Nico Papinutto, PhD
Associate Professor
Neurology
School of Medicine

Publications (68)

Top publication keywords:
Image Interpretation, Computer-AssistedBrainMultiple Sclerosis, Relapsing-RemittingAmyotrophic Lateral SclerosisSpinal CordCervical CordMultiple SclerosisAtrophyMotor Neuron DiseaseDiffusion Magnetic Resonance ImagingMagnetic Resonance ImagingWhite MatterSex CharacteristicsGray MatterNeck

• Cervical spinal cord atrophy in amyotrophic lateral sclerosis across disease stages.
  Annals of clinical and translational neurology 2023 Nigri A, Dalla Bella E, Ferraro S, Medina Carrion JP, Demichelis G, Bersano E, Consonni M, Bischof A, Stanziano M, Palermo S, Lauria G, Bruzzone MG, Papinutto N
• Spinal Cord Atrophy Predicts Progressive Disease in Relapsing Multiple Sclerosis.
  Annals of neurology 2022 Bischof A, Papinutto N, Keshavan A, Rajesh A, Kirkish G, Zhang X, Mallott JM, Asteggiano C, Sacco S, Gundel TJ, Zhao C, Stern WA, Caverzasi E, Zhou Y, Gomez R, Ragan NR, Santaniello A, Zhu AH, Juwono …
• Structural connectivity of the human anterior temporal lobe: A diffusion magnetic resonance imaging study.
  Human brain mapping 2016 Papinutto N, Galantucci S, Mandelli ML, Gesierich B, Jovicich J, Caverzasi E, Henry RG, Seeley WW, Miller BL, Shapiro KA, Gorno-Tempini ML
• 2D phase-sensitive inversion recovery imaging to measure in vivo spinal cord gray and white matter areas in clinically feasible acquisition times.
  Journal of magnetic resonance imaging : JMRI 2014 Papinutto N, Schlaeger R, Panara V, Caverzasi E, Ahn S, Johnson KJ, Zhu AH, Stern WA, Laub G, Hauser SL, Henry RG
• Q-ball of inferior fronto-occipital fasciculus and beyond.
  PloS one 2014 Caverzasi E, Papinutto N, Amirbekian B, Berger MS, Henry RG

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• Multicenter validation of automated detection of paramagnetic rim lesions on brain MRI in multiple sclerosis.
  Journal of neuroimaging : official journal of the American Society of Neuroimaging 2024 Chen L, Ren Z, Clark KA, Lou C, Liu F, Cao Q, Manning AR, Martin ML, Luskin E, O'Donnell CM, Azevedo CJ, Calabresi PA, Freeman L, Henry RG, Longbrake EE, Oh J, Papinutto N, Bilello M, Song JW, Kaisey …
• A simplified approach to define cervical vertebral levels in spinal cord MRI studies.
  Journal of neuroimaging : official journal of the American Society of Neuroimaging 2024 Papinutto N, Perretti I, Mallott J, Cheng S, Cooper T, Gomez R, Stern WA, Pichiecchio A, Caverzasi E, Henry RG
• Multicenter automated central vein sign detection performs as well as manual assessment for the diagnosis of multiple sclerosis.
  AJNR. American journal of neuroradiology 2024 Manning AR, Letchuman V, Martin ML, Gombos E, Roberts-Fitzgerald T, Cao Q, Raza P, O'Donnell CM, Renner B, Daboul L, Rodrigues P, Ramos M, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi PA,…
• Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2024 Toljan K, Daboul L, Raza P, Martin ML, Cao Q, O'Donnell CM, Rodrigues P, Derbyshire J, Azevedo CJ, Bar-Or A, Caverzasi E, Calabresi PA, Cree BA, Freeman L, Henry RG, Longbrake EE, Oh J, Papinutto N, …
• Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study.
