Owen Wolkowitz, MD
Professor Emeritus
Psychiatry
School of Medicine

He has been involved in psychiatric research for over 35 years, with an emphasis on stress-related mental illnesses such as Major Depression and PTSD, and he is presently Co-Director of the UCSF Depression Center. He obtained his MD degree from the University of Maryland and received his psychiatric residency training at Stanford University, after which he completed a fellowship in psychopharmacology research at the National Institute of Mental Health. His research focus is the identification of moderators and mediators of stress effects on psychiatric and comorbid physical health, with a goal of identifying novel targets for therapeutic intervention. He views many psychiatric illnesses not strictly as “mental illnesses” but as body-wide perturbations that affect the brain. He studies steroid and neurosteroid hormones, inflammation, oxidative stress, cell aging (such as telomeres, telomerase and epigenetic aging), metabolomics, mitochondrial physiology, neurotrophic factors, and neuroimaging as well as the roles of genetics and early life adversity. His team is now venturing into new directions in the gut microbiome and induced pluripotent stem cells in depression, the latter to predict individual patient responses to specific antidpressants. He was awarded the 2015 Academic J. Elliott Royer Award by the UCSF School of Medicine in “recognition of his significant cotributions to the advancement of Psychiatry.” He has published over 250 peer-reviewed papers and chapters, and he co-edited the American Psychiatric Press textbook on clinical psychoneuroendocrinology. His research, continuously funded by the NIMH, the US Department of Defense and private foundations since 1988, currently focuses on the possibility of accelerated biological aging in psychiatric conditions as well as “precision psychiatry.”

• Circulating cell-free mitochondrial DNA levels and glucocorticoid sensitivity in a cohort of male veterans with and without combat-related PTSD.
  Translational psychiatry 2024 Blalock ZN, Wu GWY, Lindqvist D, Trumpff C, Flory JD, Lin J, Reus VI, Rampersaud R, Hammamieh R, Gautam A, SBPBC, Doyle FJ, Marmar CR, Jett M, Yehuda R, Wolkowitz OM, Mellon SH
• Integrated analysis of proteomics, epigenomics and metabolomics data revealed divergent pathway activation patterns in the recent versus chronic post-traumatic stress disorder.
  Brain, behavior, and immunity 2023 Muhie S, Gautam A, Misganaw B, Yang R, Mellon SH, Hoke A, Flory J, Daigle B, Swift K, PTSD Systems Biology Consortium, Hood L, Doyle FJ, Wolkowitz OM, Marmar CR, Ressler K, Yehuda R, Hammamieh R, Jett…
• Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression.
  Scientific reports 2023 Rampersaud R, Wu GWY, Reus VI, Lin J, Blackburn EH, Epel ES, Hough CM, Mellon SH, Wolkowitz OM
• Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers.
  Cell reports. Medicine 2023 Muhie S, Gautam A, Yang R, Misganaw B, Daigle BJ, Mellon SH, Flory JD, Abu-Amara D, Lee I, Wang K, Rampersaud R, PTSD Systems Biology Consortium, Hood L, Yehuda R, Marmar CR, Wolkowitz OM, Ressler KJ,…
• Associations of stress and stress-related psychiatric disorders with GrimAge acceleration: review and suggestions for future work.
  Translational psychiatry 2023 Protsenko E, Wolkowitz OM, Yaffe K
• The Genetic Basis for the Increased Prevalence of Metabolic Syndrome among Post-Traumatic Stress Disorder Patients.
  International journal of molecular sciences 2022 Misganaw B, Yang R, Gautam A, Muhie S, Mellon SH, Wolkowitz OM, Ressler KJ, Doyle FJ, Marmar CR, Jett M, Hammamieh R
• Dimensions of childhood adversity differentially affect biological aging in major depression.
  Translational psychiatry 2022 Rampersaud R, Protsenko E, Yang R, Reus V, Hammamieh R, Wu GWY, Epel E, Jett M, Gautam A, Mellon SH, Wolkowitz OM
• Blood-based mitochondrial respiratory chain function in major depression.
  Translational psychiatry 2021 Fernström J, Mellon SH, McGill MA, Picard M, Reus VI, Hough CM, Lin J, Epel ES, Wolkowitz OM, Lindqvist D
• Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder.
  Molecular psychiatry 2021 Goetzl EJ, Wolkowitz OM, Srihari VH, Reus VI, Goetzl L, Kapogiannis D, Heninger GR, Mellon SH
• Correction: A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD.
  Molecular psychiatry 2021 Yang R, Wu GWY, Verhoeven JE, Gautam A, Reus VI, Kang JI, Flory JD, Abu-Amara D, PTSD Systems Biology Consortium, Hood L, Doyle FJ, Yehuda R, Marmar CR, Jett M, Hammamieh R, Mellon SH, Wolkowitz OM
• Serum brain-derived neurotrophic factor remains elevated after long term follow-up of combat veterans with chronic post-traumatic stress disorder.
  Psychoneuroendocrinology 2021 Wu GWY, Wolkowitz OM, Reus VI, Kang JI, Elnar M, Sarwal R, Flory JD, Abu-Amara D, Hammamieh R, Gautam A, Doyle FJ, Yehuda R, Marmar CR, Jett M, Mellon SH, SBPBC
• An immunogenomic phenotype predicting behavioral treatment response: Toward precision psychiatry for mothers and children with trauma exposure.
  Brain, behavior, and immunity 2021 Aschbacher K, Cole S, Hagan M, Rivera L, Baccarella A, Wolkowitz OM, Lieberman AF, Bush NR
• Utilization of machine learning for identifying symptom severity military-related PTSD subtypes and their biological correlates.
  Translational psychiatry 2021 Siegel CE, Laska EM, Lin Z, Xu M, Abu-Amara D, Jeffers MK, Qian M, Milton N, Flory JD, Hammamieh R, Daigle BJ, Gautam A, Dean KR, Reus VI, Wolkowitz OM, Mellon SH, Ressler KJ, Yehuda R, Wang K, Hood L…
• "GrimAge," an epigenetic predictor of mortality, is accelerated in major depressive disorder.
  Translational psychiatry 2021 Protsenko E, Yang R, Nier B, Reus V, Hammamieh R, Rampersaud R, Wu GWY, Hough CM, Epel E, Prather AA, Jett M, Gautam A, Mellon SH, Wolkowitz OM
• Epigenetic biotypes of post-traumatic stress disorder in war-zone exposed veteran and active duty males.
  Molecular psychiatry 2020 Yang R, Gautam A, Getnet D, Daigle BJ, Miller S, Misganaw B, Dean KR, Kumar R, Muhie S, Wang K, Lee I, Abu-Amara D, Flory JD, PTSD Systems Biology Consortium, Hood L, Wolkowitz OM, Mellon SH, Doyle FJ…
• HPA axis regulation and epigenetic programming of immune-related genes in chronically stressed and non-stressed mid-life women.
  Brain, behavior, and immunity 2020 Palma-Gudiel H, Prather AA, Lin J, Oxendine JD, Guintivano J, Xia K, Rubinow DR, Wolkowitz O, Epel ES, Zannas AS
• Pre-deployment risk factors for PTSD in active-duty personnel deployed to Afghanistan: a machine-learning approach for analyzing multivariate predictors.
