Onur Cil, MD, PhD
Assistant Professor
Pediatrics
School of Medicine

Our research is focused on membrane proteins including calcium-sensing receptor (CaSR), SLC26A3 (DRA), SLC26A4 (Pendrin), SLC26A6 (PAT1), CFTR, TMEM16A and urea transporters.

• Incidence and Mitigation of Corneal Pseudomicrocysts Induced by Antibody–Drug Conjugates (ADCs).
  Current Ophthalmology Reports 2024 Ethan S. Lindgren, Rongshan Yan, Onur Cil, Alan S. Verkman, Matilda F. Chan, Gerami D. Seitzman, Asim V. Farooq, Laura A. Huppert, Hope S. Rugo, Paula R. Pohlmann, Janice Lu, Laura J. Esserman, Neel D…
• Crypt and Villus Enterochromaffin Cells are Distinct Stress Sensors in the Gut.
  bioRxiv : the preprint server for biology 2024 Touhara KK, Rossen ND, Deng F, Chu T, Cil O, Li Y, Julius D
• Substituted 4-methylcoumarin inhibitors of SLC26A3 (DRA) for treatment of constipation and hyperoxaluria.
  RSC Medicinal Chemistry 2024 Maria Ahmadi, Livia de Souza Goncalves, Alan S. Verkman, Onur Cil, Marc O. Anderson
• Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment.
  Translational research : the journal of laboratory and clinical medicine 2023 Yottasan P, Chu T, Chhetri PD, Cil O
• Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment.
  Translational Research 2023 Pattareeya Yottasan, Tifany Chu, Parth D. Chhetri, Onur Cil
• Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders.
  RSC medicinal chemistry 2023 Chu T, Karmakar J, Haggie PM, Tan JA, Master R, Ramaswamy K, Verkman AS, Anderson MO, Cil O
• Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas.
  Translational research : the journal of laboratory and clinical medicine 2023 Chu T, Yottasan P, Goncalves LS, Oak AA, Lin R, Tse M, Donowitz M, Cil O
• Structure of human NCC: insights into the inhibition mechanism of thiazides.
  Signal transduction and targeted therapy 2023 de Souza Goncalves L, Yottasan P, Cil O
• Case report: Short-term eculizumab use in atypical HUS associated with Lemierre's syndrome and post-infectious glomerulonephritis.
  Frontiers in medicine 2023 Sadiq S, Urisman A, Cil O
• Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action.
  European journal of medicinal chemistry 2023 Cil O, Anderson MO, de Souza Goncalves L, Tan JA, Haggie PM, Verkman AS
• Genetic testing in children with nephrolithiasis and nephrocalcinosis.
  Pediatric nephrology (Berlin, Germany) 2023 Gefen AM, Sethna CB, Cil O, Perwad F, Schoettler M, Michael M, Angelo JR, Safdar A, Amlie-Wolf L, Hunley TE, Ellison JS, Feig D, Zaritsky J
• Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders.
  RSC Medicinal Chemistry 2023 Tifany Chu, Joy Karmakar, Peter M. Haggie, Joseph-Anthony Tan, Riya Master, Keerthana Ramaswamy, Alan S. Verkman, Marc O. Anderson, Onur Cil
• Ocular Surface Ion Transport and Dry Eye Disease.
  Current Ophthalmology Reports 2022 Ethan S. Lindgren, Onur Cil, Alan S. Verkman, Neel D. Pasricha
• Ocular Surface Ion Transport and Dry Eye Disease.
  Current ophthalmology reports 2022 Lindgren ES, Cil O, Verkman AS, Pasricha ND
• Cystinuria: An Overview of Diagnosis and Medical Management.
  Turkish archives of pediatrics 2022 Sadiq S, Cil O
• Lubiprostone is non-selective activator of cAMP-gated ion channels and Clc-2 has a minor role in its prosecretory effect in intestinal epithelial cells.
  Molecular pharmacology 2022 Oak AA, Chu T, Yottasan P, Chhetri PD, Zhu J, Du Bois J, Cil O
• SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine.