  bioRxiv : the preprint server for biology 2024 Labounek R, Bondy MT, Paulson AL, Bédard S, Abramovic M, Alonso-Ortiz E, Atcheson NT, Barlow LR, Barry RL, Barth M, Battiston M, Büchel C, Budde MD, Callot V, Combes A, De Leener B, Descoteaux M, de …
• A multicenter pilot study evaluating simplified central vein assessment for the diagnosis of multiple sclerosis.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2023 Daboul L, O'Donnell CM, Amin M, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi PA, Cree BA, Freeman L, Henry RG, Longbrake EE, Oh J, Papinutto N, Pelletier D, Prchkovska V, …
• Susceptibility-based imaging aids accurate distinction of pediatric-onset MS from myelin oligodendrocyte glycoprotein antibody-associated disease.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2023 Sacco S, Virupakshaiah A, Papinutto N, Schoeps VA, Akula A, Zhao H, Arona J, Stern WA, Chong J, Hart J, Zamvil SS, Sati P, Henry RG, Waubant E
• MWF of the corpus callosum is a robust measure of remyelination: Results from the ReBUILD trial.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Caverzasi E, Papinutto N, Cordano C, Kirkish G, Gundel TJ, Zhu A, Akula AV, Boscardin WJ, Neeb H, Henry RG, Chan JR, Green AJ
• Association of daily physical activity with brain volumes and cervical spinal cord areas in multiple sclerosis.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2022 Block VJ, Cheng S, Juwono J, Cuneo R, Kirkish G, Alexander AM, Khan M, Akula A, Caverzasi E, Papinutto N, Stern WA, Pletcher MJ, Marcus GM, Olgin JE, Hauser SL, Gelfand JM, Bove R, Cree BA, Henry RG
• Differences in Age-related Retinal and Cortical Atrophy Rates in Multiple Sclerosis.
  Neurology 2022 Cordano C, Nourbakhsh B, Yiu HH, Papinutto N, Caverzasi E, Abdelhak A, Oertel FC, Beaudry-Richard A, Santaniello A, Sacco S, Bennett DJ, Gomez A, Sigurdson CJ, Hauser SL, Magliozzi R, Cree BAC, Henry …
• Effect of GBCA Use on Detection and Diagnostic Performance of the Central Vein Sign: Evaluation Using a 3-T FLAIR* Sequence in Patients With Suspected Multiple Sclerosis.
  AJR. American journal of roentgenology 2022 Daboul L, O'Donnell CM, Cao Q, Amin M, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree BAC, Freeman L, Henry RG, Longbrake EE, Nakamura K, Oh J, Papinutto N, Pelletier D…
• Multisite MRI reproducibility of lateral ventricular volume using the NAIMS cooperative pilot dataset.
  Journal of neuroimaging : official journal of the American Society of Neuroimaging 2022 Jakimovski D, Zivadinov R, Bergsland N, Oh J, Martin M, Shinohara RT, Bakshi R, Calabresi PA, Papinutto N, Pelletier D, Dwyer MG
• Reply to "Spinal Cord Atrophy Is a Preclinical Marker of Progressive MS".
  Annals of neurology 2022 Bischof A, Papinutto N, Keshavan A, Rajesh A, Kirkish G, Zhang X, Mallott JM, Asteggiano C, Sacco S, Gundel TJ, Zhao C, Stern WA, Caverzasi E, Zhou Y, Gomez R, Ragan NR, Santaniello A, Zhu AH, Juwono …
• Simultaneous assessment of regional distributions of atrophy across the neuraxis in MS patients.
  NeuroImage. Clinical 2022 Freund P, Papinutto N, Bischof A, Azzarito M, Kirkish G, Ashburner J, Thompson A, Hauser SL, Henry RG
• Generic acquisition protocol for quantitative MRI of the spinal cord.
  Nature protocols 2021 Cohen-Adad J, Alonso-Ortiz E, Abramovic M, Arneitz C, Atcheson N, Barlow L, Barry RL, Barth M, Battiston M, Büchel C, Budde M, Callot V, Combes AJE, De Leener B, Descoteaux M, de Sousa PL, Dostál M, …
• Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers.
