Ophir Klein, PhD, MD
Professor
Orofacial Sciences
School of Dentistry

He serves as Chief of the Division of Medical Genetics, Chair of the Division of Craniofacial Anomalies, Interim Director of the Institute for Human Genetics, and Director of the Program in Craniofacial Biology. The Klein laboratory focuses on understanding how organs form in developing embryos and how they regenerate in adults. When developmental and regenerative processes go awry, then birth defects, cancer and other diseases can result. The group's research is centered on understanding how development and regeneration normally occur in the hope of one day treating diseases that result from abnormalities in these processes. A central focus in the lab is craniofacial and dental development, as malformations in these organs are among the most common congenital abnormalities and have profound impacts on the lives of patients and their families. The maintenance, repair and growth of many adult organs, such as the bone marrow, skin, brain, and gastrointestinal tract, depend on tissue-specific populations of stem cells. The lab uses the rodent incisor, which grows continuously throughout the life of the animal, as a model system to understand adult stem cells. We intend to use the insights provided by our experiments in mice to guide us in the use of stem cells in regenerating dental and craniofacial tissues as a paradigm for developing replacement organs. Another major area of study is regeneration of the gastrointestinal tract. The amazing ability of the mammalian gastrointestinal epithelium to renew has long fascinated biologists. Our research aims to address fundamental questions in this field, including the identity, regulation and plasticity of intestinal stem cells. Finally, the laboratory is interested in how positive and negative modulators of signaling affect development, homeostasis and cancer. We are studying the roles of these molecules in the patterning and outgrowth of teeth, taste papillae, the oral mucosa, and other tissues and organs.

• Sprouty genes regulate activated fibroblasts in mammary epithelial development and breast cancer.
  Cell death & disease 2024 Li J, Ma R, Wang X, Lu Y, Chen J, Feng D, Zhou J, Xia K, Klein O, Xie H, Lu P
• Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development.
  Nature cell biology 2024 Shroff NP, Xu P, Kim S, Shelton ER, Gross BJ, Liu Y, Gomez CO, Ye Q, Drennon TY, Hu JK, Green JBA, Campàs O, Klein OD
• 2023 ASHG Lifetime Achievement Award: Neil Risch.
  American journal of human genetics 2024 Klein O
• Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.
  Nature cell biology 2024 Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz …
• MAGIC matrices: freeform bioprinting materials to support complex and reproducible organoid morphogenesis.
  bioRxiv : the preprint server for biology 2024 Graham AJ, Khoo MWL, Srivastava V, Viragova S, Parekh K, Morley CD, Bird M, Lebel P, Kumar S, Klein O, Gómez-Sjöberg R, Gartner ZJ
• An interactive atlas of three-dimensional syndromic facial morphology.
  American journal of human genetics 2024 Aponte JD, Bannister JJ, Hoskens H, Matthews H, Katsura K, Da Silva C, Cruz T, Pilz JHM, Spritz RA, Forkert ND, Claes P, Bernier FP, Klein OD, Katz DC, Hallgrímsson B
• Conserved and derived expression patterns and positive selection on dental genes reveal complex evolutionary context of ever-growing rodent molars.
  bioRxiv : the preprint server for biology 2023 Calamari ZT, Song A, Cohen E, Akter M, Roy RD, Hallikas O, Christensen MM, Li P, Marangoni P, Jernvall J, Klein OD
• Syndrome-informed phenotyping identifies a polygenic background for achondroplasia-like facial variation in the general population.
  bioRxiv : the preprint server for biology 2023 Vanneste M, Hoskens H, Goovaerts S, Matthews H, Aponte JD, Cole J, Shriver M, Marazita ML, Weinberg SM, Walsh S, Richmond S, Klein OD, Spritz RA, Peeters H, Hallgrímsson B, Claes P
• Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral.
  International journal of oral science 2023 Kim HY, Cooley V, Kim EJ, Li S, Lee JM, Sheyfer D, Liu W, Klein OD, Joester D, Jung HS
• YAP-Driven Malignant Reprogramming of Epithelial Stem Cells at Single Cell Resolution.
  Research square 2023 Gutkind JS, Faraji F, Ramirez S, Clubb L, Sato K, Quiroz PA, Galloway W, Mikulski Z, Hoang T, Medetgul-Ernar K, Marangoni P, Jones K, Officer A, Molinolo A, Kim K, Sakaguchi K, Califano J, Smith Q, …
• Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis.
  The Journal of clinical investigation 2023 Reyes EA, Castillo-Azofeifa D, Rispal J, Wald T, Zwick RK, Palikuqi B, Mujukian A, Rabizadeh S, Gupta AR, Gardner JM, Boffelli D, Gartner ZJ, Klein OD
• SPRY4-dependent ERK negative feedback demarcates functional adult stem cells in the male mouse germline†.
  Biology of reproduction 2023 Luo Y, Yamada M, N'Tumba-Byn T, Asif H, Gao M, Hu Y, Marangoni P, Liu Y, Evans T, Rafii S, Klein OD, Voss HU, Hadjantonakis AK, Elemento O, Martin LA, Seandel M
• Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.
  bioRxiv : the preprint server for biology 2023 Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz …
• Bcl-6 expression by CD4+ T cells determines concomitant immunity and host resistance across distinct parasitic infections.
  Mucosal immunology 2023 Meli AP, Russell GA, Swaminathan S, Weichselbaum L, MacMahon CA, Pernet E, Karo-Atar D, Rogers D, Rochette A, Fontes G, Mandl JN, Divangahi M, Klein OD, Gregorieff A, Stäger S, King IL
• Patterning and folding of intestinal villi by active mesenchymal dewetting.
  bioRxiv : the preprint server for biology 2023 Huycke TR, Miyazaki H, Häkkinen TJ, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ
• Direct reprogramming of oral epithelial progenitor cells to cancer stem cells at single cell resolution in vivo.
  bioRxiv : the preprint server for biology 2023 Faraji F, Ramirez SI, Clubb LM, Sato K, Quiroz PYA, Galloway WMG, Mikulski Z, Hoang TS, Medetgul-Ernar K, Marangoni P, Jones KB, Officer A, Molinolo AA, Kim K, Sakaguchi K, Califano JA, Smith Q, Klein…
• Reconnecting, Recommitting, and Renewing.
  Journal of dental research 2023 Klein OD
• NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy.
  bioRxiv : the preprint server for biology 2023 Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC, Bush NAO, Hervey-Jumper SL, Klein OD, Toedebusch CM, Horbinski CM, Magill ST, Bhaduri A, …
• Author Correction: MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses.
