Noriyuki Kasahara, MD, PhD
Professor
Neurological Surgery
School of Medicine

- Development of gene therapy, oncolytic virotherapy, and immunotherapy strategies for translational application to cancer - Development of genetic engineering strategies for translational application to transplantation and regenerative medicine.

Awards

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• Clinical Impact Award, Global Life Science Innovation Competition, University of California, San Francisco (UCSF) - QB3, 2006
• New Investigator Award, Cooley's Anemia Foundation, 1998
• Career Development Award, Stop Cancer Foundation, 1996
• Chancellor Julius R. Krevans’ Distinguished Dissertation Award, University of California, San Francisco (UCSF), 1995
• Young Investigators Research Award, Tokyo Medical & Dental University, 1994

Education & Training

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• Post-Doc Gene Therapy Howard Hughes Medical Institute, UCSF 1995
• Ph.D. Endocrinology University of California, San Francisco (UCSF) 1994
• M.D. Endocrinology Tokyo Medical & Dental University 1993
• Residency Laboratory Medicine University of California, San Francisco (UCSF) 1993
• M.B. Medicine Tokyo Medical & Dental University 1986

Interests

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• transplantation
• viral vector
• gene therapy
• cancer
• oncolytic virotherapy
• regenerative medicine
• immunotherapy
• genetic engineering
• glioma

Websites

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• UCSF Brain Tumor Center faculty profile - Kasahara (braintumorcenter.ucsf.edu)

Grants and Projects

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• GALV-Based Retroviral Replicating Vectors for Glioma Gene Therapy, NIH, 2019-2022
• Retroviral Replicating Vector-mediated Gene Therapy for Ovarian Cancer, NIH, 2017-2022
• GALV-Based Retroviral Replicating Vectors for Glioma Gene Therapy, NIH, 2019-2021
• Stem cell-based carriers for RCR vector delivery to glioblastoma, California Institute for Regenerative Medicine (CIRM), 2011-2014
• Translational Development of Replication-Competent Retrovirus Vectors, NIH, 2010-2014
• Cellular Transduction with Replication-Competent Retrovirus Vectors, NIH, 2007-2011
• Combining Virotherapy and Immunotherapy for Cancer, NIH, 2004-2010
• Down-Regulation of Alloreactive Immune Responses to hES Cell-Derived Graft Tissues, California Institute for Regenerative Medicine (CIRM), 2007-2009
• Cellular Trans. by Retrotransposon-Adenovirus Hybrid Ve., NIH, 2002-2007
• Transcriptional Targeting of Retroviral Replication, NIH, 2000-2004
• Anti-angiogenic Gene Therapy for Rheumatoid Arthritis, NIH, 1999-2002
• Novel Adenovirus-retroelement Hybrid Vectors, NIH, 1998-2000
• Development of Adenoviral Protein/dna Conjugate Vectors, NIH, 1999-2000

Publications (153)

Top publication keywords:
Transduction, GeneticRetroviridaeCytosine DeaminaseGenetic TherapyLeukemia Virus, MurineProdrugsLeukemia Virus, Gibbon ApeFlucytosineLentivirusGliomaMesotheliomaOncolytic VirotherapyAdenoviridaeGenetic VectorsMoloney murine leukemia virus

• Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity.
  Neuro-oncology 2017 Hiraoka K, Inagaki A, Kato Y, Huang TT, Mitchell LA, Kamijima S, Takahashi M, Matsumoto H, Hacke K, Kruse CA, Ostertag D, Robbins JM, Gruber HE, Jolly DJ, Kasahara N
• Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma.
  Science translational medicine 2016 Cloughesy TF, Landolfi J, Hogan DJ, Bloomfield S, Carter B, Chen CC, Elder JB, Kalkanis SN, Kesari S, Lai A, Lee IY, Liau LM, Mikkelsen T, Nghiemphu PL, Piccioni D, Walbert T, Chu A, Das A, Diago OR, …
• Reduction of HLA class I expression by ribonucleic acid interference mitigates allogenicity of human primary and Immortalized cells.
  Clinical transplants 2013 Lemp NA, Haga K, Hacke K, Treger JA, Bogan BT, Faure-Kumar E, Logg CR, Kruse CA, Cicciarelli JC, Kasahara N
• Combined preconditioning and in vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrow.
  Experimental hematology 2011 Hacke K, Szakmary A, Cuddihy AR, Rozengurt N, Lemp NA, Aubrecht J, Lawson GW, Rao NP, Crooks GM, Schiestl RH, Kasahara N
• Adenovirus-retrovirus hybrid vectors achieve highly enhanced tumor transduction and antitumor efficacy in vivo.
  Molecular therapy : the journal of the American Society of Gene Therapy 2010 Kubo S, Haga K, Tamamoto A, Palmer DJ, Ng P, Okamura H, Kasahara N
• L1 retrotransposition in nondividing and primary human somatic cells.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Kubo S, Seleme MC, Soifer HS, Perez JL, Moran JV, Kazazian HH, Kasahara N
• Single-shot, multicycle suicide gene therapy by replication-competent retrovirus vectors achieves long-term survival benefit in experimental glioma.
  Molecular therapy : the journal of the American Society of Gene Therapy 2005 Tai CK, Wang WJ, Chen TC, Kasahara N
• Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa.
  Nature genetics 2002 Chen M, Kasahara N, Keene DR, Chan L, Hoeffler WK, Finlay D, Barcova M, Cannon PM, Mazurek C, Woodley DT
• Tissue-specific targeting of retroviral vectors through ligand-receptor interactions.
  Science (New York, N.Y.) 1994 Kasahara N, Dozy AM, Kan YW

