Ons Zakraoui, PhD
Associate Specialist
Radiation Oncology
School of Medicine

Publications (14)

Top publication keywords:
CyclohexenesSingle-Domain AntibodiesDisintegrinsEucalyptusImmunotherapy, AdoptiveCell Cycle CheckpointsColonic NeoplasmsNeovascularization, PathologicViper VenomsAntigens, Differentiation, B-LymphocyteOils, VolatileVascular Endothelial Growth Factor ADown-RegulationCD27 LigandViperidae

• Affinity-matured CD72-targeting nanobody CAR T cells enhance elimination of antigen-low B-cell malignancies.
  Journal for immunotherapy of cancer 2025 Izgutdina A, Rashid T, Temple WC, Aminov S, Patiño-Escobar B, Walunj S, Geng H, Takamatsu H, Gil-Alós D, Kang AS, Ramos E, Chen SY, Johnson H, Nix MA, Naik A, Li M, Yuan CM, Wang HW, Sahu S, Larson RC…
• Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype.
  Cellular and molecular life sciences : CMLS 2025 Arcuschin CD, Kahrizi K, Sayaman RW, DiBenedetto C, Salaberry PJ, Pirker R, Shen Y, Zakraoui O, Schwarzer C, Scapozza A, Caruso JA, Betancur P, Saba JD, Coppé JP, Barcellos-Hoff MH, Kappes D, van 't …
• Deciphering the Mechanisms Underlying the Antitumor Effects of Eucalyptus Essential Oil and Its Component 3-Cyclohexene-1-Methanol Against Human Colon Cancer Cells.
  International journal of molecular sciences 2025 Ben Hamouda S, Zakraoui O, Souissi S, Bouzeyen R, Essafi M, Essafi-Benkhadir K
• Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR T cells.
  Blood 2025 Kasap C, Izgutdina A, Patiño-Escobar B, Kang AS, Chilakapati N, Akagi N, Manoj A, Johnson H, Rashid T, Werner J, Barpanda A, Geng H, Lin YT, Rampersaud S, Gil-Alós D, Sobh A, Dupéré-Richer D, Aleman A…
• Affinity-matured CD72-targeting Nanobody CAR T-cells Enhance Elimination of Antigen-Low B-cell Malignancies.
  bioRxiv : the preprint server for biology 2025 Izgutdina A, Rashid T, Temple WC, Patiño-Escobar B, Walunj S, Geng H, Takamatsu H, Gil-Alós D, Kang AS, Ramos E, Chen SY, Johnson H, Nix MA, Naik A, Yuan CM, Wang HW, Aminov S, Sahu S, Larson RC, …

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• Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4 + cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype.
  bioRxiv : the preprint server for biology 2024 Arcuschin CD, Kahrizi K, Sayaman RW, DiBenedetto C, Shen Y, Salaberry PJ, Zakroui O, Schwarzer C, Scapozza A, Betancur P, Saba JD, Coppé JP, Barcellos-Hoff MH, Kappes D, van 't Veer L, Schor IE, Muñoz…
• Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells.
  bioRxiv : the preprint server for biology 2024 Kasap C, Izgutdina A, Patiño-Escobar B, Kang A, Chilakapati N, Akagi N, Johnson H, Rashid T, Werner J, Barpanda A, Geng H, Lin YT, Rampersaud S, Gil-Alós D, Sobh A, Dupéré-Richer D, Wicaksono G, …
• CC5 and CC8, Two Disintegrin Isoforms from Cerastes cerastes Snake Venom Decreased Inflammation Response In Vitro and In Vivo.
  International journal of molecular sciences 2023 Morjen M, Zakraoui O, Abdelkafi-Koubaa Z, Srairi-Abid N, Marrakchi N, Essafi-Benkhadir K, Jebali J
• Lebecetin, a snake venom C-type lectin protein, modulates LPS-induced inflammatory cytokine production in human THP-1-derived macrophages.
  Toxicon : official journal of the International Society on Toxinology 2020 Jebali J, Zakraoui O, Aissaoui D, Abdelkafi-Koubaa Z, Srairi-Abid N, Marrakchi N, Essafi-Benkhadir K
• Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A.
  PLoS neglected tropical diseases 2018 Harigua-Souiai E, Abdelkrim YZ, Bassoumi-Jamoussi I, Zakraoui O, Bouvier G, Essafi-Benkhadir K, Banroques J, Desdouits N, Munier-Lehmann H, Barhoumi M, Tanner NK, Nilges M, Blondel A, Guizani I
• Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-κB Signaling.
  Marine drugs 2017 Tarhouni-Jabberi S, Zakraoui O, Ioannou E, Riahi-Chebbi I, Haoues M, Roussis V, Kharrat R, Essafi-Benkhadir K
• Lebein, a Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells.
  Toxins 2016 Hammouda MB, Montenegro MF, Sánchez-Del-Campo L, Zakraoui O, Aloui Z, Riahi-Chebbi I, Karoui H, Rodríguez-López JN, Essafi-Benkhadir K
• Quince peel polyphenolic extract blocks human colon adenocarcinoma LS174 cell growth and potentiates 5-fluorouracil efficacy.
  Cancer cell international 2016 Riahi-Chebbi I, Haoues M, Essafi M, Zakraoui O, Fattouch S, Karoui H, Essafi-Benkhadir K
• Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression.
  Molecular carcinogenesis 2016 Zakraoui O, Marcinkiewicz C, Aloui Z, Othman H, Grépin R, Haoues M, Essafi M, Srairi-Abid N, Gasmi A, Karoui H, Pagès G, Essafi-Benkhadir K