Norbert Schuff, PhD
Professor Emeritus
Radiology
School of Medicine

I study brain diseases such as Alzheimer's and Parkinson's using imaging. My main interests are improving diagnosis and assessing treatment efficacy. I accomplish this by developing novel computational methods for analyzing brain images using MRI physics as well as modern concepts of probability theory and statistical learning.

Expertise: Neuroimaging

Specialty: Neurodegenerative diseases

Professional Interests: MRI, statistical learning, information theory, brain aging, Alzheimer's disease, Parkinson's disease

Education and Training:

• Bachelor of Science: University of Heidelberg, Germany - Physics and Astronomy
• Masters of Science: University of Heidelberg, Germany - Physics and Astronomy
• Doctor of Physics: University of Heidelberg, Germany - Physics
• Research Assistant: Max Planck Institute for Medical Research, Germany
• Postdoctoral Fellowship: University of California, San Francisco - Radiology

• Progression of brain atrophy in PSP and CBS over 6 months and 1 year.
  Neurology 2016 Dutt S, Binney RJ, Heuer HW, Luong P, Attygalle S, Bhatt P, Marx GA, Elofson J, Tartaglia MC, Litvan I, McGinnis SM, Dickerson BC, Kornak J, Waltzman D, Voltarelli L, Schuff N, Rabinovici GD, Kramer …
• Diagnostic utility of ASL-MRI and FDG-PET in the behavioral variant of FTD and AD.
  Annals of clinical and translational neurology 2016 Tosun D, Schuff N, Rabinovici GD, Ayakta N, Miller BL, Jagust W, Kramer J, Weiner MM, Rosen HJ
• Progression of Microstructural Degeneration in Progressive Supranuclear Palsy and Corticobasal Syndrome: A Longitudinal Diffusion Tensor Imaging Study.
  PloS one 2016 Zhang Y, Walter R, Ng P, Luong PN, Dutt S, Heuer H, Rojas-Rodriguez JC, Tsai R, Litvan I, Dickerson BC, Tartaglia MC, Rabinovici G, Miller BL, Rosen HJ, Schuff N, Boxer AL
• Discriminative Power of Arterial Spin Labeling Magnetic Resonance Imaging and 18F-Fluorodeoxyglucose Positron Emission Tomography Changes for Amyloid-β-Positive Subjects in the Alzheimer's Disease Continuum.
  Neuro-degenerative diseases 2015 Tosun D, Schuff N, Jagust W, Weiner MW, Alzheimer''s Disease Neuroimaging Initiative
• Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection.
  The Lancet. Neurology 2015 Teipel S, Drzezga A, Grothe MJ, Barthel H, Chételat G, Schuff N, Skudlarski P, Cavedo E, Frisoni GB, Hoffmann W, Thyrian JR, Fox C, Minoshima S, Sabri O, Fellgiebel A
• Data-driven regions of interest for longitudinal change in frontotemporal lobar degeneration.
  NeuroImage. Clinical 2015 Pankov A, Binney RJ, Staffaroni AM, Kornak J, Attygalle S, Schuff N, Weiner MW, Kramer JH, Dickerson BC, Miller BL, Rosen HJ
• Diffusion imaging of nigral alterations in early Parkinson's disease with dopaminergic deficits.
  Movement disorders : official journal of the Movement Disorder Society 2015 Schuff N, Wu IW, Buckley S, Foster ED, Coffey CS, Gitelman DR, Mendick S, Seibyl J, Simuni T, Zhang Y, Jankovic J, Hunter C, Tanner CM, Rees L, Factor S, Berg D, Wurster I, Gauss K, Sprenger F, Seppi …
• Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2015 Jack CR, Barnes J, Bernstein MA, Borowski BJ, Brewer J, Clegg S, Dale AM, Carmichael O, Ching C, DeCarli C, Desikan RS, Fennema-Notestine C, Fjell AM, Fletcher E, Fox NC, Gunter J, Gutman BA, Holland …
• Amyloid in dementia associated with familial FTLD: not an innocent bystander.
  Neurocase 2015 Naasan G, Rabinovici GD, Ghosh P, Elofson JD, Miller BL, Coppola G, Karydas A, Fong J, Perry D, Lee SE, Yokoyama JS, Seeley WW, Kramer JH, Weiner MW, Schuff N, Jagust WJ, Grinberg LT, Pribadi M, Yang …
• Diffusion tensor imaging of the nigrostriatal fibers in Parkinson's disease.
  Movement disorders : official journal of the Movement Disorder Society 2015 Zhang Y, Wu IW, Buckley S, Coffey CS, Foster E, Mendick S, Seibyl J, Schuff N
• Directed network motifs in Alzheimer's disease and mild cognitive impairment.
  PloS one 2015 Friedman EJ, Young K, Tremper G, Liang J, Landsberg AS, Schuff N, Alzheimer's Disease Neuroimaging Initiative
• Bayesian segmentation of brainstem structures in MRI.
