Oren Rosenberg, MD, PhD
Associate Professor
Medicine
School of Medicine

I am a physician-scientist who studies and treats infectious diseases. The goal of my laboratory is to discover and exploit molecular vulnerabilities in bacteria in order to design faster, cheaper, less toxic and more effective therapeutics to treat life-threatening infections.

Education & Training

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• Fellowship Internal Medicine, Division of Infectious Diseases University of California, San Francisco 2013
• Internship and Residency Internal Medicine Brigham and Women's Hospital 2009
• MD/PhD Yale University School of Medicine 2007

Websites

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• Rosenberg Lab (rosenberg.ucsf.edu)

Grants and Projects

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• Sensing living P. aeruginosa using D-alanine derived radiotracers, NIH, 2021-2025
• Protein secretion in bacterial pathogens, NIH, 2017-2022
• Clinical translation of D-amino acid derived PET tracers for imaging spinalinfection, NIH, 2017-2021
• Structural and functional studies of M. tuberculosis type VII secretion, NIH, 2011-2015

Publications (58)

Top publication keywords:
Type VII Secretion SystemsBacterial Secretion SystemsChlamydia trachomatisSorting NexinsGram-Negative Bacterial InfectionsMycobacterium smegmatisBacteriaPneumonia, BacterialReceptor, IGF Type 2Genetic TechniquesPseudomonas InfectionsBacteriological TechniquesPseudomonas aeruginosaCRISPR-Cas SystemsBacterial Proteins

• Deep mutational scanning of EccD3 reveals the molecular basis of its essentiality in the mycobacterium ESX secretion system.
  bioRxiv : the preprint server for biology 2024 Trinidad DD, Macdonald CB, Rosenberg OS, Fraser JS, Coyote-Maestas W
• How Mycobacterium tuberculosis builds a home: Single-cell analysis reveals M. tuberculosis ESX-1-mediated accumulation of anti-inflammatory macrophages in infected mouse lungs.
  bioRxiv : the preprint server for biology 2024 Zheng W, Borja M, Dorman L, Liu J, Zhou A, Seng A, Arjyal R, Sunshine S, Nalyvayko A, Pisco A, Rosenberg O, Neff N, Zha BS
• Bioorthogonal Radiolabeling of Azide-Modified Bacteria Using [18F]FB-sulfo-DBCO.
  Bioconjugate chemistry 2024 Alanizi AA, Sorlin AM, Parker MFL, López-Álvarez M, Qin H, Lee SH, Blecha J, Rosenberg OS, Engel J, Ohliger MA, Flavell RR, Wilson DM
• Investigating Pseudomonas aeruginosa Gene Function During Pathogenesis Using Mobile-CRISPRi.
  Methods in molecular biology (Clifton, N.J.) 2024 Yu MA, Banta AB, Ward RD, Prasad NK, Kwon MS, Rosenberg OS, Peters JM
• Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq.
  Nature communications 2023 Sunshine S, Puschnik AS, Replogle JM, Laurie MT, Liu J, Zha BS, Nuñez JK, Byrum JR, McMorrow AH, Frieman MB, Winkler J, Qiu X, Rosenberg OS, Leonetti MD, Ye CJ, Weissman JS, DeRisi JL, Hein MY