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• Targeted Suicide Gene Therapy with Retroviral Replicating Vectors for Experimental Canine Cancers.
  International journal of molecular sciences 2024 Sonoda-Fukuda E, Takeuchi Y, Ogawa N, Noguchi S, Takarada T, Kasahara N, Kubo S
• In vivo selection of anti-HIV-1 gene-modified human hematopoietic stem/progenitor cells to enhance engraftment and HIV-1 inhibition.
  Molecular therapy : the journal of the American Society of Gene Therapy 2023 Guo Q, Zhang J, Parikh K, Brinkley A, Lin S, Zakarian C, Pernet O, Shimizu S, Khamaikawin W, Hacke K, Kasahara N, An DS
• Therapeutic Efficacy of Prodrug Activator Gene Therapy Using Retroviral Replicating Vectors for Human Ovarian Cancer.
  Anticancer research 2023 Isoda L, Sonoda-Fukuda E, Fujino H, Takarada T, Hasegawa K, Kasahara N, Kubo S
• Retroviral Replicating Vectors Mediated Prodrug Activator Gene Therapy in a Gastric Cancer Model.
  International journal of molecular sciences 2023 Fujino H, Sonoda-Fukuda E, Isoda L, Kawabe A, Takarada T, Kasahara N, Kubo S
• Retroviral Replicating Vector Toca 511 (Vocimagene Amiretrorepvec) for Prodrug Activator Gene Therapy of Lung Cancer.
  Cancers 2022 Kushiya H, Hiraoka K, Suzuki T, Inoko K, Inagaki A, Niwa H, Sasaki K, Nakamura T, Tsuchikawa T, Shichinohe T, Jolly DJ, Kasahara N, Hirano S
• The immunogenetics of viral antigen response is associated with subtype-specific glioma risk and survival.
  American journal of human genetics 2022 Guerra G, Kachuri L, Wendt G, Hansen HM, Mack SJ, Molinaro AM, Rice T, Bracci P, Wiencke JK, Kasahara N, Eckel-Passow JE, Jenkins RB, Wrensch M, Francis SS
• Clinical development of retroviral replicating vector Toca 511 for gene therapy of cancer.
  Expert opinion on biological therapy 2021 Collins SA, Shah AH, Ostertag D, Kasahara N, Jolly DJ
• Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank.
  Neuro-oncology 2021 Chuntova P, Chow F, Watchmaker PB, Galvez M, Heimberger AB, Newell EW, Diaz A, DePinho RA, Li MO, Wherry EJ, Mitchell D, Terabe M, Wainwright DA, Berzofsky JA, Herold-Mende C, Heath JR, Lim M, …
• Immunologic aspects of viral therapy for glioblastoma and implications for interactions with immunotherapies.
  Journal of neuro-oncology 2021 Haddad AF, Young JS, Mummaneni NV, Kasahara N, Aghi MK
• Introduction to immunotherapy for brain tumor patients: challenges and future perspectives.
  Neuro-oncology practice 2020 Montoya ML, Kasahara N, Okada H
• Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model.
  International journal of molecular sciences 2020 Chen SH, Sun JM, Chen BM, Lin SC, Chang HF, Collins S, Chang D, Wu SF, Lu YC, Wang W, Chen TC, Kasahara N, Wang HE, Tai CK
• A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Rodriguez-Blanco J, Li B, Long J, Shen C, Yang F, Orton D, Collins S, Kasahara N, Ayad NG, McCrea HJ, Roussel MF, Weiss WA, Capobianco AJ, Robbins DJ
• Dual-vector prodrug activator gene therapy using retroviral replicating vectors.
  Cancer gene therapy 2018 Kubo S, Takagi-Kimura M, Tagawa M, Kasahara N
• Durable complete responses in some recurrent high-grade glioma patients treated with Toca 511 + Toca FC.
  Neuro-oncology 2018 Cloughesy TF, Landolfi J, Vogelbaum MA, Ostertag D, Elder JB, Bloomfield S, Carter B, Chen CC, Kalkanis SN, Kesari S, Lai A, Lee IY, Liau LM, Mikkelsen T, Nghiemphu P, Piccioni D, Accomando W, Diago …
• Efficient tumor transduction and antitumor efficacy in experimental human osteosarcoma using retroviral replicating vectors.
  Cancer gene therapy 2018 Kubo S, Takagi-Kimura M, Kasahara N
• Therapeutic activity of retroviral replicating vector-mediated prodrug activator gene therapy for pancreatic cancer.
  Cancer gene therapy 2018 Inoko K, Hiraoka K, Inagaki A, Takahashi M, Kushibiki T, Hontani K, Takano H, Sato S, Takeuchi S, Nakamura T, Tsuchikawa T, Shichinohe T, Gruber HE, Jolly DJ, Kasahara N, Hirano S
• A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models.
  Molecular therapy oncolytics 2017 Yagiz K, Rodriguez-Aguirre ME, Lopez Espinoza F, Montellano TT, Mendoza D, Mitchell LA, Ibanez CE, Kasahara N, Gruber HE, Jolly DJ, Robbins JM
• Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model.
  Neuro-oncology 2017 Mitchell LA, Lopez Espinoza F, Mendoza D, Kato Y, Inagaki A, Hiraoka K, Kasahara N, Gruber HE, Jolly DJ, Robbins JM
• Epithelial membrane protein-2 (EMP2) promotes angiogenesis in glioblastoma multiforme.
  Journal of neuro-oncology 2017 Qin Y, Takahashi M, Sheets K, Soto H, Tsui J, Pelargos P, Antonios JP, Kasahara N, Yang I, Prins RM, Braun J, Gordon LK, Wadehra M
• Pathogens and glioma: a history of unexpected discoveries ushering in novel therapy.
  Journal of neurosurgery 2017 Shah AH, Jusué-Torres I, Ivan ME, Komotar RJ, Kasahara N