  NeuroImage 2015 Iglesias JE, Van Leemput K, Bhatt P, Casillas C, Dutt S, Schuff N, Truran-Sacrey D, Boxer A, Fischl B, Alzheimer's Disease Neuroimaging Initiative
• Quantitative framework for prospective motion correction evaluation.
  Magnetic resonance in medicine 2015 Pannetier NA, Stavrinos T, Ng P, Herbst M, Zaitsev M, Young K, Matson G, Schuff N
• A fast algorithm for denoising magnitude diffusion-weighted images with rank and edge constraints.
  Magnetic resonance in medicine 2015 Lam F, Liu D, Song Z, Schuff N, Liang ZP
• Sensitive measures of executive dysfunction in non-demented Parkinson's disease.
  Parkinsonism & related disorders 2014 Bott NT, Johnson ET, Schuff N, Galifianakis N, Subas T, Pollock J, Pressman P, Kramer JH, Possin KL
• Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment.
  Neurobiology of aging 2014 Nosheny RL, Insel PS, Truran D, Schuff N, Jack CR, Aisen PS, Shaw LM, Trojanowski JQ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Directed progression brain networks in Alzheimer's disease: properties and classification.
  Brain connectivity 2014 Friedman EJ, Young K, Asif D, Jutla I, Liang M, Wilson S, Landsberg AS, Schuff N, Alzheimer’s Disease Neuroimaging Initiative
• Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment.
  Brain : a journal of neurology 2014 Mattsson N, Tosun D, Insel PS, Simonson A, Jack CR, Beckett LA, Donohue M, Jagust W, Schuff N, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Denoising diffusion-weighted magnitude MR images using rank and edge constraints.
  Magnetic resonance in medicine 2014 Lam F, Babacan SD, Haldar JP, Weiner MW, Schuff N, Liang ZP
• MR vascular fingerprinting: A new approach to compute cerebral blood volume, mean vessel radius, and oxygenation maps in the human brain.
  NeuroImage 2013 Christen T, Pannetier NA, Ni WW, Qiu D, Moseley ME, Schuff N, Zaharchuk G
• Reduced FDG-PET brain metabolism and executive function predict clinical progression in elderly healthy subjects.
  NeuroImage. Clinical 2013 Ewers M, Brendel M, Rizk-Jackson A, Rominger A, Bartenstein P, Schuff N, Weiner MW, Alzheimer's Disease Neuroimaging Initiative (ADNI)
• Numerical modeling of susceptibility-related MR signal dephasing with vessel size measurement: phantom validation at 3T.
  Magnetic resonance in medicine 2013 Pannetier NA, Sohlin M, Christen T, Schad L, Schuff N
• Locally linear embedding (LLE) for MRI based Alzheimer's disease classification.
  NeuroImage 2013 Liu X, Tosun D, Weiner MW, Schuff N, Alzheimer's Disease Neuroimaging Initiative
• MRI markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements.
  PloS one 2013 Zhang Y, Schuff N, Camacho M, Chao LL, Fletcher TP, Yaffe K, Woolley SC, Madison C, Rosen HJ, Miller BL, Weiner MW
• Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease.
  JAMA neurology 2013 Protas HD, Chen K, Langbaum JB, Fleisher AS, Alexander GE, Lee W, Bandy D, de Leon MJ, Mosconi L, Buckley S, Truran-Sacrey D, Schuff N, Weiner MW, Caselli RJ, Reiman EM
• Voxel-wise co-analysis of macro- and microstructural brain alteration in mild cognitive impairment and Alzheimer's disease using anatomical and diffusion MRI.
  Journal of neuroimaging : official journal of the American Society of Neuroimaging 2013 Cardenas VA, Tosun D, Chao LL, Fletcher PT, Joshi S, Weiner MW, Schuff N
• Voxelwise multivariate analysis of multimodality magnetic resonance imaging.
  Human brain mapping 2013 Naylor MG, Cardenas VA, Tosun D, Schuff N, Weiner M, Schwartzman A
• Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2013 Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW
• The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2013 Mackin RS, Insel P, Tosun D, Mueller SG, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Lee JY, Jack CR, Aisen PS, Petersen RC, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• MRI signatures of brain macrostructural atrophy and microstructural degradation in frontotemporal lobar degeneration subtypes.
  Journal of Alzheimer's disease : JAD 2013 Zhang Y, Tartaglia MC, Schuff N, Chiang GC, Ching C, Rosen HJ, Gorno-Tempini ML, Miller BL, Weiner MW
• Standardization of analysis sets for reporting results from ADNI MRI data.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2012 Wyman BT, Harvey DJ, Crawford K, Bernstein MA, Carmichael O, Cole PE, Crane PK, DeCarli C, Fox NC, Gunter JL, Hill D, Killiany RJ, Pachai C, Schwarz AJ, Schuff N, Senjem ML, Suhy J, Thompson PM, …
• T2-based arterial spin labeling measurements of blood to tissue water transfer in human brain.
  Journal of magnetic resonance imaging : JMRI 2012 Gregori J, Schuff N, Kern R, Günther M
• The Effect of Subsyndromal Symptoms of Depression and White Matter Lesions on Disability for Individuals With Mild Cognitive Impairment.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2012 Mackin RS, Insel P, Tosun D, Mueller SG, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Lee JY, Jack CR, Aisen PS, Petersen RC, Weiner MW, the Alzheimer's Disease Neuroimaging Initiative
• Different associations of white matter lesions with depression and cognition.