  Molecular psychiatry 2020 Schultebraucks K, Qian M, Abu-Amara D, Dean K, Laska E, Siegel C, Gautam A, Guffanti G, Hammamieh R, Misganaw B, Mellon SH, Wolkowitz OM, Blessing EM, Etkin A, Ressler KJ, Doyle FJ, Jett M, Marmar CR
• Pre-treatment allostatic load and metabolic dysregulation predict SSRI response in major depressive disorder: a preliminary report.
  Psychological medicine 2020 Hough CM, Bersani FS, Mellon SH, Morford AE, Lindqvist D, Reus VI, Epel ES, Wolkowitz OM
• A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD.
  Molecular psychiatry 2020 Yang R, Wu GWY, Verhoeven JE, Gautam A, Reus VI, Kang JI, Flory JD, Abu-Amara D, PTSD Systems Biology Consortium, Hood L, Doyle FJ, Yehuda R, Marmar CR, Jett M, Hammamieh R, Mellon SH, Wolkowitz OM
• Effect of Combat Exposure and Posttraumatic Stress Disorder on Telomere Length and Amygdala Volume.
  Biological psychiatry. Cognitive neuroscience and neuroimaging 2020 Kang JI, Mueller SG, Wu GWY, Lin J, Ng P, Yehuda R, Flory JD, Abu-Amara D, Reus VI, Gautam A, PTSD Systems Biology Consortium, Hammamieh R, Doyle FJ, Jett M, Marmar CR, Mellon SH, Wolkowitz OM
• Frailty Index as a clinical measure of biological age in psychiatry.
  Journal of affective disorders 2020 Bersani FS, Canevelli M, Cesari M, Maggioni E, Pasquini M, Wolkowitz OM, Ferracuti S, Biondi M, Bruno G
• Vitamin D and inflammation in major depressive disorder.
  Journal of affective disorders 2020 Grudet C, Wolkowitz OM, Mellon SH, Malm J, Reus VI, Brundin L, Nier BM, Dhabhar FS, Hough CM, Westrin Å, Lindqvist D
• Novel Pharmacological Targets for Combat PTSD-Metabolism, Inflammation, The Gut Microbiome, and Mitochondrial Dysfunction.
  Military medicine 2020 Bersani FS, Mellon SH, Lindqvist D, Kang JI, Rampersaud R, Somvanshi PR, Doyle FJ, Hammamieh R, Jett M, Yehuda R, Marmar CR, Wolkowitz OM
• Improvement in indices of cellular protection after psychological treatment for social anxiety disorder.
  Translational psychiatry 2019 Månsson KNT, Lindqvist D, Yang LL, Svanborg C, Isung J, Nilsonne G, Bergman-Nordgren L, El Alaoui S, Hedman-Lagerlöf E, Kraepelien M, Högström J, Andersson G, Boraxbekk CJ, Fischer H, Lavebratt C, …
• Association of comorbid depression with inpatient outcomes in critical limb ischemia.
  Vascular medicine (London, England) 2019 Zahner GJ, Cortez A, Duralde E, Ramirez JL, Wang S, Hiramoto J, Cohen BE, Wolkowitz OM, Arya S, Hills NK, Grenon SM
• Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder.
  Molecular psychiatry 2019 Dean KR, Hammamieh R, Mellon SH, Abu-Amara D, Flory JD, Guffanti G, Wang K, Daigle BJ, Gautam A, Lee I, Yang R, Almli LM, Bersani FS, Chakraborty N, Donohue D, Kerley K, Kim TK, Laska E, Young Lee M, …
• Accelerated aging in serious mental disorders.
  Current opinion in psychiatry 2019 Bersani FS, Mellon SH, Reus VI, Wolkowitz OM
• Cortisol, moderated by age, is associated with antidepressant treatment outcome and memory improvement in Major Depressive Disorder: A retrospective analysis.
  Psychoneuroendocrinology 2019 Jain FA, Connolly CG, Reus VI, Meyerhoff DJ, Yang TT, Mellon SH, Mackin S, Hough CM, Morford A, Wolkowitz OM
• Mechanistic inferences on metabolic dysfunction in posttraumatic stress disorder from an integrated model and multiomic analysis: role of glucocorticoid receptor sensitivity.
  American journal of physiology. Endocrinology and metabolism 2019 Somvanshi PR, Mellon SH, Flory JD, Abu-Amara D, PTSD Systems Biology Consortium;, Wolkowitz OM, Yehuda R, Jett M, Hood L, Marmar C, Doyle FJ
• Accelerating research on biological aging and mental health: Current challenges and future directions.
  Psychoneuroendocrinology 2019 Han LKM, Verhoeven JE, Tyrka AR, Penninx BWJH, Wolkowitz OM, Månsson KNT, Lindqvist D, Boks MP, Révész D, Mellon SH, Picard M
• Metabolomic analysis of male combat veterans with post traumatic stress disorder.
  PloS one 2019 Mellon SH, Bersani FS, Lindqvist D, Hammamieh R, Donohue D, Dean K, Jett M, Yehuda R, Flory J, Reus VI, Bierer LM, Makotkine I, Abu Amara D, Henn Haase C, Coy M, Doyle FJ, Marmar C, Wolkowitz OM
• Plasma serotonin levels are associated with antidepressant response to SSRIs.
  Journal of affective disorders 2019 Holck A, Wolkowitz OM, Mellon SH, Reus VI, Nelson JC, Westrin Å, Lindqvist D
• Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder.
  Psychiatry research 2019 Khan MS, Wu GWY, Reus VI, Hough CM, Lindqvist D, Westrin Å, Nier BM, Wolkowitz OM, Mellon SH
• Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status.
  Molecular neuropsychiatry 2018 Verhoeven JE, Yang R, Wolkowitz OM, Bersani FS, Lindqvist D, Mellon SH, Yehuda R, Flory JD, Lin J, Abu-Amara D, Makotkine I, Marmar C, Jett M, Hammamieh R
• Posttraumatic stress disorder, symptoms, and white matter abnormalities among combat-exposed veterans.
  Brain imaging and behavior 2018 Aschbacher K, Mellon SH, Wolkowitz OM, Henn-Haase C, Yehuda R, Flory JD, Bierer LM, Abu-Amara D, Marmar CR, Mueller SG
• Depression severity is associated with increased inflammation in veterans with peripheral artery disease.
  Vascular medicine (London, England) 2018 Hernandez NV, Ramirez JL, Khetani SA, Spaulding KA, Gasper WJ, Hiramoto J, Lindqvist D, Wolkowitz OM, Hills NK, Grenon SM, Zahner GJ
• Accelerated biological aging in serious mental disorders.
  World psychiatry : official journal of the World Psychiatric Association (WPA) 2018 Wolkowitz OM
• The association of comorbid depression with mortality and amputation in veterans with peripheral artery disease.
  Journal of vascular surgery 2018 Arya S, Lee S, Zahner GJ, Cohen BE, Hiramoto J, Wolkowitz OM, Khakharia A, Binney ZO, Grenon SM
• Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress Disorder.
  Biological psychiatry 2018 Mellon SH, Gautam A, Hammamieh R, Jett M, Wolkowitz OM
• High levels of mitochondrial DNA are associated with adolescent brain structural hypoconnectivity and increased anxiety but not depression.
