Pao-Tien Chuang, MD, PhD
Professor
Cardiovascular Research Inst
School of Medicine

Websites

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• Profile at www.cvri.ucsf.edu (cvri.ucsf.edu)

Grants and Projects

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• Molecular mechanisms of alveolar development and regeneration, NIH, 2018-2022
• Sufu-interacting proteins provide novel insight into mammalian Hedgehog signaling, NIH, 2015-2019
• The lineage and function of neuroendocrine cells in lung homeostasis and injury, NIH, 2013-2017
• Epithelial Progenitor Cells in Lung Repair and Regeneration, NIH, 2012-2016
• Development and Control of Pulmonary alveolar Stability, NIH, 1979-2015
• The molecular mechanisms by which mammalian Fused regulates motile cilia function, NIH, 2008-2014
• Molecular Mechanisms of Mammalian Hedgehog Signal Transduction, NIH, 2008-2013
• Control of Hedgehog protein gradient formation in vertebrates, NIH, 2001-2013

Publications (56)

Top publication keywords:
Wnt-5a ProteinLungReceptor Tyrosine Kinase-like Orphan ReceptorsMyofibroblastsWnt ProteinsSignal TransductionTrans-ActivatorsNeuroendocrine CellsCiliaRepressor ProteinsPulmonary AlveoliFocal AdhesionsHedgehog ProteinsMechanistic Target of Rapamycin Complex 1Kruppel-Like Transcription Factors

• The alveolus: Our current knowledge of how the gas exchange unit of the lung is constructed and repaired.
  2024 Kuan Zhang, Erica Yao, Thin Aung, Pao-Tien Chuang
• Lung patterning: Is a distal-to-proximal gradient of cell allocation and fate decision a general paradigm?: A gradient of distal-to-proximal distribution and differentiation of tip progenitors produces distinct compartments in the lung.
  BioEssays : news and reviews in molecular, cellular and developmental biology 2023 Zhang K, Aung T, Yao E, Chuang PT
• Monitoring the performance of a dedicated weaning unit using risk-adjusted control charts for the weaning rate in prolonged mechanical ventilation.
  Journal of the Formosan Medical Association = Taiwan yi zhi 2023 Huang HF, Jerng JS, Hsu PJ, Lin NH, Lin LM, Hung SM, Kuo YW, Ku SC, Chuang PY, Chen SY
• mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity.
  Nature communications 2022 Zhang K, Yao E, Chuang E, Chen B, Chuang EY, Chuang PT
• Wnt5a-Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions.
  PLoS biology 2022 Zhang K, Yao E, Chuang E, Chen B, Chuang EY, Volk RF, Hofmann KL, Zaro B, Chuang PT