  BMC neurology 2012 Lee JY, Insel P, Mackin RS, Schuff N, Chui H, DeCarli C, Park KH, Mueller SG, Weiner MW
• Patterns of Reduced Cortical Thickness in Late-Life Depression and Relationship to Psychotherapeutic Response.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2012 Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW
• Improved diffusion imaging through SNR-enhancing joint reconstruction.
  Magnetic resonance in medicine 2012 Haldar JP, Wedeen VJ, Nezamzadeh M, Dai G, Weiner MW, Schuff N, Liang ZP
• White matter alterations in cognitively normal apoE ε2 carriers: insight into Alzheimer resistance?
  AJNR. American journal of neuroradiology 2012 Chiang GC, Zhan W, Schuff N, Weiner MW
• Arterial spin labeling MRI study of age and gender effects on brain perfusion hemodynamics.
  Magnetic resonance in medicine 2011 Liu Y, Zhu X, Feinberg D, Guenther M, Gregori J, Weiner MW, Schuff N
• CSF biomarker and PIB-PET-derived beta-amyloid signature predicts metabolic, gray matter, and cognitive changes in nondemented subjects.
  Cerebral cortex (New York, N.Y. : 1991) 2011 Ewers M, Insel P, Jagust WJ, Shaw L, Trojanowski JQ, Aisen P, Petersen RC, Schuff N, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative (ADNI)
• MRI patterns of atrophy and hypoperfusion associations across brain regions in frontotemporal dementia.
  NeuroImage 2011 Tosun D, Rosen H, Miller BL, Weiner MW, Schuff N
• Impact of apolipoprotein E4-cerebrospinal fluid β-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2011 Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Thompson PM, Reiman EM, Jack CR, Fox NC, Jagust WJ, Harvey DJ, Beckett LA, Gamst A, Aisen PS, Petersen RC, Weiner MW, …
• Regional alterations of brain microstructure in Parkinson's disease using diffusion tensor imaging.
  Movement disorders : official journal of the Movement Disorder Society 2011 Zhan W, Kang GA, Glass GA, Zhang Y, Shirley C, Millin R, Possin KL, Nezamzadeh M, Weiner MW, Marks WJ, Schuff N
• Progression of white matter degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging study.
  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2011 Zhang Y, Schuff N, Woolley SC, Chiang GC, Boreta L, Laxamana J, Katz JS, Weiner MW
• Joint assessment of structural, perfusion, and diffusion MRI in Alzheimer's disease and frontotemporal dementia.
  International journal of Alzheimer's disease 2011 Zhang Y, Schuff N, Ching C, Tosun D, Zhan W, Nezamzadeh M, Rosen HJ, Kramer JH, Gorno-Tempini ML, Miller BL, Weiner MW
• Changes in brain anatomy during the course of posttraumatic stress disorder.
  Psychiatry research 2011 Cardenas VA, Samuelson K, Lenoci M, Studholme C, Neylan TC, Marmar CR, Schuff N, Weiner MW
• Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes.
  Radiology 2011 Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang S, Jack CR, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment.
  Brain : a journal of neurology 2011 Tosun D, Schuff N, Mathis CA, Jagust W, Weiner MW, Alzheimer's Disease NeuroImaging Initiative
• Accurate measurement of brain changes in longitudinal MRI scans using tensor-based morphometry.
  NeuroImage 2011 Hua X, Gutman B, Boyle CP, Rajagopalan P, Leow AD, Yanovsky I, Kumar AR, Toga AW, Jack CR, Schuff N, Alexander GE, Chen K, Reiman EM, Weiner MW, Thompson PM, Alzheimer's Disease Neuroimaging …
• DTI studies in patients with Alzheimer's disease, mild cognitive impairment, or normal cognition with evaluation of the intrinsic background gradients.
  Neuroradiology 2011 Jahng GH, Xu S, Weiner MW, Meyerhoff DJ, Park S, Schuff N
• Imaging the Alzheimer brain.
  Journal of Alzheimer's disease : JAD 2011 Ashford JW, Salehi A, Furst A, Bayley P, Frisoni GB, Jack CR, Sabri O, Adamson MM, Coburn KL, Olichney J, Schuff N, Spielman D, Edland SD, Black S, Rosen A, Kennedy D, Weiner M, Perry G
• Neuroanatomical correlates of apathy in ALS using 4 Tesla diffusion tensor MRI.
  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2011 Woolley SC, Zhang Y, Schuff N, Weiner MW, Katz JS
• Relationship between CSF biomarkers of Alzheimer's disease and rates of regional cortical thinning in ADNI data.
  Journal of Alzheimer's disease : JAD 2011 Tosun D, Schuff N, Shaw LM, Trojanowski JQ, Weiner MW, Alzheimer's Disease NeuroImaging Initiative
• Diffeomorphic image registration of diffusion MRI using spherical harmonics.