  Scientific data 2023 Devine J, Vidal-García M, Liu W, Neves A, Lo Vercio LD, Green RM, Richbourg HA, Marchini M, Unger CM, Nickle AC, Radford B, Young NM, Gonzalez PN, Schuler RE, Bugacov A, Rolian C, Percival CJ, …
• Intracellular pH dynamics regulates intestinal stem cell lineage specification.
  Nature communications 2023 Liu Y, Reyes E, Castillo-Azofeifa D, Klein OD, Nystul T, Barber DL
• The developmental basis for scaling of mammalian tooth size.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Christensen MM, Hallikas O, Das Roy R, Väänänen V, Stenberg OE, Häkkinen TJ, François JC, Asher RJ, Klein OD, Holzenberger M, Jernvall J
• Precise modulation of transcription factor levels identifies features underlying dosage sensitivity.
  Nature genetics 2023 Naqvi S, Kim S, Hoskens H, Matthews HS, Spritz RA, Klein OD, Hallgrímsson B, Swigut T, Claes P, Pritchard JK, Wysocka J
• Piezo inhibition prevents and rescues scarring by targeting the adipocyte to fibroblast transition.
  bioRxiv : the preprint server for biology 2023 Griffin MF, Talbott HE, Guardino NJ, Guo JL, Spielman AF, Chen K, Parker JBL, Mascharak S, Henn D, Liang N, King M, Cotterell AC, Bauer-Rowe KE, Abbas DB, Diaz Deleon NM, Sivaraj D, Fahy EJ, Downer M,…
• A Suite of Mouse Reagents for Studying Amelogenesis.
  bioRxiv : the preprint server for biology 2023 Wald T, Verma A, Cooley V, Marangoni P, Cazares O, Sharir A, Sandoval EJ, Sung D, Najibi H, Drennon TY, Bush JO, Joester D, Klein OD
• EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids.
  JCI insight 2023 Childs CJ, Holloway EM, Sweet CW, Tsai YH, Wu A, Vallie A, Eiken MK, Capeling MM, Zwick RK, Palikuqi B, Trentesaux C, Wu JH, Pellón-Cardenas O, Zhang CJ, Glass I, Loebel C, Yu Q, Camp JG, Sexton JZ, …
• Comparing 2D and 3D representations for face-based genetic syndrome diagnosis.
  European journal of human genetics : EJHG 2023 Bannister JJ, Wilms M, Aponte JD, Katz DC, Klein OD, Bernier FP, Spritz RA, Hallgrímsson B, Forkert ND
• Privacy, bias and the clinical use of facial recognition technology: A survey of genetics professionals.
  American journal of medical genetics. Part C, Seminars in medical genetics 2023 Aboujaoude E, Light J, Brown JEH, Boscardin WJ, Hallgrímsson B, Klein OD
• A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling.
  Cell stem cell 2023 Castillo-Azofeifa D, Wald T, Reyes EA, Gallagher A, Schanin J, Vlachos S, Lamarche-Vane N, Bomidi C, Blutt S, Estes MK, Nystul T, Klein OD
• Harnessing synthetic biology to engineer organoids and tissues.
  Cell stem cell 2023 Trentesaux C, Yamada T, Klein OD, Lim WA
• Programming multicellular assembly with synthetic cell adhesion molecules.
  Nature 2022 Stevens AJ, Harris AR, Gerdts J, Kim KH, Trentesaux C, Ramirez JT, McKeithan WL, Fattahi F, Klein OD, Fletcher DA, Lim WA
• Editorial overview: How to generate and maintain organs-organoids, regeneration, and beyond.
  Current opinion in genetics & development 2022 Klein OD, Nishinakamura R
• Detecting 3D syndromic faces as outliers using unsupervised normalizing flow models.
  Artificial intelligence in medicine 2022 Bannister JJ, Wilms M, Aponte JD, Katz DC, Klein OD, Bernier FPJ, Spritz RA, Hallgrímsson B, Forkert ND
• Cellular shape reinforces niche to stem cell signaling in the small intestine.
  Science advances 2022 Pentinmikko N, Lozano R, Scharaw S, Andersson S, Englund JI, Castillo-Azofeifa D, Gallagher A, Broberg M, Song KY, Sola Carvajal A, Speidel AT, Sundstrom M, Allbritton N, Stevens MM, Klein OD, …
• A dominant negative mutation uncovers cooperative control of caudal Wolffian duct development by Sprouty genes.
  Cellular and molecular life sciences : CMLS 2022 Altés G, Vaquero M, Cuesta S, Anerillas C, Macià A, Espinet C, Ribera J, Bellusci S, Klein OD, Yeramian A, Dolcet X, Egea J, Encinas M
• Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury.
  Cell stem cell 2022 Palikuqi B, Rispal J, Reyes EA, Vaka D, Boffelli D, Klein O
• Refining nosology by modelling variation among facial phenotypes: the RASopathies.
  Journal of medical genetics 2022 Matthews H, Vanneste M, Katsura K, Aponte D, Patton M, Hammond P, Baynam G, Spritz R, Klein OD, Hallgrimsson B, Peeters H, Claes P
• A Deep Invertible 3-D Facial Shape Model for Interpretable Genetic Syndrome Diagnosis.
  IEEE journal of biomedical and health informatics 2022 Bannister JJ, Wilms M, Aponte JD, Katz DC, Klein OD, Bernier FPJ, Spritz RA, Hallgrimsson B, Forkert ND
• Good Neighbors: The Niche that Fine Tunes Mammalian Intestinal Regeneration.
  Cold Spring Harbor perspectives in biology 2022 Palikuqi B, Rispal J, Klein O
• MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses.
  Scientific data 2022 Devine J, Vidal-García M, Liu W, Neves A, Lo Vercio LD, Green RM, Richbourg HA, Marchini M, Unger CM, Nickle AC, Radford B, Young NM, Gonzalez PN, Schuler RE, Bugacov A, Rolian C, Percival CJ, …
• CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids.
  Nature communications 2022 Lo M, Sharir A, Paul MD, Torosyan H, Agnew C, Li A, Neben C, Marangoni P, Xu L, Raleigh DR, Jura N, Klein OD
• Parallels in signaling between development and regeneration in ectodermal organs.
  Current topics in developmental biology 2022 Pincha N, Marangoni P, Haque A, Klein OD
• Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage.
  The Journal of clinical investigation 2022 Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG
• SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal.