• Renal Transplant Patients Biopsied for Cause and Tested for C4d, DSA, and IgG Subclasses and C1q: Which Humoral Markers Improve Diagnosis and Outcomes?
  Journal of immunology research 2017 Cicciarelli JC, Lemp NA, Chang Y, Koss M, Hacke K, Kasahara N, Burns KM, Min DI, Naraghi R, Shah T
• Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells.
  Cancer immunology, immunotherapy : CII 2016 Kozlowska AK, Tseng HC, Kaur K, Topchyan P, Inagaki A, Bui VT, Kasahara N, Cacalano N, Jewett A
• Factors in the Selection of Surface Disinfectants for Use in a Laboratory Animal Setting.
  Journal of the American Association for Laboratory Animal Science : JAALAS 2016 Campagna MV, Faure-Kumar E, Treger JA, Cushman JD, Grogan TR, Kasahara N, Lawson GW
• Extensive Replication of a Retroviral Replicating Vector Can Expand the A Bulge in the Encephalomyocarditis Virus Internal Ribosome Entry Site and Change Translation Efficiency of the Downstream Transgene.
  Human gene therapy methods 2016 Lin AH, Liu Y, Burrascano C, Cunanan K, Logg CR, Robbins JM, Kasahara N, Gruber H, Ibañez C, Jolly DJ
• Differential Targeting of Stem Cells and Differentiated Glioblastomas by NK Cells.
  Journal of Cancer 2015 Tseng HC, Inagaki A, Bui VT, Cacalano N, Kasahara N, Man YG, Jewett A
• Combinatorial anti-angiogenic gene therapy in a human malignant mesothelioma model.
  Oncology reports 2015 Kubo S, Takagi-Kimura M, Kasahara N
• Enhancement of the antigen-specific cytotoxic T lymphocyte-inducing ability in the PMDC11 leukemic plasmacytoid dendritic cell line via lentiviral vector-mediated transduction of the caTLR4 gene.
  Molecular medicine reports 2015 Iwabuchi M, Narita M, Uchiyama T, Iwaya S, Oiwa E, Nishizawa Y, Hashimoto S, Bonehill A, Kasahara N, Takizawa J, Takahashi M
• Radial mobility and cytotoxic function of retroviral replicating vector transduced, non-adherent alloresponsive T lymphocytes.
  Journal of visualized experiments : JoVE 2015 Erickson KL, Hickey MJ, Kato Y, Malone CC, Owens GC, Prins RM, Liau LM, Kasahara N, Kruse CA
• Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model.
  Human gene therapy 2015 Huang TT, Parab S, Burnett R, Diago O, Ostertag D, Hofman FM, Espinoza FL, Martin B, Ibañez CE, Kasahara N, Gruber HE, Pertschuk D, Jolly DJ, Robbins JM
• Putative immunogenicity expression profiling using human pluripotent stem cells and derivatives.
  Stem cells translational medicine 2015 Awe JP, Gschweng EH, Vega-Crespo A, Voutila J, Williamson MH, Truong B, Kohn DB, Kasahara N, Byrne JA
• Short conserved sequences of HIV-1 are highly immunogenic and shift immunodominance.
  Journal of virology 2014 Yang OO, Ali A, Kasahara N, Faure-Kumar E, Bae JY, Picker LJ, Park H
• p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells.
  The Journal of biological chemistry 2014 Veena MS, Wilken R, Zheng JY, Gholkar A, Venkatesan N, Vira D, Ahmed S, Basak SK, Dalgard CL, Ravichandran S, Batra RK, Kasahara N, Elashoff D, Fishbein MC, Whitelegge JP, Torres JZ, Wang MB, …
• Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector.
  Cancer gene therapy 2014 Takahashi M, Valdes G, Hiraoka K, Inagaki A, Kamijima S, Micewicz E, Gruber HE, Robbins JM, Jolly DJ, McBride WH, Iwamoto KS, Kasahara N
• Maintaining therapeutic activity in the operating room: compatibility of a gamma-retroviral replicating vector with clinical materials and biofluids.
  Molecular therapy. Methods & clinical development 2014 Burnett R, Ibañez CE, Pettersson PL, Chen CI, Parab S, Huang T, Robbins J, Bankiewicz K, Aghi M, Logg C, Kasahara N, Pertschuk D, Gruber HE, Jolly DJ
• MicroRNA 142-3p attenuates spread of replicating retroviral vector in hematopoietic lineage-derived cells while maintaining an antiviral immune response.
  Human gene therapy 2014 Lin AH, Timberlake N, Logg CR, Liu Y, Kamijima S, Diago O, Wong K, Gammon DK, Ostertag D, Hacke K, Yang EC, Gruber H, Kasahara N, Jolly DJ
• Mucosal gene therapy using a pseudotyped lentivirus vector encoding murine interleukin-10 (mIL-10) suppresses the development and relapse of experimental murine colitis.
  BMC gastroenterology 2014 Matsumoto H, Haga K, Ohno I, Hiraoka K, Kimura T, Hermann K, Kasahara N, Anton P, McGowan I
• Epithelial membrane protein-2 (EMP2) activates Src protein and is a novel therapeutic target for glioblastoma.
  The Journal of biological chemistry 2014 Qin Y, Fu M, Takahashi M, Iwanami A, Kuga D, Rao RG, Sudhakar D, Huang T, Kiyohara M, Torres K, Dillard C, Inagaki A, Kasahara N, Goodglick L, Braun J, Mischel PS, Gordon LK, Wadehra M
• Clinicopathological and prognostic significance of interleukin-8 expression and its relationship to KRAS mutation in lung adenocarcinoma.
  British journal of cancer 2014 Sunaga N, Kaira K, Tomizawa Y, Shimizu K, Imai H, Takahashi G, Kakegawa S, Ohtaki Y, Nagashima T, Kasahara N, Kawashima O, Hisada T, Saito R, Yamada M
• Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo.
  Hepatology (Baltimore, Md.) 2013 Reebye V, Sætrom P, Mintz PJ, Huang KW, Swiderski P, Peng L, Liu C, Liu X, Lindkaer-Jensen S, Zacharoulis D, Kostomitsopoulos N, Kasahara N, Nicholls JP, Jiao LR, Pai M, Spalding DR, Mizandari M, …
• Highly efficient tumor transduction and antitumor efficacy in experimental human malignant mesothelioma using replicating gibbon ape leukemia virus.
  Cancer gene therapy 2013 Kubo S, Takagi-Kimura M, Logg CR, Kasahara N
• Contextual effect of repression of bone morphogenetic protein activity in prostate cancer.
  Endocrine-related cancer 2013 Pham LK, Liang M, Adisetiyo HA, Liao CP, Cohen MB, Tahara SM, Frenkel B, Kasahara N, Roy-Burman P
• Enhanced antitumor efficacy of fiber-modified, midkine promoter-regulated oncolytic adenovirus in human malignant mesothelioma.
  Cancer science 2013 Takagi-Kimura M, Yamano T, Tamamoto A, Okamura N, Okamura H, Hashimoto-Tamaoki T, Tagawa M, Kasahara N, Kubo S
• Combining cellular and gene therapy approaches for treatment of intracranial tumors.
  Oncoimmunology 2013 Hickey MJ, Kasahara N, Mueller BM, Kruse CA
• Exploiting human CD34+ stem cell-conditioned medium for tissue repair.
  Molecular therapy : the journal of the American Society of Gene Therapy 2013 Mintz PJ, Huang KW, Reebye V, Nteliopoulos G, Lai HS, Sætrom P, Kasahara N, Jensen S, Pai M, Gordon MY, Marley SB, Behan R, Spalding DR, Haoudi A, Emara MM, Nicholls J, Rossi JJ, Habib NA
• Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model.
  Cancer gene therapy 2013 Huang TT, Hlavaty J, Ostertag D, Espinoza FL, Martin B, Petznek H, Rodriguez-Aguirre M, Ibañez CE, Kasahara N, Gunzburg W, Gruber HE, Pertschuk D, Jolly DJ, Robbins JM
• Luminescence-based assay to screen preservation solutions for optimal ability to maintain viability of rat intestinal grafts.
  Transplantation proceedings 2013 Kasahara N, Kikuchi T, Doi J, Teratani T, Fujimoto Y, Uemoto S, Yasuda Y, Kobayashi E
• Combined alloreactive CTL cellular therapy with prodrug activator gene therapy in a model of breast cancer metastatic to the brain.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Hickey MJ, Malone CC, Erickson KL, Lin A, Soto H, Ha ET, Kamijima S, Inagaki A, Takahashi M, Kato Y, Kasahara N, Mueller BM, Kruse CA
• A Short-activating RNA Oligonucleotide Targeting the Islet β-cell Transcriptional Factor MafA in CD34(+) Cells.
  Molecular therapy. Nucleic acids 2013 Reebye V, Sætrom P, Mintz PJ, Rossi JJ, Kasahara N, Nteliopoulos G, Nicholls J, Haoudi A, Gordon M, Habib NA
• Genetic modification of mouse bone marrow by lentiviral vector-mediated delivery of hypoxanthine-Guanine phosphoribosyltransferase short hairpin RNA confers chemoprotection against 6-thioguanine cytotoxicity.
  Transplantation proceedings 2013 Hacke K, Treger JA, Bogan BT, Schiestl RH, Kasahara N
• Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors in a rodent brain tumor model.
  Cancer gene therapy 2013 Yin D, Zhai Y, Gruber HE, Ibanez CE, Robbins JM, Kells AP, Kasahara N, Forsayeth J, Jolly DJ, Bankiewicz KS
• The innovative evolution of cancer gene and cellular therapies.
  Cancer gene therapy 2013 Lam P, Khan G, Stripecke R, Hui KM, Kasahara N, Peng KW, Guinn BA
• Immunoglobulin G subclass analysis of HLA donor specific antibodies in heart and renal transplant recipients.
  Clinical transplants 2013 Cicciarelli JC, Kasahara N, Lemp NA, Adamson R, Dembitsky W, Browne B, Steinberg S
• RIN3 is a negative regulator of mast cell responses to SCF.
  PloS one 2012 Janson C, Kasahara N, Prendergast GC, Colicelli J
• Enhancement of antigen presenting ability in the leukemic plasmacytoid dendritic cell line (PMDC05) by lentiviral vector-mediated transduction of CD80 gene.
  Leukemia research 2012 Yamahira A, Narita M, Ishii K, Jayathilake RM, Iwabuchi M, Satoh N, Uchiyama T, Taniguchi T, Hashimoto S, Kasahara N, Faure E, Bogan B, Takizawa J, Sone H, Takahashi M
• Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells.
  Molecular therapy. Nucleic acids 2012 Voutila J, Sætrom P, Mintz P, Sun G, Alluin J, Rossi JJ, Habib NA, Kasahara N
• MicroRNA-181a* Targets Nanog in a Subpopulation of CD34(+) Cells Isolated From Peripheral Blood.
  Molecular therapy. Nucleic acids 2012 Mintz PJ, Sætrom P, Reebye V, Lundbæk MB, Lao K, Rossi JJ, Gaensler KM, Kasahara N, Nicholls JP, Jensen S, Haoudi A, Emara MM, Gordon MY, Habib NA
• Cryptic transcripts from a ubiquitous plasmid origin of replication confound tests for cis-regulatory function.
  Nucleic acids research 2012 Lemp NA, Hiraoka K, Kasahara N, Logg CR
• Design and selection of Toca 511 for clinical use: modified retroviral replicating vector with improved stability and gene expression.