  IEEE transactions on medical imaging 2010 Geng X, Ross TJ, Gu H, Shin W, Zhan W, Chao YP, Lin CP, Schuff N, Yang Y
• Hippocampal volume differences in Gulf War veterans with current versus lifetime posttraumatic stress disorder symptoms.
  Biological psychiatry 2010 Apfel BA, Ross J, Hlavin J, Meyerhoff DJ, Metzler TJ, Marmar CR, Weiner MW, Schuff N, Neylan TC
• Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects.
  Neurology 2010 Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Jack CR, Aisen PS, Petersen RC, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Nonlinear time course of brain volume loss in cognitively normal and impaired elders.
  Neurobiology of aging 2010 Schuff N, Tosun D, Insel PS, Chiang GC, Truran D, Aisen PS, Jack CR, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease.
  Human brain mapping 2010 Mueller SG, Schuff N, Yaffe K, Madison C, Miller B, Weiner MW
• Insomnia severity is associated with a decreased volume of the CA3/dentate gyrus hippocampal subfield.
  Biological psychiatry 2010 Neylan TC, Mueller SG, Wang Z, Metzler TJ, Lenoci M, Truran D, Marmar CR, Weiner MW, Schuff N
• An MRI substudy of a donepezil clinical trial in mild cognitive impairment.
  Neurobiology of aging 2010 Schuff N, Suhy J, Goldman R, Xu Y, Sun Y, Truran-Sacrey D, Murthy A
• Relations between brain tissue loss, CSF biomarkers, and the ApoE genetic profile: a longitudinal MRI study.
  Neurobiology of aging 2010 Tosun D, Schuff N, Truran-Sacrey D, Shaw LM, Trojanowski JQ, Aisen P, Peterson R, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Improved pseudo-continuous arterial spin labeling for mapping brain perfusion.
  Journal of magnetic resonance imaging : JMRI 2010 Nezamzadeh M, Matson GB, Young K, Weiner MW, Schuff N
• Patterns of altered cortical perfusion and diminished subcortical integrity in posttraumatic stress disorder: an MRI study.
  NeuroImage 2010 Schuff N, Zhang Y, Zhan W, Lenoci M, Ching C, Boreta L, Mueller SG, Wang Z, Marmar CR, Weiner MW, Neylan TC
• Update on the magnetic resonance imaging core of the Alzheimer's disease neuroimaging initiative.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2010 Jack CR, Bernstein MA, Borowski BJ, Gunter JL, Fox NC, Thompson PM, Schuff N, Krueger G, Killiany RJ, Decarli CS, Dale AM, Carmichael OW, Tosun D, Weiner MW, Alzheimer's Disease Neuroimaging …
• Joint analysis of structural and perfusion MRI for cognitive assessment and classification of Alzheimer's disease and normal aging.
  NeuroImage 2010 Tosun D, Mojabi P, Weiner MW, Schuff N
• Comparing 3 T and 1.5 T MRI for tracking Alzheimer's disease progression with tensor-based morphometry.
  Human brain mapping 2010 Ho AJ, Hua X, Lee S, Leow AD, Yanovsky I, Gutman B, Dinov ID, Leporé N, Stein JL, Toga AW, Jack CR, Bernstein MA, Reiman EM, Harvey DJ, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM, …
• Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease.
  NeuroImage 2010 Leung KK, Barnes J, Ridgway GR, Bartlett JW, Clarkson MJ, Macdonald K, Schuff N, Fox NC, Ourselin S, Alzheimer's Disease Neuroimaging Initiative
• Concordance and discordance between brain perfusion and atrophy in frontotemporal dementia.
  Brain imaging and behavior 2010 Shimizu S, Zhang Y, Laxamana J, Miller BL, Kramer JH, Weiner MW, Schuff N
• Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder.
  Archives of general psychiatry 2010 Wang Z, Neylan TC, Mueller SG, Lenoci M, Truran D, Marmar CR, Weiner MW, Schuff N
• Gray matter perfusion correlates with disease severity in ALS.
  Neurology 2010 Rule RR, Schuff N, Miller RG, Weiner MW
• Mapping Alzheimer's disease progression in 1309 MRI scans: power estimates for different inter-scan intervals.
  NeuroImage 2010 Hua X, Lee S, Hibar DP, Yanovsky I, Leow AD, Toga AW, Jack CR, Bernstein MA, Reiman EM, Harvey DJ, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM, Alzheimer's Disease Neuroimaging Initiative
• Influences of lobar gray matter and white matter lesion load on cognition and mood.
  Psychiatry research 2010 Mueller SG, Mack WJ, Mungas D, Kramer JH, Cardenas-Nicolson V, Lavretsky H, Greene M, Schuff N, Chui HC, Weiner MW
• A new sensitive MRI marker for memory deficits in normal aging.
  Neurology 2010 Schuff N
• ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia.
  Alzheimer disease and associated disorders 2010 Chao LL, Buckley ST, Kornak J, Schuff N, Madison C, Yaffe K, Miller BL, Kramer JH, Weiner MW
• Multivariate statistical mapping of spectroscopic imaging data.