  Journal of affective disorders 2018 Tymofiyeva O, Henje Blom E, Ho TC, Connolly CG, Lindqvist D, Wolkowitz OM, Lin J, LeWinn KZ, Sacchet MD, Han LKM, Yuan JP, Bhandari SP, Xu D, Yang TT
• Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2018 Lindqvist D, Wolkowitz OM, Picard M, Ohlsson L, Bersani FS, Fernström J, Westrin Å, Hough CM, Lin J, Reus VI, Epel ES, Mellon SH
• Increased circulating blood cell counts in combat-related PTSD: Associations with inflammation and PTSD severity.
  Psychiatry research 2017 Lindqvist D, Mellon SH, Dhabhar FS, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Aschbacher K, Bersani FS, Marmar CR, Wolkowitz OM
• Whole-genome DNA methylation status associated with clinical PTSD measures of OIF/OEF veterans.
  Translational psychiatry 2017 Hammamieh R, Chakraborty N, Gautam A, Muhie S, Yang R, Donohue D, Kumar R, Daigle BJ, Zhang Y, Amara DA, Miller SA, Srinivasan S, Flory J, Yehuda R, Petzold L, Wolkowitz OM, Mellon SH, Hood L, Doyle …
• Telomere length is inversely correlated with urinary stress hormone levels in healthy controls but not in un-medicated depressed individuals-preliminary findings.
  Journal of psychosomatic research 2017 Fair B, Mellon SH, Epel ES, Lin J, Révész D, Verhoeven JE, Penninx BW, Reus VI, Rosser R, Hough CM, Mahan L, Burke HM, Blackburn EH, Wolkowitz OM
• Severity of anxiety- but not depression- is associated with oxidative stress in Major Depressive Disorder.
  Journal of affective disorders 2017 Steenkamp LR, Hough CM, Reus VI, Jain FA, Epel ES, James SJ, Morford AE, Mellon SH, Wolkowitz OM, Lindqvist D
• Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans.
  Psychoneuroendocrinology 2017 Blessing EM, Reus V, Mellon SH, Wolkowitz OM, Flory JD, Bierer L, Lindqvist D, Dhabhar F, Li M, Qian M, Abu-Amara D, Galatzer-Levy I, Yehuda R, Marmar CR
• Depression, telomeres and mitochondrial DNA: between- and within-person associations from a 10-year longitudinal study.
  Molecular psychiatry 2017 Verhoeven JE, Révész D, Picard M, Epel EE, Wolkowitz OM, Matthews KA, Penninx BWJH, Puterman E
• Higher serum DHEA concentrations before and after SSRI treatment are associated with remission of major depression.
  Psychoneuroendocrinology 2016 Hough CM, Lindqvist D, Epel ES, Denis MS, Reus VI, Bersani FS, Rosser R, Mahan L, Burke HM, Wolkowitz OM, Mellon SH
• Oxidative stress, inflammation and treatment response in major depression.
  Psychoneuroendocrinology 2016 Lindqvist D, Dhabhar FS, James SJ, Hough CM, Jain FA, Bersani FS, Reus VI, Verhoeven JE, Epel ES, Mahan L, Rosser R, Wolkowitz OM, Mellon SH
• Unresolved Issues in Longitudinal Telomere Length Research: Response to Susser et al.
  The American journal of psychiatry 2016 Verhoeven JE, Lin J, Révész D, Wolkowitz OM, Penninx BW
• Leukocyte telomere length: Effects of schizophrenia, age, and gender.
  Journal of psychiatric research 2016 Wolkowitz OM, Jeste DV, Martin AS, Lin J, Daly RE, Reuter C, Kraemer H
• Increased pro-inflammatory milieu in combat related PTSD - A new cohort replication study.
  Brain, behavior, and immunity 2016 Lindqvist D, Dhabhar FS, Mellon SH, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Bersani FS, Marmar CR, Wolkowitz OM
• The Association Between Psychiatric Disorders and Telomere Length: A Meta-Analysis Involving 14,827 Persons.
  Psychosomatic medicine 2016 Darrow SM, Verhoeven JE, Révész D, Lindqvist D, Penninx BW, Delucchi KL, Wolkowitz OM, Mathews CA
• Cortisol/DHEA ratio and hippocampal volume: A pilot study in major depression and healthy controls.
  Psychoneuroendocrinology 2016 Jin RO, Mason S, Mellon SH, Epel ES, Reus VI, Mahan L, Rosser RL, Hough CM, Burke HM, Mueller SG, Wolkowitz OM
• Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary report.
  Molecular neuropsychiatry 2016 Hough CM, Bersani FS, Mellon SH, Epel ES, Reus VI, Lindqvist D, Lin J, Mahan L, Rosser R, Burke H, Coetzee J, Nelson JC, Blackburn EH, Wolkowitz OM
• Elevated plasma F2-isoprostane levels in schizophrenia.
  Schizophrenia research 2016 Lee EE, Eyler LT, Wolkowitz OM, Martin AS, Reuter C, Kraemer H, Jeste DV
• Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment.
  Translational psychiatry 2016 Mellon SH, Wolkowitz OM, Schonemann MD, Epel ES, Rosser R, Burke HB, Mahan L, Reus VI, Stamatiou D, Liew CC, Cole SW
• A population of atypical CD56(-)CD16(+) natural killer cells is expanded in PTSD and is associated with symptom severity.
  Brain, behavior, and immunity 2016 Bersani FS, Wolkowitz OM, Milush JM, Sinclair E, Eppling L, Aschbacher K, Lindqvist D, Yehuda R, Flory J, Bierer LM, Matokine I, Abu-Amara D, Reus VI, Coy M, Hough CM, Marmar CR, Mellon SH
• Depressive and Anxiety Disorders Showing Robust, but Non-Dynamic, 6-Year Longitudinal Association With Short Leukocyte Telomere Length.
  The American journal of psychiatry 2016 Verhoeven JE, van Oppen P, Révész D, Wolkowitz OM, Penninx BW
• Neuroscience-informed Auditory Training in Schizophrenia: A Final Report of the Effects on Cognition and Serum Brain-Derived Neurotrophic Factor.
  Schizophrenia research. Cognition 2016 Fisher M, Mellon SH, Wolkowitz O, Vinogradov S
• Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder.
  Translational psychiatry 2015 Henje Blom E, Han LK, Connolly CG, Ho TC, Lin J, LeWinn KZ, Simmons AN, Sacchet MD, Mobayed N, Luna ME, Paulus M, Epel ES, Blackburn EH, Wolkowitz OM, Yang TT
• Association of dimensional psychological health measures with telomere length in male war veterans.
  Journal of affective disorders 2015 Bersani FS, Lindqvist D, Mellon SH, Epel ES, Yehuda R, Flory J, Henn-Hasse C, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM
• Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation.
  Brain, behavior, and immunity 2015 Bersani FS, Wolkowitz OM, Lindqvist D, Yehuda R, Flory J, Bierer LM, Makotine I, Abu-Amara D, Coy M, Reus VI, Epel ES, Marmar C, Mellon SH
• Evidence for disrupted gray matter structural connectivity in posttraumatic stress disorder.
