Ophelia Yin, MD
Assistant Professor
Ob/Gyn, Reproductive Sciences
School of Medicine

She has notable expertise in caring for pregnant people who have had a solid organ transplant (including kidney, liver, heart, lung, pancreas, dual-organ and uterine transplants), helping them navigate the preconception, pregnancy and postpartum periods. In collaboration with neurologists, she supports pregnant patients affected by neurological conditions, such as multiple sclerosis, myasthenia gravis, epilepsy, stroke, vascular malformations, aneurysms, and other brain or spine problems. Her experience encompasses managing severe cases of placental disorders, including preeclampsia, and pregnancy-impacting autoimmune disease.

In her research, Yin works with the Transplant Pregnancy Registry International to advance care for transplant patients using a team-based approach. With the UCSF March of Dimes Prematurity Research Center, she investigates how the immune system contributes to complications in pregnancy and conducts translational studies – which apply lab findings to real-world patient care – focused on preeclampsia, placental abnormalities and preterm birth. She has been a scholar in the Chan Zuckerberg Biohub Physician-Scientist Program.

At Princeton University, Yin earned an undergraduate degree in ecology and evolutionary biology, with concentrations in bioengineering and in global health and health policy. She earned her medical degree at the Johns Hopkins University School of Medicine, where she was elected to the Alpha Omega Alpha Honor Medical Society. She completed a residency in obstetrics and gynecology at the University of California, Los Angeles, where she served as administrative chief resident, followed by a fellowship in maternal-fetal medicine at UCSF. During her medical training, she earned awards for community service, teaching, research and patient care. She is active in multiple national medical societies, including the Society for Maternal-Fetal Medicine, Society for Reproductive Investigation and American Society of Transplantation.

Yin grew up in Southern California and loves being back in her home state. Outside of work, she enjoys spending time with her husband, cats, family and friends. She loves nature, reading, traveling, and trying new foods and experiences in San Francisco.