  Developmental cell 2022 Yu T, Cazares O, Tang AD, Kim HY, Wald T, Verma A, Liu Q, Barcellos-Hoff MH, Floor SN, Jung HS, Brooks AN, Klein OD
• LGL1 binds to Integrin β1 and inhibits downstream signaling to promote epithelial branching in the mammary gland.
  Cell reports 2022 Ma R, Gong D, You H, Xu C, Lu Y, Bergers G, Werb Z, Klein OD, Petritsch CK, Lu P
• MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model.
  Disease models & mechanisms 2021 Tidyman WE, Goodwin AF, Maeda Y, Klein OD, Rauen KA
• Publisher Correction: Application of full-genome analysis to diagnose rare monogenic disorders.
  NPJ genomic medicine 2021 Shieh JT, Penon-Portmann M, Wong KHY, Levy-Sakin M, Verghese M, Slavotinek A, Gallagher RC, Mendelsohn BA, Tenney J, Beleford D, Perry H, Chow SK, Sharo AG, Brenner SE, Qi Z, Yu J, Klein OD, Martin D,…
• Application of full-genome analysis to diagnose rare monogenic disorders.
  NPJ genomic medicine 2021 Shieh JT, Penon-Portmann M, Wong KHY, Levy-Sakin M, Verghese M, Slavotinek A, Gallagher RC, Mendelsohn BA, Tenney J, Beleford D, Perry H, Chow SK, Sharo AG, Brenner SE, Qi Z, Yu J, Klein OD, Martin D,…
• Salivary gland: A budding genius.
  Developmental cell 2021 Cazares O, Haque AS, Klein OD
• Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar tooth development.
  Development (Cambridge, England) 2021 Kim R, Yu T, Li J, Prochazka J, Sharir A, Green JBA, Klein OD
• Large-scale open-source three-dimensional growth curves for clinical facial assessment and objective description of facial dysmorphism.
  Scientific reports 2021 Matthews HS, Palmer RL, Baynam GS, Quarrell OW, Klein OD, Spritz RA, Hennekam RC, Walsh S, Shriver M, Weinberg SM, Hallgrimsson B, Hammond P, Penington AJ, Peeters H, Claes PD
• Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids.
  Cell stem cell 2021 Tallapragada NP, Cambra HM, Wald T, Keough Jalbert S, Abraham DM, Klein OD, Klein AM
• Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition.
  Developmental cell 2021 Sanman LE, Chen IW, Bieber JM, Steri V, Trentesaux C, Hann B, Klein OD, Wu LF, Altschuler SJ
• KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.
  JCI insight 2020 Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, …
• Engineering synthetic morphogen systems that can program multicellular patterning.
  Science (New York, N.Y.) 2020 Toda S, McKeithan WL, Hakkinen TJ, Lopez P, Klein OD, Lim WA
• Asymmetric Stratification-Induced Polarity Loss and Coordinated Individual Cell Movements Drive Directional Migration of Vertebrate Epithelium.
  Cell reports 2020 Lu Y, Deng R, You H, Xu Y, Antos C, Sun J, Klein OD, Lu P
• Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth.
  Nature communications 2020 Krivanek J, Soldatov RA, Kastriti ME, Chontorotzea T, Herdina AN, Petersen J, Szarowska B, Landova M, Matejova VK, Holla LI, Kuchler U, Zdrilic IV, Vijaykumar A, Balic A, Marangoni P, Klein OD, Neves …
• FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research.
  Development (Cambridge, England) 2020 Samuels BD, Aho R, Brinkley JF, Bugacov A, Feingold E, Fisher S, Gonzalez-Reiche AS, Hacia JG, Hallgrimsson B, Hansen K, Harris MP, Ho TV, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD…
• Sox2 Controls Periderm and Rugae Development to Inhibit Oral Adhesions.
  Journal of dental research 2020 Sweat YY, Sweat M, Yu W, Sanz-Navarro M, Zhang L, Sun Z, Eliason S, Klein OD, Michon F, Chen Z, Amendt BA
• FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling.
  BMC biology 2020 Wu J, Tian Y, Han L, Liu C, Sun T, Li L, Yu Y, Lamichhane B, D'Souza RN, Millar SE, Krumlauf R, Ornitz DM, Feng JQ, Klein O, Zhao H, Zhang F, Linhardt RJ, Wang X
• YAP/TAZ Regulate Elevation and Bone Formation of the Mouse Secondary Palate.
  Journal of dental research 2020 Goodwin AF, Chen CP, Vo NT, Bush JO, Klein OD
• LGR5 in breast cancer and ductal carcinoma in situ: a diagnostic and prognostic biomarker and a therapeutic target.
  BMC cancer 2020 Hagerling C, Owyong M, Sitarama V, Wang CY, Lin C, van den Bijgaart RJE, Koopman CD, Brenot A, Nanjaraj A, Wärnberg F, Jirström K, Klein OD, Werb Z, Plaks V
• Fully Automatic Landmarking of Syndromic 3D Facial Surface Scans Using 2D Images.
  Sensors (Basel, Switzerland) 2020 Bannister JJ, Crites SR, Aponte JD, Katz DC, Wilms M, Klein OD, Bernier FPJ, Spritz RA, Hallgrímsson B, Forkert ND
• Automated syndrome diagnosis by three-dimensional facial imaging.
  Genetics in medicine : official journal of the American College of Medical Genetics 2020 Hallgrímsson B, Aponte JD, Katz DC, Bannister JJ, Riccardi SL, Mahasuwan N, McInnes BL, Ferrara TM, Lipman DM, Neves AB, Spitzmacher JAJ, Larson JR, Bellus GA, Pham AM, Aboujaoude E, Benke TA, …
• The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community.
  G3 (Bethesda, Md.) 2020 Wall E, Scoles J, Joo A, Klein O, Quinonez C, Bush JO, Martin GR, Laird DJ
• Safety and immunogenicity of Fc-EDA, a recombinant ectodysplasin A1 replacement protein, in human subjects.
  British journal of clinical pharmacology 2020 Körber I, Klein OD, Morhart P, Faschingbauer F, Grange DK, Clarke A, Bodemer C, Maitz S, Huttner K, Kirby N, Durand C, Schneider H
• Lgr5+ telocytes are a signaling source at the intestinal villus tip.
  Nature communications 2020 Bahar Halpern K, Massalha H, Zwick RK, Moor AE, Castillo-Azofeifa D, Rozenberg M, Farack L, Egozi A, Miller DR, Averbukh I, Harnik Y, Weinberg-Corem N, de Sauvage FJ, Amit I, Klein OD, Shoshkes-Carmel…
• From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells.