  Magnetic resonance in medicine 2010 Young K, Govind V, Sharma K, Studholme C, Maudsley AA, Schuff N
• Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2009 Schuff N, Matsumoto S, Kmiecik J, Studholme C, Du A, Ezekiel F, Miller BL, Kramer JH, Jagust WJ, Chui HC, Weiner MW
• Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls.
  Human brain mapping 2009 Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Hua X, Toga AW, Jack CR, Schuff N, Weiner MW, Thompson PM, Alzheimer's Disease Neuroimaging Initiative
• In-vivo investigation of the human cingulum bundle using the optimization of MR diffusion spectrum imaging.
  European journal of radiology 2009 Nezamzadeh M, Wedeen VJ, Wang R, Zhang Y, Zhan W, Young K, Meyerhoff DJ, Weiner MW, Schuff N
• Optimizing power to track brain degeneration in Alzheimer's disease and mild cognitive impairment with tensor-based morphometry: an ADNI study of 515 subjects.
  NeuroImage 2009 Hua X, Lee S, Yanovsky I, Leow AD, Chou YY, Ho AJ, Gutman B, Toga AW, Jack CR, Bernstein MA, Reiman EM, Harvey DJ, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM, Alzheimer's Disease …
• Influence of selecting EPI readout-encoding bandwidths on arterial spin labeling perfusion MRI.
  Magma (New York, N.Y.) 2009 Jahng GH, Schuff N
• Patterns of cerebral hypoperfusion in amnestic and dysexecutive MCI.
  Alzheimer disease and associated disorders 2009 Chao LL, Pa J, Duarte A, Schuff N, Weiner MW, Kramer JH, Miller BL, Freeman KM, Johnson JK
• Measurement of MRI scanner performance with the ADNI phantom.
  Medical physics 2009 Gunter JL, Bernstein MA, Borowski BJ, Ward CP, Britson PJ, Felmlee JP, Schuff N, Weiner M, Jack CR
• Brain atrophy associated with baseline and longitudinal measures of cognition.
  Neurobiology of aging 2009 Cardenas VA, Chao LL, Studholme C, Yaffe K, Miller BL, Madison C, Buckley ST, Mungas D, Schuff N, Weiner MW
• White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI.
  Brain : a journal of neurology 2009 Zhang Y, Schuff N, Du AT, Rosen HJ, Kramer JH, Gorno-Tempini ML, Miller BL, Weiner MW
• Patterns of structural complexity in Alzheimer's disease and frontotemporal dementia.
  Human brain mapping 2009 Young K, Du AT, Kramer J, Rosen H, Miller B, Weiner M, Schuff N
• Alzheimer's disease neuroimaging initiative: a one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition.
  NeuroImage 2009 Leow AD, Yanovsky I, Parikshak N, Hua X, Lee S, Toga AW, Jack CR, Bernstein MA, Britson PJ, Gunter JL, Ward CP, Borowski B, Shaw LM, Trojanowski JQ, Fleisher AS, Harvey D, Kornak J, Schuff N, …
• MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers.
  Brain : a journal of neurology 2009 Schuff N, Woerner N, Boreta L, Kornfield T, Shaw LM, Trojanowski JQ, Thompson PM, Jack CR, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Characterization of white matter degeneration in elderly subjects by magnetic resonance diffusion and FLAIR imaging correlation.
  NeuroImage 2009 Zhan W, Zhang Y, Mueller SG, Lorenzen P, Hadjidemetriou S, Schuff N, Weiner MW
• K-Bayes reconstruction for perfusion MRI. I: concepts and application.
  Journal of digital imaging 2009 Kornak J, Young K, Schuff N, Du A, Maudsley AA, Weiner MW
• Advances in neuroimaging of traumatic brain injury and posttraumatic stress disorder.
  Journal of rehabilitation research and development 2009 Van Boven RW, Harrington GS, Hackney DB, Ebel A, Gauger G, Bremner JD, D'Esposito M, Detre JA, Haacke EM, Jack CR, Jagust WJ, Le Bihan D, Mathis CA, Mueller S, Mukherjee P, Schuff N, Chen A, Weiner MW
• An integrated multimodality MR brain imaging study: gray matter tissue loss mediates the association between cerebral hypoperfusion and Alzheimer's disease.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2009 Tosun D, Schuff N, Weiner M
• Diffusion MRI registration using orientation distribution functions.
  Information processing in medical imaging : proceedings of the ... conference 2009 Geng X, Ross TJ, Zhan W, Gu H, Chao YP, Lin CP, Christensen GE, Schuff N, Yang Y
• Potential role of high-field MRI for studies in Parkinson's disease.
  Movement disorders : official journal of the Movement Disorder Society 2009 Schuff N
• Regional myo-inositol concentration in mild cognitive impairment Using 1H magnetic resonance spectroscopic imaging.
  Alzheimer disease and associated disorders 2009 Siger M, Schuff N, Zhu X, Miller BL, Weiner MW
• Patterns of age-related water diffusion changes in human brain by concordance and discordance analysis.
