Olivier Mailhot, PhD
Postdoctoral Scholar
Pharmaceutical Chemistry
School of Pharmacy

Education & Training

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• PhD Bioinformatics Université de Montréal 12/2022

Publications (11)

Top publication keywords:
MicroRNAsSpike Glycoprotein, CoronavirusUbiquitinReceptors, Opioid, muAptamers, NucleotideProteinsMachine LearningHemorrhagic Fever, EbolaRNA, CatalyticEbolavirusMotionSoftwareBenchmarkingNucleocapsid ProteinsProtein Conformation

• The impact of library size and scale of testing on virtual screening.
  Nature chemical biology 2025 Liu F, Mailhot O, Glenn IS, Vigneron SF, Bassim V, Xu X, Fonseca-Valencia K, Smith MS, Radchenko DS, Fraser JS, Moroz YS, Irwin JJ, Shoichet BK
• Understanding and Predicting Ligand Efficacy in the μ-Opioid Receptor through Quantitative Dynamical Analysis of Complex Structures.
  Journal of chemical information and modeling 2024 Galdino GT, Mailhot O, Najmanovich R
• The impact of Library Size and Scale of Testing on Virtual Screening.
  bioRxiv : the preprint server for biology 2024 Liu F, Mailhot O, Glenn IS, Vigneron SF, Bassim V, Xu X, Fonseca-Valencia K, Smith MS, Radchenko DS, Fraser JS, Moroz YS, Irwin JJ, Shoichet BK
• Ebola virus VP35 interacts non-covalently with ubiquitin chains to promote viral replication.
  PLoS biology 2024 Rodríguez-Salazar CA, van Tol S, Mailhot O, Gonzalez-Orozco M, Galdino GT, Warren AN, Teruel N, Behera P, Afreen KS, Zhang L, Juelich TL, Smith JK, Zylber MI, Freiberg AN, Najmanovich RJ, Giraldo MI, …
• DockOpt: A Tool for Automatic Optimization of Docking Models.
  Journal of chemical information and modeling 2024 Knight IS, Mailhot O, Tang KG, Irwin JJ

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• The DynaSig-ML Python package: automated learning of biomolecular dynamics-function relationships.
  Bioinformatics (Oxford, England) 2023 Mailhot O, Major F, Najmanovich R
• Sequence-sensitive elastic network captures dynamical features necessary for miR-125a maturation.
  PLoS computational biology 2022 Mailhot O, Frappier V, Major F, Najmanovich RJ
• The NRGTEN Python package: an extensible toolkit for coarse-grained normal mode analysis of proteins, nucleic acids, small molecules and their complexes.
  Bioinformatics (Oxford, England) 2021 Mailhot O, Najmanovich R
• Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants.
  PLoS computational biology 2021 Teruel N, Mailhot O, Najmanovich RJ
• RNA-Puzzles Round IV: 3D structure predictions of four ribozymes and two aptamers.
  RNA (New York, N.Y.) 2020 Miao Z, Adamiak RW, Antczak M, Boniecki MJ, Bujnicki J, Chen SJ, Cheng CY, Cheng Y, Chou FC, Das R, Dokholyan NV, Ding F, Geniesse C, Jiang Y, Joshi A, Krokhotin A, Magnus M, Mailhot O, Major F, Mann …
• A three-way inter-molecular network accounts for the CaVα2δ1-induced functional modulation of the pore-forming CaV1.2 subunit.
  The Journal of biological chemistry 2018 Briot J, Mailhot O, Bourdin B, Tétreault MP, Najmanovich R, Parent L