  Current opinion in cell biology 2020 Trentesaux C, Striedinger K, Pomerantz JH, Klein OD
• Molecular and cellular mechanisms of tooth development, homeostasis and repair.
  Development (Cambridge, England) 2020 Yu T, Klein OD
• Generation of Knockout Gene-Edited Human Intestinal Organoids.
  Methods in molecular biology (Clifton, N.J.) 2020 Rajendra C, Wald T, Barber K, Spence JR, Fattahi F, Klein OD
• Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress.
  Cell stem cell 2019 Byrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ, Williams SE
• Use of organoids to study regenerative responses to intestinal damage.
  American journal of physiology. Gastrointestinal and liver physiology 2019 Blutt SE, Klein OD, Donowitz M, Shroyer N, Guha C, Estes MK
• Downregulation of FGF Signaling by Spry4 Overexpression Leads to Shape Impairment, Enamel Irregularities, and Delayed Signaling Center Formation in the Mouse Molar.
  JBMR plus 2019 Marangoni P, Charles C, Ahn Y, Seidel K, Jheon A, Ganss B, Krumlauf R, Viriot L, Klein OD
• Case Report of Floating-Harbor Syndrome With Bilateral Cleft Lip.
  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2019 Ko J, Pomerantz JH, Perry H, Shieh JT, Slavotinek AM, Oberoi S, Klein OD
• Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development.
  International journal of molecular sciences 2019 El Shahawy M, Reibring CG, Hallberg K, Neben CL, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A
• The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting.
  American journal of medical genetics. Part A 2019 Taneyhill LA, Moody SA, Cox T, Klein OD, Marcucio R, Schneider RA, Trainor PA
• Atoh1+ secretory progenitors possess renewal capacity independent of Lgr5+ cells during colonic regeneration.
  The EMBO journal 2019 Castillo-Azofeifa D, Fazio EN, Nattiv R, Good HJ, Wald T, Pest MA, de Sauvage FJ, Klein OD, Asfaha S
• Introduction to themed series on intestinal stem cells and the NIDDK Intestinal Stem Cell Consortium.
  American journal of physiology. Gastrointestinal and liver physiology 2018 Wang TC, Martin MG, Kuo CJ, Klein OD, Niland J
• Intestinal renewal across the animal kingdom: comparing stem cell activity in mouse and Drosophila.
  American journal of physiology. Gastrointestinal and liver physiology 2018 Zwick RK, Ohlstein B, Klein OD
• Prominin-1 controls stem cell activation by orchestrating ciliary dynamics.
  The EMBO journal 2018 Singer D, Thamm K, Zhuang H, Karbanová J, Gao Y, Walker JV, Jin H, Wu X, Coveney CR, Marangoni P, Lu D, Grayson PRC, Gulsen T, Liu KJ, Ardu S, Wann AK, Luo S, Zambon AC, Jetten AM, Tredwin C, Klein OD…
• Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development.
  Frontiers in genetics 2018 Prochazkova M, Prochazka J, Marangoni P, Klein OD
• Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage.
  Development (Cambridge, England) 2018 May AJ, Cruz-Pacheco N, Emmerson E, Gaylord EA, Seidel K, Nathan S, Muench MO, Klein OD, Knox SM
• Tissue Mechanical Forces and Evolutionary Developmental Changes Act Through Space and Time to Shape Tooth Morphology and Function.
  BioEssays : news and reviews in molecular, cellular and developmental biology 2018 Calamari ZT, Hu JK, Klein OD
• Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration.
  Nature 2018 Ransom RC, Carter AC, Salhotra A, Leavitt T, Marecic O, Murphy MP, Lopez ML, Wei Y, Marshall CD, Shen EZ, Jones RE, Sharir A, Klein OD, Chan CKF, Wan DC, Chang HY, Longaker MT
• LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
  Nature communications 2018 Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA
• Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.
  Nature 2018 Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD
• The intestinal epithelial response to damage.
  Science China. Life sciences 2018 Weichselbaum L, Klein OD
• Bmi1-Progenitor Cell Ablation Impairs the Angiogenic Response to Myocardial Infarction.
  Arteriosclerosis, thrombosis, and vascular biology 2018 Herrero D, Cañón S, Pelacho B, Salvador-Bernáldez M, Aguilar S, Pogontke C, Carmona RM, Salvador JM, Perez-Pomares JM, Klein OD, Prósper F, Jimenez-Borreguero LJ, Bernad A
• An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery.
  NPJ genomic medicine 2018 Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Söylemez O, Sutti S, Kooshesh K, Qiu H, Fay CJ, Perroni …
• Publisher Correction: FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells.
  Nature communications 2018 Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E
• SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis.
  Development (Cambridge, England) 2018 Castillo-Azofeifa D, Seidel K, Gross L, Golden EJ, Jacquez B, Klein OD, Barlow LA
• Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor.
  Cell stem cell 2018 Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y
• Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia.
  eLife 2018 McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD
• FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells.
  Nature communications 2018 Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E
• Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care.
  Journal of dental research 2018 Giannobile WV, Chai Y, Chen Y, Healy KE, Klein O, Lane N, Longaker MT, Lotz JC, Mooney DJ, Sfeir CS, Urata M, Wagner WR, Wu BM, Kohn DH
• Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation.
  Cell reports 2018 Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MK
• Bmi1+ Progenitor Cell Dynamics in Murine Cornea During Homeostasis and Wound Healing.
  Stem cells (Dayton, Ohio) 2018 Kalha S, Shrestha B, Sanz Navarro M, Jones KB, Klein OD, Michon F
• Plasticity within the niche ensures the maintenance of a Sox2+ stem cell population in the mouse incisor.
  Development (Cambridge, England) 2018 Sanz-Navarro M, Seidel K, Sun Z, Bertonnier-Brouty L, Amendt BA, Klein OD, Michon F
• Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a.
  Human molecular genetics 2018 Ching ST, Infante CR, Du W, Sharir A, Park S, Menke DB, Klein OD
• Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme.
  Developmental cell 2017 Hughes AJ, Miyazaki H, Coyle MC, Zhang J, Laurie MT, Chu D, Vavrušová Z, Schneider RA, Klein OD, Gartner ZJ
• Body size and allometric variation in facial shape in children.
  American journal of physical anthropology 2017 Larson JR, Manyama MF, Cole JB, Gonzalez PN, Percival CJ, Liberton DK, Ferrara TM, Riccardi SL, Kimwaga EA, Mathayo J, Spitzmacher JA, Rolian C, Jamniczky HA, Weinberg SM, Roseman CC, Klein O, …
• Meeting report: a hard look at the state of enamel research.