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• Evaluating the Performance of Pathogen-Targeted Positron Emission Tomography Radiotracers in a Rat Model of Vertebral Discitis-Osteomyelitis.
  The Journal of infectious diseases 2023 Parker MFL, López-Álvarez M, Alanizi AA, Luu JM, Polvoy I, Sorlin AM, Qin H, Lee S, Rabbitt SJ, Pichardo-González PA, Ordonez AA, Blecha J, Rosenberg OS, Flavell RR, Engel J, Jain SK, Ohliger MA, …
• Chemoenzymatic Syntheses of Fluorine-18-Labeled Disaccharides from [18F] FDG Yield Potent Sensors of Living Bacteria In Vivo.
  Journal of the American Chemical Society 2023 Sorlin AM, López-Álvarez M, Rabbitt SJ, Alanizi AA, Shuere R, Bobba KN, Blecha J, Sakhamuri S, Evans MJ, Bayles KW, Flavell RR, Rosenberg OS, Sriram R, Desmet T, Nidetzky B, Engel J, Ohliger MA, …
• Chemoenzymatic syntheses of fluorine-18-labeled disaccharides from [ 18 F]FDG yield potent sensors of living bacteria in vivo.
  bioRxiv : the preprint server for biology 2023 Sorlin AM, López-Álvarez M, Rabbitt SJ, Alanizi AA, Shuere R, Bobba KN, Blecha J, Sakhamuri S, Evans MJ, Bayles KW, Flavell RR, Rosenberg OS, Sriram R, Desmet T, Nidetzky B, Engel J, Ohliger MA, …
• Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps.
  Structure (London, England : 1993) 2023 Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Mehmood H, Pawar KI, Pourmal S, Smith AM, Zhou F, QCRG …
• Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.
  Nature structural & molecular biology 2023 Kim SK, Dickinson MS, Finer-Moore J, Guan Z, Kaake RM, Echeverria I, Chen J, Pulido EH, Sali A, Krogan NJ, Rosenberg OS, Stroud RM
• Structure and dynamics of the essential endogenous mycobacterial polyketide synthase PKs13 by cryogenic electron microscopy.
  Biophysical Journal 2023 Robert M. Stroud, Sun Kyung Kim, Miles Sasha S. Dickinson, Oren S. Rosenberg
• Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.
  bioRxiv : the preprint server for biology 2023 Kim SK, Dickinson MS, Finer-Moore J, Guan Z, Kaake RM, Echeverria I, Chen J, Pulido EH, Sali A, Krogan NJ, Rosenberg OS, Stroud RM
• Workshop-based learning and networking: a scalable model for research capacity strengthening in low- and middle-income countries.
  Global health action 2022 Perier C, Nasinghe E, Charles I, Ssetaba LJ, Ahyong V, Bangs D, Beatty PR, Czudnochowski N, Diallo A, Dugan E, Fabius JM, Fong Baker H, Gardner J, Isaacs S, Joanah B, Kalantar K, Kateete D, Knight M, …
• P-65 Cyclic [68Ga] and [18F]AlF-labeled peptides for specific detection of human angiotensin-converting enzyme 2.
  Nuclear Medicine and Biology 2022 David Wilson, Anju Anju, Matthew Parker, Niranjan Meher, Joseph Blecha, Oren Rosenberg, Michael Ohliger, Robert Flavell
• Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps.
  bioRxiv : the preprint server for biology 2022 Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Pawar KI, Pourmal S, Smith AM, Zhou F, QCRG Structural …
• Nuclear imaging of bacterial infection: the state of the art and future directions.
  Chinese Journal of Nuclear Medicine and Molecular Imaging 2022 Ilona Polvoy, Robert R. Flavell, Oren S. Rosenberg, Michael A. Ohliger, David M. Wilson
• Imaging joint infections using D-methyl-11C-methionine PET/MRI: initial experience in humans.
  European journal of nuclear medicine and molecular imaging 2022 Polvoy I, Seo Y, Parker M, Stewart M, Siddiqua K, Manacsa HS, Ravanfar V, Blecha J, Hope TA, Vanbrocklin H, Flavell RR, Barry J, Hansen E, Villanueva-Meyer JE, Engel J, Rosenberg OS, Wilson DM, …
• Cbp1, a fungal virulence factor under positive selection, forms an effector complex that drives macrophage lysis.
  PLoS pathogens 2022 Azimova D, Herrera N, Duvenage L, Voorhies M, Rodriguez RA, English BC, Hoving JC, Rosenberg O, Sil A
• Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation.