  Molecular therapy : the journal of the American Society of Gene Therapy 2012 Perez OD, Logg CR, Hiraoka K, Diago O, Burnett R, Inagaki A, Jolson D, Amundson K, Buckley T, Lohse D, Lin A, Burrascano C, Ibanez C, Kasahara N, Gruber HE, Jolly DJ
• PET imaging for gene & cell therapy.
  Current gene therapy 2012 Collins SA, Hiraoka K, Inagaki A, Kasahara N, Tangney M
• High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting.
  PloS one 2012 Cronin M, Akin AR, Collins SA, Meganck J, Kim JB, Baban CK, Joyce SA, van Dam GM, Zhang N, van Sinderen D, O'Sullivan GC, Kasahara N, Gahan CG, Francis KP, Tangney M
• Retroviral replicating vectors in cancer.
  Methods in enzymology 2012 Logg CR, Robbins JM, Jolly DJ, Gruber HE, Kasahara N
• Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.
  Neuro-oncology 2011 Ostertag D, Amundson KK, Lopez Espinoza F, Martin B, Buckley T, Galvão da Silva AP, Lin AH, Valenta DT, Perez OD, Ibañez CE, Chen CI, Pettersson PL, Burnett R, Daublebsky V, Hlavaty J, Gunzburg W, …
• The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation.
  Gastroenterology 2011 Nitsche C, Edderkaoui M, Moore RM, Eibl G, Kasahara N, Treger J, Grippo PJ, Mayerle J, Lerch MM, Gukovskaya AS
• Replication-competent retrovirus vector-mediated prodrug activator gene therapy in experimental models of human malignant mesothelioma.
  Cancer gene therapy 2011 Kawasaki Y, Tamamoto A, Takagi-Kimura M, Maeyama Y, Yamaoka N, Terada N, Okamura H, Kasahara N, Kubo S
• Lentiviral vectors for induction of self-differentiation and conditional ablation of dendritic cells.
  Gene therapy 2011 Pincha M, Salguero G, Wedekind D, Sundarasetty BS, Lin A, Kasahara N, Brugman MH, Jirmo AC, Modlich U, Gutzmer R, Büsche G, Ganser A, Stripecke R
• Complete regression of human malignant mesothelioma xenografts following local injection of midkine promoter-driven oncolytic adenovirus.
  The journal of gene medicine 2010 Kubo S, Kawasaki Y, Yamaoka N, Tagawa M, Kasahara N, Terada N, Okamura H
• Optimization of enzyme-substrate pairing for bioluminescence imaging of gene transfer using Renilla and Gaussia luciferases.
  The journal of gene medicine 2010 Kimura T, Hiraoka K, Kasahara N, Logg CR
• Enhanced efficiency of prodrug activation therapy by tumor-selective replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene.
  Cancer gene therapy 2010 Tai CK, Wang W, Lai YH, Logg CR, Parker WB, Li YF, Hong JS, Sorscher EJ, Chen TC, Kasahara N
• Effective in vivo and ex vivo gene transfer to intestinal mucosa by VSV-G-pseudotyped lentiviral vectors.
  BMC gastroenterology 2010 Matsumoto H, Kimura T, Haga K, Kasahara N, Anton P, McGowan I
• In vivo stable transduction of humanized liver tissue in chimeric mice via high-capacity adenovirus-lentivirus hybrid vector.
  Human gene therapy 2010 Kubo S, Kataoka M, Tateno C, Yoshizato K, Kawasaki Y, Kimura T, Faure-Kumar E, Palmer DJ, Ng P, Okamura H, Kasahara N
• International Society for Cell and Gene Therapy of Cancer 2009 Annual Meeting held in Cork, Ireland.
  Human gene therapy 2010 Guinn B, Casey G, Möller MG, Kasahara N, O'Sullivan GC, Peng KW, Tangney M
• ASSOCIATION BETWEEN DE NOVO DONOR SPECIFIC HLA ANTIBODY, C4D STAINING IN RENAL GRAFT BIOPSY AND GRAFT OUTCOME: A SINGLE CENTER EXPERIENCE.
  Journal of nephrology and renal transplantation 2009 Cicciarelli J, Cho YW, Koss M, Helstab-Houston K, Mendez R, Kasahara N, Hutchinson IV, Shah T
• Suppression of HLA expression by lentivirus-mediated gene transfer of siRNA cassettes and in vivo chemoselection to enhance hematopoietic stem cell transplantation.
  Immunologic research 2009 Hacke K, Falahati R, Flebbe-Rehwaldt L, Kasahara N, Gaensler KM
• PTEN knockout prostate cancer as a model for experimental immunotherapy.
  The Journal of urology 2008 Haga K, Tomioka A, Liao CP, Kimura T, Matsumoto H, Ohno I, Hermann K, Logg CR, Jiao J, Tanaka M, Hirao Y, Wu H, Kruse CA, Roy-Burman P, Kasahara N
• Splicing mediates the activity of four putative cellular internal ribosome entry sites.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Baranick BT, Lemp NA, Nagashima J, Hiraoka K, Kasahara N, Logg CR
• Replication-competent retrovirus vectors for cancer gene therapy.
  Frontiers in bioscience : a journal and virtual library 2008 Tai CK, Kasahara N
• CREB is a critical regulator of normal hematopoiesis and leukemogenesis.
  Blood 2007 Cheng JC, Kinjo K, Judelson DR, Chang J, Wu WS, Schmid I, Shankar DB, Kasahara N, Stripecke R, Bhatia R, Landaw EM, Sakamoto KM
• Highly efficient gene delivery for bladder cancers by intravesically administered replication-competent retroviral vectors.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Kikuchi E, Menendez S, Ozu C, Ohori M, Cordon-Cardo C, Logg CR, Kasahara N, Bochner BH
• Therapeutic efficacy of replication-competent retrovirus vector-mediated suicide gene therapy in a multifocal colorectal cancer metastasis model.