  International journal of oral science 2017 Klein OD, Duverger O, Shaw W, Lacruz RS, Joester D, Moradian-Oldak J, Pugach MK, Wright JT, Millar SE, Kulkarni AB, Bartlett JD, Diekwisch TG, DenBesten P, Simmer JP
• Feedback regulation of RTK signaling in development.
  Developmental biology 2017 Neben CL, Lo M, Jura N, Klein OD
• Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2017 Naveau A, Zhang B, Meng B, Sutherland MT, Prochazkova M, Wen T, Marangoni P, Jones KB, Cox TC, Ganss B, Jheon AH, Klein OD
• IRF6 and SPRY4 Signaling Interact in Periderm Development.
  Journal of dental research 2017 Kousa YA, Roushangar R, Patel N, Walter A, Marangoni P, Krumlauf R, Klein OD, Schutte BC
• Lineage tracing of epithelial cells in developing teeth reveals two strategies for building signaling centers.
  The Journal of biological chemistry 2017 Du W, Hu JK, Du W, Klein OD
• Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid.
  PLoS genetics 2017 El Shahawy M, Reibring CG, Neben CL, Hallberg K, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A
• Automatic recognition of the XLHED phenotype from facial images.
  American journal of medical genetics. Part A 2017 Hadj-Rabia S, Schneider H, Navarro E, Klein O, Kirby N, Huttner K, Wolf L, Orin M, Wohlfart S, Bodemer C, Grange DK
• Ras Signaling Regulates Stem Cells and Amelogenesis in the Mouse Incisor.
  Journal of dental research 2017 Zheng X, Goodwin AF, Tian H, Jheon AH, Klein OD
• A review of craniofacial and dental findings of the RASopathies.
  Orthodontics & craniofacial research 2017 Cao H, Alrejaye N, Klein OD, Goodwin AF, Oberoi S
• FGF signaling refines Wnt gradients to regulate the patterning of taste papillae.
  Development (Cambridge, England) 2017 Prochazkova M, Häkkinen TJ, Prochazka J, Spoutil F, Jheon AH, Ahn Y, Krumlauf R, Jernvall J, Klein OD
• The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape.
  G3 (Bethesda, Md.) 2017 Percival CJ, Marangoni P, Tapaltsyan V, Klein O, Hallgrímsson B
• From snapshots to movies: Understanding early tooth development in four dimensions.
  Developmental dynamics : an official publication of the American Association of Anatomists 2017 Kim R, Green JBA, Klein OD
• EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells.
  Stem cell reports 2017 Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO
• Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Wald T, Spoutil F, Osickova A, Prochazkova M, Benada O, Kasparek P, Bumba L, Klein OD, Sedlacek R, Sebo P, Prochazka J, Osicka R
• Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab.
  Annals of oncology : official journal of the European Society for Medical Oncology 2017 Menzies AM, Johnson DB, Ramanujam S, Atkinson VG, Wong ANM, Park JJ, McQuade JL, Shoushtari AN, Tsai KK, Eroglu Z, Klein O, Hassel JC, Sosman JA, Guminski A, Sullivan RJ, Ribas A, Carlino MS, Davies …
• Human Facial Shape and Size Heritability and Genetic Correlations.
  Genetics 2016 Cole JB, Manyama M, Larson JR, Liberton DK, Ferrara TM, Riccardi SL, Li M, Mio W, Klein OD, Santorico SA, Hallgrímsson B, Spritz RA
• In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development.
  Development (Cambridge, England) 2016 Tsai YH, Nattiv R, Dedhia PH, Nagy MS, Chin AM, Thomson M, Klein OD, Spence JR
• Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal.
  Development (Cambridge, England) 2016 Sun Z, Yu W, Sanz Navarro M, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, …
• SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P
• Watching a deep dive: Live imaging provides lessons about tooth invagination.
  The Journal of cell biology 2016 Sharir A, Klein OD
• Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology.
  PLoS genetics 2016 Shaffer JR, Orlova E, Lee MK, Leslie EJ, Raffensperger ZD, Heike CL, Cunningham ML, Hecht JT, Kau CH, Nidey NL, Moreno LM, Wehby GL, Murray JC, Laurie CA, Laurie CC, Cole J, Ferrara T, Santorico S, …
• Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape.
  PLoS genetics 2016 Cole JB, Manyama M, Kimwaga E, Mathayo J, Larson JR, Liberton DK, Lukowiak K, Ferrara TM, Riccardi SL, Li M, Mio W, Prochazkova M, Williams T, Li H, Jones KL, Klein OD, Santorico SA, Hallgrimsson B, …
• αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development.
  Nature communications 2016 Li CY, Hu J, Lu H, Lan J, Du W, Galicia N, Klein OD
• Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis.
  JCI insight 2016 Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD
• JCI insight
  Dual epithelial and immune cell function of Dvl1 regulates gut mircobiota composition and intestinal homeostasis. 2016 Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD.
• Modeling craniofacial and skeletal congenital birth defects to advance therapies.
  Human molecular genetics 2016 Neben CL, Roberts RR, Dipple KM, Merrill AE, Klein OD
• The FaceBase Consortium: a comprehensive resource for craniofacial researchers.
  Development (Cambridge, England) 2016 Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J, FaceBase …
• Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling.
  Bone 2016 Joo A, Long R, Cheng Z, Alexander C, Chang W, Klein OD
• Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors.
  Molecular psychiatry 2016 Belinson H, Nakatani J, Babineau BA, Birnbaum RY, Ellegood J, Bershteyn M, McEvilly RJ, Long JM, Willert K, Klein OD, Ahituv N, Lerch JP, Rosenfeld MG, Wynshaw-Boris A
• Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM
• Expression of FGFs during early mouse tongue development.
  Gene expression patterns : GEP 2015 Du W, Prochazka J, Prochazkova M, Klein OD
• Development of synovial membrane in the temporomandibular joint of the human fetus.
  European journal of histochemistry : EJH 2015 Carvalho de Moraes LO, Tedesco RC, Arraez-Aybar LA, Klein O, Mérida-Velasco JR, Alonso LG
• Craniofacial Stem Cells in Health and Disease.
  Journal of dental research 2015 Klein OD, Nör JE
• From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models.
  Current topics in developmental biology 2015 Goodwin AF, Kim R, Bush JO, Klein OD
• Inhibition of Notch Signaling During Mouse Incisor Renewal Leads to Enamel Defects.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015 Jheon AH, Prochazkova M, Meng B, Wen T, Lim YJ, Naveau A, Espinoza R, Cox TC, Sone ED, Ganss B, Siebel CW, Klein OD
• Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model.