  Molecular & cellular proteomics : MCP 2022 Solomon PE, Kirkemo LL, Wilson GM, Leung KK, Almond MH, Sayles LC, Sweet-Cordero EA, Rosenberg OS, Coon JJ, Wells JA
• Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020.
  Antimicrobial agents and chemotherapy 2022 Prasad NK, Seiple IB, Cirz RT, Rosenberg OS
• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
  medRxiv : the preprint server for health sciences 2021 Tsitsiklis A, Zha BS, Byrne A, DeVoe C, Rackaityte E, Levan S, Sunshine S, Mick E, Ghale R, Love C, Tarashansky AJ, Pisco A, Albright J, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, …
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  Research square 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  bioRxiv : the preprint server for biology 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
  Research square 2021 Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson…
• Cyclic 68Ga-Labeled Peptides for Specific Detection of Human Angiotensin-Converting Enzyme 2.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2021 Parker MFL, Blecha J, Rosenberg O, Ohliger M, Flavell RR, Wilson DM
• Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA
• Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
  Science (New York, N.Y.) 2020 Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor…
• Nuclear Imaging of Bacterial Infection: The State of the Art and Future Directions.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2020 Polvoy I, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM
• Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
  bioRxiv : the preprint server for biology 2020 Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Lim SA, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Zhou XX, Hobman TC, Kortemme T, Wells JA
• Small Molecule Sensors Targeting the Bacterial Cell Wall.
  ACS infectious diseases 2020 Parker MFL, Flavell RR, Luu JM, Rosenberg OS, Ohliger MA, Wilson DM
• A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
  Nature 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, …
• Arabinofuranose-derived positron-emission tomography radiotracers for detection of pathogenic microorganisms.
  Journal of labelled compounds & radiopharmaceuticals 2020 Kalita M, Parker MFL, Luu JM, Stewart MN, Blecha JE, VanBrocklin HF, Evans MJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM
• A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
  bioRxiv : the preprint server for biology 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, …
• Sensing Living Bacteria in Vivo Using d-Alanine-Derived 11C Radiotracers.
  ACS central science 2020 Parker MFL, Luu JM, Schulte B, Huynh TL, Stewart MN, Sriram R, Yu MA, Jivan S, Turnbaugh PJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM
• The structure of the endogenous ESX-3 secretion system.
  eLife 2019 Poweleit N, Czudnochowski N, Nakagawa R, Trinidad DD, Murphy KC, Sassetti CM, Rosenberg OS
• High Enantiomeric Excess In-Loop Synthesis of d-[methyl-11C]Methionine for Use as a Diagnostic Positron Emission Tomography Radiotracer in Bacterial Infection.
  ACS infectious diseases 2019 Stewart MN, Parker MFL, Jivan S, Luu JM, Huynh TL, Schulte B, Seo Y, Blecha JE, Villanueva-Meyer JE, Flavell RR, VanBrocklin HF, Ohliger MA, Rosenberg O, Wilson DM
• Modulating Pathogenesis with Mobile-CRISPRi.
  Journal of bacteriology 2019 Qu J, Prasad NK, Yu MA, Chen S, Lyden A, Herrera N, Silvis MR, Crawford E, Looney MR, Peters JM, Rosenberg OS
• Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria.
  mBio 2019 Fay A, Czudnochowski N, Rock JM, Johnson JR, Krogan NJ, Rosenberg O, Glickman MS
• Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs.
  Nature communications 2019 Kundert K, Lucas JE, Watters KE, Fellmann C, Ng AH, Heineike BM, Fitzsimmons CM, Oakes BL, Qu J, Prasad N, Rosenberg OS, Savage DF, El-Samad H, Doudna JA, Kortemme T
