Nicole Delrosso
Assistant Researcher
Cellular Molecular Pharmacology
School of Medicine

Awards

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• ARCS Foundation Award
• NIH Director’s Early Independence Award (DP5)
• NSF Graduate Research Fellowship

Education & Training

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• BA Biophysics Hampshire College
• PhD Biophysics Stanford University

Websites

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• Biophysics Graduate Program (biophysics.ucsf.edu)
• Cellular and Molecular Pharmacology Department (cmp.ucsf.edu)
• DelRosso Lab (delrossolab.com)
• Institute for Human Genetics (humangenetics.ucsf.edu)

Publications (12)

Top publication keywords:
Molecular Motor ProteinsMutagenesisBasic-Leucine Zipper Transcription FactorsSumoylationChromatinGene Expression RegulationNanoparticlesEpigenesis, GeneticDNAProtein DomainsHigh-Throughput Screening AssaysTranscription, GeneticNanotechnologyCytoskeletonTranscription Factors

• Bifunctional transcriptional effector domains control gene expression pulses in an occupancy-dependent manner.
  bioRxiv : the preprint server for biology 2025 Andrews CJ, Costa EJ, Janer Carattini GL, DelRosso NV, Fujimori T, Shimasawa M, Bintu L
• ADAPT-M: A workflow for rapid, quantitative in vitro measurements of enriched protein libraries.
  bioRxiv : the preprint server for biology 2025 Perez CP, DelRosso NV, Noland CL, Parekh U, Choe CA, Eguchi RR, Wen Q, Fordyce PM, Huang PS
• Mutations to transcription factor MAX allosterically increase DNA selectivity by altering folding and binding pathways.
  Nature communications 2025 Hastings R, Aditham AK, DelRosso N, Suzuki PH, Fordyce PM
• Development of compact transcriptional effectors using high-throughput measurements in diverse contexts.
  Nature biotechnology 2024 Tycko J, Van MV, DelRosso N, Ye H, Yao D, Valbuena R, Vaughan-Jackson A, Xu X, Ludwig C, Spees K, Liu K, Gu M, Khare V, Mukund AX, Suzuki PH, Arana S, Zhang C, Du PP, Ornstein TS, Hess GT, Kamber RA, …
• High-throughput affinity measurements of direct interactions between activation domains and co-activators.
  bioRxiv : the preprint server for biology 2024 DelRosso N, Suzuki PH, Griffith D, Lotthammer JM, Novak B, Kocalar S, Sheth MU, Holehouse AS, Bintu L, Fordyce P

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• Using High-Throughput Measurements to Identify Principles of Transcriptional and Epigenetic Regulators.
  Methods in molecular biology (Clifton, N.J.) 2024 DelRosso N, Bintu L
• Large-scale mapping and mutagenesis of human transcriptional effector domains.
  Nature 2023 DelRosso N, Tycko J, Suzuki P, Andrews C, Mukund A, Liongson I, Ludwig C, Spees K, Fordyce P, Bassik MC, Bintu L
• High-Throughput Affinity Measurements of Transcription Factor and DNA Mutations Reveal Affinity and Specificity Determinants.
  Cell systems 2020 Aditham AK, Markin CJ, Mokhtari DA, DelRosso N, Fordyce PM
• High-Throughput Discovery and Characterization of Human Transcriptional Effectors.
  Cell 2020 Tycko J, DelRosso N, Hess GT, Banerjee A, Mukund A, Van MV, Ego BK, Yao D, Spees K, Suzuki P, Marinov GK, Kundaje A, Bassik MC, Bintu L
• Accurate quantification of astrocyte and neurotransmitter fluorescence dynamics for single-cell and population-level physiology.
  Nature neuroscience 2019 Wang Y, DelRosso NV, Vaidyanathan TV, Cahill MK, Reitman ME, Pittolo S, Mi X, Yu G, Poskanzer KE
• A Molecular Circuit Regenerator to Implement Iterative Strand Displacement Operations.
  Angewandte Chemie (International ed. in English) 2017 DelRosso NV, Hews S, Spector L, Derr ND
• Exploiting molecular motors as nanomachines: the mechanisms of de novo and re-engineered cytoskeletal motors.
  Current opinion in biotechnology 2017 DelRosso NV, Derr ND