Nitesh Khandelwal, PhD
Specialist
Biochemistry and Biophysics
School of Medicine

Publications (29)

Top publication keywords:
Membrane FluiditySaccharomyces cerevisiae ProteinsCandida albicansCandida glabrataAzolesCarboxy-LyasesVacuolesAntifungal AgentsSaccharomyces cerevisiaeATP-Binding Cassette TransportersDrug Resistance, FungalMicrobial Sensitivity TestsFungal ProteinsCandidiasisFluconazole

• Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A.
  bioRxiv : the preprint server for biology 2024 Khandelwal NK, Gupta M, Gomez JE, Barkho S, Guan Z, Eng AY, Kawate T, Balasubramani SG, Sali A, Hung DT, Stroud RM
• Cryo-EM reveals a phosphorylated R-domain envelops the NBD1 catalytic domain in an ABC transporter.
  Life science alliance 2024 Souza Amado de Carvalho R, Rasel MSI, Khandelwal NK, Tomasiak TM
• Structural Basis of Aquaporin-4 Autoantibody Binding in Neuromyelitis Optica.
  bioRxiv : the preprint server for biology 2024 Gupta M, Khandelwal NK, Nelson A, Hwang P, Pourmal S, Bennett JL, Stroud RM
• Structural Basis for Oxidized Glutathione Recognition by the Yeast Cadmium Factor 1.
  bioRxiv : the preprint server for biology 2024 Soong TH, Hotze C, Khandelwal NK, Tomasiak TM
• Cryo-EM structure of the tetra-phosphorylated R-domain in Ycf1 reveals key interactions for transport regulation.
  bioRxiv : the preprint server for biology 2024 de Carvalho RSA, Rasel SI, Khandelwal NK, Tomasiak TM