  Scientific reports 2015 Marangoni P, Charles C, Tafforeau P, Laugel-Haushalter V, Joo A, Bloch-Zupan A, Klein OD, Viriot L
• Identification of novel Fgf enhancers and their role in dental evolution.
  Evolution & development 2015 Tapaltsyan V, Charles C, Hu J, Mindell D, Ahituv N, Wilson GM, Black BL, Viriot L, Klein OD
• Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo.
  Stem cell reports 2015 Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein OD, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR
• DLX4 is associated with orofacial clefting and abnormal jaw development.
  Human molecular genetics 2015 Wu D, Mandal S, Choi A, Anderson A, Prochazkova M, Perry H, Gil-Da-Silva-Lopes VL, Lao R, Wan E, Tang PL, Kwok PY, Klein O, Zhuan B, Slavotinek AM
• Further supporting evidence for the SATB2-associated syndrome found through whole exome sequencing.
  American journal of medical genetics. Part A 2015 Zarate YA, Perry H, Ben-Omran T, Sellars EA, Stein Q, Almureikhi M, Simmons K, Klein O, Fish J, Feingold M, Douglas J, Kruer MC, Si Y, Mao R, McKnight D, Gibellini F, Retterer K, Slavotinek A
• Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice.
  PloS one 2015 Thys A, Vandenberghe P, Hague P, Klein OD, Erneux C, Vanderwinden JM
• Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis.
  Cell reports 2015 Tian H, Biehs B, Chiu C, Siebel CW, Wu Y, Costa M, de Sauvage FJ, Klein OD
• In vitro generation of human pluripotent stem cell derived lung organoids.
  eLife 2015 Dye BR, Hill DR, Ferguson MA, Tsai YH, Nagy MS, Dyal R, Wells JM, Mayhew CN, Nattiv R, Klein OD, White ES, Deutsch GH, Spence JR
• Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster).
  International journal of oral science 2015 Jheon AH, Prochazkova M, Sherman M, Manoli DS, Shah NM, Carbone L, Klein O
• Developing and regenerating a sense of taste.
  Current topics in developmental biology 2015 Barlow LA, Klein OD
• Replaying evolutionary transitions from the dental fossil record.
  Nature 2014 Harjunmaa E, Seidel K, Häkkinen T, Renvoisé E, Corfe IJ, Kallonen A, Zhang ZQ, Evans AR, Mikkola ML, Salazar-Ciudad I, Klein OD, Jernvall J
• Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium.
  Development (Cambridge, England) 2014 Castillo D, Seidel K, Salcedo E, Ahn C, de Sauvage FJ, Klein OD, Barlow LA
• Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells.
  Development (Cambridge, England) 2014 Michailovici I, Harrington HA, Azogui HH, Yahalom-Ronen Y, Plotnikov A, Ching S, Stumpf MP, Klein OD, Seger R, Tzahor E
• Craniofacial morphometric analysis of individuals with X-linked hypohidrotic ectodermal dysplasia.
  Molecular genetics & genomic medicine 2014 Goodwin AF, Larson JR, Jones KB, Liberton DK, Landan M, Wang Z, Boekelheide A, Langham M, Mushegyan V, Oberoi S, Brao R, Wen T, Johnson R, Huttner K, Grange DK, Spritz RA, Hallgrímsson B, Jheon AH, …
• Isolation and culture of dental epithelial stem cells from the adult mouse incisor.
  Journal of visualized experiments : JoVE 2014 Chavez MG, Hu J, Seidel K, Li C, Jheon A, Naveau A, Horst O, Klein OD
• Crosstalk between miR-34a and Notch Signaling Promotes Differentiation in Apical Papilla Stem Cells (SCAPs).
  Journal of dental research 2014 Sun F, Wan M, Xu X, Gao B, Zhou Y, Sun J, Cheng L, Klein OD, Zhou X, Zheng L
• The WNT10A gene in ectodermal dysplasias and selective tooth agenesis.
  American journal of medical genetics. Part A 2014 Mues G, Bonds J, Xiang L, Vieira AR, Seymen F, Klein O, D'Souza RN
• Dental findings in 14q terminal deletion syndrome.
  Clinical dysmorphology 2014 Mendelsohn BA, Jeng LLB, Oberoi S, Klein OD
• Craniofacial and dental development in Costello syndrome.
  American journal of medical genetics. Part A 2014 Goodwin AF, Oberoi S, Landan M, Charles C, Massie JC, Fairley C, Rauen KA, Klein OD
• Tooth, hair and claw: comparing epithelial stem cell niches of ectodermal appendages.
  Experimental cell research 2014 Naveau A, Seidel K, Klein OD
• Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor.
  Cell stem cell 2014 Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y
• Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia.
  Developmental biology 2013 Ching ST, Cunha GR, Baskin LS, Basson MA, Klein OD
• Fibroblast growth factor signaling in mammalian tooth development.
  Odontology 2013 Li CY, Prochazka J, Goodwin AF, Klein OD
• On the cutting edge of organ renewal: Identification, regulation, and evolution of incisor stem cells.
  Genesis (New York, N.Y. : 2000) 2013 Kuang-Hsien Hu J, Mushegyan V, Klein OD
• Current trends in stem cell therapy for improvement of bone quality.
  Histology and histopathology 2013 Yamada Y, Nakamura S, Klein OD, Ito K
• American Journal of Medical Genetics Part A
  The society of craniofacial genetics and developmental biology 35th annual meeting 2013 Klein OD, Bush JO, Knox SM, Jheon AH, Cordero DR, Richtsmeier JT
• Developmental disorders of the dentition: an update.
  American journal of medical genetics. Part C, Seminars in medical genetics 2013 Klein OD, Oberoi S, Huysseune A, Hovorakova M, Peterka M, Peterkova R
• Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation.
  Human molecular genetics 2013 Goodwin AF, Tidyman WE, Jheon AH, Sharir A, Zheng X, Charles C, Fagin JA, McMahon M, Diekwisch TG, Ganss B, Rauen KA, Klein OD
• Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an effort to formulate a departmental policy.
  The Journal of pediatrics 2013 Oishi PE, Klein OD, Keller RL, University of California San Francisco Neonatology and Pediatric Critical Care Early Faculty Develop
• Inductive ability of human developing and differentiated dental mesenchyme.
  Cells, tissues, organs 2013 Zheng L, Warotayanont R, Stahl J, Kunimatsu R, Klein O, DenBesten PK, Zhang Y
• Oral epithelial stem cells in tissue maintenance and disease: the first steps in a long journey.