  Scientific data 2021 Cohen-Adad J, Alonso-Ortiz E, Abramovic M, Arneitz C, Atcheson N, Barlow L, Barry RL, Barth M, Battiston M, Büchel C, Budde M, Callot V, Combes AJE, De Leener B, Descoteaux M, de Sousa PL, Dostál M, …
• Neurite Orientation Dispersion and Density Imaging for Assessing Acute Inflammation and Lesion Evolution in MS.
  AJNR. American journal of neuroradiology 2020 Sacco S, Caverzasi E, Papinutto N, Cordano C, Bischof A, Gundel T, Cheng S, Asteggiano C, Kirkish G, Mallott J, Stern WA, Bastianello S, Bove RM, Gelfand JM, Goodin DS, Green AJ, Waubant E, Wilson MR,…
• Intensity warping for multisite MRI harmonization.
  NeuroImage 2020 Wrobel J, Martin ML, Bakshi R, Calabresi PA, Elliot M, Roalf D, Gur RC, Gur RE, Henry RG, Nair G, Oh J, Papinutto N, Pelletier D, Reich DS, Rooney WD, Satterthwaite TD, Stern W, Prabhakaran K, Sicotte…
• Imaging correlates of visual function in multiple sclerosis.
  PloS one 2020 Caverzasi E, Cordano C, Zhu AH, Zhao C, Bischof A, Kirkish G, Bennett DJ, Devereux M, Baker N, Inman J, Yiu HH, Papinutto N, Gelfand JM, Cree BAC, Hauser SL, Henry RG, Green AJ
• MRI Measurement of Upper Cervical Spinal Cord Cross-Sectional Area in Children.
  Journal of neuroimaging : official journal of the American Society of Neuroimaging 2020 Papinutto N, Cordano C, Asteggiano C, Caverzasi E, Mandelli ML, Lauricella M, Yabut N, Neylan M, Kirkish G, Gorno-Tempini ML, Henry RG
• Longitudinal Disconnection Tractograms to Investigate the Functional Consequences of White Matter Damage: An Automated Pipeline.
  Journal of neuroimaging : official journal of the American Society of Neuroimaging 2020 Jordan KM, Keshavan A, Caverzasi E, Osorio J, Papinutto N, Amirbekian B, Berger MS, Henry RG
• Intersubject Variability and Normalization Strategies for Spinal Cord Total Cross-Sectional and Gray Matter Areas.
  Journal of neuroimaging : official journal of the American Society of Neuroimaging 2019 Papinutto N, Asteggiano C, Bischof A, Gundel TJ, Caverzasi E, Stern WA, Bastianello S, Hauser SL, Henry RG
• Longitudinal quantitative magnetic resonance imaging in adrenomyeloneuropathy.
  European journal of neurology 2019 Politi LS, Castellano A, Papinutto N, Mauro E, Pareyson D, Henry RG, Falini A, Salsano E
• Silent progression in disease activity-free relapsing multiple sclerosis.
  Annals of neurology 2019 University of California, San Francisco MS-EPIC Team, Cree BAC, Hollenbach JA, Bove R, Kirkish G, Sacco S, Caverzasi E, Bischof A, Gundel T, Zhu AH, Papinutto N, Stern WA, Bevan C, Romeo A, Goodin DS,…
• Differential intrinsic functional connectivity changes in semantic variant primary progressive aphasia.
  NeuroImage. Clinical 2019 Battistella G, Henry M, Gesierich B, Wilson SM, Borghesani V, Shwe W, Miller Z, Deleon J, Miller BL, Jovicich J, Papinutto N, Dronkers NF, Seeley WW, Mandelli ML, Gorno-Tempini ML
• Multisite reliability and repeatability of an advanced brain MRI protocol.
  Journal of magnetic resonance imaging : JMRI 2019 Schwartz DL, Tagge I, Powers K, Ahn S, Bakshi R, Calabresi PA, Todd Constable R, Grinstead J, Henry RG, Nair G, Papinutto N, Pelletier D, Shinohara R, Oh J, Reich DS, Sicotte NL, Rooney WD, NAIMS …
• Measurement of spinal cord atrophy using phase sensitive inversion recovery (PSIR) imaging in motor neuron disease.