  Cancer research 2007 Hiraoka K, Kimura T, Logg CR, Tai CK, Haga K, Lawson GW, Kasahara N
• Lentiviral vectors with CMV or MHCII promoters administered in vivo: immune reactivity versus persistence of expression.
  Molecular therapy : the journal of the American Society of Gene Therapy 2007 Kimura T, Koya RC, Anselmi L, Sternini C, Wang HJ, Comin-Anduix B, Prins RM, Faure-Kumar E, Rozengurt N, Cui Y, Kasahara N, Stripecke R
• Adaptive evolution of a tagged chimeric gammaretrovirus: identification of novel cis-acting elements that modulate splicing.
  Journal of molecular biology 2007 Logg CR, Baranick BT, Lemp NA, Kasahara N
• Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines.
  Molecular therapy : the journal of the American Society of Gene Therapy 2007 Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R
• Recent advances and current challenges in tumor immunology and immunotherapy.
  Molecular therapy : the journal of the American Society of Gene Therapy 2007 Guinn BA, Kasahara N, Farzaneh F, Habib NA, Norris JS, Deisseroth AB
• Replication-competent vectors and empty virus-like particles: new retroviral vector designs for cancer gene therapy or vaccines.
  Molecular therapy : the journal of the American Society of Gene Therapy 2007 Dalba C, Bellier B, Kasahara N, Klatzmann D
• Delivery of replication-competent retrovirus expressing Escherichia coli purine nucleoside phosphorylase increases the metabolism of the prodrug, fludarabine phosphate and suppresses the growth of bladder tumor xenografts.
  Cancer gene therapy 2007 Kikuchi E, Menendez S, Ozu C, Ohori M, Cordon-Cardo C, Logg CR, Kasahara N, Bochner BH
• Adenoviral receptor expression of normal bladder and transitional cell carcinoma of the bladder.
  Urologia internationalis 2007 Buscarini M, Quek ML, Gilliam-Hegarich S, Kasahara N, Bochner B
• Calcium phosphate coprecipitation greatly enhances transduction of cardiac myocytes and vascular smooth muscle cells by lentivirus vectors.
  Experimental and clinical cardiology 2007 Sakoda T, Kasahara N, Kedes L, Ohyanagi M
• Lentiviral vector-mediated gene transfer to endotherial cells compared with adenoviral and retroviral vectors.
  Preparative biochemistry & biotechnology 2007 Sakoda T, Kasahara N, Kedes L, Ohyanagi M
• Permanent, lowered HLA class I expression using lentivirus vectors with shRNA constructs: Averting cytotoxicity by alloreactive T lymphocytes.
  Transplantation proceedings 2006 Haga K, Lemp NA, Logg CR, Nagashima J, Faure-Kumar E, Gomez GG, Kruse CA, Mendez R, Stripecke R, Kasahara N, Kasahara NA, Cicciarelli JC
• Tumor-selective gene expression in a hepatic metastasis model after locoregional delivery of a replication-competent retrovirus vector.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Hiraoka K, Kimura T, Logg CR, Kasahara N
• International Society for Cell and Gene Therapy of Cancer (ISCGT) annual meeting: conference overview and introduction to the symposium papers.
  Cancer immunology, immunotherapy : CII 2006 Guinn BA, Norris JS, Huang L, Farzaneh F, Kasahara N, Deisseroth AB
• The strange case of TGN1412.
  Cancer immunology, immunotherapy : CII 2006 Farzaneh L, Kasahara N, Farzaneh F
• Transcriptional targeting of adenovirus vectors with the squamous cell carcinoma-specific antigen-2 promoter for selective apoptosis induction in lung cancer.
  Cancer gene therapy 2006 Oshikiri T, Miyamoto M, Hiraoka K, Shichinohe T, Kawarada Y, Kato K, Suzuoki M, Nakakubo Y, Kondo S, Dosaka-Akita H, Kasahara N, Katoh H
• Use of replication-competent retroviral vectors in an immunocompetent intracranial glioma model.
  Neurosurgical focus 2006 Wang W, Tai CK, Kershaw AD, Solly SK, Klatzmann D, Kasahara N, Chen TC
• Beyond oncolytic virotherapy: replication-competent retrovirus vectors for selective and stable transduction of tumors.
  Current gene therapy 2005 Dalba C, Klatzmann D, Logg CR, Kasahara N
• Retargeting of adenoviral vector using basic fibroblast growth factor ligand for malignant glioma gene therapy.
  Journal of neurosurgery 2005 Wang W, Zhu NL, Chua J, Swenson S, Costa FK, Schmitmeier S, Sosnowski BA, Shichinohe T, Kasahara N, Chen TC
• Retrotransposon-adenovirus hybrid vectors: efficient delivery and stable integration of transgenes via a two-stage mechanism.
  Current gene therapy 2004 Soifer HS, Kasahara N
• Development of packaging cell lines for generation of adeno-associated virus vectors by lentiviral gene transfer of trans-complementary components.
  European journal of haematology 2004 Nakamura S, Nakamura R, Shibata K, Kobayashi M, Sahara N, Shigeno K, Shinjo K, Naito K, Ohnishi K, Kasahara N, Iwaki Y
• Intradermal injection of lentiviral vectors corrects regenerated human dystrophic epidermolysis bullosa skin tissue in vivo.
  Molecular therapy : the journal of the American Society of Gene Therapy 2004 Woodley DT, Keene DR, Atha T, Huang Y, Ram R, Kasahara N, Chen M