  Neurobiology of aging 2008 Zhang Y, Du AT, Hayasaka S, Jahng GH, Hlavin J, Zhan W, Weiner MW, Schuff N
• Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls.
  NeuroImage 2008 Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Toga AW, Jack CR, Schuff N, Weiner MW, Thompson PM, Alzheimer's Disease Neuroimaging Initiative
• Restoration of MRI data for intensity non-uniformities using local high order intensity statistics.
  Medical image analysis 2008 Hadjidemetriou S, Studholme C, Mueller S, Weiner M, Schuff N
• Diffusion anisotropy indexes are sensitive to selecting the EPI readout-encoding bandwidth at high-field MRI.
  Magnetic resonance imaging 2008 Jahng GH, Weiner MW, Schuff N
• The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods.
  Journal of magnetic resonance imaging : JMRI 2008 Jack CR, Bernstein MA, Fox NC, Thompson P, Alexander G, Harvey D, Borowski B, Britson PJ, L Whitwell J, Ward C, Dale AM, Felmlee JP, Gunter JL, Hill DL, Killiany R, Schuff N, Fox-Bosetti S, Lin C, …
• 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry.
  NeuroImage 2008 Hua X, Leow AD, Lee S, Klunder AD, Toga AW, Lepore N, Chou YY, Brun C, Chiang MC, Barysheva M, Jack CR, Bernstein MA, Britson PJ, Ward CP, Whitwell JL, Borowski B, Fleisher AS, Fox NC, Boyes RG, …
• Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder.
  Psychiatry research 2008 Schuff N, Neylan TC, Fox-Bosetti S, Lenoci M, Samuelson KW, Studholme C, Kornak J, Marmar CR, Weiner MW
• Computational atlases of severity of white matter lesions in elderly subjects with MRI.
  Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention 2008 Hadjidemetriou S, Lorenzen P, Schuff N, Mueller S, Weiner M
• Neuropathological basis of magnetic resonance images in aging and dementia.
  Annals of neurology 2008 Jagust WJ, Zheng L, Harvey DJ, Mack WJ, Vinters HV, Weiner MW, Ellis WG, Zarow C, Mungas D, Reed BR, Kramer JH, Schuff N, DeCarli C, Chui HC
• Subcortical lacunes are associated with executive dysfunction in cognitively normal elderly.
  Stroke 2007 Carey CL, Kramer JH, Josephson SA, Mungas D, Reed BR, Schuff N, Weiner MW, Chui HC
• Imaging of mild cognitive impairment and early dementia.
  The British journal of radiology 2007 Schuff N, Zhu XP
• Measuring structural complexity in brain images.
  NeuroImage 2007 Young K, Schuff N
• Accelerated 3D echo-planar spectroscopic imaging at 4 Tesla using modified blipped phase-encoding.
  Magnetic resonance in medicine 2007 Ebel A, Schuff N
• Improved arterial spin labeling method: applications for measurements of cerebral blood flow in human brain at high magnetic field MRI.
  Medical physics 2007 Jahng GH, Weiner MW, Schuff N
• Patterns of white matter atrophy in frontotemporal lobar degeneration.
  Archives of neurology 2007 Chao LL, Schuff N, Clevenger EM, Mueller SG, Rosen HJ, Gorno-Tempini ML, Kramer JH, Miller BL, Weiner MW
• Intensity non-uniformity correction using N3 on 3-T scanners with multichannel phased array coils.
  NeuroImage 2007 Boyes RG, Gunter JL, Frost C, Janke AL, Yeatman T, Hill DL, Bernstein MA, Thompson PM, Weiner MW, Schuff N, Alexander GE, Killiany RJ, DeCarli C, Jack CR, Fox NC, ADNI Study
• Improved model-based magnetic resonance spectroscopic imaging.
  IEEE transactions on medical imaging 2007 Jacob M, Zhu X, Ebel A, Schuff N, Liang ZP
• Spectral phase-corrected GRAPPA reconstruction of three-dimensional echo-planar spectroscopic imaging (3D-EPSI).
  Magnetic resonance in medicine 2007 Zhu X, Ebel A, Ji JX, Schuff N
• Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia.
  Brain : a journal of neurology 2007 Du AT, Schuff N, Kramer JH, Rosen HJ, Gorno-Tempini ML, Rankin K, Miller BL, Weiner MW
• Restoration of MRI Data for Field Nonuniformities using High Order Neighborhood Statistics.
  Proceedings of SPIE--the International Society for Optical Engineering 2007 Hadjidemetriou S, Studholme C, Mueller S, Weiner M, Schuff N
• Voxel-based T2 relaxation rate measurements in temporal lobe epilepsy (TLE) with and without mesial temporal sclerosis.
  Epilepsia 2007 Mueller SG, Laxer KD, Schuff N, Weiner MW
• Bayesian parallel imaging with edge-preserving priors.
  Magnetic resonance in medicine 2007 Raj A, Singh G, Zabih R, Kressler B, Wang Y, Schuff N, Weiner M
• Correction of local B0 shifts in 3D EPSI of the human brain at 4 T.