  PloS one 2018 Olney NT, Bischof A, Rosen H, Caverzasi E, Stern WA, Lomen-Hoerth C, Miller BL, Henry RG, Papinutto N
• Evaluation of Intra- and Interscanner Reliability of MRI Protocols for Spinal Cord Gray Matter and Total Cross-Sectional Area Measurements.
  Journal of magnetic resonance imaging : JMRI 2018 Papinutto N, Henry RG
• Abnormal age-related cortical folding and neurite morphology in children with developmental dyslexia.
  NeuroImage. Clinical 2018 Caverzasi E, Mandelli ML, Hoeft F, Watson C, Meyer M, Allen IE, Papinutto N, Wang C, Gandini Wheeler-Kingshott CAM, Marco EJ, Mukherjee P, Miller ZA, Miller BL, Hendren R, Shapiro KA, Gorno-Tempini ML
• An Automated Statistical Technique for Counting Distinct Multiple Sclerosis Lesions.
  AJNR. American journal of neuroradiology 2018 Dworkin JD, Linn KA, Oguz I, Fleishman GM, Bakshi R, Nair G, Calabresi PA, Henry RG, Oh J, Papinutto N, Pelletier D, Rooney W, Stern W, Sicotte NL, Reich DS, Shinohara RT, North American Imaging in …
• The NAIMS cooperative pilot project: Design, implementation and future directions.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2017 Oh J, Bakshi R, Calabresi PA, Crainiceanu C, Henry RG, Nair G, Papinutto N, Constable RT, Reich DS, Pelletier D, Rooney W, Schwartz D, Tagge I, Shinohara RT, Simon JH, Sicotte NL, NAIMS Cooperative …
• Spinal cord microstructure integrating phase-sensitive inversion recovery and diffusional kurtosis imaging.
  Neuroradiology 2017 Panara V, Navarra R, Mattei PA, Piccirilli E, Cotroneo AR, Papinutto N, Henry RG, Uncini A, Caulo M
• Volumetric Analysis from a Harmonized Multisite Brain MRI Study of a Single Subject with Multiple Sclerosis.
  AJNR. American journal of neuroradiology 2017 Shinohara RT, Oh J, Nair G, Calabresi PA, Davatzikos C, Doshi J, Henry RG, Kim G, Linn KA, Papinutto N, Pelletier D, Pham DL, Reich DS, Rooney W, Roy S, Stern W, Tummala S, Yousuf F, Zhu A, Sicotte NL…
• Gradient nonlinearity effects on upper cervical spinal cord area measurement from 3D T1 -weighted brain MRI acquisitions.
  Magnetic resonance in medicine 2017 Papinutto N, Bakshi R, Bischof A, Calabresi PA, Caverzasi E, Constable RT, Datta E, Kirkish G, Nair G, Oh J, Pelletier D, Pham DL, Reich DS, Rooney W, Roy S, Schwartz D, Shinohara RT, Sicotte NL, …
• Investigating Microstructural Abnormalities and Neurocognition in Sub-Acute and Chronic Traumatic Brain Injury Patients with Normal-Appearing White Matter: A Preliminary Diffusion Tensor Imaging Study.
  Frontiers in neurology 2017 Hashim E, Caverzasi E, Papinutto N, Lewis CE, Jing R, Charles O, Zhang S, Lin A, Graham SJ, Schweizer TA, Bharatha A, Cusimano MD
• Spinal cord grey matter segmentation challenge.
  NeuroImage 2017 Prados F, Ashburner J, Blaiotta C, Brosch T, Carballido-Gamio J, Cardoso MJ, Conrad BN, Datta E, Dávid G, Leener B, Dupont SM, Freund P, Wheeler-Kingshott CAMG, Grussu F, Henry R, Landman BA, …
• Long-term evolution of multiple sclerosis disability in the treatment era.