  Psychiatry research 2015 Mueller SG, Ng P, Neylan T, Mackin S, Wolkowitz O, Mellon S, Yan X, Flory J, Yehuda R, Marmar CR, Weiner MW
• Telomerase activation as a possible mechanism of action for psychopharmacological interventions.
  Drug discovery today 2015 Bersani FS, Lindqvist D, Mellon SH, Penninx BW, Verhoeven JE, Révész D, Reus VI, Wolkowitz OM
• Mitochondrial DNA copy number is reduced in male combat veterans with PTSD.
  Progress in neuro-psychopharmacology & biological psychiatry 2015 Bersani FS, Morley C, Lindqvist D, Epel ES, Picard M, Yehuda R, Flory J, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM, Mellon SH
• A Preliminary Study: Efficacy of Mindfulness-Based Cognitive Therapy versus Sertraline as First-line Treatments for Major Depressive Disorder.
  Mindfulness 2015 Eisendrath SJ, Gillung E, Delucchi K, Mathalon DH, Yang TT, Satre DD, Rosser R, Sipe WE, Wolkowitz OM
• Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.
  Neuroscience and biobehavioral reviews 2015 Lindqvist D, Epel ES, Mellon SH, Penninx BW, Révész D, Verhoeven JE, Reus VI, Lin J, Mahan L, Hough CM, Rosser R, Bersani FS, Blackburn EH, Wolkowitz OM
• Is Post-Traumatic Stress Disorder Associated with Premature Senescence? A Review of the Literature.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2015 Lohr JB, Palmer BW, Eidt CA, Aailaboyina S, Mausbach BT, Wolkowitz OM, Thorp SR, Jeste DV
• Anxiety disorders and accelerated cellular ageing.
  The British journal of psychiatry : the journal of mental science 2015 Verhoeven JE, Révész D, van Oppen P, Epel ES, Wolkowitz OM, Penninx BW
• PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression.
  Psychiatry research 2015 Wolkowitz OM, Mellon SH, Lindqvist D, Epel ES, Blackburn EH, Lin J, Reus VI, Burke H, Rosser R, Mahan L, Mackin S, Yang T, Weiner M, Mueller S
• WITHDRAWN: Precuneal and amygdala spontaneous activity and functional connectivity in war-zone-related PTSD.
  Psychiatry research 2014 Yan X, Lazar M, Shalev AY, Neylan TC, Wolkowitz OM, Brown AD, Henn-Haase C, Yehuda R, Flory JD, Abu-Amara D, Sodickson DK, Marmar CR
• Adverse consequences of glucocorticoid medication: psychological, cognitive, and behavioral effects.
  The American journal of psychiatry 2014 Judd LL, Schettler PJ, Brown ES, Wolkowitz OM, Sternberg EM, Bender BG, Bulloch K, Cidlowski JA, de Kloet ER, Fardet L, Joëls M, Leung DY, McEwen BS, Roozendaal B, Van Rossum EF, Ahn J, Brown DW, …
• Telomere length and cortisol reactivity in children of depressed mothers.
  Molecular psychiatry 2014 Gotlib IH, LeMoult J, Colich NL, Foland-Ross LC, Hallmayer J, Joormann J, Lin J, Wolkowitz OM
• Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls-preliminary findings.
  Psychiatry research 2014 Lindqvist D, Mueller S, Mellon SH, Su Y, Epel ES, Reus VI, Rosser R, Mahan L, Mackin RS, Yang TT, Wolkowitz OM
• Cellular aging in depression: Permanent imprint or reversible process?: An overview of the current evidence, mechanistic pathways, and targets for interventions.
  BioEssays : news and reviews in molecular, cellular and developmental biology 2014 Verhoeven JE, Révész D, Wolkowitz OM, Penninx BW
• Adverse childhood experiences and leukocyte telomere maintenance in depressed and healthy adults.
  Journal of affective disorders 2014 Chen SH, Epel ES, Mellon SH, Lin J, Reus VI, Rosser R, Kupferman E, Burke H, Mahan L, Blackburn EH, Wolkowitz OM
• Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress.
  Brain, behavior, and immunity 2014 Lindqvist D, Wolkowitz OM, Mellon S, Yehuda R, Flory JD, Henn-Haase C, Bierer LM, Abu-Amara D, Coy M, Neylan TC, Makotkine I, Reus VI, Yan X, Taylor NM, Marmar CR, Dhabhar FS
• Dysregulated physiological stress systems and accelerated cellular aging.
  Neurobiology of aging 2013 Révész D, Verhoeven JE, Milaneschi Y, de Geus EJ, Wolkowitz OM, Penninx BW
• Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study.
  Molecular psychiatry 2013 Verhoeven JE, Révész D, Epel ES, Lin J, Wolkowitz OM, Penninx BW
• Resting-state functional connectivity of subgenual anterior cingulate cortex in depressed adolescents.
  Biological psychiatry 2013 Connolly CG, Wu J, Ho TC, Hoeft F, Wolkowitz O, Eisendrath S, Frank G, Hendren R, Max JE, Paulus MP, Tapert SF, Banerjee D, Simmons AN, Yang TT
• Altered cerebral perfusion in executive, affective, and motor networks during adolescent depression.
  Journal of the American Academy of Child and Adolescent Psychiatry 2013 Ho TC, Wu J, Shin DD, Liu TT, Tapert SF, Yang G, Connolly CG, Frank GK, Max JE, Wolkowitz O, Eisendrath S, Hoeft F, Banerjee D, Hood K, Hendren RL, Paulus MP, Simmons AN, Yang TT
• Spontaneous brain activity in combat related PTSD.
  Neuroscience letters 2013 Yan X, Brown AD, Lazar M, Cressman VL, Henn-Haase C, Neylan TC, Shalev A, Wolkowitz OM, Hamilton SP, Yehuda R, Sodickson DK, Weiner MW, Marmar CR
• Stress and telomere biology: a lifespan perspective.
  Psychoneuroendocrinology 2013 Shalev I, Entringer S, Wadhwa PD, Wolkowitz OM, Puterman E, Lin J, Epel ES
• Good stress, bad stress and oxidative stress: insights from anticipatory cortisol reactivity.
  Psychoneuroendocrinology 2013 Aschbacher K, O'Donovan A, Wolkowitz OM, Dhabhar FS, Su Y, Epel E
• Dysregulated diurnal cortisol pattern is associated with glucocorticoid resistance in women with major depressive disorder.
  Biological psychology 2013 Jarcho MR, Slavich GM, Tylova-Stein H, Wolkowitz OM, Burke HM
• Dysregulated relationship of inflammation and oxidative stress in major depression.
  Brain, behavior, and immunity 2012 Rawdin BJ, Mellon SH, Dhabhar FS, Epel ES, Puterman E, Su Y, Burke HM, Reus VI, Rosser R, Hamilton SP, Nelson JC, Wolkowitz OM
• BDNF serum concentrations show no relationship with diagnostic group or medication status in neurodegenerative disease.
  Current Alzheimer research 2012 Woolley JD, Strobl EV, Shelly WB, Karydas AM, Robin Ketelle RN, Wolkowitz OM, Miller BL, Rankin KP
• Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere length.
