Nicole Delrosso
Assistant Researcher
Cellular Molecular Pharmacology
School of Medicine

Awards

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• ARCS Foundation Award
• NSF Graduate Research Fellowship

Education & Training

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• BA Biophysics Hampshire College
• PhD Biophysics Stanford University

Websites

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• Biophysics Graduate Program (biophysics.ucsf.edu)
• Cellular and Molecular Pharmacology Department (cmp.ucsf.edu)
• DelRosso Lab (delrossolab.com)
• Institute for Human Genetics (humangenetics.ucsf.edu)

Publications (7)

Top publication keywords:
Repressor ProteinsMutagenesisSumoylationChromatinGene Expression RegulationThermodynamicsEpigenesis, GeneticProtein FoldingGenes, ReporterDNAProtein DomainsHigh-Throughput Screening AssaysTranscription, GeneticEpigenomicsTranscription Factors

• Mutations to transcription factor MAX allosterically increase DNA selectivity by altering folding and binding pathways.
  Nature communications 2025 Hastings R, Aditham AK, DelRosso N, Suzuki PH, Fordyce PM
• Development of compact transcriptional effectors using high-throughput measurements in diverse contexts.
  Nature biotechnology 2024 Tycko J, Van MV, DelRosso N, Ye H, Yao D, Valbuena R, Vaughan-Jackson A, Xu X, Ludwig C, Spees K, Liu K, Gu M, Khare V, Mukund AX, Suzuki PH, Arana S, Zhang C, Du PP, Ornstein TS, Hess GT, Kamber RA, …
• High-throughput affinity measurements of direct interactions between activation domains and co-activators.
  bioRxiv : the preprint server for biology 2024 DelRosso N, Suzuki PH, Griffith D, Lotthammer JM, Novak B, Kocalar S, Sheth MU, Holehouse AS, Bintu L, Fordyce P
• Using High-Throughput Measurements to Identify Principles of Transcriptional and Epigenetic Regulators.
  Methods in molecular biology (Clifton, N.J.) 2024 DelRosso N, Bintu L
• Large-scale mapping and mutagenesis of human transcriptional effector domains.
  Nature 2023 DelRosso N, Tycko J, Suzuki P, Andrews C, Mukund A, Liongson I, Ludwig C, Spees K, Fordyce P, Bassik MC, Bintu L
• High-Throughput Affinity Measurements of Transcription Factor and DNA Mutations Reveal Affinity and Specificity Determinants.
  Cell systems 2020 Aditham AK, Markin CJ, Mokhtari DA, DelRosso N, Fordyce PM
• High-Throughput Discovery and Characterization of Human Transcriptional Effectors.
  Cell 2020 Tycko J, DelRosso N, Hess GT, Banerjee A, Mukund A, Van MV, Ego BK, Yao D, Spees K, Suzuki P, Marinov GK, Kundaje A, Bassik MC, Bintu L