  International journal of oral science 2013 Jones KB, Klein OD
• The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation.
  Development (Cambridge, England) 2013 Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, Zhang Z, McManus MT, Klein OD, Amendt BA
• Characterization of X-linked hypohidrotic ectodermal dysplasia (XL-HED) hair and sweat gland phenotypes using phototrichogram analysis and live confocal imaging.
  American journal of medical genetics. Part A 2013 Jones KB, Goodwin AF, Landan M, Seidel K, Tran DK, Hogue J, Chavez M, Fete M, Yu W, Hussein T, Johnson R, Huttner K, Jheon AH, Klein OD
• The dynamics of supernumerary tooth development are differentially regulated by Sprouty genes.
  Journal of experimental zoology. Part B, Molecular and developmental evolution 2013 Lagronova-Churava S, Spoutil F, Vojtechova S, Lesot H, Peterka M, Klein OD, Peterkova R
• If a stem cell dies in the crypt, and no one is around to see it….
  Cell stem cell 2013 Nusse YM, Klein OD
• Sox2 marks epithelial competence to generate teeth in mammals and reptiles.
  Development (Cambridge, England) 2013 Juuri E, Jussila M, Seidel K, Holmes S, Wu P, Richman J, Heikinheimo K, Chuong CM, Arnold K, Hochedlinger K, Klein O, Michon F, Thesleff I
• Injectable bone tissue engineering using expanded mesenchymal stem cells.
  Stem cells (Dayton, Ohio) 2013 Yamada Y, Nakamura S, Ito K, Umemura E, Hara K, Nagasaka T, Abe A, Baba S, Furuichi Y, Izumi Y, Klein OD, Wakabayashi T
• Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis.
  Cell reports 2013 Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z
• Sprouty genes regulate proliferation and survival of human embryonic stem cells.
  Scientific reports 2013 Felfly H, Klein OD
• Summary of the IADR Cariology Research, Craniofacial Biology, and Mineralized Tissue Groups Symposium, Iguaçu Falls, Brazil, June 2012: Gene-environment Interactions and Epigenetics in Oral Diseases: Enamel Formation and its Clinical Impact on Tooth Defects, Caries, and Erosion.
  Dentistry 3000 2013 Modesto A, Klein O, Tenuta LM, Gerlach RF, Vieira AR
• microRNA miR-34a regulates cytodifferentiation and targets multi-signaling pathways in human dental papilla cells.
  PloS one 2012 Wan M, Gao B, Sun F, Tang Y, Ye L, Fan Y, Klein OD, Zhou X, Zheng L
• Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules.
  Developmental biology 2012 Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ
• A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9.
  Nature genetics 2012 Justice CM, Yagnik G, Kim Y, Peter I, Jabs EW, Erazo M, Ye X, Ainehsazan E, Shi L, Cunningham ML, Kimonis V, Roscioli T, Wall SA, Wilkie AO, Stoler J, Richtsmeier JT, Heuzé Y, Sanchez-Lara PA, Buckley…
• Craniofacial and dental development in cardio-facio-cutaneous syndrome: the importance of Ras signaling homeostasis.
  Clinical genetics 2012 Goodwin AF, Oberoi S, Landan M, Charles C, Groth J, Martinez A, Fairley C, Weiss LA, Tidyman WE, Klein OD, Rauen KA
• Characterization of dental epithelial stem cells from the mouse incisor with two-dimensional and three-dimensional platforms.
  Tissue engineering. Part C, Methods 2012 Chavez MG, Yu W, Biehs B, Harada H, Snead ML, Lee JS, Desai TA, Klein OD
• Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors.
  Developmental cell 2012 Juuri E, Saito K, Ahtiainen L, Seidel K, Tummers M, Hochedlinger K, Klein OD, Thesleff I, Michon F
• Stem cell and biomaterials research in dental tissue engineering and regeneration.
  Dental clinics of North America 2012 Horst OV, Chavez MG, Jheon AH, Desai T, Klein OD
• BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor.
  PloS one 2012 Kyrylkova K, Kyryachenko S, Biehs B, Klein O, Kioussi C, Leid M
• From molecules to mastication: the development and evolution of teeth.
  Wiley interdisciplinary reviews. Developmental biology 2012 Jheon AH, Seidel K, Biehs B, Klein OD
• E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor.
  Developmental biology 2012 Li CY, Cha W, Luder HU, Charles RP, McMahon M, Mitsiadis TA, Klein OD
• Spry1 and spry2 are essential for development of the temporomandibular joint.
  Journal of dental research 2012 Purcell P, Jheon A, Vivero MP, Rahimi H, Joo A, Klein OD
• The genome architecture of the Collaborative Cross mouse genetic reference population.
  Genetics 2012 Collaborative Cross Consortium
• Expression of microRNAs in the stem cell niche of the adult mouse incisor.
  PloS one 2011 Jheon AH, Li CY, Wen T, Michon F, Klein OD
• Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling.
  Development (Cambridge, England) 2011 Charles C, Hovorakova M, Ahn Y, Lyons DB, Marangoni P, Churava S, Biehs B, Jheon A, Lesot H, Balooch G, Krumlauf R, Viriot L, Peterkova R, Klein OD
• FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size.
  PLoS genetics 2011 Petersen CI, Jheon AH, Mostowfi P, Charles C, Ching S, Thirumangalathu S, Barlow LA, Klein OD
• Shh expression in a rudimentary tooth offers new insights into development of the mouse incisor.
  Journal of experimental zoology. Part B, Molecular and developmental evolution 2011 Hovorakova M, Prochazka J, Lesot H, Smrckova L, Churava S, Boran T, Kozmik Z, Klein O, Peterkova R, Peterka M
• The FaceBase Consortium: a comprehensive program to facilitate craniofacial research.
  Developmental biology 2011 Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Hallgrimsson B, Iwata J, Klein O, Marazita ML, Murray JC, Murray S, de …
• PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.
  Journal of cell science 2011 Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD
• Genotype-phenotype analysis of the branchio-oculo-facial syndrome.
  American journal of medical genetics. Part A 2011 Milunsky JM, Maher TM, Zhao G, Wang Z, Mulliken JB, Chitayat D, Clemens M, Stalker HJ, Bauer M, Burch M, Chénier S, Cunningham ML, Drack AV, Janssens S, Karlea A, Klatt R, Kini U, Klein O, Lachmeijer …
• Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor.