  Brain, behavior, and immunity 2012 O'Donovan A, Tomiyama AJ, Lin J, Puterman E, Adler NE, Kemeny M, Wolkowitz OM, Blackburn EH, Epel ES
• Does cellular aging relate to patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length.
  Physiology & behavior 2011 Tomiyama AJ, O'Donovan A, Lin J, Puterman E, Lazaro A, Chan J, Dhabhar FS, Wolkowitz O, Kirschbaum C, Blackburn E, Epel E
• Maintenance of a positive outlook during acute stress protects against pro-inflammatory reactivity and future depressive symptoms.
  Brain, behavior, and immunity 2011 Aschbacher K, Epel E, Wolkowitz OM, Prather AA, Puterman E, Dhabhar FS
• Higher fasting glucose levels are associated with reduced circulating angiogenic cell migratory capacity among healthy individuals.
  American journal of cardiovascular disease 2011 Aschbacher K, Chen Q, Varga M, Haddad DJ, Yeghiazarians Y, Epel E, Wolkowitz OM, Springer ML
• Physical activity moderates effects of stressor-induced rumination on cortisol reactivity.
  Psychosomatic medicine 2011 Puterman E, O'Donovan A, Adler NE, Tomiyama AJ, Kemeny M, Wolkowitz OM, Epel E
• Serum BDNF levels before treatment predict SSRI response in depression.
  Progress in neuro-psychopharmacology & biological psychiatry 2011 Wolkowitz OM, Wolf J, Shelly W, Rosser R, Burke HM, Lerner GK, Reus VI, Nelson JC, Epel ES, Mellon SH
• Divergent trajectories of physical, cognitive, and psychosocial aging in schizophrenia.
  Schizophrenia bulletin 2011 Jeste DV, Wolkowitz OM, Palmer BW
• Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder.
  Biological psychiatry 2011 O'Donovan A, Epel E, Lin J, Wolkowitz O, Cohen B, Maguen S, Metzler T, Lenoci M, Blackburn E, Neylan TC
• Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings.
  PloS one 2011 Wolkowitz OM, Mellon SH, Epel ES, Lin J, Dhabhar FS, Su Y, Reus VI, Rosser R, Burke HM, Kupferman E, Compagnone M, Nelson JC, Blackburn EH
• Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response.
  Molecular psychiatry 2011 Wolkowitz OM, Mellon SH, Epel ES, Lin J, Reus VI, Rosser R, Burke H, Compagnone M, Nelson JC, Dhabhar FS, Blackburn EH
• Of sound mind and body: depression, disease, and accelerated aging.
  Dialogues in clinical neuroscience 2011 Wolkowitz OM, Reus VI, Mellon SH
• Intensive meditation training, immune cell telomerase activity, and psychological mediators.
  Psychoneuroendocrinology 2010 Jacobs TL, Epel ES, Lin J, Blackburn EH, Wolkowitz OM, Bridwell DA, Zanesco AP, Aichele SR, Sahdra BK, MacLean KA, King BG, Shaver PR, Rosenberg EL, Ferrer E, Wallace BA, Saron CD
• Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline.
  Brain research 2010 Lin J, Kroenke CH, Epel E, Kenna HA, Wolkowitz OM, Blackburn E, Rasgon NL
• Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorder.
  Progress in neuro-psychopharmacology & biological psychiatry 2010 Berger W, Mehra A, Lenoci M, Metzler TJ, Otte C, Tarasovsky G, Mellon SH, Wolkowitz OM, Marmar CR, Neylan TC
• Depression gets old fast: do stress and depression accelerate cell aging?
  Depression and anxiety 2010 Wolkowitz OM, Epel ES, Reus VI, Mellon SH
• Dynamics of telomerase activity in response to acute psychological stress.
  Brain, behavior, and immunity 2009 Epel ES, Lin J, Dhabhar FS, Wolkowitz OM, Puterman E, Karan L, Blackburn EH
• Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance.
  Journal of immunological methods 2009 Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, Bigos M, Wolkowitz O, Mellon S, Blackburn E
• Glucocorticoids. Mood, memory, and mechanisms.
  Annals of the New York Academy of Sciences 2009 Wolkowitz OM, Burke H, Epel ES, Reus VI
• Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression.
  Journal of psychiatric research 2009 Dhabhar FS, Burke HM, Epel ES, Mellon SH, Rosser R, Reus VI, Wolkowitz OM
• Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia?
  Biological psychiatry 2009 Vinogradov S, Fisher M, Holland C, Shelly W, Wolkowitz O, Mellon SH
• Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women.
  Brain, behavior, and immunity 2008 O'Donovan A, Lin J, Tillie J, Tillie JM, Dhabhar FS, Wolkowitz OM, Wolkowitz O, Blackburn EH, Blackburn E, Epel ES, Epel E
• Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS).
  Frontiers in neuroendocrinology 2008 Maninger N, Wolkowitz OM, Reus VI, Epel ES, Mellon SH
• When blue turns to grey: do stress and depression accelerate cell aging?
  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2008 Wolkowitz OM, Epel ES, Mellon S
• The "steroid dementia syndrome": a possible model of human glucocorticoid neurotoxicity.
  Neurocase 2007 Wolkowitz OM, Lupien SJ, Bigler ED
• Catecholamine response to methamphetamine is related to glucocorticoid levels but not to pleasurable subjective response.
  Pharmacopsychiatry 2006 Harris DS, Reus VI, Wolkowitz O, Jacob P, Everhart ET, Wilson M, Mendelson JE, Jones RT
• Cell aging in relation to stress arousal and cardiovascular disease risk factors.
  Psychoneuroendocrinology 2005 Epel ES, Lin J, Wilhelm FH, Wolkowitz OM, Cawthon R, Adler NE, Dolbier C, Mendes WB, Blackburn EH
• Repeated psychological stress testing in stimulant-dependent patients.
  Progress in neuro-psychopharmacology & biological psychiatry 2005 Harris DS, Reus VI, Wolkowitz OM, Mendelson JE, Jones RT
• Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients.
  Neurology 2005 Chao LL, Schuff N, Kramer JH, Du AT, Capizzano AA, O'Neill J, Wolkowitz OM, Jagust WJ, Chui HC, Miller BL, Yaffe K, Weiner MW
• The "steroid dementia syndrome": an unrecognized complication of glucocorticoid treatment.
  Annals of the New York Academy of Sciences 2004 Wolkowitz OM, Lupien SJ, Bigler E, Levin RB, Canick J
• Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation.
  Psychoneuroendocrinology 2004 Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM
• Hormonal changes with cholesterol reduction: a double-blind pilot study.
  Journal of clinical pharmacy and therapeutics 2004 Ormiston T, Wolkowitz OM, Reus VI, Johnson R, Manfredi F
• Behavioral implications of lowering cholesterol levels: a double-blind pilot study.
  Psychosomatics 2003 Ormiston T, Wolkowitz OM, Reus VI, Manfredi F
• Neurotransmitters, neurosteroids and neurotrophins: new models of the pathophysiology and treatment of depression.
  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2003 Wolkowitz OM, Reus VI
• Altering cortisol level does not change the pleasurable effects of methamphetamine in humans.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003 Harris DS, Reus VI, Wolkowitz OM, Mendelson JE, Jones RT
• DHEA treatment of Alzheimer's disease: a randomized, double-blind, placebo-controlled study.