• Making dendritic cells from the inside out: lentiviral vector-mediated gene delivery of granulocyte-macrophage colony-stimulating factor and interleukin 4 into CD14+ monocytes generates dendritic cells in vitro.
  Human gene therapy 2004 Koya RC, Weber JS, Kasahara N, Lau R, Villacres MC, Levine AM, Stripecke R
• Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland.
  Gene therapy 2004 Wang Y, Xie J, Yarber FA, Mazurek C, Trousdale MD, Medina-Kauwe LK, Kasahara N, Hamm-Alvarez SF
• Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer.
  Human gene therapy 2004 Qiao R, Zhou B, Harboe-Schmidt E, Kasahara N, Kim KJ, Liebler JM, Crandall ED, Borok Z
• Inhibition of orthotopic human bladder tumor growth by lentiviral gene transfer of endostatin.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2004 Kikuchi E, Menendez S, Ohori M, Cordon-Cardo C, Kasahara N, Bochner BH
• Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1.
  The Journal of biological chemistry 2004 Li B, Navarro S, Kasahara N, Comai L
• Retrovirus-mediated gene transfer to tumors: utilizing the replicative power of viruses to achieve highly efficient tumor transduction in vivo.
  Methods in molecular biology (Clifton, N.J.) 2004 Logg CR, Kasahara N
• Potent maturation of monocyte-derived dendritic cells after CD40L lentiviral gene delivery.
  Journal of immunotherapy (Hagerstown, Md. : 1997) 2003 Koya RC, Kasahara N, Favaro PM, Lau R, Ta HQ, Weber JS, Stripecke R
• The use of lentiviral vectors in gene therapy of leukemia: combinatorial gene delivery of immunomodulators into leukemia cells by state-of-the-art vectors.
  Blood cells, molecules & diseases 2003 Stripecke R, Koya RC, Ta HQ, Kasahara N, Levine AM
• Antibody-mediated targeting of replication-competent retroviral vectors.
  Human gene therapy 2003 Tai CK, Logg CR, Park JM, Anderson WF, Press MF, Kasahara N
• Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells.
  Journal of cell science 2003 Wang Y, Jerdeva G, Yarber FA, da Costa SR, Xie J, Qian L, Rose CM, Mazurek C, Kasahara N, Mircheff AK, Hamm-Alvarez SF
• An efficient gene transduction system for studying gene function in primary human dermal fibroblasts and epidermal keratinocytes.
  Clinical and experimental dermatology 2003 Chen M, Li W, Fan J, Kasahara N, Woodley D
• Highly efficient and tumor-restricted gene transfer to malignant gliomas by replication-competent retroviral vectors.
  Human gene therapy 2003 Wang WJ, Tai CK, Kasahara N, Chen TC
• Lentivirus vector-mediated gene transfer to cardiomyocytes.
  Methods in molecular biology (Clifton, N.J.) 2003 Sakoda T, Kasahara N, Kedes L
• Tissue-specific transcriptional targeting of a replication-competent retroviral vector.
  Journal of virology 2002 Logg CR, Logg A, Matusik RJ, Bochner BH, Kasahara N
• High expression of tumor-associated antigen RCAS1 in pancreatic ductal adenocarcinoma is an unfavorable prognostic marker.
  International journal of cancer 2002 Hiraoka K, Hida Y, Miyamoto M, Oshikiri T, Suzuoki M, Nakakubo Y, Shinohara T, Itoh T, Shichinohe T, Kondo S, Kasahara N, Katoh H
• A novel, helper-dependent, adenovirus-retrovirus hybrid vector: stable transduction by a two-stage mechanism.
  Molecular therapy : the journal of the American Society of Gene Therapy 2002 Soifer H, Higo C, Logg CR, Jih LJ, Shichinohe T, Harboe-Schmidt E, Mitani K, Kasahara N
• An important role for protein kinase C-delta in human keratinocyte migration on dermal collagen.
  Experimental cell research 2002 Li W, Nadelman C, Gratch NS, Li W, Chen M, Kasahara N, Woodley DT
• Nonviral gene delivery to human breast cancer cells by targeted Ad5 penton proteins.
  Gene therapy 2001 Medina-Kauwe LK, Maguire M, Kasahara N, Kedes L
• Vesicular stomatitis virus G-pseudotyped lentivirus vectors mediate efficient apical transduction of polarized quiescent primary alveolar epithelial cells.
  Journal of virology 2001 Borok Z, Harboe-Schmidt JE, Brody SL, You Y, Zhou B, Li X, Cannon PM, Kim KJ, Crandall ED, Kasahara N
• Development of lentiviral vectors for antiangiogenic gene delivery.
  Cancer gene therapy 2001 Shichinohe T, Bochner BH, Mizutani K, Nishida M, Hegerich-Gilliam S, Naldini L, Kasahara N
• Recent advances in retrovirus vector-mediated gene therapy: teaching an old vector new tricks.
  Current opinion in molecular therapeutics 2001 Weber E, Anderson WF, Kasahara N
• Genomic stability of murine leukemia viruses containing insertions at the Env-3' untranslated region boundary.
  Journal of virology 2001 Logg CR, Logg A, Tai CK, Cannon PM, Kasahara N
• 3PO, a novel nonviral gene delivery system using engineered Ad5 penton proteins.
  Gene therapy 2001 Medina-Kauwe LK, Kasahara N, Kedes L
