Norman Oppenheimer, PhD
Professor Emeritus
Pharmaceutical Chemistry
School of Pharmacy

Grants and Projects

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• Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
• Resource for Biocomputing, Visualization, and Informatics, NIH/NCRR, 1976-2012
• Alcohol Dehydrogenase Catalyzed Sequential Oxidations, NIH, 1995-2000
• Mercury 400 Mhz Broadband Nmr System, NIH, 1998-1999
• Structure-function Relations in Pyridine Coenzymes, NIH, 1979-1997
• Mechanism of Double Strand Scission of Dna by Bleomycin, NIH, 1988-1991
• QE 300 NMR SPECTROMETER, NIH, 1989-1990
• 1986 Gordon Research Conference--Enzymes &Coenzymes, NIH, 1986
• Mechanism of Bleomycin, NIH, 1979-1986

Publications (19)

Top publication keywords:
Spectrophotometry, UltravioletCatalytic DomainSubstrate SpecificityCyclic ADP-RiboseNiacinamideADP-ribosyl Cyclase 1Adenosine Diphosphate RiboseADP-ribosyl CyclaseNADAntigens, CDAlcoholsDeuteriumChemistry Techniques, SyntheticAlcohol Dehydrogenase2-Propanol

• Alteration in substrate specificity of horse liver alcohol dehydrogenase by an acyclic nicotinamide analog of NAD(+).
  DNA repair 2014 Malver O, Sebastian MJ, Oppenheimer NJ
• Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.
  PloS one 2012 Egea PF, Muller-Steffner H, Kuhn I, Cakir-Kiefer C, Oppenheimer NJ, Stroud RM, Kellenberger E, Schuber F
• Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38.
  The Journal of biological chemistry 2009 Graeff R, Liu Q, Kriksunov IA, Kotaka M, Oppenheimer N, Hao Q, Lee HC
• Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase.
  The Journal of biological chemistry 2009 Liu Q, Graeff R, Kriksunov IA, Jiang H, Zhang B, Oppenheimer N, Lin H, Potter BV, Lee HC, Hao Q
• CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism.
  International immunology 2006 Lund FE, Muller-Steffner H, Romero-Ramirez H, Moreno-García ME, Partida-Sánchez S, Makris M, Oppenheimer NJ, Santos-Argumedo L, Schuber F

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• Activation of T cell calcium influx by the second messenger ADP-ribose.
  The Journal of biological chemistry 2005 Gasser A, Glassmeier G, Fliegert R, Langhorst MF, Meinke S, Hein D, Krüger S, Weber K, Heiner I, Oppenheimer N, Schwarz JR, Guse AH
• CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Krebs C, Adriouch S, Braasch F, Koestner W, Leiter EH, Seman M, Lund FE, Oppenheimer N, Haag F, Koch-Nolte F
• Extracellular NAD+ regulates intracellular free calcium concentration in human monocytes.
  The Biochemical journal 2004 Gerth A, Nieber K, Oppenheimer NJ, Hauschildt S
• CD38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes.
  European journal of biochemistry 2004 Moreno-García ME, Partida-Sánchez S, Primack J, Sumoza-Toledo A, Muller-Steffner H, Schuber F, Oppenheimer N, Lund FE, Santos-Argumedo L
• Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity.
  Immunity 2004 Partida-Sánchez S, Goodrich S, Kusser K, Oppenheimer N, Randall TD, Lund FE
• Chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic ADP ribose.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Partida-Sánchez S, Iribarren P, Moreno-García ME, Gao JL, Murphy PM, Oppenheimer N, Wang JM, Lund FE
• Fluorometric studies of ligand-induced conformational changes of CD38.
  Biochimica et biophysica acta 2003 Lacapère JJ, Boulla G, Lund FE, Primack J, Oppenheimer N, Schuber F, Deterre P
• Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases.
  The Journal of biological chemistry 2003 Jackson MD, Schmidt MT, Oppenheimer NJ, Denu JM
• Novel hydrolysis-resistant analogues of cyclic ADP-ribose: modification of the "northern" ribose and calcium release activity.
  Biochemistry 2002 Guse AH, Cakir-Kiefer C, Fukuoka M, Shuto S, Weber K, Bailey VC, Matsuda A, Mayr GW, Oppenheimer N, Schuber F, Potter BV
• Reactions of Charged Substrates. 8. The Nucleophilic Substitution Reactions of (4-Methoxybenzyl)dimethylsulfonium Chloride.
  The Journal of organic chemistry 1997 Buckley N, Oppenheimer NJ
• Reactions of Charged Substrates. 6. The Methoxymethyl Carbenium Ion Problem. 1. A Semiempirical Study of the Kinetic and Thermodynamic Stabilities of Linear and Cyclic Oxo- and Thiocarbenium Ions Generated from Pyridinium and Dimethylanilinium Ions.
  The Journal of organic chemistry 1996 Buckley N, Oppenheimer NJ
• Reactions of Charged Substrates. 7. The Methoxymethyl Carbenium Ion Problem. 2. A Semiempirical Study of the Kinetic and Thermodynamic Stabilities of Linear and Cyclic Oxo- and Thiocarbenium Ions Generated from Aldehyde Hydrates, Hemiacetals, Acetals, and Methyl Ribosides and Glucosides.
  The Journal of organic chemistry 1996 Buckley N, Oppenheimer NJ
• Reactions of Charged Substrates. 5. The Solvolysis and Sodium Azide Substitution Reactions of Benzylpyridinium Ions in Deuterium Oxide.
  The Journal of organic chemistry 1996 Buckley N, Oppenheimer NJ
• Reactions of Charged Substrates. 4. The Gas-Phase Dissociation of (4-Substituted benzyl)dimethylsulfoniums and -pyridiniums.
  The Journal of organic chemistry 1996 Buckley N, Maltby D, Burlingame AL, Oppenheimer NJ