Oriana Kreutzfeld, PhD
Assistant Researcher
Medicine
School of Medicine

Publications (17)

Top publication keywords:
AntimalarialsPlasmodium bergheiAcridonesPlasmodium falciparumLife Cycle StagesDrug ResistanceParasitic Sensitivity TestsMalariaAcridinesMalaria, FalciparumPlasmodiumMalaria VaccinesProtozoan ProteinsFolic Acid AntagonistsUganda

• Emergence and spread of Plasmodium falciparum PX1 polymorphisms associated with decreased susceptibility to antimalarials in Uganda.
  Nature medicine 2026 Niaré K, Tafesse B, Treat M, Sadler JM, Okitwi M, Orena S, Asua V, Kreutzfeld O, Legac J, Marglous J, Nsobya SL, Yeka A, Richard D, Ferdig MT, Mukherjee A, Rosenthal PJ, Juliano JJ, Bailey JA, Conrad …
• Structure-Activity Relationship Study of Antimalarial Asparagine-Derived Proteasome Inhibitors.
  ACS omega 2026 Zhang H, Li D, Hsu HC, Vishwanatha A, Zhan W, Yukawa T, Visone J, Imaeda T, Okamoto R, Fajtova P, Hara R, Kawasaki M, Sato K, Michino M, Garg S, Kreutzfeld O, Tumwebaze PK, Orena S, Okitwi M, Aso K, …
• Potent acridone antimalarial against all three life stages of Plasmodium.
  Nature communications 2026 Kancharla P, Dodean RA, Li Y, Zhang X, Kelly S, Charlton J, Binauhan AJ, Navarrete K, Garcia L, Mu J, Lu J, Caridha D, Madejczyk MS, Jin X, Dennis WE, Kudyba K, McEnearney S, Lee PJ, Blount C, DeLuca …
• Optimization of Prodiginines as Single-Dose Curative Antimalarials.
  Journal of medicinal chemistry 2025 Kumar A, Li Y, Zhang X, Gaddam M, Caridha D, Madejczyk MS, Jin X, Dennis WE, Chetree R, Blount C, DeLuca J, Vuong C, Kudyba K, Roncal N, Ashraf K, Lee PJ, Pannone K, Leed S, Dinh HT, Mdaki K, …
• A novel locus associated with decreased susceptibility of Plasmodium falciparum to lumefantrine and dihydroartemisinin has emerged and spread in Uganda.
  bioRxiv : the preprint server for biology 2025 Niare K, Tafesse B, Treat M, Sadler J, Okitwi M, Orena S, Asua V, Kreutzfeld O, Legac J, Samuel NL, Yeka A, Rosenthal PJ, Juliano JJ, Bailey JA, Conrad MD

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• Potent Acridone Antimalarial against All Three Life Stages of Plasmodium.
  Research square 2025 Kancharla P, Dodean RA, Li Y, Zhang X, Kelly S, Charlton J, Binauhan A, Garcia L, Caridha D, Madejczyk MS, Jin X, Dennis WE, Kudyba K, McEnearney S, Lee PJ, Blount C, DeLuca J, Vuong C, Pannone K, …
• Optimization of Tambjamines Active against Multiple Stages of Malaria Parasites.
  Journal of medicinal chemistry 2025 Kumar A, Li Y, Zhang X, Jin X, Dennis WE, Chetree R, Blount C, Caridha D, Madejczyk MS, Lee PJ, Pannone K, DeLuca J, Vuong C, Leed S, Dinh HT, Mdaki K, Mahato R, Sen P, Mondal T, Phukan K, Saha A, …
• Development of Next-Generation Antimalarial Acridones with Radical Cure Potential.
  Journal of medicinal chemistry 2025 Dodean RA, Li Y, Zhang X, Caridha D, Madejczyk MS, Jin X, Dennis WE, Chetree R, Kudyba K, McEnearney S, Lee PJ, Blount C, DeLuca J, Vuong C, Pannone K, Dinh HT, Mdaki K, Leed S, Martin ML, Pybus BS, …
• The extended recovery ring-stage survival assay is a scalable alternative for artemisinin susceptibility phenotyping of fresh Plasmodium falciparum isolates.
  Antimicrobial agents and chemotherapy 2024 Okitwi M, Shoue DA, Checkley LA, Orena S, Ceja FG, Taremwa Y, Tumwebaze PK, Katairo T, Byaruhanga O, Sievert MA, Garg S, Kreutzfeld OK, Legac J, Bailey JA, Nsobya SL, Conrad MD, Rosenthal PJ, Ferdig …
• Ex vivo susceptibilities to ganaplacide and diversity in potential resistance mediators in Ugandan Plasmodium falciparum isolates.
  Antimicrobial agents and chemotherapy 2024 Kreutzfeld O, Orena S, Okitwi M, Tumwebaze PK, Byaruhanga O, Katairo T, Conrad MD, Legac J, Garg S, Crudale R, Aydemir O, Giesbrecht D, Nsobya SL, Blasco B, Duffey M, Rouillier M, Bailey JA, Cooper RA…
• Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline.
  Microbiology spectrum 2023 Kreutzfeld O, Tumwebaze PK, Okitwi M, Orena S, Byaruhanga O, Katairo T, Conrad MD, Rasmussen SA, Legac J, Aydemir O, Giesbrecht D, Forte B, Campbell P, Smith A, Kano H, Nsobya SL, Blasco B, Duffey M, …
• Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors.
  Antimicrobial agents and chemotherapy 2022 Garg S, Kreutzfeld O, Chelebieva S, Tumwebaze PK, Byaruhanga O, Okitwi M, Orena S, Katairo T, Nsobya SL, Conrad MD, Aydemir O, Legac J, Gould AE, Bayles BR, Bailey JA, Duffey M, Lin G, Kirkman LA, …
• Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates.
  The Journal of infectious diseases 2022 Kreutzfeld O, Tumwebaze PK, Byaruhanga O, Katairo T, Okitwi M, Orena S, Rasmussen SA, Legac J, Conrad MD, Nsobya SL, Aydemir O, Bailey JA, Duffey M, Cooper RA, Rosenthal PJ
• Absence of PEXEL-Dependent Protein Export in Plasmodium Liver Stages Cannot Be Restored by Gain of the HSP101 Protein Translocon ATPase.
  Frontiers in genetics 2021 Kreutzfeld O, Grützke J, Ingmundson A, Müller K, Matuschewski K
• Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates.
  Antimicrobial agents and chemotherapy 2021 Kreutzfeld O, Rasmussen SA, Ramanathan AA, Tumwebaze PK, Byaruhanga O, Katairo T, Asua V, Okitwi M, Orena S, Legac J, Conrad MD, Nsobya SL, Aydemir O, Bailey J, Duffey M, Bayles BR, Vaidya AB, Cooper …
• Rapid deployment of SARS-CoV-2 testing: The CLIAHUB.
  PLoS pathogens 2020 Crawford ED, Acosta I, Ahyong V, Anderson EC, Arevalo S, Asarnow D, Axelrod S, Ayscue P, Azimi CS, Azumaya CM, Bachl S, Bachmutsky I, Bhaduri A, Brown JB, Batson J, Behnert A, Boileau RM, Bollam SR, …
• Engineering of Genetically Arrested Parasites (GAPs) For a Precision Malaria Vaccine.
  Frontiers in cellular and infection microbiology 2017 Kreutzfeld O, Müller K, Matuschewski K