Olga Tymofiyeva, PhD
Associate Professor
Radiology
School of Medicine

Her main research interest is non-invasive mapping of structural and functional connectivity in the developing brain, from premature neonates to adolescents and young adults. She develops and applies advanced MRI techniques to study the neurobiological substrates of mental disorders (in particular, adolescent depression) and effects of mind-body interventions on children and adolescents. Dr. Tymofiyeva is currently the Principal Investigator for an NIH-funded study of brain plasticity in adolescents undergoing a mindfulness meditation training, the "BrainChange" study: https://radiology.ucsf.edu/research/labs/BrainChange.

• A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma.
  Frontiers in human neuroscience 2022 Tymofiyeva O, Hu R, Kidambi R, Nguyen C, Max JE, Yang TT
• The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment.
  Brain, behavior, & immunity - health 2022 Freimer D, Yang TT, Ho TC, Tymofiyeva O, Leung C
• Resting state brain subnetwork relates to prosociality and compassion in adolescents.
  Frontiers in psychology 2022 Sipes BS, Jakary A, Li Y, Max JE, Yang TT, Tymofiyeva O
• 2.45 Neural Correlates of Smartphone Dependence and Links to Depression in Adolescents.
  Journal of the American Academy of Child & Adolescent Psychiatry 2022 Brandon Nguyen, Olga Tymofiyeva, Benjamin S. Sipes, Angela Jakary, Daniel Freimer, Yi Li, Tony T. Yang
• Novel Psychiatric Disorder 6 Months After Traumatic Brain Injury in Children and Adolescents.
  The Journal of neuropsychiatry and clinical neurosciences 2022 Max JE, Drake I, Vaida F, Hesselink JR, Ewing-Cobbs L, Schachar RJ, Chapman SB, Bigler ED, Wilde EA, Saunders AE, Yang TT, Tymofiyeva O, Levin HS
• A Feasibility Study of a Remotely-Delivered Mindfulness-Based Training for Adolescents During the COVID-19 Pandemic.
  Frontiers in psychiatry 2022 Tymofiyeva O, Hu MY, Sipes BS, Jakary A, Glidden DV, Jariwala N, Bhandari S, Parks KC, Nguyen C, Henje E, Yang TT
• A Domain-General Developmental "Do-GooD" Network Model of Prosocial Cognition in Adolescence: A Systematic Review.
  Frontiers in behavioral neuroscience 2022 Sipes BS, Yang TT, Parks KC, Jariwala N, Tymofiyeva O
• Novel Oppositional Defiant Disorder 12 Months After Traumatic Brain Injury in Children and Adolescents.
  The Journal of neuropsychiatry and clinical neurosciences 2022 Lowet DS, Vaida F, Hesselink JR, Levin HS, Ewing-Cobbs L, Schachar RJ, Chapman SB, Bigler ED, Wilde EA, Saunders AE, Yang TT, Tymofiyeva O, Max JE
• Neonatal brain injury influences structural connectivity and childhood functional outcomes.
  PloS one 2022 Ramirez A, Peyvandi S, Cox S, Gano D, Xu D, Tymofiyeva O, McQuillen PS
• Novel Oppositional Defiant Disorder 6 Months After Traumatic Brain Injury in Children and Adolescents.
  The Journal of neuropsychiatry and clinical neurosciences 2021 Lowet DS, Kolan A, Vaida F, Hesselink JR, Levin HS, Ewing-Cobbs L, Schachar RJ, Chapman SB, Bigler ED, Wilde EA, Saunders AE, Yang TT, Tymofiyeva O, Arif H, Max JE
• 1.3 A Feasibility Study of a Remotely Delivered Mindfulness Training for Adolescents During the COVID-19 Pandemic.
