Nikolaos Kyritsis, PhD
Assistant Professor
Neurological Surgery
School of Medicine

Molecular neuroscientist with a great interest in traumatic spinal cord (mostly) and brain injuries and the use of high throughput big data analytics for biomarker discovery and functional interventions.

Awards

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• Individual Grant from Wings for Life (extension), Wings for Life, 2020-2021
• Best Poster Award at the International Symposium for Neural Regeneration, ISNR, 2020
• Best Poster Award at the Wings for Life Annual Meeting, Wings for Life, 2019
• Individual Grant from Wings for Life, Wings for Life, 2018-2020
• EMBO Long Term Fellowship, EMBO, 2015-2017
• Travel Grant for the International Symposium for Neural Regeneration, ISNR, 2015
• Award for the best PhD thesis in 2013, CRTD e.V. (friends and donors of CRTD), 2014
• PhD student award in Regenerative Medicine for the most outstanding publication, Berlin-Brandenburg School for Regenerative Medicine (BSRT), 2013
• Travel Grant to Abcam Meeting “New Avenues for Brain Repair: Programming and Reprogramming the CNS", DIGS-BB, 2013
• Travel Grant for the Conference "The molecular and cellular basis of regeneration and tissue repair", EMBO, 2012
• Scholarship for studies abroad, Leonidas Charalambous-Kolokythas Scholarship Foundation, 2009

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California 06/2022
• Postdoc Spinal Cord Injury University of California San Francisco (UCSF) 2020
• Ph.D. Molecular Neurobiology International Max Planck Research School/ TU Dresden 2013
• BSc/MSc Biology University of Ioannina 2009

Interests

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• CNS injuries
• RNAseq
• Neuroinflammation
• R programming
• Traumatic Brain Injury
• Biomarkers
• Neural Stem Cells
• Spinal Cord Injury
• CNS regeneration
• Biostatistics

Websites

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• Posts on X nikos_kyritsis (X.com)

Publications (18)

Top publication keywords:
Neural Stem CellsSpinal Cord InjuriesZebrafishRegenerationCommon Data ElementsEncephalitisRNAActivating Transcription Factor 3Cerebrospinal Fluid PressureBrain InjuriesCentral Nervous SystemArterial PressureNeurogenesisGene OntologyNerve Regeneration

• Acute inflammation initiates the regenerative response in the adult zebrafish brain.
  Science (New York, N.Y.) 2012 Kyritsis N, Kizil C, Zocher S, Kroehne V, Kaslin J, Freudenreich D, Iltzsche A, Brand M
• ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke.
  Clinical and translational medicine 2024 Pan JZ, Wang Z, Sun W, Pan P, Li W, Sun Y, Chen S, Lin A, Tan W, He L, Greene J, Yao V, An L, Liang R, Li Q, Yu J, Zhang L, Kyritsis N, Fernandez XD, Moncivais S, Mendoza E, Fung P, Wang G, Niu X, Du …
• Hypotension requiring vasopressor treatment and increased cardiac complications in elderly spinal cord injury patients: a prospective TRACK-SCI registry study.
  Journal of neurosurgery. Spine 2023 Agarwal N, Blitstein J, Lui A, Torres-Espin A, Vasnarungruengkul C, Burke J, Mummaneni PV, Dhall SS, Weinstein PR, Duong-Fernandez X, Chou A, Pan J, Singh V, Ferguson AR, Hemmerle DD, Kyritsis N, …
• Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome.
  PloS one 2022 Chou A, Torres-Espin A, Kyritsis N, Huie JR, Khatry S, Funk J, Hay J, Lofgreen A, Shah R, McCann C, Pascual LU, Amorim E, Weinstein PR, Manley GT, Dhall SS, Pan JZ, Bresnahan JC, Beattie MS, Whetstone…
• Decision tree-based machine learning analysis of intraoperative vasopressor use to optimize neurological improvement in acute spinal cord injury.
  Neurosurgical focus 2022 Agarwal N, Aabedi AA, Torres-Espin A, Chou A, Wozny TA, Mummaneni PV, Burke JF, Ferguson AR, Kyritsis N, Dhall SS, Weinstein PR, Duong-Fernandez X, Pan J, Singh V, Hemmerle DD, Talbott JF, Whetstone …

