Nilanjana Chatterjee, PhD
Asst. Professional Researcher
Medicine
School of Medicine

Biochemist and Cancer Biologist with extensive research experience in chromatin, epigenetics, transcription, oncogenic signaling, drug discovery and downstream process development. Expertise in elucidating mechanisms of cancer drug resistance, synthetic lethality and rational combination therapies. Spearheaded multiple projects and driven them to completion by leading and working with multi-disciplinary teams, industry partners and CROs and forging productive cross-functional collaborations.

Awards

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• June L. Biedler Scholar-in-Training Award, AACR, 2025
• Doreen J. Putrah Cancer Research Foundation Scholar-in-Training Award, AACR, 2023
• Invited Speaker & Best Abstract Award, PTEN and its pathways scientific meeting, Harvard Medical School, 2019
• Ruth L. Kirschstein NRSA Postdoctoral Fellowship in Molecular & Cellular Mechanisms in Cancer, NCI, 2017-2019
• Ruth L. Kirschstein NRSA Postdoctoral Fellowship in Molecular Pathology of Cancer, NCI, 2017-2018
• Best Poster Award, Southeastern Regional Yeast Meeting, 2010
• Research Assistantship for PhD degree, Southern Illinois University, 2004-2011
• Graduate Aptitude Test in Engineering & GATE scholarship, Govt. of India, 1999-2001

Education & Training

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• MSc Biochemistry Calcutta University
• Bsc Chemistry (Hons) Calcutta University
• MTech Biotechnology & Biochemical Engineering Indian Institute of Technology
• PhD Biochemistry Southern Illinois University
• Postdoctoral training Stem Cell Biology, Cancer Epigenetics & Drug Resistance University of California

Websites

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• LinkedIn (linkedin.com)

Publications (17)

Top publication keywords:
Saccharomyces cerevisiaeTranscription FactorsNucleosomesHistonesDNA-Binding ProteinsAdenosine TriphosphateNuclear ProteinsPTEN PhosphohydrolaseOncogene Proteins, FusionFactor XSaccharomyces cerevisiae ProteinsNeoplasmsReal-Time Polymerase Chain ReactionDrug Resistance, NeoplasmChromatin Assembly and Disassembly

• Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer.
  The Journal of clinical investigation 2022 Nanjo S, Wu W, Karachaliou N, Blakely CM, Suzuki J, Chou YT, Ali SM, Kerr DL, Olivas VR, Shue J, Rotow J, Mayekar MK, Haderk F, Chatterjee N, Urisman A, Yeo JC, Skanderup AJ, Tan AC, Tam WL, Arrieta O…
• Brahma safeguards canalization of cardiac mesoderm differentiation.
  Nature 2022 Hota SK, Rao KS, Blair AP, Khalilimeybodi A, Hu KM, Thomas R, So K, Kameswaran V, Xu J, Polacco BJ, Desai RV, Chatterjee N, Hsu A, Muncie JM, Blotnick AM, Winchester SAB, Weinberger LS, Hüttenhain R, …
• Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules.
  Cell 2021 Tulpule A, Guan J, Neel DS, Allegakoen HR, Lin YP, Brown D, Chou YT, Heslin A, Chatterjee N, Perati S, Menon S, Nguyen TA, Debnath J, Ramirez AD, Shi X, Yang B, Feng S, Makhija S, Huang B, Bivona TG
• Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.
  Cell reports 2019 Chatterjee N, Pazarentzos E, Mayekar MK, Gui P, Allegakoen DV, Hrustanovic G, Olivas V, Lin L, Verschueren E, Johnson JR, Hofree M, Yan JJ, Newton BW, Dollen JV, Earnshaw CH, Flanagan J, Chan E, …
• Polytherapy and Targeted Cancer Drug Resistance.
  Trends in cancer 2019 Chatterjee N, Bivona TG

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• Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins.
  Cancer research 2018 Neel DS, Allegakoen DV, Olivas V, Mayekar MK, Hemmati G, Chatterjee N, Blakely CM, McCoach CE, Rotow JK, Le A, Karachaliou N, Rosell R, Riess JW, Nichols R, Doebele RC, Bivona TG
• SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells.
  eLife 2016 Myers SA, Peddada S, Chatterjee N, Friedrich T, Tomoda K, Krings G, Thomas S, Maynard J, Broeker M, Thomson M, Pollard K, Yamanaka S, Burlingame AL, Panning B
• Stepwise nucleosome translocation by RSC remodeling complexes.
  eLife 2016 Harada BT, Hwang WL, Deindl S, Chatterjee N, Bartholomew B, Zhuang X
• Histone Acetylation near the Nucleosome Dyad Axis Enhances Nucleosome Disassembly by RSC and SWI/SNF.
  Molecular and cellular biology 2015 Chatterjee N, North JA, Dechassa ML, Manohar M, Prasad R, Luger K, Ottesen JJ, Poirier MG, Bartholomew B
• Extranucleosomal DNA enhances the activity of the LSD1/CoREST histone demethylase complex.
  Nucleic acids research 2015 Kim SA, Chatterjee N, Jennings MJ, Bartholomew B, Tan S
• Accurate estimation of nucleic acids by amplification efficiency dependent PCR.
  PloS one 2012 Chatterjee N, Banerjee T, Datta S
• Disparity in the DNA translocase domains of SWI/SNF and ISW2.
  Nucleic acids research 2012 Dechassa ML, Hota SK, Sen P, Chatterjee N, Prasad P, Bartholomew B
• Encyclopedia of Signaling Molecules Springer Press
  SWI/SNF Chromatin Remodeling Complex 2012 Sen P, Chatterjee N, and Bartholomew B
• Histone H3 tail acetylation modulates ATP-dependent remodeling through multiple mechanisms.
  Nucleic acids research 2011 Chatterjee N, Sinha D, Lemma-Dechassa M, Tan S, Shogren-Knaak MA, Bartholomew B
• Phosphorylation of histone H3(T118) alters nucleosome dynamics and remodeling.
  Nucleic acids research 2011 North JA, Javaid S, Ferdinand MB, Chatterjee N, Picking JW, Shoffner M, Nakkula RJ, Bartholomew B, Ottesen JJ, Fishel R, Poirier MG
• SWI/SNF has intrinsic nucleosome disassembly activity that is dependent on adjacent nucleosomes.
  Molecular cell 2010 Dechassa ML, Sabri A, Pondugula S, Kassabov SR, Chatterjee N, Kladde MP, Bartholomew B
• Handbook of Cell Signaling, Oxford-Academic Press
  The SWI/SNF and RSC Nucleosome Remodeling Complexes 2009 Chatterjee N, Sen P and Bartholomew B