• Clinical outcomes in patients with unintended pregnancy after liver transplantation: A multicenter registry cohort study.
  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2024 Walia A, Yin O, Coscia L, Afshar Y, Irani R, Constantinescu S, Moritz M, Sarkar M
• Differences in neonatal sepsis among immunosuppression regimens in pregnancies of transplant recipients.
  American journal of obstetrics & gynecology MFM 2024 Pithia N, Yin O, Coscia LA, Constantinescu S, Moritz MJ, Afshar Y
• Data-driven insights can transform women's reproductive health.
  npj women's health 2024 Oskotsky TT, Yin O, Khan U, Arnaout L, Sirota M
• Placenta accreta spectrum disorder at single-cell resolution: a loss of boundary limits in the decidua and endothelium.
  American journal of obstetrics and gynecology 2024 Afshar Y, Yin O, Jeong A, Martinez G, Kim J, Ma F, Jang C, Tabatabaei S, You S, Tseng HR, Zhu Y, Krakow D
• Associations with spontaneous and indicated preterm birth in a densely phenotyped EHR cohort.
  medRxiv : the preprint server for health sciences 2023 Costello JM, Takasuka H, Roger J, Yin O, Tang A, Oskotsky T, Sirota M, Capra JA
• Pregnancy after deceased donor vs living donor kidney transplant: associated obstetric and graft outcomes.
  American journal of obstetrics and gynecology 2023 Yin O, Coscia L, Constantinescu S, Moritz MJ, Afshar Y, Irani RA
• Emergent prelabor cesarean delivery in solid organ transplant recipients: associated risk factors and outcomes.
  American journal of obstetrics & gynecology MFM 2022 Chung K, Yin O, Kallapur A, Bass L, Coscia L, Constantinescu S, Moritz M, Afshar Y
• The role of Hippo pathway signaling and A-kinase anchoring protein 13 in primordial follicle activation and inhibition.
  F&S science 2022 Maher JY, Islam MS, Yin O, Brennan J, Gough E, Driggers P, Segars J
• Extracorporeal membrane oxygenation in pregnancy: details on novel therapies and cardiac, preeclampsia, and mood disorder complications.
  American journal of obstetrics and gynecology 2022 Yin O, Richley M, Afshar Y
• Extracorporeal membrane oxygenation in pregnancy: a bridge to delivery and pulmonary recovery for COVID-19-related severe respiratory failure.
  American journal of obstetrics and gynecology 2021 Yin O, Richley M, Hadaya J, Mei J, Mok T, Fahim M, Pluym ID, Rao R, Martin C, Han CS, Benharash P, Afshar Y
• Mode of Obstetric Delivery in Kidney and Liver Transplant Recipients and Associated Maternal, Neonatal, and Graft Morbidity During 5 Decades of Clinical Practice.
  JAMA network open 2021 Yin O, Kallapur A, Coscia L, Kwan L, Tandel M, Constantinescu SA, Moritz MJ, Afshar Y
• Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders.
  Nature communications 2021 Afshar Y, Dong J, Zhao P, Li L, Wang S, Zhang RY, Zhang C, Yin O, Han CS, Einerson BD, Gonzalez TL, Zhang H, Zhou A, Yang Z, Chou SJ, Sun N, Cheng J, Zhu H, Wang J, Zhang TX, Lee YT, Wang JJ, Teng PC,…
• Pregnancy care in solid organ transplant recipients.
  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2021 Kallapur A, Jang C, Yin O, Mei JY, Afshar Y
• Differentiating Acute Rejection From Preeclampsia After Kidney Transplantation.
  Obstetrics and gynecology 2021 Yin O, Kallapur A, Coscia L, Constantinescu S, Moritz M, Afshar Y
• Discordant congenital heart defects in monochorionic twins: Risk factors and proposed pathophysiology.
  PloS one 2021 Imany-Shakibai H, Yin O, Russell MR, Sklansky M, Satou G, Afshar Y
• Maternal Central Blood Pressure Is Associated with Fetal Middle Cerebral Artery Dopplers.
  Reproductive sciences (Thousand Oaks, Calif.) 2020 Woods A, Afshar Y, Yin O, Jones WM, Kwan L, Zhang H, Koos BJ, DeVore G
• Central hemodynamics are associated with fetal outcomes in pregnancies of advanced maternal age.
  Pregnancy hypertension 2019 Yin O, Woods A, Koos B, DeVore G, Afshar Y
• Edoxaban Versus Warfarin in Patients With Atrial Fibrillation and History of Liver Disease.
  Journal of the American College of Cardiology 2019 Qamar A, Antman EM, Ruff CT, Nordio F, Murphy SA, Grip LT, Greenberger NJ, Yin OQP, Choi Y, Lanz HJ, Mercuri MF, Braunwald E, Giugliano RP
• Association between polycystic ovary syndrome and hot flash presentation during the midlife period.
  Menopause (New York, N.Y.) 2018 Yin O, Zacur HA, Flaws JA, Christianson MS
• Lesbian, gay, bisexual, transgender content on reproductive endocrinology and infertility clinic websites.
  Fertility and sterility 2017 Wu HY, Yin O, Monseur B, Selter J, Collins LJ, Lau BD, Christianson MS
• Hysteroscopic polypectomy prior to infertility treatment: A cost analysis and systematic review.
  European journal of obstetrics, gynecology, and reproductive biology 2017 Mouhayar Y, Yin O, Mumford SL, Segars JH
• In Vitro Activation: A Dip Into the Primordial Follicle Pool?
  The Journal of clinical endocrinology and metabolism 2016 Yin O, Cayton K, Segars JH
• The Student Curriculum Review Team: How we catalyze curricular changes through a student-centered approach.
  Medical teacher 2014 Hsih KW, Iscoe MS, Lupton JR, Mains TE, Nayar SK, Orlando MS, Parzuchowski AS, Sabbagh MF, Schulz JC, Shenderov K, Simkin DJ, Vakili S, Vick JB, Xu T, Yin O, Goldberg HR