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• A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange.
  Developmental cell 2022 Zhang K, Yao E, Wang SA, Chuang E, Wong J, Minichiello L, Schroeder A, Eckalbar W, Wolters PJ, Chuang PT
• Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria.
  eLife 2022 Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT
• A mammalian Wnt5a-Ror2-Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis.
  eLife 2020 Zhang K, Yao E, Lin C, Chou YT, Wong J, Li J, Wolters PJ, Chuang PT
• Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury.
  Stem cells (Dayton, Ohio) 2017 Yao E, Lin C, Wu Q, Zhang K, Song H, Chuang PT
• YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis.
  eLife 2017 Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson-Peer K, Chuang PT
• Selective Ablation of Tumor Suppressors in Parafollicular C Cells Elicits Medullary Thyroid Carcinoma.
  The Journal of biological chemistry 2017 Song H, Lin C, Yao E, Zhang K, Li X, Wu Q, Chuang PT
• A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth.
  Developmental biology 2015 Lin C, Yao E, Chuang PT
• Hedgehog signaling: From basic research to clinical applications.
  Journal of the Formosan Medical Association = Taiwan yi zhi 2015 Yao E, Chuang PT
• Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.
  Genes & development 2014 Lin C, Yao E, Wang K, Nozawa Y, Shimizu H, Johnson JR, Chen JN, Krogan NJ, Chuang PT
• Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development.
  Developmental biology 2014 Lin C, Chen MH, Yao E, Song H, Gacayan R, Hui CC, Chuang PT
• A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers.
  Developmental cell 2014 Zhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang PT, Hopyan S, Hui CC
• Mammalian Fused is essential for sperm head shaping and periaxonemal structure formation during spermatogenesis.
  Developmental biology 2014 Nozawa YI, Yao E, Gacayan R, Xu SM, Chuang PT
• Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct.
  Developmental dynamics : an official publication of the American Association of Anatomists 2013 Nozawa YI, Yao E, Lin C, Yang JH, Wilson CW, Gacayan R, Chuang PT
• Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction.
  Current opinion in genetics & development 2013 Nozawa YI, Lin C, Chuang PT
• Alveolar type II cells possess the capability of initiating lung tumor development.
  PloS one 2012 Lin C, Song H, Huang C, Yao E, Gacayan R, Xu SM, Chuang PT
• Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Song H, Yao E, Lin C, Gacayan R, Chen MH, Chuang PT
• The path to chemotaxis and transcription is smoothened.
  Science signaling 2012 Lin C, Nozawa YI, Chuang PT
• A cell-based screen for inhibitors of flagella-driven motility in Chlamydomonas reveals a novel modulator of ciliary length and retrograde actin flow.
  Cytoskeleton (Hoboken, N.J.) 2011 Engel BD, Ishikawa H, Feldman JL, Wilson CW, Chuang PT, Snedecor J, Williams J, Sun Z, Marshall WF
• Mechanism and evolution of cytosolic Hedgehog signal transduction.
  Development (Cambridge, England) 2010 Wilson CW, Chuang PT
• Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.
  Genes & development 2009 Chen MH, Wilson CW, Li YJ, Law KK, Lu CS, Gacayan R, Zhang X, Hui CC, Chuang PT
• Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.
  PloS one 2009 Wilson CW, Chen MH, Chuang PT
• Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.
  Nature 2009 Wilson CW, Nguyen CT, Chen MH, Yang JH, Gacayan R, Huang J, Chen JN, Chuang PT
• Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression.
  Developmental cell 2008 Mak KK, Bi Y, Wan C, Chuang PT, Clemens T, Young M, Yang Y
• Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.
  Development (Cambridge, England) 2008 Mak KK, Kronenberg HM, Chuang PT, Mackem S, Yang Y
• Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms.
  Nature cell biology 2007 Corbit KC, Shyer AE, Dowdle WE, Gaulden J, Singla V, Chen MH, Chuang PT, Reiter JF
• SnapShot: hedgehog signaling pathway.
  Cell 2007 Chen MH, Wilson CW, Chuang PT
• The hedgehog regulated oncogenes Gli1 and Gli2 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activation.
  Oncogene 2006 Gerber AN, Wilson CW, Li YJ, Chuang PT
• Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation.
  Development (Cambridge, England) 2006 Mak KK, Chen MH, Day TF, Chuang PT, Yang Y
• Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened.
  Developmental biology 2006 Ochi H, Pearson BJ, Chuang PT, Hammerschmidt M, Westerfield M
• New "hogs" in Hedgehog transport and signal reception.
  Cell 2006 Wilson CW, Chuang PT
• GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis.
  Development (Cambridge, England) 2006 Hu MC, Mo R, Bhella S, Wilson CW, Chuang PT, Hui CC, Rosenblum ND
• Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development.
  Molecular and cellular biology 2005 Chen MH, Gao N, Kawakami T, Chuang PT
• N-myristoyltransferase 1 is essential in early mouse development.
  The Journal of biological chemistry 2005 Yang SH, Shrivastav A, Kosinski C, Sharma RK, Chen MH, Berthiaume LG, Peters LL, Chuang PT, Young SG, Bergo MO
• Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein.
  The Journal of experimental medicine 2004 Vogt A, Chuang PT, Hebert J, Hwang J, Lu Y, Kopelovich L, Athar M, Bickers DR, Epstein EH
• Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.
  Genes & development 2004 Chen MH, Li YJ, Kawakami T, Xu SM, Chuang PT
• Continuous lateral rotational therapy in the medical intensive care unit.
  Journal of the Formosan Medical Association = Taiwan yi zhi 2003 Wang JY, Chuang PY, Lin CJ, Yu CJ, Yang PC
• Combined activities of hedgehog signaling inhibitors regulate pancreas development.
  Development (Cambridge, England) 2003 Kawahira H, Ma NH, Tzanakakis ES, McMahon AP, Chuang PT, Hebrok M
• Branching morphogenesis of the lung: new molecular insights into an old problem.
  Trends in cell biology 2003 Chuang PT, McMahon AP
• Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung.
  Genes & development 2003 Chuang PT, Kawcak T, McMahon AP
• BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
  Nucleic acids research 2003 Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
• Activation of expression of hedgehog target genes in basal cell carcinomas.
  The Journal of investigative dermatology 2001 Bonifas JM, Pennypacker S, Chuang PT, McMahon AP, Williams M, Rosenthal A, De Sauvage FJ, Epstein EH
• Hedgehog signaling is required for pituitary gland development.
  Development (Cambridge, England) 2001 Treier M, O'Connell S, Gleiberman A, Price J, Szeto DP, Burgess R, Chuang PT, McMahon AP, Rosenfeld MG
• Determination of the chromosomal location and genomic structure of the Hedgehog-Interacting Protein gene, and analysis of its role in Holoprosencephaly.
  International Journal of Genomics 2000 Liang Huo, Erich Roessler, Amalia Dutra, Pao-Tien Chuang, A. P. McMahon, Maximilian Muenke
• Determination of the chromosomal location and genomic structure of theHedgehog-Interacting Protein gene, and analysis of its role in Holoprosencephaly.
  International Journal of Genomics 2000 Liang Huo, Erich Roessler, Amalia Dutra, Pao-Tien Chuang, A. P. McMahon, Maximilian Muenke
• On the range of hedgehog signaling.
  Current opinion in genetics & development 2000 Chuang PT, Kornberg TB
• Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein.
  Nature 1999 Chuang PT, McMahon AP
• MIX-1: an essential component of the C. elegans mitotic machinery executes X chromosome dosage compensation.
  Cell 1998 Lieb JD, Albrecht MR, Chuang PT, Meyer BJ
• Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb.
  Development (Cambridge, England) 1997 Yang Y, Drossopoulou G, Chuang PT, Duprez D, Marti E, Bumcrot D, Vargesson N, Clarke J, Niswander L, McMahon A, Tickle C
• Hedgehogs in the clinic.
  Nature medicine 1996 McMahon AP, Chuang PT
• DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation.
  Development (Cambridge, England) 1995 Hsu DR, Chuang PT, Meyer BJ
• DPY-27:a chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome.
  Cell 1994 Chuang PT, Albertson DG, Meyer BJ