  Neurology 2003 Wolkowitz OM, Kramer JH, Reus VI, Costa MM, Yaffe K, Walton P, Raskind M, Peskind E, Newhouse P, Sack D, De Souza E, Sadowsky C, Roberts E, DHEA-Alzheimer's Disease Collaborative Research
• Benzodiazepines in schizophrenia: prefrontal cortex atrophy predicts clinical response to alprazolam augmentation.
  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2002 Seeley WW, Turetsky N, Reus VI, Wolkowitz OM
• Double-blind antiglucocorticoid treatment in schizophrenia and schizoaffective disorder: a pilot study.
  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2002 Marco EJ, Wolkowitz OM, Vinogradov S, Poole JH, Lichtmacher J, Reus VI
• Dehydroepiandrosterone supplementation and bone turnover in middle-aged to elderly men.
  The Journal of clinical endocrinology and metabolism 2002 Kahn AJ, Halloran B, Wolkowitz O, Brizendine L
• Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD.
  Neurology 2002 Schuff N, Capizzano AA, Du AT, Amend DL, O'Neill J, Norman D, Kramer J, Jagust W, Miller B, Wolkowitz OM, Yaffe K, Weiner MW
• Antiglucocorticoid drugs in the treatment of depression.
  Expert opinion on investigational drugs 2001 Reus VI, Wolkowitz OM
• Cortisol levels predict cognitive impairment induced by electroconvulsive therapy.
  Biological psychiatry 2001 Neylan TC, Canick JD, Hall SE, Reus VI, Sapolsky RM, Wolkowitz OM
• Stress hormone-related psychopathology: pathophysiological and treatment implications.
  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2001 Wolkowitz OM, Epel ES, Reus VI
• Movement disorder, memory, psychiatric symptoms and serum DHEA levels in schizophrenic and schizoaffective patients.
  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2001 Harris DS, Wolkowitz OM, Reus VI
• Severity of depression in abstinent alcoholics is associated with monoamine metabolites and dehydroepiandrosterone-sulfate concentrations.
  Psychiatry research 1999 Heinz A, Weingartner H, George D, Hommer D, Wolkowitz OM, Linnoila M
• Treatment of depression with antiglucocorticoid drugs.
  Psychosomatic medicine 1999 Wolkowitz OM, Reus VI
• Estrogen replacement therapy and cognitive decline in memory-impaired post-menopausal women.
  Biological psychiatry 1999 Costa MM, Reus VI, Wolkowitz OM, Manfredi F, Lieberman M
• Antiglucocorticoid treatment of depression: double-blind ketoconazole.
  Biological psychiatry 1999 Wolkowitz OM, Reus VI, Chan T, Manfredi F, Raum W, Johnson R, Canick J
• Double-blind treatment of major depression with dehydroepiandrosterone.
  The American journal of psychiatry 1999 Wolkowitz OM, Reus VI, Keebler A, Nelson N, Friedland M, Brizendine L, Roberts E
• Selective alteration of personality and social behavior by serotonergic intervention.
  The American journal of psychiatry 1998 Knutson B, Wolkowitz OM, Cole SW, Chan T, Moore EA, Johnson RC, Terpstra J, Turner RA, Reus VI
• Partial reversal of stress-induced behavioral sensitization to amphetamine following metyrapone treatment.
  Brain research 1998 Reid MS, Ho LB, Tolliver BK, Wolkowitz OM, Berger SP
• Glucocorticoid medication, memory and steroid psychosis in medical illness.
  Annals of the New York Academy of Sciences 1997 Wolkowitz OM, Reus VI, Canick J, Levin B, Lupien S
• Dehydroepiandrosterone (DHEA) treatment of depression.
  Biological psychiatry 1997 Wolkowitz OM, Reus VI, Roberts E, Manfredi F, Chan T, Raum WJ, Ormiston S, Johnson R, Canick J, Brizendine L, Weingartner H
• Serotonergic intervention increases affiliative behavior in humans.
  Annals of the New York Academy of Sciences 1997 Knutson B, Cole S, Wolkowitz O, Reus V, Chan T, Moore E
• Antiglucocorticoid treatments in psychiatry.
  Psychoneuroendocrinology 1997 Reus VI, Wolkowitz OM, Frederick S
• The effects of clozapine on symptom reduction, neurocognitive function, and clinical management in treatment-refractory state hospital schizophrenic inpatients.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1996 Hoff AL, Faustman WO, Wieneke M, Espinoza S, Costa M, Wolkowitz O, Csernansky JG
• Dexamethasone for depression.
  The American journal of psychiatry 1996 Wolkowitz OM, Reus VI, Manfredi F, Chan T, Ormiston S, Johnson R
• Novel strategies for treatment-resistant depression.
  The Psychiatric clinics of North America 1996 Hornig-Rohan M, Wolkowitz OM, Amsterdam JD
• Human pharmacokinetics and tolerability of L-365,260, a novel cholecystokinin-B antagonist.
  Journal of clinical pharmacology 1996 Grasing K, Murphy MG, Lin J, Swigar M, Freedholm D, Clarke L, Zhang J, Wolkowitz OM, Weingartner H, Putnam K, Seibold JR
• Antidepressant and cognition-enhancing effects of DHEA in major depression.
  Annals of the New York Academy of Sciences 1995 Wolkowitz OM, Reus VI, Roberts E, Manfredi F, Chan T, Ormiston S, Johnson R, Canick J, Brizendine L, Weingartner H
• Differences in CSF concentrations of thyrotropin-releasing hormone in depressed patients and normal subjects: negative findings.
  The American journal of psychiatry 1994 Roy A, Wolkowitz OM, Bissette G, Nemeroff CB
• Prospective controlled studies of the behavioral and biological effects of exogenous corticosteroids.
  Psychoneuroendocrinology 1994 Wolkowitz OM
• Beneficial effects of nalmefene augmentation in neuroleptic-stabilized schizophrenic patients.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1993 Rapaport MH, Wolkowitz O, Kelsoe JR, Pato C, Konicki PE, Pickar D
• Neuropsychiatric effects of anabolic steroids in male normal volunteers.
  JAMA 1993 Su TP, Pagliaro M, Schmidt PJ, Pickar D, Wolkowitz O, Rubinow DR
• Rational polypharmacy in schizophrenia.
  Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 1993 Wolkowitz OM
• Steroid modulation of human memory: biochemical correlates.
  Biological psychiatry 1993 Wolkowitz OM, Weingartner H, Rubinow DR, Jimerson D, Kling M, Berretini W, Thompson K, Breier A, Doran A, Reus VI
• Ketoconazole administration in hypercortisolemic depression.
  The American journal of psychiatry 1993 Wolkowitz OM, Reus VI, Manfredi F, Ingbar J, Brizendine L, Weingartner H
• Quantitative electroencephalographic correlates of steroid administration in man.
  Neuropsychobiology 1993 Wolkowitz OM, Coppola R, Breier A, Doran AR, Rubinow DR, Berrettini WH, Kling MA, Pickar D
• Plasma levels of catecholamines and corticotrophin during acute glucopenia induced by 2-deoxy-D-glucose in normal man.