  Magnetic resonance imaging 2006 Ebel A, Maudsley AA, Schuff N
• Volumetric correlates of memory and executive function in normal elderly, mild cognitive impairment and Alzheimer's disease.
  Neuroscience letters 2006 Duarte A, Hayasaka S, Du A, Schuff N, Jahng GH, Kramer J, Miller B, Weiner M
• Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging.
  NMR in biomedicine 2006 Maudsley AA, Darkazanli A, Alger JR, Hall LO, Schuff N, Studholme C, Yu Y, Ebel A, Frew A, Goldgof D, Gu Y, Pagare R, Rousseau F, Sivasankaran K, Soher BJ, Weber P, Young K, Zhu X
• Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging.
  Alzheimer disease and associated disorders 2006 Zhu X, Schuff N, Kornak J, Soher B, Yaffe K, Kramer JH, Ezekiel F, Miller BL, Jagust WJ, Weiner MW
• Longitudinal stability of MRI for mapping brain change using tensor-based morphometry.
  NeuroImage 2006 Leow AD, Klunder AD, Jack CR, Toga AW, Dale AM, Bernstein MA, Britson PJ, Gunter JL, Ward CP, Whitwell JL, Borowski BJ, Fleisher AS, Fox NC, Harvey D, Kornak J, Schuff N, Studholme C, Alexander GE, …
• A non-parametric approach for co-analysis of multi-modal brain imaging data: application to Alzheimer's disease.
  NeuroImage 2006 Hayasaka S, Du AT, Duarte A, Kornak J, Jahng GH, Weiner MW, Schuff N
• N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.
  Advances in experimental medicine and biology 2006 Schuff N, Meyerhoff DJ, Mueller S, Chao L, Sacrey DT, Laxer K, Weiner MW
• Dissociations in hippocampal and frontal contributions to episodic memory performance.
  Neuropsychology 2005 Kramer JH, Rosen HJ, Du AT, Schuff N, Hollnagel C, Weiner MW, Miller BL, Delis DC
• Achieving sufficient spectral bandwidth for volumetric 1H echo-planar spectroscopic imaging at 4 Tesla.
  Magnetic resonance in medicine 2005 Ebel A, Maudsley AA, Weiner MW, Schuff N
• Longitudinal volumetric MRI change and rate of cognitive decline.
  Neurology 2005 Mungas D, Harvey D, Reed BR, Jagust WJ, DeCarli C, Beckett L, Mack WJ, Kramer JH, Weiner MW, Schuff N, Chui HC
• Age effects on atrophy rates of entorhinal cortex and hippocampus.
  Neurobiology of aging 2005 Du AT, Schuff N, Chao LL, Kornak J, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW
• Sensitive and fast T1 mapping based on two inversion recovery images and a reference image.
  Medical physics 2005 Jahng GH, Stables L, Ebel A, Matson GB, Meyerhoff DJ, Weiner MW, Schuff N
• Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T.
  Neurobiology of aging 2005 Kaiser LG, Schuff N, Cashdollar N, Weiner MW
• White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy.
  Neurobiology of aging 2005 Du AT, Schuff N, Chao LL, Kornak J, Ezekiel F, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW
• Summarizing complexity in high dimensions.
  Physical review letters 2005 Young K, Chen Y, Kornak J, Matson GB, Schuff N
• Four-phase single-capillary stepwise model for kinetics in arterial spin labeling MRI.
  Magnetic resonance in medicine 2005 Li KL, Zhu X, Hylton N, Jahng GH, Weiner MW, Schuff N
• Human brain: reliability and reproducibility of pulsed arterial spin-labeling perfusion MR imaging.
  Radiology 2005 Jahng GH, Song E, Zhu XP, Matson GB, Weiner MW, Schuff N
• Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience.
  Radiology 2005 Johnson NA, Jahng GH, Weiner MW, Miller BL, Chui HC, Jagust WJ, Gorno-Tempini ML, Schuff N
• Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla.
  NMR in biomedicine 2005 Kaiser LG, Schuff N, Cashdollar N, Weiner MW
• Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: Boundary Shift Integral versus tracing of the entorhinal cortex and hippocampus.
  Alzheimer disease and associated disorders 2004 Ezekiel F, Chao L, Kornak J, Du AT, Cardenas V, Truran D, Jagust W, Chui H, Miller B, Yaffe K, Schuff N, Weiner M
• Hippocampal volume and retention in Alzheimer's disease.
  Journal of the International Neuropsychological Society : JINS 2004 Kramer JH, Schuff N, Reed BR, Mungas D, Du AT, Rosen HJ, Jagust WJ, Miller BL, Weiner MW, Chui HC
• Deformation tensor morphometry of semantic dementia with quantitative validation.
  NeuroImage 2004 Studholme C, Cardenas V, Blumenfeld R, Schuff N, Rosen HJ, Miller B, Weiner M
• Attention, learning, and memory in posttraumatic stress disorder.
  Journal of traumatic stress 2004 Neylan TC, Lenoci M, Rothlind J, Metzler TJ, Schuff N, Du AT, Franklin KW, Weiss DS, Weiner MW, Marmar CR
• Forgetting in dementia with and without subcortical lacunes.