  JCI insight 2021 Cil O, Haggie PM, Tan JT, Rivera AA, Verkman AS
• 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation.
  Journal of medicinal chemistry 2019 Lee S, Cil O, Haggie PM, Verkman AS
• Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Cil O, Anderson MO, Yen R, Kelleher B, Huynh TL, Seo Y, Nilsen SP, Turner JR, Verkman AS
• Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS
• Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea.
  JCI insight 2019 Duan T, Cil O, Thiagarajah JR, Verkman AS
• SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation.
  JCI insight 2018 Haggie PM, Cil O, Lee S, Tan JA, Rivera AA, Phuan PW, Verkman AS
• Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1.
  Journal of medicinal chemistry 2018 Lee S, Cil O, Diez-Cecilia E, Anderson MO, Verkman AS
• Monogenic Causes of Proteinuria in Children.
  Frontiers in medicine 2018 Cil O, Perwad F
• Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A).
  Journal of medicinal chemistry 2017 Truong EC, Phuan PW, Reggi AL, Ferrera L, Galietta LJV, Levy SE, Moises AC, Cil O, Diez-Cecilia E, Lee S, Verkman AS, Anderson MO
• High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators.
  Journal of medicinal chemistry 2017 Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth MJ
• Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS
• Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation.
  Translational research : the journal of laboratory and clinical medicine 2016 Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS
• A Turkish BCS1L mutation causes GRACILE-like disorder.
  The Turkish journal of pediatrics 2016 Serdaroglu E, Takci S, Kotarsky H, Çil O, Utine E, Yigit S, Fellman V
• MCP1 2518 A/G polymorphism affects progression of childhood focal segmental glomerulosclerosis.
  Renal failure 2015 Besbas N, Kalyoncu M, Cil O, Ozgul RK, Bakkaloglu A, Ozaltin F
• Genetic abnormalities and prognosis in patients with congenital and infantile nephrotic syndrome.
  Pediatric nephrology (Berlin, Germany) 2015 Cil O, Besbas N, Duzova A, Topaloglu R, Peco-Antic A, Korkmaz E, Ozaltin F
• Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Esteva-Font C, Cil O, Phuan PW, Su T, Lee S, Anderson MO, Verkman AS
• Small-molecule inhibitors of urea transporters.
  Sub-cellular biochemistry 2014 Verkman AS, Esteva-Font C, Cil O, Anderson MO, Li F, Li M, Lei T, Ren H, Yang B
• A novel mutation in protein C gene (PROC) causing severe phenotype in neonatal period.
  Pediatric blood & cancer 2013 Unal S, Gumruk F, Yigit S, Tuncer M, Tavil B, Cil O, Takci S, Urata M, Hotta T, Kang D, Cetin M
• Protective effect of coenzyme Q10 in paclitaxel-induced peripheral neuropathy in rats.
  Neurosciences (Riyadh, Saudi Arabia) 2013 Celebi N, Cil H, Cil O, Canbay O, Onur R, Aypar U
• Role of CXCR1 (CKR-1) in inflammation of experimental mesangioproliferative glomerulonephritis.
  Renal failure 2013 Ozaltin F, Besbas N, Iskit AB, Cil O, Akcoren Z, Kale G, Bakkaloglu A
• The diuretic effect of urea analog dimethylthiourea in female Wistar rats.
  Human & experimental toxicology 2012 Cil O, Ertunc M, Onur R
• Endothelial dysfunction and increased responses to renal nerve stimulation in rat kidneys during rhabdomyolysis-induced acute renal failure: role of hydroxyl radical.
  Renal failure 2012 Cil O, Ertunc M, Gucer KS, Ozaltin F, Iskit AB, Onur R
• Evidence for pathogenicity of atypical splice mutations in autosomal dominant polycystic kidney disease.
  Clinical journal of the American Society of Nephrology : CJASN 2009 Wang K, Zhao X, Chan S, Cil O, He N, Song X, Paterson AD, Pei Y