  Annals of neurology 2016 University of California, San Francisco MS-EPIC Team:, Cree BA, Gourraud PA, Oksenberg JR, Bevan C, Crabtree-Hartman E, Gelfand JM, Goodin DS, Graves J, Green AJ, Mowry E, Okuda DT, Pelletier D, von …
• Gray matter segmentation of the spinal cord with active contours in MR images.
  NeuroImage 2016 Datta E, Papinutto N, Schlaeger R, Zhu A, Carballido-Gamio J, Henry RG
• Neurite Orientation Dispersion and Density Imaging Color Maps to Characterize Brain Diffusion in Neurologic Disorders.
  Journal of neuroimaging : official journal of the American Society of Neuroimaging 2016 Caverzasi E, Papinutto N, Castellano A, Zhu AH, Scifo P, Riva M, Bello L, Falini A, Bharatha A, Henry RG
• Quantitative MRI of the spinal cord and brain in adrenomyeloneuropathy: in vivo assessment of structural changes.
  Brain : a journal of neurology 2016 Castellano A, Papinutto N, Cadioli M, Brugnara G, Iadanza A, Scigliuolo G, Pareyson D, Uziel G, Köhler W, Aubourg P, Falini A, Henry RG, Politi LS, Salsano E
• Power estimation for non-standardized multisite studies.
  NeuroImage 2016 Keshavan A, Paul F, Beyer MK, Zhu AH, Papinutto N, Shinohara RT, Stern W, Amann M, Bakshi R, Bischof A, Carriero A, Comabella M, Crane JC, D'Alfonso S, Demaerel P, Dubois B, Filippi M, Fleischer V, …
• Secure attachment status is associated with white matter integrity in healthy young adults.
  Neuroreport 2015 Serra M, De Pisapia N, Rigo P, Papinutto N, Jager J, Bornstein MH, Venuti P
• Identifying preoperative language tracts and predicting postoperative functional recovery using HARDI q-ball fiber tractography in patients with gliomas.
  Journal of neurosurgery 2015 Caverzasi E, Hervey-Jumper SL, Jordan KM, Lobach IV, Li J, Panara V, Racine CA, Sankaranarayanan V, Amirbekian B, Papinutto N, Berger MS, Henry RG
• Association Between Thoracic Spinal Cord Gray Matter Atrophy and Disability in Multiple Sclerosis.
  JAMA neurology 2015 Schlaeger R, Papinutto N, Zhu AH, Lobach IV, Bevan CJ, Bucci M, Castellano A, Gelfand JM, Graves JS, Green AJ, Jordan KM, Keshavan A, Panara V, Stern WA, von Büdingen HC, Waubant E, Goodin DS, Cree BA…
• Retrospective head motion correction approaches for diffusion tensor imaging: Effects of preprocessing choices on biases and reproducibility of scalar diffusion metrics.
  Journal of magnetic resonance imaging : JMRI 2015 Kreilkamp BA, Zacà D, Papinutto N, Jovicich J
• Age, gender and normalization covariates for spinal cord gray matter and total cross-sectional areas at cervical and thoracic levels: A 2D phase sensitive inversion recovery imaging study.
  PloS one 2015 Papinutto N, Schlaeger R, Panara V, Zhu AH, Caverzasi E, Stern WA, Hauser SL, Henry RG
• White matter involvement in sporadic Creutzfeldt-Jakob disease.
  Brain : a journal of neurology 2014 Caverzasi E, Mandelli ML, DeArmond SJ, Hess CP, Vitali P, Papinutto N, Oehler A, Miller BL, Lobach IV, Bastianello S, Geschwind MD, Henry RG
• Spinal cord gray matter atrophy correlates with multiple sclerosis disability.
  Annals of neurology 2014 Schlaeger R, Papinutto N, Panara V, Bevan C, Lobach IV, Bucci M, Caverzasi E, Gelfand JM, Green AJ, Jordan KM, Stern WA, von Büdingen HC, Waubant E, Zhu AH, Goodin DS, Cree BA, Hauser SL, Henry RG
• Interpersonal competence in young adulthood and right laterality in white matter.
