Neil Trivedi, MD
Professor
Medicine
School of Medicine

Education & Training

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• Diversity, Equity, and Inclusion Champion Training UCSF 2018
• Fellowship Pulmonary/Critical Care UCSF 2007
• Residency Internal Medicine UCSF 2004
• MD Medical School UCLA 2001
• BA Biology and Psychology University of Pennsylvania 1996

Grants and Projects

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• A Genomic, Proteomic, and Clinical Analysis of Mast Cell Proteases, Veterans Affairs, 2009-2014
• Biomarkers for early detection of lung allograft rejection, NIH, 2008

Publications (27)

Top publication keywords:
Bronchiolitis ObliteransMyeloproliferative DisordersMast CellsGene DosageMastocytosisLymphocytesLung TransplantationTryptasesPoint MutationBronchiPeptide HydrolasesBronchitisPrimatesEvolution, MolecularChimerism

• Genetically defined individual reference ranges for tryptase limit unnecessary procedures and unmask myeloid neoplasms.
  Blood advances 2023 Chovanec J, Tunc I, Hughes J, Halstead J, Mateja A, Liu Y, O'Connell MP, Kim J, Park YH, Wang Q, Le Q, Pirooznia M, Trivedi NN, Bai Y, Yin Y, Hsu AP, McElwee J, Lassiter S, Nelson C, Bandoh J, …
• Association of Mental Health Treatment With Outcomes for US Veterans Diagnosed With Non-Small Cell Lung Cancer.
  JAMA oncology 2020 Berchuck JE, Meyer CS, Zhang N, Berchuck CM, Trivedi NN, Cohen B, Wang S
• An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
  Cell 2020 Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, …
• An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
  Cell 2019 Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, …
• Fibrodysplasia Ossificans Progressiva and Its Implications in Podiatric Medicine: A Case Report.
  Journal of the American Podiatric Medical Association 2019 Bolognini N, Trivedi NN, Au AS, Vora N

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• Disparities in lung cancer outcomes for veterans with comorbid mental disorders.
  Journal of Clinical Oncology 2019 Jacob E Berchuck, Craig Meyer, Ning Zhang, Neil Trivedi, Beth Cohen, Sunny Wang
• Gene signatures common to allograft rejection are associated with lymphocytic bronchitis.
  Clinical transplantation 2019 Greenland JR, Wang P, Brotman JJ, Ahuja R, Chong TA, Kleinhenz ME, Leard LE, Golden JA, Hays SR, Kukreja J, Singer JP, Rajalingam R, Jones K, Laszik ZG, Trivedi NN, Greenland NY, Blanc PD
• Analytical validation of a novel multi-analyte plasma test for lung nodule characterization.
  Biomedical research and reviews 2018 Trivedi NN, Brown JK, Rubenstein T, Rostykus AD, Fish AL, Yu H, Carbonell L, Juang A, Kamer S, Patel B, Sidhu M, Vuong D, Wang S, Beggs M, Wu AH, Arjomandi M
• Risk assessment for indeterminate pulmonary nodules using a novel, plasma-protein based biomarker assay.
  Biomedical research and clinical practice 2018 Trivedi NN, Arjomandi M, Brown JK, Rubenstein T, Rostykus AD, Esposito S, Axler E, Beggs M, Yu H, Carbonell L, Juang A, Kamer S, Patel B, Wang S, Fish AL, Haddad Z, Wu AH
• MA23.03 Risk Assessment for Indeterminate Pulmonary Nodules Using a Novel, Plasma-Protein Based Biomarker Assay.
  Journal of Thoracic Oncology 2018 A. Fish, A. Vachani, M. Beggs, L. Carbonell, Z. Haddad, A. Juang, S. Kamer, B. Patel, H. Yu, A. Wu, P. Massion, M. Arjomandi, J. Brown, N. Trivedi, T. Rubenstein
• Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.
  Nature genetics 2016 Lyons JJ, Yu X, Hughes JD, Le QT, Jamil A, Bai Y, Ho N, Zhao M, Liu Y, O'Connell MP, Trivedi NN, Nelson C, DiMaggio T, Jones N, Matthews H, Lewis KL, Oler AJ, Carlson RJ, Arkwright PD, Hong C, Agama S…
• Phenotypic variability in human skin mast cells.
  Experimental dermatology 2016 Babina M, Guhl S, Artuc M, Trivedi NN, Zuberbier T
• (828) CD25+ Regulatory T Cells in Bronchoalveolar Lavage Fluid Are Associated with Lung Allograft Rejection.
  The Journal of Heart and Lung Transplantation 2014 J.R. Greenland, C.M. Wong, R. Ahuja, M. Gottschall, N.N. Trivedi, J. Kukreja, S.R. Hays, J.P. Singer, J.A. Golden, Q. Tang, G.H. Caughey
• Bronchoalveolar lavage cell immunophenotyping facilitates diagnosis of lung allograft rejection.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2014 Greenland JR, Jewell NP, Gottschall M, Trivedi NN, Kukreja J, Hays SR, Singer JP, Golden JA, Caughey GH
• Large-Airway Lymphocytic Bronchitis Predicts Bronchiolitis Obliterans Syndrome.
  The Journal of Heart and Lung Transplantation 2013 J.R. Greenland, K.D. Jones, S.R. Hays, J.A. Golden, A. Urisman, N.P. Jewell, G.H. Caughey, N.N. Trivedi
• Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors.
  The Journal of biological chemistry 2013 Raman K, Trivedi NN, Raymond WW, Ganesan R, Kirchhofer D, Verghese GM, Craik CS, Schneider EL, Nimishakavi S, Caughey GH
• Chapter 591 Human a-, ß- and d-Tryptases.
  Handbook of Proteolytic Enzymes 2013 Neil N. Trivedi, George H. Caughey
• Chapter 592 ?-Tryptase.
  Handbook of Proteolytic Enzymes 2013 Neil N. Trivedi, George H. Caughey
• Association of large-airway lymphocytic bronchitis with bronchiolitis obliterans syndrome.
  American journal of respiratory and critical care medicine 2012 Greenland JR, Jones KD, Hays SR, Golden JA, Urisman A, Jewell NP, Caughey GH, Trivedi NN
• How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Raymond WW, Trivedi NN, Makarova A, Ray M, Craik CS, Caughey GH
• Mast cell peptidases: chameleons of innate immunity and host defense.
  American journal of respiratory cell and molecular biology 2009 Trivedi NN, Caughey GH
• Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.
  The Journal of allergy and clinical immunology 2009 Trivedi NN, Tamraz B, Chu C, Kwok PY, Caughey GH
• An Inactivating, Frame-shifted Mutation of ,III Tryptase is Common in People of Northern and Western European Ancestory.
  Journal of Allergy and Clinical Immunology 2009 N. Trivedi, B. Tamraz, P.Y. Kwok, G.H. Caughey
• Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases.
  The Journal of biological chemistry 2008 Caughey GH, Beauchamp J, Schlatter D, Raymond WW, Trivedi NN, Banner D, Mauser H, Fingerle J
• Chimerism, point mutation, and truncation dramatically transformed mast cell delta-tryptases during primate evolution.
  The Journal of allergy and clinical immunology 2008 Trivedi NN, Raymond WW, Caughey GH
• Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Trivedi NN, Tong Q, Raman K, Bhagwandin VJ, Caughey GH
• Clinical problem-solving. A gut feeling.
  The New England journal of medicine 2003 Haberer J, Trivedi NN, Kohlwes J, Tierney L