horcajadas JA, Lloyd KC, Donjacour A, Maltepe E, Rinaudo PF
• Effect of the method of conception and embryo transfer procedure on mid-gestation placenta and fetal development in an IVF mouse model.
  Human reproduction (Oxford, England) 2010 Delle Piane L, Lin W, Liu X, Donjacour A, Minasi P, Revelli A, Maltepe E, Rinaudo PF
• Preimplantation mouse embryo selection guided by light-induced dielectrophoresis.
  PloS one 2010 Valley JK, Swinton P, Boscardin WJ, Lue TF, Rinaudo PF, Wu MC, Garcia MM
• Fertilization rate is an independent predictor of implantation rate.
  Fertility and sterility 2009 Rosen MP, Shen S, Rinaudo PF, Huddleston HG, McCulloch CE, Cedars MI
• Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics.
  Reproductive biology and endocrinology : RB&E 2009 Revelli A, Delle Piane L, Casano S, Molinari E, Massobrio M, Rinaudo P
• The effect of follicular fluid hormones on oocyte recovery after ovarian stimulation: FSH level predicts oocyte recovery.
  Reproductive biology and endocrinology : RB&E 2009 Rosen MP, Zamah AM, Shen S, Dobson AT, McCulloch CE, Rinaudo PF, Lamb JD, Cedars MI
• Fetal origins of perinatal morbidity and/or adult disease.
  Seminars in reproductive medicine 2008 Rinaudo PF, Lamb J
• A quantitative assessment of follicle size on oocyte developmental competence.
  Fertility and sterility 2008 Rosen MP, Shen S, Dobson AT, Rinaudo PF, McCulloch CE, Cedars MI
• Effect of in vitro fertilization on gene expression and development of mouse preimplantation embryos.
  Reproduction (Cambridge, England) 2007 Giritharan G, Talbi S, Donjacour A, Di Sebastiano F, Dobson AT, Rinaudo PF
• Methylenetetrahydrofolate reductase (MTHFR) is associated with ovarian follicular activity.
  Fertility and sterility 2007 Rosen MP, Shen S, McCulloch CE, Rinaudo PF, Cedars MI, Dobson AT
• A computational parameter study of embryo transfer.
  Annals of biomedical engineering 2007 Lauko IG, Rinaudo P, Dashev S
• Methylenetetrahydrofolate reductase C677T and A1298C variants do not affect ongoing pregnancy rates following IVF.
  Human reproduction (Oxford, England) 2006 Dobson AT, Davis RM, Rosen MP, Shen S, Rinaudo PF, Chan J, Cedars MI
• Effects of oxygen tension on gene expression in preimplantation mouse embryos.
  Fertility and sterility 2006 Rinaudo PF, Giritharan G, Talbi S, Dobson AT, Schultz RM
• Effects of embryo culture on global pattern of gene expression in preimplantation mouse embryos.
  Reproduction (Cambridge, England) 2004 Rinaudo P, Schultz RM
• Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined.
  Obstetrics and gynecology 2004 Barnhart KT, Sammel MD, Rinaudo PF, Zhou L, Hummel AC, Guo W
• Acute and chronic presentation of ectopic pregnancy may be two clinical entities.
  Fertility and sterility 2003 Barnhart KT, Rinaudo P, Hummel A, Pena J, Sammel MD, Chittams J
• Do assisted reproductive technologies cause adverse fetal outcomes?
  Fertility and sterility 2003 Kovalevsky G, Rinaudo P, Coutifaris C
• Sequential assessment of individually cultured human embryos as an indicator of subsequent good quality blastocyst development.
  Human reproduction (Oxford, England) 2003 Neuber E, Rinaudo P, Trimarchi JR, Sakkas D
• Primary psoas abscess complicating a normal vaginal delivery.
  Obstetrics and gynecology 2002 Shahabi S, Klein JP, Rinaudo PF
• Microinjection of mitochondria into zygotes creates a model for studying the inheritance of mitochondrial DNA during preimplantation development.
  Fertility and sterility 1999 Rinaudo P, Niven-Fairchild T, Buradagunta S, Massobrio M, Revelli A, Keefe DL
• Atrial septal defect and pregnancy: a retrospective analysis of obstetrical outcome before and after surgical correction.
  Minerva cardioangiologica 1998 Actis Dato GM, Rinaudo P, Revelli A, Actis Dato A, Punta G, Centofanti P, Cavaglià M, Barbato L, Massobrio M
• Dissociation between intracellular calcium elevation and development of human oocytes treated with calcium ionophore.
  Fertility and sterility 1997 Rinaudo P, Pepperell JR, Buradgunta S, Massobrio M, Keefe DL
• Hormone induction of ascorbic acid transport in immature granulosa cells.
  Endocrinology 1996 Behrman HR, Preston SL, Aten RF, Rinaudo P, Zreik TG
• Identification of calcium flux in single preimplantation mouse embryos with the calcium-sensitive vibrating probe.
  The Biological bulletin 1995 Keefe D, Pepperell J, Rinaudo P, Kunkel J, Smith P