Ori Lieberman, MD, PhD
RESIDENT
Neurology
School of Medicine

Awards

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• Fellow, AIM-AHEAD BRIDGE2AI Clinical Care Training Program, 2025
• Regeneron Prize for Creative Innovation, 2017

Education & Training

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• MD Medicine Columbia University 05/2021
• PhD Neurobiology and Behavior Columbia University 11/2019
• MPhil Neurobiology and Behavior Columbia University 2015
• BS Biochemistry University of Maryland at College Park 05/2013

Grants and Projects

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• , Benioff Center for Microbiome Medicine, 2023
• Regulation of striatal maturation by dopamine and macroautophagy: implications for neuropsychiatric disorders, NIH, 2017-2021

Publications (26)

Top publication keywords:
1-Methyl-4-phenylpyridiniumParkinson DiseaseVentral Tegmental AreaDopamineDeliriumNeostriatumNeuronsCorpus StriatumCritical IllnessParasympathetic Nervous SystemBrain DiseasesDopaminergic NeuronsAutophagySubstantia NigraAutophagy-Related Protein 7

• Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery.
  JAMA 2025 Lieberman OJ, LaHue SC
• Dysregulated acetylcholine-mediated dopamine neurotransmission in the eIF4E Tg mouse model of autism spectrum disorders.
  Cell reports 2024 Carbonell-Roig J, Aaltonen A, Wilson K, Molinari M, Cartocci V, McGuirt A, Mosharov E, Kehr J, Lieberman OJ, Sulzer D, Borgkvist A, Santini E
• Diagnostic Approach to the Patient with Altered Mental Status.
  Seminars in neurology 2024 Lieberman OJ, Berkowitz AL
• Characteristics, Complications, and Outcomes of Critical Illness in Patients with Parkinson Disease.
  Neurocritical care 2024 Lieberman OJ, Douglas VC, LaHue SC
• 5-HT1B receptors mediate dopaminergic inhibition of vesicular fusion and GABA release from striatonigral synapses.
  bioRxiv : the preprint server for biology 2024 Molinari M, Lieberman OJ, Sulzer D, Santini E, Borgkvist A

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• Dysregulated acetylcholine-mediated dopamine neurotransmission in the eIF4E Tg mouse model of autism spectrum disorders.
  bioRxiv : the preprint server for biology 2024 Carbonell-Roig J, Aaltonen A, Cartocci V, McGuirt A, Mosharov E, Kehr J, Lieberman OJ, Sulzer D, Borgkvist A, Santini E
• Reexamining cholinesterase inhibitors for the prevention and treatment of delirium in high-risk populations.
  Critical care (London, England) 2023 Lieberman OJ, Douglas VC, LaHue SC
• Donepezil treatment is associated with improved outcomes in critically ill dementia patients via a reduction in delirium.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2022 Lieberman OJ, Lee S, Zabinski J
• Risk Factors for New Neurologic Diagnoses in Hospitalized Patients With COVID-19: A Case-Control Study in New York City.
  Neurology. Clinical practice 2022 Thakur KT, Chu VT, Hughes C, Kim CY, Fleck-Derderian S, Barrett CE, Matthews E, Balbi A, Bilski A, Chomba M, Lieberman O, Jacobson SD, Agarwal S, Roh D, Park S, Ssonko V, Silver WG, Vargas WD, …
• Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.
  Science advances 2022 Kuo SH, Tasset I, Cheng MM, Diaz A, Pan MK, Lieberman OJ, Hutten SJ, Alcalay RN, Kim S, Ximénez-Embún P, Fan L, Kim D, Ko HS, Yacoubian T, Kanter E, Liu L, Tang G, Muñoz J, Sardi SP, Li A, Gan L, …
• Subcellular and regional localization of mRNA translation in midbrain dopamine neurons.
  Cell reports 2022 Hobson BD, Kong L, Angelo MF, Lieberman OJ, Mosharov EV, Herzog E, Sulzer D, Sims PA
• Coordinated Postnatal Maturation of Striatal Cholinergic Interneurons and Dopamine Release Dynamics in Mice.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 McGuirt AF, Post MR, Pigulevskiy I, Sulzer D, Lieberman OJ
• Involvement of Autophagy in Levodopa-Induced Dyskinesia.
  Movement disorders : official journal of the Movement Disorder Society 2021 Feyder M, Plewnia C, Lieberman OJ, Spigolon G, Piccin A, Urbina L, Dehay B, Li Q, Nilsson P, Altun M, Santini E, Sulzer D, Bezard E, Borgkvist A, Fisone G
• GIRK channels in Alzheimer's disease.
  Aging 2020 Lieberman OJ, Bartolini F, Miniaci MC
• mTOR Suppresses Macroautophagy During Striatal Postnatal Development and Is Hyperactive in Mouse Models of Autism Spectrum Disorders.
  Frontiers in cellular neuroscience 2020 Lieberman OJ, Cartocci V, Pigulevskiy I, Molinari M, Carbonell J, Broseta MB, Post MR, Sulzer D, Borgkvist A, Santini E
• Autophagic bias in the striatum.
  Autophagy 2020 Pigulevskiy I, Lieberman OJ, Sulzer D
• Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy.
  eLife 2020 Lieberman OJ, Frier MD, McGuirt AF, Griffey CJ, Rafikian E, Yang M, Yamamoto A, Borgkvist A, Santini E, Sulzer D
• The Synaptic Autophagy Cycle.
  Journal of molecular biology 2019 Lieberman OJ, Sulzer D
• Dopamine Triggers the Maturation of Striatal Spiny Projection Neuron Excitability during a Critical Period.
  Neuron 2018 Lieberman OJ, McGuirt AF, Mosharov EV, Pigulevskiy I, Hobson BD, Choi S, Frier MD, Santini E, Borgkvist A, Sulzer D
• Roles for neuronal and glial autophagy in synaptic pruning during development.
  Neurobiology of disease 2018 Lieberman OJ, McGuirt AF, Tang G, Sulzer D
• Can Interactions Between α-Synuclein, Dopamine and Calcium Explain Selective Neurodegeneration in Parkinson's Disease?
  Frontiers in neuroscience 2018 Post MR, Lieberman OJ, Mosharov EV
• α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin.
  eNeuro 2017 Lieberman OJ, Choi SJ, Kanter E, Saverchenko A, Frier MD, Fiore GM, Wu M, Kondapalli J, Zampese E, Surmeier DJ, Sulzer D, Mosharov EV
• Synaptic plasticity may underlie l-DOPA induced dyskinesia.
  Current opinion in neurobiology 2017 Borgkvist A, Lieberman OJ, Sulzer D
• Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.
  Nature microbiology 2017 Vanaerschot M, Lucantoni L, Li T, Combrinck JM, Ruecker A, Kumar TRS, Rubiano K, Ferreira PE, Siciliano G, Gulati S, Henrich PP, Ng CL, Murithi JM, Corey VC, Duffy S, Lieberman OJ, Veiga MI, Sinden RE…
• High-throughput screening using the differential radial capillary action of ligand assay identifies ebselen as an inhibitor of diguanylate cyclases.
  ACS chemical biology 2013 Lieberman OJ, Orr MW, Wang Y, Lee VT
• Detection of cyclic diguanylate G-octaplex assembly and interaction with proteins.
  PloS one 2013 Lieberman OJ, DeStefano JJ, Lee VT