• Enabling genetic analysis of diverse bacteria with Mobile-CRISPRi.
  Nature microbiology 2019 Peters JM, Koo BM, Patino R, Heussler GE, Hearne CC, Qu J, Inclan YF, Hawkins JS, Lu CHS, Silvis MR, Harden MM, Osadnik H, Peters JE, Engel JN, Dutton RJ, Grossman AD, Gross CA, Rosenberg OS
• [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism.
  ACS infectious diseases 2018 Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson DM
• Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-13C]Pyruvate.
  ACS infectious diseases 2018 Sriram R, Sun J, Villanueva-Meyer J, Mutch C, De Los Santos J, Peters J, Korenchan DE, Neumann K, Van Criekinge M, Kurhanewicz J, Rosenberg O, Wilson D, Ohliger MA
• Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers.
  Scientific reports 2017 Neumann KD, Villanueva-Meyer JE, Mutch CA, Flavell RR, Blecha JE, Kwak T, Sriram R, VanBrocklin HF, Rosenberg OS, Ohliger MA, Wilson DM
• Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction.
  eLife 2017 Elwell CA, Czudnochowski N, von Dollen J, Johnson JR, Nakagawa R, Mirrashidi K, Krogan NJ, Engel JN, Rosenberg OS
• Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection.
  Cell host & microbe 2015 Mirrashidi KM, Elwell CA, Verschueren E, Johnson JR, Frando A, Von Dollen J, Rosenberg O, Gulbahce N, Jang G, Johnson T, Jäger S, Gopalakrishnan AM, Sherry J, Dunn JD, Olive A, Penn B, Shales M, Cox …
• Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion.
  Cell 2015 Rosenberg OS, Dovala D, Li X, Connolly L, Bendebury A, Finer-Moore J, Holton J, Cheng Y, Stroud RM, Cox JS
• Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Lohse MB, Rosenberg OS, Cox JS, Stroud RM, Finer-Moore JS, Johnson AD
• First report of tenosynovitis in an immunocompetent person caused by Mycobacterium heraklionense.
  JMM Case Reports 2014 Malak Abedalthagafi, Oren Rosenberg, Steve Miller
• The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing.
  RNA (New York, N.Y.) 2014 Hadjivassiliou H, Rosenberg OS, Guthrie C
• Molecular Determinants of Substrate Specificity in Type VII Secretion Systems.
  Biophysical Journal 2014 Dustin Dovala, Oren S. Rosenberg, Jeffery S. Cox
• Immune reconstitution reactions in human immunodeficiency virus-negative patients: report of a case and review of the literature.
  JAMA dermatology 2013 Scharschmidt TC, Amerson EH, Rosenberg OS, Jacobs RA, McCalmont TH, Shinkai K
• A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme.
  Cell 2011 Luke H. Chao, Margaret M. Stratton, Il-Hyung Lee, Oren S. Rosenberg, Joshua Levitz, Daniel J. Mandell, Tanja Kortemme, Jay T. Groves, Howard Schulman, John Kuriyan
• A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme.
  Cell 2011 Chao LH, Stratton MM, Lee IH, Rosenberg OS, Levitz J, Mandell DJ, Kortemme T, Groves JT, Schulman H, Kuriyan J
• EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Rosenberg OS, Dovey C, Tempesta M, Robbins RA, Finer-Moore JS, Stroud RM, Cox JS
• Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II.
  The FEBS journal 2006 Rosenberg OS, Deindl S, Comolli LR, Hoelz A, Downing KH, Nairn AC, Kuriyan J
• Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme.
  Cell 2005 Rosenberg OS, Deindl S, Sung RJ, Nairn AC, Kuriyan J
• Sulfadoxine-pyrimethamine in treatment of malaria in Western Kenya: increasing resistance and underdosing.
  Antimicrobial agents and chemotherapy 2003 Terlouw DJ, Nahlen BL, Courval JM, Kariuki SK, Rosenberg OS, Oloo AJ, Kolczak MS, Hawley WA, Lal AA, Kuile FO
• Treatment history and treatment dose are important determinants of sulfadoxine-pyrimethamine efficacy in children with uncomplicated malaria in Western Kenya.
  The Journal of infectious diseases 2003 Terlouw DJ, Courval JM, Kolczak MS, Rosenberg OS, Oloo AJ, Kager PA, Lal AA, Nahlen BL, ter Kuile FO