  The Clinical neuropsychologist 2004 Kramer JH, Mungas D, Reed BR, Schuff N, Weiner MW, Miller BL, Chui HC
• Right and left medial orbitofrontal volumes show an opposite relationship to agreeableness in FTD.
  Dementia and geriatric cognitive disorders 2004 Rankin KP, Rosen HJ, Kramer JH, Schauer GF, Weiner MW, Schuff N, Miller BL
• Cortisol levels are positively correlated with hippocampal N-acetylaspartate.
  Biological psychiatry 2003 Neylan TC, Schuff N, Lenoci M, Yehuda R, Weiner MW, Marmar CR
• Magnetic resonance spectroscopic imaging reconstruction with deformable shape-intensity models.
  Magnetic resonance in medicine 2003 Zhu XP, Du AT, Jahng GH, Soher BJ, Maudsley AA, Weiner MW, Schuff N
• Cinguloparietal atrophy distinguishes Alzheimer disease from semantic dementia.
  Archives of neurology 2003 Boxer AL, Rankin KP, Miller BL, Schuff N, Weiner M, Gorno-Tempini ML, Rosen HJ
• Improved perfusion-weighted MRI by a novel double inversion with proximal labeling of both tagged and control acquisitions.
  Magnetic resonance in medicine 2003 Jahng GH, Zhu XP, Matson GB, Weiner MW, Schuff N
• Evidence of neuronal injury outside the medial temporal lobe in temporal lobe epilepsy: N-acetylaspartate concentration reductions detected with multisection proton MR spectroscopic imaging--initial experience.
  Radiology 2003 Vermathen P, Laxer KD, Schuff N, Matson GB, Weiner MW
• Emotion comprehension in the temporal variant of frontotemporal dementia.
  Brain : a journal of neurology 2002 Rosen HJ, Perry RJ, Murphy J, Kramer JH, Mychack P, Schuff N, Weiner M, Levenson RW, Miller BL
• Multisection proton MR spectroscopy for mesial temporal lobe epilepsy.
  AJNR. American journal of neuroradiology 2002 Capizzano AA, Vermathen P, Laxer KD, Matson GB, Maudsley AA, Soher BJ, Schuff NW, Weiner MW
• Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease.
  Movement disorders : official journal of the Movement Disorder Society 2002 O'Neill J, Schuff N, Marks WJ, Feiwell R, Aminoff MJ, Weiner MW
• Quantitative magnetic resonance imaging differences between Alzheimer disease with and without subcortical lacunes.
  Alzheimer disease and associated disorders 2002 Hsu YY, Schuff N, Amend DL, Du AT, Norman D, Chui HC, Jagust WJ, Weiner MW
• Patterns of cerebral atrophy in primary progressive aphasia.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2002 Rosen HJ, Kramer JH, Gorno-Tempini ML, Schuff N, Weiner M, Miller BL
• Clinical Chemistry
  Non-invasive Imaging and Spectroscopy - Broad Applications using Magnetic Resonance. 1992 Hornung P.A. and Schuff N., Vol. 38 (9), 160, (1992).
• Biol Psychiatry
  19F nuclear magnetic resonance spectroscopy of neuroleptics: the first in vivo pharmacokinetics of trifluoperazine in the rat brain and the first in vivo spectrum of fluphenazine in the human brain. 1991 Bartels M, Gunther U, Albert K, Mann K, Schuff N, Stuckstedte H.
• Proceedings of the Material Research Society,
  A Study of Changes in Poly(methyl-methacrylate) PMMA Resulting from the Adsorption of Methanol using NMR Imaging. 1991 Schuff N., Hornung P.A. and Williams E.H. , Vol. 217, 55, (1991).
• Journal of Magnetic Resonance
  Analytical Method for the Compensation of Eddy-Current Effects Induced by Pulsed Magnetic Field Gradients in NMR Systems. 1990 Jehenson P., Westphal M. and Schuff N.
• Journal of Psychology Research: Neuroimaging,
  Non-invasive In-vivo Detection of a Fluorinated Neuroleptic in the Human Brain by 19F NMR Spectroscopy 1990 Durst P., Schuff N., Croq M.A., Mokrani M.C. and Macher J.P
• Journal of Magnetic Resonance
  INEPT Enhanced 13C Spectroscopy using Double-tuned Surface Coils. 1988 Norris D., Schuff N. and Leibfritz D.
• RoFo, Fortschritte auf dem Gebiet der Rontgenstrahlung und Nuklearmedizin
  MR Tomographie und Spektroskopie der Skelettmuskulatur bei hohen Magnetfeldstarken 1986 Rodiek S., Juretschke H-P., Hoepfel D. and Schuff N.
• Journal of Magnetic Resonance
  Rate Constants of Flipping, and Shielding Tensors of Stationary Water Molecules in Potassium Oxalate Monohydrate 1985 Schuff N. and Haeberlen U.
• Journal of Magnetic Resonance
  2D Correlation Spectroscopy in Homonuclear Dipolar-Coupled Solids. Journal of Magnetic Resonance 1983 Schuff N. and Haeberlen U.