  Journal of cognitive neuroscience 2013 De Pisapia N, Serra M, Rigo P, Jager J, Papinutto N, Esposito G, Venuti P, Bornstein MH
• Reproducibility and biases in high field brain diffusion MRI: An evaluation of acquisition and analysis variables.
  Magnetic resonance imaging 2013 Papinutto ND, Maule F, Jovicich J
• Experimental validation of Villain's conjecture about magnetic ordering in quasi-1D helimagnets.
  Journal of Magnetism and Magnetic Materials 2010 F. Cinti, A. Rettori, M.G. Pini, M. Mariani, E. Micotti, A. Lascialfari, N. Papinutto, A. Amato, A. Caneschi, D. Gatteschi, M. Affronte
• Two-step magnetic ordering in quasi-one-dimensional helimagnets: possible experimental validation of villain's conjecture about a chiral spin liquid phase.
  Physical review letters 2008 Cinti F, Rettori A, Pini MG, Mariani M, Micotti E, Lascialfari A, Papinutto N, Amato A, Caneschi A, Gatteschi D, Affronte M
• Normalization of language BOLD fMRI using cerebral vasoreactivity maps
  The Neuroradiology Journal 2008 G. Basso, S. Magon, J. Schwarzbach, M. Orsini, N. Papinutto
• On the magnetic field dependence of the susceptibility at the quantum critical point in CeCu5.9Au0.1.
  Physica B Condensed Matter 2006 P. Carretta, M. Giovannini, M.J. Graf, N. Papinutto, A. Rigamonti, K. Sullivan
• Correlated Spin Dynamics and Phase Transitions in Pure and in Disordered 2D S = 1/2 Antiferromagnets: Insights from NMR-NQR.
  Novel NMR and EPR techniques 2006 A. Rigamonti, P. Carretta, N. Papinutto
• Spin dilution in frustrated two-dimensional S= 12 antiferromagnets on a square lattice.
  Physical Review B 2005 N. Papinutto, P. Carretta, S. Gonthier, P. Millet
• From weakly antiferromagnetic metal to quantum criticality: NQR and µSR results for CeCu6-xAux with 0?x?0.8.
  Physica B Condensed Matter 2005 N. Papinutto, M.J. Graf, P. Carretta, A. Rigamonti, M. Giovannini
• Magnetic field effect at the quantum critical point in CeCu6-xAux from Cu NQR–NMR relaxation.
  Journal of Magnetism and Magnetic Materials 2004 P Carretta, M Giovannini, N Papinutto, A Rigamonti
• Magnetic properties of frustrated two-dimensional S = 1/2 antiferromagnets on a square lattice.
  Journal of Physics Condensed Matter 2004 Pietro Carretta, Nico Papinutto, Roberto Melzi, Patrice Millet, Sabine Gonthier, Philippe Mendels, Pawel Wzietek
• Dynamical susceptibility and magnetic-field effect at the quantum critical point in CeCu6-xAux from Cu NQR-NMR relaxation.
  Physical Review B 2003 P. Carretta, M. Giovannini, M. Horvatic, N. Papinutto, A. Rigamonti
• Frustration driven lattice distortions in Li2VOSiO4 and VOMoO4
  Acta Physica Polonica B 2003 P. Carretta, N. Papinutto, C.B. Azzoni, M.C. Mozzati, E. Pavarini, S. Gonthier and P. Millet
• Frustration-driven structural distortion in VOMoO4.
  Physical Review B 2002 P. Carretta, N. Papinutto, C. B. Azzoni, M. C. Mozzati, E. Pavarini, S. Gonthier, P. Millet
• Very-low-frequency excitations in frustrated two-dimensional S = 1/2 Heisenberg antiferromagnets.
  Physical review letters 2002 Carretta P, Melzi R, Papinutto N, Millet P