Nyarie Sithole, PhD, MSc
Visiting Scholar
Medicine
School of Medicine

Awards

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• Wellcome Trust Research Career Development Award, University of Cambridge, UK, 2023
• NIHR Academic Clinical Lecturer, Infectious Diseases, University of Cambridge, UK, 2019-2021
• Wellcome Trust Clinical Research Fellowship, University of Cambridge, UK, 2013-2016
• Teacher of the Month - June, Oxford University Teaching Hospital, 2012
• Evelyn Research Fellowship, University of Cambridge, UK, 2010-2011
• British Chevening Scholarship, Liverpool School of Tropical Medicine, 2008-2009
• Glen Williams Award, Best MSc Student, Liverpool School of Tropical Medicine, 2008

Education & Training

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• PhD Doctor of Philosophy in Medicine University of Cambridge 05/2017
• General Internal Medicine Oxford University Teaching Hospital
• FRCP Medicine Royal College of Physicians, London
• MSc MSc Infectious Diseases and Tropical Medicine University of Liverpool,
• MBChB Medicine and Surgery University of Zimbabwe Medical School

Interests

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• Mycobacterium tuberculosis
• FcyR antibodies effector functions
• Long COVID
• HIV and viral gene regul

Grants and Projects

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• Mechanisms of antibody mediated protection against Mycobacterium tuberculosis, Wellcome Trust, 2023-2028

Publications (18)

Top publication keywords:
RNA Splice SitesNeurosyphilisInfluenza, HumanDeliriumT-LymphocytesTranscription FactorsAlternative SplicingSensitivity and SpecificityGene Expression Regulation, ViralAntibodies, ViralHIV-1Treponema pallidumOseltamivirtat Gene Products, Human Immunodeficiency VirusDEAD-box RNA Helicases

• Comparison of different T cell assays for the retrospective determination of SARS-CoV-2 infection.
  The Journal of general virology 2024 Krishna B, Metaxaki M, Perera M, Wills M, Sithole N
• Coronavirus disease 2019-related myocardial injury is associated with immune dysregulation in symptomatic patients with cardiac magnetic resonance imaging abnormalities.
  Cardiovascular research 2024 Corovic A, Zhao X, Huang Y, Newland SR, Gopalan D, Harrison J, Giakomidi D, Chen S, Yarkoni NS, Wall C, Peverelli M, Sriranjan R, Gallo A, Graves MJ, Sage A, Lyons PA, Sithole N, Bennett MR, Rudd JHF,…
• Long COVID: what is known and what gaps need to be addressed.
  British medical bulletin 2023 Krishna B, Wills M, Sithole N
• Reduced Incidence of Long Coronavirus Disease Referrals to the Cambridge University Teaching Hospital Long Coronavirus Disease Clinic.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2023 Krishna BA, Metaxaki M, Wills MR, Sithole N
• Oseltamivir is protective for in-patient mortality in PCR confirmed influenza B and influenza A(H3N2) infections in an historic cohort of 1,048 patients hospitalised during the 2016-17 and 2017-18  influenza seasons.
  The Journal of infection 2023 Reacher M, Warne B, Verlander NQ, Popay A, Reeve L, Jones NK, Ranellou K, Sithole N, Carpenter R, Everden A, Jarman E, Khalid A, Lam K, Myers C, Ren S, Rolfe KJ, Sutton T, Christou S, Wright C, …
• Demographic, behavioural and occupational risk factors associated with SARS-CoV-2 infection in UK healthcare workers: a retrospective observational study.
  BMJ open 2022 Cooper DJ, Lear S, Sithole N, Shaw A, Stark H, Ferris M, CITIID-NIHR BioResource COVID-19 collaboration consortium, Bradley J, Maxwell P, Goodfellow I, Weekes MP, Seaman S, Baker S
• Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID.
  EBioMedicine 2022 Krishna BA, Lim EY, Mactavous L, NIHR BioResource Team, Lyons PA, Doffinger R, Bradley JR, Smith KGC, Sinclair J, Matheson NJ, Lehner PJ, Wills MR, Sithole N
• Investigation of healthcare-associated SARS-CoV-2 infection: Learning outcomes from an investigative process in the initial phase of the pandemic.
  Journal of infection prevention 2022 Ramsay I, Sharrocks K, Warne B, Sithole N, Ravji P, Bousfield R, Jones N, Leong CE, Suliman M, Tsui R, Toleman MS, Moody C, Smith R, Whitehorn J, Gouliouris T, Penciu F, Hofling C, Cunningham C, Enoch…
• Multivariate profile and acute-phase correlates of cognitive deficits in a COVID-19 hospitalised cohort.
  EClinicalMedicine 2022 Hampshire A, Chatfield DA, MPhil AM, Jolly A, Trender W, Hellyer PJ, Giovane MD, Newcombe VFJ, Outtrim JG, Warne B, Bhatti J, Pointon L, Elmer A, Sithole N, Bradley J, Kingston N, Sawcer SJ, Bullmore …
• The great imitator: neurosyphilis presenting as subacute confusion.
  British journal of hospital medicine (London, England : 2005) 2021 G N, Moore E, Sithole N
• Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study.
  Cell reports. Medicine 2020 Collier DA, Assennato SM, Warne B, Sithole N, Sharrocks K, Ritchie A, Ravji P, Routledge M, Sparkes D, Skittrall J, Smielewska A, Ramsey I, Goel N, Curran M, Enoch D, Tassell R, Lineham M, Vaghela D, …
• DDX5 potentiates HIV-1 transcription as a co-factor of Tat.
  Retrovirology 2020 Sithole N, Williams CA, Abbink TEM, Lever AML
• DDX17 Specifically, and Independently of DDX5, Controls Use of the HIV A4/5 Splice Acceptor Cluster and Is Essential for Efficient Replication of HIV.
  Journal of molecular biology 2018 Sithole N, Williams CA, Vaughan AM, Kenyon JC, Lever AML
• The roles of DEAD box helicases in the life cycle of HIV-1.
  Lancet (London, England) 2015 Sithole N, Williams C, Vaughan A, Lever A

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• Spontaneous, persistent, T cell-dependent IFN-γ release in patients who progress to Long Covid.
  Science advances 2024 Krishna BA, Lim EY, Metaxaki M, Jackson S, Mactavous L, NIHR BioResource, Lyons PA, Doffinger R, Bradley JR, Smith KGC, Sinclair J, Matheson NJ, Lehner PJ, Sithole N, Wills MR
• Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study
  2023 Tsvetanov KA,…. Rowe, JB., Menon, DK., *The Cambridge NeuroCOVID Group,
• Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.
  Brain : a journal of neurology 2022 Needham EJ, Ren AL, Digby RJ, Norton EJ, Ebrahimi S, Outtrim JG, Chatfield DA, Manktelow AE, Leibowitz MM, Newcombe VFJ, Doffinger R, Barcenas-Morales G, Fonseca C, Taussig MJ, Burnstein RM, Samanta …
• Changing Epidemiology of Rotavirus Diarrhoea in Northeast Brazil after the introduction of national rotavirus vaccination
  Changing Epidemiology of Rotavirus Diarrhoea in Northeast Brazil after the introduction of national rotavirus vaccination 2010 Sithole Nyaradzai