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• Appendicular Fracture and Polytrauma Correlate with Outcome of Spinal Cord Injury: A Transforming Research and Clinical Knowledge in Spinal Cord Injury Study.
  Journal of neurotrauma 2022 Miclau TA, Torres-Espin A, Morshed S, Morioka K, Huie JR, El Naga AN, Chou A, Pascual L, Duong-Fernandez X, Kuo YH, Weinstein P, Dhall SS, Bresnahan JC, Beattie MS, Digiorgio A, Ferguson AR, …
• Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury.
  eLife 2021 Torres-Espín A, Haefeli J, Ehsanian R, Torres D, Almeida CA, Huie JR, Chou A, Morozov D, Sanderson N, Dirlikov B, Suen CG, Nielson JL, Kyritsis N, Hemmerle DD, Talbott JF, Manley GT, Dhall SS, …
• Diagnostic blood RNA profiles for human acute spinal cord injury.
  The Journal of experimental medicine 2021 Kyritsis N, Torres-Espín A, Schupp PG, Huie JR, Chou A, Duong-Fernandez X, Thomas LH, Tsolinas RE, Hemmerle DD, Pascual LU, Singh V, Pan JZ, Talbott JF, Whetstone WD, Burke JF, DiGiorgio AM, Weinstein…
• Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury.
  Scientific reports 2021 Huie JR, Ferguson AR, Kyritsis N, Pan JZ, Irvine KA, Nielson JL, Schupp PG, Oldham MC, Gensel JC, Lin A, Segal MR, Ratan RR, Bresnahan JC, Beattie MS
• Reproducible analysis of disease space via principal components using the novel R package syndRomics.
  eLife 2021 Torres-Espín A, Chou A, Huie JR, Kyritsis N, Upadhyayula PS, Ferguson AR
• Injury volume extracted from MRI predicts neurologic outcome in acute spinal cord injury: A prospective TRACK-SCI pilot study.
  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2020 Mummaneni N, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris M, Pascual LU, Ferguson AR, Russell Huie J, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Weinstein PR, …
• Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics.
  Neurosurgical focus 2020 Tsolinas RE, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris MH, Yue JK, Winkler EA, Suen CG, Pascual LU, Ferguson AR, Huie JR, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, …
• Clinical Implementation of Novel Spinal Cord Perfusion Pressure Protocol in Acute Traumatic Spinal Cord Injury at U.S. Level I Trauma Center: TRACK-SCI Study.
  World neurosurgery 2019 Yue JK, Hemmerle DD, Winkler EA, Thomas LH, Fernandez XD, Kyritsis N, Pan JZ, Pascual LU, Singh V, Weinstein PR, Talbott JF, Huie JR, Ferguson AR, Whetstone WD, Manley GT, Beattie MS, Bresnahan JC, …
• Convolutional Neural Network-Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury.
  AJNR. American journal of neuroradiology 2019 McCoy DB, Dupont SM, Gros C, Cohen-Adad J, Huie RJ, Ferguson A, Duong-Fernandez X, Thomas LH, Singh V, Narvid J, Pascual L, Kyritsis N, Beattie MS, Bresnahan JC, Dhall S, Whetstone W, Talbott JF, …
• Effects of inflammation on stem cells: together they strive?
  EMBO reports 2015 Kizil C, Kyritsis N, Brand M
• Neuroinflammation and central nervous system regeneration in vertebrates.
  Trends in cell biology 2013 Kyritsis N, Kizil C, Brand M
• Regenerative neurogenesis from neural progenitor cells requires injury-induced expression of Gata3.
  Developmental cell 2012 Kizil C, Kyritsis N, Dudczig S, Kroehne V, Freudenreich D, Kaslin J, Brand M
• The chemokine receptor cxcr5 regulates the regenerative neurogenesis response in the adult zebrafish brain.
  Neural development 2012 Kizil C, Dudczig S, Kyritsis N, Machate A, Blaesche J, Kroehne V, Brand M