• Receptor-specific targeting mediated by the coexpression of a targeted murine leukemia virus envelope protein and a binding-defective influenza hemagglutinin protein.
  Human gene therapy 2001 Lin AH, Kasahara N, Wu W, Stripecke R, Empig CL, Anderson WF, Cannon PM
• The effect of fibroblast growth factor 8, isoform b, on the biology of prostate carcinoma cells and their interaction with stromal cells.
  Cancer research 2000 Song Z, Powell WC, Kasahara N, van Bokhoven A, Miller GJ, Roy-Burman P
• Development and characterization of a recombinant truncated type VII collagen "minigene". Implication for gene therapy of dystrophic epidermolysis bullosa.
  The Journal of biological chemistry 2000 Chen M, O'Toole EA, Muellenhoff M, Medina E, Kasahara N, Woodley DT
• Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes.
  The Journal of biological chemistry 2000 Smith E, Redman RA, Logg CR, Coetzee GA, Kasahara N, Frenkel B
• Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B.
  The Journal of biological chemistry 2000 Mohan R, Sivak J, Ashton P, Russo LA, Pham BQ, Kasahara N, Raizman MB, Fini ME
• A high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes.
  Journal of molecular and cellular cardiology 1999 Sakoda T, Kasahara N, Hamamori Y, Kedes L
• DNA sequence comparison considering both amino acid and nucleotide insertions/deletions because of evolution and experimental error.
  Journal of biotechnology 1999 Irie R, Hiraoka S, Kasahara N, Nagai K
• Corneal incision phacoemulsification and internal bleb revision.
  Ophthalmic surgery and lasers 1996 Kasahara N, Sibayan SA, Montenegro MH, Simmons RB, Smith TJ
• Ligand-directed retroviral targeting of human breast cancer cells.
  Proceedings of the National Academy of Sciences of the United States of America 1995 Han X, Kasahara N, Kan YW
• Protein tyrosine kinases expressed in glomeruli and cultured glomerular cells: Flt-1 and VEGF expression in renal mesangial cells.
  Biochemical and biophysical research communications 1995 Takahashi T, Shirasawa T, Miyake K, Yahagi Y, Maruyama N, Kasahara N, Kawamura T, Matsumura O, Mitarai T, Sakai O
• Suppression of mammary tumors by oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil in SHN virgin mice.
  Anti-cancer drugs 1993 Sakamoto S, Mizuno M, Kudo H, Suzuki S, Kasahara N, Sugiura Y, Mori T, Nagasawa H
• Deletional analysis of the human renin promoter: transcriptional activation by the SV40 enhancer enables identification of promoter regulatory elements in non-renin-expressing cells.
  The Bulletin of Tokyo Medical and Dental University 1993 Kasahara N
• Effects of luteinizing hormone-releasing hormone analogue on DNA synthesis in rat prostate and uterus.
  In vivo (Athens, Greece) 1993 Sakamoto S, Tajima M, Sawaki K, Suzuki S, Kudo H, Sassa S, Kuwa K, Sugiura Y, Kasahara N, Nagasawa H
• Thermal effects on DNA synthesis in bone marrow cells of patients with acute myeloblastic leukemia.
  Anticancer research 1992 Kudo H, Sakamoto S, Suzuki S, Kuwa K, Nakayama T, Sugiura Y, Kasahara N, Tomiyama J, Adachi Y
• Suppression by 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil of preneoplastic mammary hyperplastic alveolar nodule formation in SHN virgin mice.
  Anticancer research 1992 Sakamoto S, Mizuno M, Sawaki K, Kudo H, Kasahara N, Suzuki S, Mori T, Nagasawa H
• Inhibition by 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil of hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene in rats.
  Anticancer research 1991 Sakamoto S, Hirai H, Taga H, Uchikoshi T, Sunaga T, Endo Y, Kudo H, Kato T, Kasahara N, Kuwa K
• [Thymidine kinase activities in sera and liver tissues during hepatocarcinogenesis in rats treated with 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB)].
  Nihon Gan Chiryo Gakkai shi 1990 Sakamoto S, Kuwa K, Kawachi Y, Kudo H, Kasahara N, Kato T, Okamoto R, Taga H, Hirai H, Sunaga T
• Thymidine kinase and alpha-fetoprotein as biochemical markers of hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene treatment in rats.
  Carcinogenesis 1990 Sakamoto S, Hirai H, Taga H, Uchikoshi T, Sunaga T, Endo Y, Kuwa K, Kudo H, Kawachi Y, Kasahara N
• Increased activities of thymidine kinase isozymes in human mammary tumours.
  The British journal of surgery 1986 Sakamoto S, Iwama T, Ebuchi M, Tsukada K, Sagara T, Kawasaki T, Murakami S, Kasahara N, Kudo H, Okamoto R
• Field trial with a further attenuated live measles virus vaccine.
  Japanese journal of microbiology 1973 Makino S, Sasaki K, Nakamura N, Nakagawa M, Kasahara N
• [Gastric polypoid carcinoma and difficult cases in terms of differential diagnosis].
  Rinsho hoshasen. Clinical radiography 1966 Sasaki K, Kasahara N, Takeshita J, Takihara T, Matsuura R
• [The story of sputum in motion. A case of the ejection of an imago lung fluke with the sputum].
  Rinsho hoshasen. Clinical radiography 1965 Abe M, Inoue M, Sasaki K, Yamagami T, Kasahara N