  Development (Cambridge, England) 2010 Seidel K, Ahn CP, Lyons D, Nee A, Ting K, Brownell I, Cao T, Carano RA, Curran T, Schober M, Fuchs E, Joyner A, Martin GR, de Sauvage FJ, Klein OD
• Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors.
  Development (Cambridge, England) 2010 Parsa S, Kuremoto K, Seidel K, Tabatabai R, Mackenzie B, Yamaza T, Akiyama K, Branch J, Koh CJ, Al Alam D, Klein OD, Bellusci S
• Clefting in trisomy 9p patients: genotype-phenotype correlation using microarray comparative genomic hybridization.
  The Journal of craniofacial surgery 2010 Jelin A, Perry H, Hogue J, Oberoi S, Cotter PD, Klein OD
• Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning.
  Development (Cambridge, England) 2010 Ahn Y, Sanderson BW, Klein OD, Krumlauf R
• Patterning by heritage in mouse molar row development.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Prochazka J, Pantalacci S, Churava S, Rothova M, Lambert A, Lesot H, Klein O, Peterka M, Laudet V, Peterkova R
• Dact1-3 mRNAs exhibit distinct expression domains during tooth development.
  Gene expression patterns : GEP 2010 Kettunen P, Kivimäe S, Keshari P, Klein OD, Cheyette BN, Luukko K
• Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Charles C, Lazzari V, Tafforeau P, Schimmang T, Tekin M, Klein O, Viriot L
• Temporal analysis of ectopic enamel production in incisors from sprouty mutant mice.
  Journal of experimental zoology. Part B, Molecular and developmental evolution 2009 Boran T, Peterkova R, Lesot H, Lyons DB, Peterka M, Klein OD
• Revitalization of a diastemal tooth primordium in Spry2 null mice results from increased proliferation and decreased apoptosis.
  Journal of experimental zoology. Part B, Molecular and developmental evolution 2009 Peterkova R, Churava S, Lesot H, Rothova M, Prochazka J, Peterka M, Klein OD
• Enamel-free teeth: Tbx1 deletion affects amelogenesis in rodent incisors.
  Developmental biology 2009 Catón J, Luder HU, Zoupa M, Bradman M, Bluteau G, Tucker AS, Klein O, Mitsiadis TA
• Continuous intravenous lidocaine in the treatment of paralytic ileus due to severe spinal cord injury.
  Acta anaesthesiologica Scandinavica 2008 Baumann A, Audibert G, Klein O, Mertes PM
• Genomic variants of ATF3 in patients with hypospadias.
  The Journal of urology 2008 Kalfa N, Liu B, Klein O, Wang MH, Cao M, Baskin LS
• Mutations of CXorf6 are associated with a range of severities of hypospadias.
  European journal of endocrinology 2008 Kalfa N, Liu B, Klein O, Ophir K, Audran F, Wang MH, Mei C, Sultan C, Baskin LS
• Acute fatal presentation of ornithine transcarbamylase deficiency in a previously healthy male.
  Hepatology international 2008 Klein OD, Kostiner DR, Weisiger K, Moffatt E, Lindeman N, Goodman S, Tuchman M, Packman S
• The branching programme of mouse lung development.
  Nature 2008 Metzger RJ, Klein OD, Martin GR, Krasnow MA
• An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors.
  Development (Cambridge, England) 2007 Klein OD, Lyons DB, Balooch G, Marshall GW, Basson MA, Peterka M, Boran T, Peterkova R, Martin GR
• Interstitial deletions of chromosome 6q: genotype-phenotype correlation utilizing array CGH.
  Clinical genetics 2007 Klein OD, Cotter PD, Moore MW, Zanko A, Gilats M, Epstein CJ, Conte F, Rauen KA
• Unraveling the molecular mechanisms that lead to supernumerary teeth in mice and men: current concepts and novel approaches.
  Cells, tissues, organs 2007 D'Souza RN, Klein OD
• Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling.
  Developmental cell 2006 Klein OD, Minowada G, Peterkova R, Kangas A, Yu BD, Lesot H, Peterka M, Jernvall J, Martin GR
• Interstitial deletion of chromosome 12q: genotype-phenotype correlation of two patients utilizing array comparative genomic hybridization.
  American journal of medical genetics. Part A 2005 Klein OD, Cotter PD, Schmidt AM, Bick DP, Tidyman WE, Albertson DG, Pinkel D, Rauen KA
• Brachydactylic multiple delta phalanges plus syndrome.
  American journal of medical genetics. Part A 2005 Ahn CP, Lachman RS, Cox VA, Blumberg B, Klein OD
• Case report: Y;6 translocation with deletion of 6p.
  Clinical dysmorphology 2005 Klein OD, Backstrand K, Cotter PD, Marco E, Sherr E, Slavotinek A
• Prader-Willi syndrome resulting from an unbalanced translocation: characterization by array comparative genomic hybridization.
  Clinical genetics 2004 Klein OD, Cotter PD, Albertson DG, Pinkel D, Tidyman WE, Moore MW, Rauen KA
• The Ultrasound Review of Obstetrics and Gynecology
  Congenital Müllerian anomalies: A review of currently available imaging modalities 2002 Raga F, Bonilla-Musoles F, Osborne NG, Casañ EM, Klein O, Bonilla F
• Assessment of endometrial volume by three-dimensional ultrasound prior to embryo transfer: clues to endometrial receptivity.
  Human reproduction (Oxford, England) 1999 Raga F, Bonilla-Musoles F, Casañ EM, Klein O, Bonilla F
• The bovine papillomavirus E5 protein requires a juxtamembrane negative charge for activation of the platelet-derived growth factor beta receptor and transformation of C127 cells.
  Journal of virology 1999 Klein O, Kegler-Ebo D, Su J, Smith S, DiMaio D
• Structural models of the bovine papillomavirus E5 protein.
  Proteins 1998 Surti T, Klein O, Aschheim K, DiMaio D, Smith SO
• Role of glutamine 17 of the bovine papillomavirus E5 protein in platelet-derived growth factor beta receptor activation and cell transformation.
  Journal of virology 1998 Klein O, Polack GW, Surti T, Kegler-Ebo D, Smith SO, DiMaio D
• Virocrine transformation: the intersection between viral transforming proteins and cellular signal transduction pathways.
  Annual review of microbiology 1998 DiMaio D, Lai CC, Klein O
• Mutational analysis of the catalytic residues lysine 230 and tyrosine 160 in the NADP(+)-dependent isocitrate dehydrogenase from Escherichia coli.
  Biochemistry 1995 Lee ME, Dyer DH, Klein OD, Bolduc JM, Stoddard BL, Koshland DE