  Journal of the American Academy of Child & Adolescent Psychiatry 2021 Olga Tymofiyeva, Melody Hu, Benjamin Sipes, Namasvi Jariwala, Angela Jakary, Ca Nguyen, Kendall Parks, Eva Henje, Tony Yang
• Traumatic Brain Injury in Children and Adolescents: Psychiatric Disorders 24 Years Later.
  The Journal of neuropsychiatry and clinical neurosciences 2021 Max JE, Troyer EA, Arif H, Vaida F, Wilde EA, Bigler ED, Hesselink JR, Yang TT, Tymofiyeva O, Wade O, Paulsen JS
• Long-Term Psychiatric Outcomes in Adults with History of Pediatric Traumatic Brain Injury.
  Journal of neurotrauma 2021 Arif H, Troyer EA, Paulsen JS, Vaida F, Wilde EA, Bigler ED, Hesselink JR, Yang TT, Tymofiyeva O, Wade O, Max JE
• Training-Induced Neural Plasticity in Youth: A Systematic Review of Structural and Functional MRI Studies.
  Frontiers in human neuroscience 2021 Tymofiyeva O, Gaschler R
• Reduced anxiety and changes in amygdala network properties in adolescents with training for awareness, resilience, and action (TARA).
  NeuroImage. Clinical 2020 Tymofiyeva O, Henje E, Yuan JP, Huang CY, Connolly CG, Ho TC, Bhandari S, Parks KC, Sipes BS, Yang TT, Xu D
• Neural Correlates of Smartphone Dependence in Adolescents.
  Frontiers in human neuroscience 2020 Tymofiyeva O, Yuan JP, Kidambi R, Huang CY, Henje E, Rubinstein ML, Jariwala N, Max JE, Yang TT, Xu D
• 1.4 CHILDHOOD TRAUMA AND AMYGDALA-ORBITOFRONTAL ANATOMICAL CONNECTIVITY IN ADOLESCENTS.
  Journal of the American Academy of Child & Adolescent Psychiatry 2020 Olga Tymofiyeva, Chiung-Yu Huang, Sarina Bhandari, Eric Lopez, Kendall Parks, Namasvi Jariwala, Benjamin Sipes, Tony T. Yang
• Gray Matter Changes in Adolescents Participating in a Meditation Training.
  Frontiers in human neuroscience 2020 Yuan JP, Connolly CG, Henje E, Sugrue LP, Yang TT, Xu D, Tymofiyeva O
• MRI Insights Into Adolescent Neurocircuitry-A Vision for the Future.
  Frontiers in human neuroscience 2020 Tymofiyeva O, Zhou VX, Lee CM, Xu D, Hess CP, Yang TT
• 4.32 SMARTPHONE DEPENDENCE, BRAIN CONNECTIVITY, AND LINKS TO DEPRESSION IN ADOLESCENTS.
  Journal of the American Academy of Child & Adolescent Psychiatry 2019 Olga Tymofiyeva, Justin Yuan, Roma Kidambi, Chiung-Yu Huang, Eva Henje Blom, Mark Rubinstein, Duan Xu, Tony T. Yang
• Application of machine learning to structural connectome to predict symptom reduction in depressed adolescents with cognitive behavioral therapy (CBT).
  NeuroImage. Clinical 2019 Tymofiyeva O, Yuan JP, Huang CY, Connolly CG, Henje Blom E, Xu D, Yang TT
• MEDU-15. STRUCTURAL BRAIN NETWORK PROPERTIES AND COGNITIVE IMPAIRMENT IN ADOLESCENTS AFTER RADIATION THERAPY.
  Neuro-Oncology 2019 Justin Yuan, Melanie Morrison, Angela Jakary, Sabine Mueller, Olga Tymofiyeva, Duan Xu, Janine Lupo
• Test-Retest Reliability of Graph Theoretic Metrics in Adolescent Brains.
  Brain connectivity 2018 Yuan JP, Henje Blom E, Flynn T, Chen Y, Ho TC, Connolly CG, Dumont Walter RA, Yang TT, Xu D, Tymofiyeva O
• Aberrant Structural Brain Connectivity in Adolescents with Attentional Problems Who Were Born Prematurely.