  Clinical autonomic research : official journal of the Clinical Autonomic Research Society 1992 Goldstein DS, Breier A, Wolkowitz OM, Pickar D, Lenders JW
• Antiglucocorticoid strategies in hypercortisolemic states.
  Psychopharmacology bulletin 1992 Wolkowitz OM, Reus VI, Manfredi F, Ingbar J, Brizendine L
• Benzodiazepine augmentation of neuroleptics in treatment-resistant schizophrenia.
  Psychopharmacology bulletin 1992 Wolkowitz OM, Turetsky N, Reus VI, Hargreaves WA
• Measurement and interpretation of changes in memory in response to drug treatments.
  Psychopharmacology bulletin 1992 Weingartner H, Eckardt M, Molchan S, Sunderland T, Wolkowitz O
• Selective effects of triazolam on memory.
  Psychopharmacology 1992 Weingartner HJ, Hommer D, Lister RG, Thompson K, Wolkowitz O
• Specificity of memory impairments with triazolam use.
  Lancet (London, England) 1991 Weingartner HJ, Eckardt MJ, Hommer DW, Mendelson W, Wolkowitz OM
• Benzodiazepines in the treatment of schizophrenia: a review and reappraisal.
  The American journal of psychiatry 1991 Wolkowitz OM, Pickar D
• MRI deep white matter hyperintensity in a psychiatric population.
  Biological psychiatry 1991 Deicken RF, Reus VI, Manfredi L, Wolkowitz OM
• Drug trials and heterogeneity in schizophrenia: the mean is not the end.
  Biological psychiatry 1990 Wolkowitz OM, Bartko JJ, Pickar D
• Plasma norepinephrine in chronic schizophrenia.
  The American journal of psychiatry 1990 Breier A, Wolkowitz OM, Roy A, Potter WZ, Pickar D
• Cognitive effects of corticosteroids.
  The American journal of psychiatry 1990 Wolkowitz OM, Reus VI, Weingartner H, Thompson K, Breier A, Doran A, Rubinow D, Pickar D
• Prednisone effects on neurochemistry and behavior. Preliminary findings.
  Archives of general psychiatry 1990 Wolkowitz OM, Rubinow D, Doran AR, Breier A, Berrettini WH, Kling MA, Pickar D
• Hunger in humans induced by MK-329, a specific peripheral-type cholecystokinin receptor antagonist.
  Biological psychiatry 1990 Wolkowitz OM, Gertz B, Weingartner H, Beccaria L, Thompson K, Liddle RA
• Cerebrospinal fluid and plasma monoamine metabolites and their relation to psychosis. Implications for regional brain dysfunction in schizophrenia.
  Archives of general psychiatry 1990 Pickar D, Breier A, Hsiao JK, Doran AR, Wolkowitz OM, Pato CN, Konicki PE, Potter WZ
• Circadian variation of plasma homovanillic acid levels is attenuated by fluphenazine in patients with schizophrenia.
  Archives of general psychiatry 1990 Doran AR, Labarca R, Wolkowitz OM, Roy A, Douillet P, Pickar D
• Use of the dexamethasone suppression test with mentally retarded persons: review and recommendations.
  American journal of mental retardation : AJMR 1990 Wolkowitz OM
• Suicidality and corticosteroid psychosis.
  Biological psychiatry 1990 Wolkowitz O
• Models for research in consultation psychiatry.
  Advances in psychosomatic medicine 1990 Rubinow DR, Denicoff KD, Schmidt PJ, Wolkowitz OM, Joffe RT
• Neurochemical and neural mechanisms of positive and negative symptoms in schizophrenia.
  Modern problems of pharmacopsychiatry 1990 Pickar D, Litman RE, Konicki PE, Wolkowitz OM, Breier A
• Prednisone effects on blood-brain barrier permeability and CNS IgG synthesis in healthy humans.
  Psychoneuroendocrinology 1990 Wolkowitz OM, Papadopoulos NM, Costello R, Breier A, Doran AR, Pickar D, Rubinow D
• Alprazolam augmentation of neuroleptics in schizophrenia.
  The American journal of psychiatry 1989 Wolkowitz OM, Breier A, Doran A, Lucas P, Kelsoe J, Paul SM, Pickar D
• Specificity of plasma HVA response to dexamethasone in psychotic depression.
  Psychiatry research 1989 Wolkowitz OM, Doran A, Breier A, Roy A, Pickar D
• High prevalence of visual hallucinations in research subjects with chronic schizophrenia.
  The American journal of psychiatry 1989 Bracha HS, Wolkowitz OM, Lohr JB, Karson CN, Bigelow LB
• Long-lasting behavioral changes following prednisone withdrawal.
  JAMA 1989 Wolkowitz OM
• Fluphenazine treatment reduces CSF somatostatin in patients with schizophrenia: correlations with CSF HVA.
  Biological psychiatry 1989 Doran AR, Rubinow DR, Wolkowitz OM, Roy A, Breier A, Pickar D
• TRH test in schizophrenic patients and controls.
  Biological psychiatry 1989 Roy A, Wolkowitz O, Doran A, Pickar D
• Benzodiazepine augmentation of neuroleptic treatment in patients with schizophrenia.
  Psychopharmacology bulletin 1989 Pato CN, Wolkowitz OM, Rapaport M, Schulz SC, Pickar D
• Early parental loss and development of adult psychopathology.
  Archives of general psychiatry 1988 Breier A, Kelsoe JR, Kirwin PD, Beller SA, Wolkowitz OM, Pickar D
• Neurobiological effects of lumbar puncture stress in psychiatric patients and healthy volunteers.
  Psychiatry research 1988 Breier A, Wolkowitz OM, Doran AR, Bellar S, Pickar D
• Single-dose naloxone acutely reduces eating in obese humans: behavioral and biochemical effects.
  Biological psychiatry 1988 Wolkowitz OM, Doran AR, Cohen MR, Cohen RM, Wise TN, Pickar D
• Alprazolam augmentation of the antipsychotic effects of fluphenazine in schizophrenic patients. Preliminary results.
  Archives of general psychiatry 1988 Wolkowitz OM, Breier A, Doran A, Kelsoe J, Lucas P, Paul SM, Pickar D
• RBC folic acid levels and cognitive performance in elderly patients: a preliminary report.
  Biological psychiatry 1988 Sommer BR, Wolkowitz OM
• Dexamethasone effects on dopamine and the "prolactin suppression test".
  Acta psychiatrica Scandinavica 1988 Wolkowitz OM
• Alternate-day corticosteroid treatment, mood and plasma HVA in patients with systemic lupus erythematosus.
  Neuropsychobiology 1988 Joffe RT, Wolkowitz OM, Rubinow DR, Denicoff K, Tsokos G, Pillemer S
• Metabolic stress effects in normal volunteers and schizophrenic patients.
  Psychopharmacology bulletin 1988 Breier A, Wolkowitz OM, Rapaport M, Paul SM, Pickar D
• Prednisone-induced behavioral and biological changes in medically healthy volunteers.
  Psychopharmacology bulletin 1988 Wolkowitz OM, Breier A, Doran A, Rubinow D, Berrettini W, Coppola R, Gold P, Pickar D
• Dysphoria associated with methylphenidate infusion in borderline personality disorder.