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• Structural basis for autoinhibition by the dephosphorylated regulatory domain of Ycf1.
  Nature communications 2024 Khandelwal NK, Tomasiak TM
• Inositol Phosphoryl Transferase, Ipt1, Is a Critical Determinant of Azole Resistance and Virulence Phenotypes in Candida glabrata.
  Journal of fungi (Basel, Switzerland) 2022 Shahi G, Kumar M, Khandelwal NK, Banerjee A, Sarkar P, Kumari S, Esquivel BD, Chauhan N, Chattopadhyay A, White TC, Gaur NA, Singh A, Prasad R
• The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation.
  Nature communications 2022 Khandelwal NK, Millan CR, Zangari SI, Avila S, Williams D, Thaker TM, Tomasiak TM
• Unmasking of CgYor1-Dependent Azole Resistance Mediated by Target of Rapamycin (TOR) and Calcineurin Signaling in Candida glabrata.
  mBio 2022 Kumari S, Kumar M, Esquivel BD, Wasi M, Pandey AK, Kumar Khandelwal N, Mondal AK, White TC, Prasad R, Gaur NA
• Measuring Gene Expression via mRNA Abundance in Candida auris.
  Methods in molecular biology (Clifton, N.J.) 2022 Wasi M, Nair R, Khandelwal NK, Prasad R
• A Conserved Motif in Intracellular Loop 1 Stabilizes the Outward-Facing Conformation of TmrAB.
  Journal of molecular biology 2021 Millan CR, Francis M, Khandelwal NK, Thompson VF, Thaker TM, Tomasiak TM
• A homologous overexpression system to study roles of drug transporters in Candida glabrata.
  FEMS yeast research 2020 Kumari S, Kumar M, Khandelwal NK, Pandey AK, Bhakt P, Kaur R, Prasad R, Gaur NA
• In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains.
  International journal of antimicrobial agents 2019 Orofino F, Truglio GI, Fiorucci D, D'Agostino I, Borgini M, Poggialini F, Zamperini C, Dreassi E, Maccari L, Torelli R, Martini C, Bernabei M, Meis JF, Khandelwal NK, Prasad R, Sanguinetti M, Bugli F,…
• ABC Transporter Genes Show Upregulated Expression in Drug-Resistant Clinical Isolates of Candida auris: A Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genes.
  Frontiers in microbiology 2019 Wasi M, Khandelwal NK, Moorhouse AJ, Nair R, Vishwakarma P, Bravo Ruiz G, Ross ZK, Lorenz A, Rudramurthy SM, Chakrabarti A, Lynn AM, Mondal AK, Gow NAR, Prasad R
• Vacuolar Sequestration of Azoles, a Novel Strategy of Azole Antifungal Resistance Conserved across Pathogenic and Nonpathogenic Yeast.
  Antimicrobial agents and chemotherapy 2019 Khandelwal NK, Wasi M, Nair R, Gupta M, Kumar M, Mondal AK, Gaur NA, Prasad R
• Lipidomics Approaches: Applied to the Study of Pathogenesis in Candida Species.
  Progress in molecular and subcellular biology 2019 Singh A, Khandelwal NK, Prasad R
• All about CDR transporters: Past, present, and future.
  Yeast (Chichester, England) 2018 Prasad R, Balzi E, Banerjee A, Khandelwal NK
• ABC transportome inventory of human pathogenic yeast Candida glabrata: Phylogenetic and expression analysis.
  PloS one 2018 Kumari S, Kumar M, Khandelwal NK, Kumari P, Varma M, Vishwakarma P, Shahi G, Sharma S, Lynn AM, Prasad R, Gaur NA
• Inventory of ABC proteins and their putative role in salt and drug tolerance in Debaryomyces hansenii.
  Gene 2018 Wasi M, Khandelwal NK, Vishwakarma P, Lynn AM, Mondal AK, Prasad R
• Identification of genome-wide binding sites of heat shock factor 1, Hsf1, under basal conditions in the human pathogenic yeast, Candida albicans.
  AMB Express 2018 Nair R, Khandelwal NK, Shariq M, Redhu AK, Gaur NA, Shaikh S, Prasad R
• Phosphatidylserine decarboxylase governs plasma membrane fluidity and impacts drug susceptibilities of Candida albicans cells.
  Biochimica et biophysica acta. Biomembranes 2018 Khandelwal NK, Sarkar P, Gaur NA, Chattopadhyay A, Prasad R
• Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling.
  The Journal of biological chemistry 2017 Khandelwal NK, Chauhan N, Sarkar P, Esquivel BD, Coccetti P, Singh A, Coste AT, Gupta M, Sanglard D, White TC, Chauvel M, d'Enfert C, Chattopadhyay A, Gaur NA, Mondal AK, Prasad R
• pHluorin enables insights into the transport mechanism of antiporter Mdr1: R215 is critical for drug/H+ antiport.
  The Biochemical journal 2016 Redhu AK, Khandelwal NK, Banerjee A, Moreno A, Falson P, Prasad R
• Yeast ABC transporters in lipid trafficking.
  Fungal genetics and biology : FG & B 2016 Prasad R, Khandelwal NK, Banerjee A
• Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence.
  The Biochemical journal 2016 Khandelwal NK, Kaemmer P, Förster TM, Singh A, Coste AT, Andes DR, Hube B, Sanglard D, Chauhan N, Kaur R, d'Enfert C, Mondal AK, Prasad R
• A New Endogenous Overexpression System of Multidrug Transporters of Candida albicans Suitable for Structural and Functional Studies.
  Frontiers in microbiology 2016 Banerjee A, Khandelwal NK, Sanglard D, Prasad R
• The ABCs of Candida albicans Multidrug Transporter Cdr1.
  Eukaryotic cell 2015 Prasad R, Banerjee A, Khandelwal NK, Dhamgaye S
• An assessment of growth media enrichment on lipid metabolome and the concurrent phenotypic properties of Candida albicans.
  PloS one 2014 Mahto KK, Singh A, Khandelwal NK, Bhardwaj N, Jha J, Prasad R
• Molecular mechanisms of action of herbal antifungal alkaloid berberine, in Candida albicans.
  PloS one 2014 Dhamgaye S, Devaux F, Vandeputte P, Khandelwal NK, Sanglard D, Mukhopadhyay G, Prasad R