  AJNR. American journal of neuroradiology 2018 Tymofiyeva O, Gano D, Trevino RJ, Glass HC, Flynn T, Lundy SM, McQuillen PS, Ferriero DM, Barkovich AJ, Xu D
• 5.48 Using MRI to Predict Depression Symptom Improvement in Depressed Adolescents Undergoing Cbt.
  Journal of the American Academy of Child & Adolescent Psychiatry 2018 Olga Tymofiyeva, Justin Yuan, Colm Connolly, Eva Henje Blom, Duan Xu, Tony T. Yang
• An exploratory examination of reappraisal success in depressed adolescents: Preliminary evidence of functional differences in cognitive control brain regions.
  Journal of affective disorders 2018 LeWinn KZ, Strigo IA, Connolly CG, Ho TC, Tymofiyeva O, Sacchet MD, Weng HY, Blom EH, Simmons AN, Yang TT
• Session 112 Emerging Multimodal Neuroimaging Findings in LATE Life Depression.
  American Journal of Geriatric Psychiatry 2018 J.C. Nelson, Scott Mackin, Duygu Tosun, Olga Tymofiyeva
• High levels of mitochondrial DNA are associated with adolescent brain structural hypoconnectivity and increased anxiety but not depression.
  Journal of affective disorders 2018 Tymofiyeva O, Henje Blom E, Ho TC, Connolly CG, Lindqvist D, Wolkowitz OM, Lin J, LeWinn KZ, Sacchet MD, Han LKM, Yuan JP, Bhandari SP, Xu D, Yang TT
• High-resolution MR imaging for dental impressions: a feasibility study.
  Clinical oral investigations 2017 Boldt J, Rottner K, Schmitter M, Hopfgartner A, Jakob P, Richter EJ, Tymofiyeva O
• Inflexible Functional Connectivity of the Dorsal Anterior Cingulate Cortex in Adolescent Major Depressive Disorder.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2017 Ho TC, Sacchet MD, Connolly CG, Margulies DS, Tymofiyeva O, Paulus MP, Simmons AN, Gotlib IH, Yang TT
• Feasibility and Preliminary Efficacy of a Novel RDoC-Based Treatment Program for Adolescent Depression: "Training for Awareness Resilience and Action" (TARA)-A Pilot Study.
  Frontiers in psychiatry 2017 Henje Blom E, Tymofiyeva O, Chesney MA, Ho TC, Moran P, Connolly CG, Duncan LG, Baldini L, Weng HY, Acree M, Goldman V, Hecht FM, Yang TT
• Microstructure of the Default Mode Network in Preterm Infants.
  AJNR. American journal of neuroradiology 2016 Cui J, Tymofiyeva O, Desikan R, Flynn T, Kim H, Gano D, Hess CP, Ferriero DM, Barkovich AJ, Xu D
• Resting-state functional connectivity of the amygdala and longitudinal changes in depression severity in adolescent depression.
  Journal of affective disorders 2016 Connolly CG, Ho TC, Blom EH, LeWinn KZ, Sacchet MD, Tymofiyeva O, Simmons AN, Yang TT
• DTI-based connectome analysis of adolescents with major depressive disorder reveals hypoconnectivity of the right caudate.
  Journal of affective disorders 2016 Tymofiyeva O, Connolly CG, Ho TC, Sacchet MD, Henje Blom E, LeWinn KZ, Xu D, Yang TT
• Large-Scale Hypoconnectivity Between Resting-State Functional Networks in Unmedicated Adolescent Major Depressive Disorder.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2016 Sacchet MD, Ho TC, Connolly CG, Tymofiyeva O, Lewinn KZ, Han LK, Blom EH, Tapert SF, Max JE, Frank GK, Paulus MP, Simmons AN, Gotlib IH, Yang TT
• The neuroscience and context of adolescent depression.