  The American journal of psychiatry 1987 Lucas PB, Gardner DL, Wolkowitz OM, Cowdry RW
• Metabolic stress produces rapid immunosuppression in humans.
  Archives of general psychiatry 1987 Breier A, Arora PK, Wolkowitz OM, Pickar D, Paul SM
• Neuroleptic responsivity of negative and positive symptoms in schizophrenia.
  The American journal of psychiatry 1987 Breier A, Wolkowitz OM, Doran AR, Roy A, Boronow J, Hommer DW, Pickar D
• Structural brain pathology in schizophrenia revisited. Prefrontal cortex pathology is inversely correlated with cerebrospinal fluid levels of homovanillic acid.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1987 Doran AR, Boronow J, Weinberger DR, Wolkowitz OM, Breier A, Pickar D
• Controllable and uncontrollable stress in humans: alterations in mood and neuroendocrine and psychophysiological function.
  The American journal of psychiatry 1987 Breier A, Albus M, Pickar D, Zahn TP, Wolkowitz OM, Paul SM
• Prednisone decreases CSF somatostatin in healthy humans: implications for neuropsychiatric illness.
  Life sciences 1987 Wolkowitz OM, Rubinow DR, Breier A, Doran AR, Davis C, Pickar D
• The effects of dexamethasone on plasma homovanillic acid and 3-methoxy-4-hydroxyphenylglycol. Evidence for abnormal corticosteroid-catecholamine interactions in major depression.
  Archives of general psychiatry 1987 Wolkowitz OM, Doran AR, Breier A, Roy A, Jimerson DC, Sutton ME, Golden RN, Paul SM, Pickar D
• Clinical and biochemical effects of verapamil administration to schizophrenic patients.
  Archives of general psychiatry 1987 Pickar D, Wolkowitz OM, Doran AR, Labarca R, Roy A, Breier A, Narang PK
• Biochemical alterations produced by neuroleptics in man: studies of plasma homovanillic acid in schizophrenic patients.
  Psychopharmacology series 1987 Pickar D, Wolkowitz OM, Labarca R, Doran AR, Breier A, Paul SM
• Diazepam-induced amnesia: a neuropharmacological model of an "organic amnestic syndrome".
  The American journal of psychiatry 1987 Wolkowitz OM, Weingartner H, Thompson K, Pickar D, Paul SM, Hommer DW
• Pharmacodynamic approaches to benzodiazepine action in man.
  Psychopharmacology series 1987 Hommer DW, Matsuo V, Wolkowitz OM, Weingartner H, Paul SM
• Methylphenidate-induced cardiac arrhythmias.
  The New England journal of medicine 1986 Lucas PB, Gardner DL, Wolkowitz OM, Tucker EE, Cowdry RW
• Serum antibodies to Epstein-Barr virus in patients with major depressive disorder.
  The American journal of psychiatry 1986 Amsterdam JD, Henle W, Winokur A, Wolkowitz OM, Pickar D, Paul SM
• The corticotropin-releasing hormone stimulation test in chronic schizophrenia.
  The American journal of psychiatry 1986 Roy A, Pickar D, Doran A, Wolkowitz O, Gallucci W, Chrousos G, Gold P
• Longitudinal measurement of plasma homovanillic acid levels in schizophrenic patients. Correlation with psychosis and response to neuroleptic treatment.
  Archives of general psychiatry 1986 Pickar D, Labarca R, Doran AR, Wolkowitz OM, Roy A, Breier A, Linnoila M, Paul SM
• Benzodiazepine sensitivity in normal human subjects.
  Archives of general psychiatry 1986 Hommer DW, Matsuo V, Wolkowitz O, Chrousos G, Greenblatt DJ, Weingartner H, Paul SM
• Chronic corticosterone administration in rats: behavioral and biochemical evidence of increased central dopaminergic activity.
  European journal of pharmacology 1986 Wolkowitz O, Sutton M, Koulu M, Labarca R, Wilkinson L, Doran A, Hauger R, Pickar D, Crawley J
• Endogenous opioid regulation of hypothalamo-pituitary-adrenal axis activity in schizophrenia.
  Biological psychiatry 1986 Wolkowitz OM, Doran AR, Breier A, Cohen MR, Pickar D
• Pre- and post-dexamethasone plasma ACTH levels in depressed patients and normal controls.
  Journal of affective disorders 1986 Roy A, Gold P, Pickar D, Wolkowitz OM, Chrousos G, Paul SM
• Combination alprazolam-neuroleptic treatment of the positive and negative symptoms of schizophrenia.
  The American journal of psychiatry 1986 Wolkowitz OM, Pickar D, Doran AR, Breier A, Tarell J, Paul SM
• Suicide and aggression in schizophrenia. Neurobiologic correlates.
  Annals of the New York Academy of Sciences 1986 Pickar D, Roy A, Breier A, Doran A, Wolkowitz O, Colison J, Agren H
• Dexamethasone increases plasma HVA but not MHPG in normal humans.
  Psychiatry research 1985 Wolkowitz OM, Sutton ME, Doran AR, Labarca R, Roy A, Thomas JW, Pickar D, Paul SM
• Effect of naloxone on food consumption in obesity.
  The New England journal of medicine 1985 Wolkowitz OM, Doran AR, Cohen MR, Cohen RM, Wise TN, Pickar D
• Pathologic gambling and other risk-taking pursuits.
  The Psychiatric clinics of North America 1985 Wolkowitz OM, Roy A, Doran AR
• Self-destructive dermatoses.
  The Psychiatric clinics of North America 1985 Doran AR, Roy A, Wolkowitz OM
• Verapamil concentrations in cerebrospinal fluid after oral administration.
  The New England journal of medicine 1985 Doran AR, Narang PK, Meigs CY, Wolkowitz OM, Roy A, Breier A, Pickar D
• Neural and molecular mechanisms in anxiety.
  The Psychiatric clinics of North America 1985 Wolkowitz OM, Paul SM
• A psychopharmacological perspective of cognitive functions. I. Theoretical overview and methodological considerations.
  Neuropsychobiology 1985 Wolkowitz OM, Tinklenberg JR, Weingartner H
• A psychopharmacological perspective of cognitive functions. II. Specific pharmacologic agents.
  Neuropsychobiology 1985 Wolkowitz OM, Tinklenberg JR, Weingartner H
• Evidence for a daily rhythm of plasma HVA in normal controls but not in schizophrenic patients.
  Psychopharmacology bulletin 1985 Doran AR, Pickar D, Labarca R, Douillet P, Wolkowitz OM, Thomas JW, Roy A, Paul SM
• Naloxone's effect on cognitive functioning in drug-free and diazepam-treated normal humans.
  Psychopharmacology 1985 Wolkowitz OM, Tinklenberg JR
• Development of differences in response latencies to right and left visual fields.
  Brain and cognition 1984 Stillman R, DeRenzo E, Wolkowitz O, Allen H, Lehman RA, Wyatt RJ
• Marijuana: differential effects on right and left hemisphere functions in man.
  Life sciences 1977 Stillman RC, Wolkowitz O, Weingartner H, Waldman I, DeRenzo EV, Wyatt RJ