  Acta paediatrica (Oslo, Norway : 1992) 2016 Henje Blom E, Ho TC, Connolly CG, LeWinn KZ, Sacchet MD, Tymofiyeva O, Weng HY, Yang TT
• Effects of rejecting diffusion directions on tensor-derived parameters.
  NeuroImage 2015 Chen Y, Tymofiyeva O, Hess CP, Xu D
• Structural MRI connectome in development: challenges of the changing brain.
  The British journal of radiology 2014 Tymofiyeva O, Hess CP, Xu D, Barkovich AJ
• Brain without anatomy: construction and comparison of fully network-driven structural MRI connectomes.
  PloS one 2014 Tymofiyeva O, Ziv E, Barkovich AJ, Hess CP, Xu D
• A machine learning approach to automated structural network analysis: application to neonatal encephalopathy.
  PloS one 2013 Ziv E, Tymofiyeva O, Ferriero DM, Barkovich AJ, Hess CP, Xu D
• Dynamic MRI of the TMJ under physical load.
  Dento maxillo facial radiology 2013 Hopfgartner AJ, Tymofiyeva O, Ehses P, Rottner K, Boldt J, Richter EJ, Jakob PM
• A DTI-based template-free cortical connectome study of brain maturation.
  PloS one 2013 Tymofiyeva O, Hess CP, Ziv E, Lee PN, Glass HC, Ferriero DM, Barkovich AJ, Xu D
• Influence of dental materials on dental MRI.
  Dento maxillo facial radiology 2013 Tymofiyeva O, Vaegler S, Rottner K, Boldt J, Hopfgartner AJ, Proff PC, Richter EJ, Jakob PM
• Diagnosis of dental abnormalities in children using 3-dimensional magnetic resonance imaging.
  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2013 Tymofiyeva O, Proff PC, Rottner K, Düring M, Jakob PM, Richter EJ
• Towards the "baby connectome": mapping the structural connectivity of the newborn brain.
  PloS one 2012 Tymofiyeva O, Hess CP, Ziv E, Tian N, Bonifacio SL, McQuillen PS, Ferriero DM, Barkovich AJ, Xu D
• On precise localization of boundaries between extended uniform objects in MRI: tooth imaging as an example.
  Magma (New York, N.Y.) 2010 Tymofiyeva O, Schmid F, von Kienlin M, Breuer FA, Rottner K, Boldt J, Richter EJ, Jakob PM
• High-resolution 3D magnetic resonance imaging and quantification of carious lesions and dental pulp in vivo.
  Magma (New York, N.Y.) 2009 Tymofiyeva O, Boldt J, Rottner K, Schmid F, Richter EJ, Jakob PM
• Three-dimensional localization of impacted teeth using magnetic resonance imaging.
  Clinical oral investigations 2009 Tymofiyeva O, Rottner K, Jakob PM, Richter EJ, Proff P
• In Vivo 3D Imaging of Carious Lesions and Dental Pulp Using Magnetic Resonance.
  World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany 2009 O. Tymofiyeva, K. Rottner, J. Boldt, F. Schmid, E. -J. Richter, P. M. Jakob
• In vivo MRI-based dental impression using an intraoral RF receiver coil.
  Concepts in Magnetic Resonance Part B 2008 O. Tymofiyeva, K. Rottner, D. Gareis, J. Boldt, F. Schmid, M.A. Lopez, E.-J. Richter, P.M. Jakob
• In vivo MRI-based dental impression using an intraoral RF receiver coil
  Concept Magn Reson B: Magn Reson Eng 2008 Tymofiyeva O, Rottner K, Gareis D, Boldt J, Schmid F, Lopez MA, Richter E-J, Jakob PM
• Correlation of MRT imaging with real-time axiography of TMJ clicks.
  Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2007 Tymofiyeva O, Proff P, Richter EJ, Jakob P, Fanghänel J, Gedrange T, Rottner K