Neil Risch, PhD, MS
Professor
Epidemiology & Biostatistics
School of Medicine

Grants and Projects

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• Pharmacogenomics of Statin Therapy, NIH, 2015-2021
• A Resource for Genetic Epidemiology Research in Adult Health and Aging, NIH, 2009-2012
• Pharmacogenetics of Membrane Transporters, NIH, 2000-2010
• Linkage Disequilibrium and Human Genetic Studies, NIH, 1998-2010
• Molecular Genetics of Autism, NIH, 1995-2001
• Statistical Methods and Applications in Human Genetics, NIH, 1988-1998
• Statistical Methods and Applications in Human Genetics, NIH, 1988-1993
• Topics in Genetic Epidemiology, NIH, 1984-1987
• Administrative Core - Pharmacogenomics of Statin Therapy (POST), NIH/NIGMS

Publications (332)

Top publication keywords:
Models, GeneticJewsDystonia Musculorum DeformansGenetics, PopulationPolymorphism, Single NucleotideLinkage DisequilibriumChromosome MappingGenetic Predisposition to DiseaseGenetic Diseases, InbornHydroxymethylglutaryl-CoA Reductase InhibitorsGene FrequencyGenome-Wide Association StudyGenetic LociGenetic LinkageGenetics, Medical

• 2023 lifetime achievement award: "If you want to go fast, go alone; if you want to go far, go together".
  American journal of human genetics 2024 Risch N
• Genetic ancestry and diagnostic yield of exome sequencing in a diverse population.
  NPJ genomic medicine 2024 Mavura Y, Sahin-Hodoglugil N, Hodoglugil U, Kvale M, Martin PM, Van Ziffle J, Devine WP, Ackerman SL, Koenig BA, Kwok PY, Norton ME, Slavotinek A, Risch N
• Author Correction: Diagnostic yield of pediatric and prenatal exome sequencing in a diverse population.
  NPJ genomic medicine 2023 Slavotinek A, Rego S, Sahin-Hodoglugil N, Kvale M, Lianoglou B, Yip T, Hoban H, Outram S, Anguiano B, Chen F, Michelson J, Cilio RM, Curry C, Gallagher RC, Gardner M, Kuperman R, Mendelsohn B, Sherr E…
• European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
  Nature communications 2023 Budu-Aggrey A, Kilanowski A, Sobczyk MK, 23andMe Research Team, Shringarpure SS, Mitchell R, Reis K, Reigo A, Estonian Biobank Research Team, Mägi R, Nelis M, Tanaka N, Brumpton BM, Thomas LF, Sole-…
• Low- and High-Density Lipoprotein Cholesterol and Dementia Risk Over 17 Years of Follow-up Among Members of a Large Health Care Plan.
  Neurology 2023 Ferguson EL, Zimmerman SC, Jiang C, Choi M, Swinnerton K, Choudhary V, Meyers TJ, Hoffmann TJ, Gilsanz P, Oni-Orisan A, Whitmer RA, Risch N, Krauss RM, Schaefer CA, Glymour MM

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• Diagnostic yield of pediatric and prenatal exome sequencing in a diverse population.
  NPJ genomic medicine 2023 Slavotinek A, Rego S, Sahin-Hodoglugil N, Kvale M, Lianoglou B, Yip T, Hoban H, Outram S, Anguiano B, Chen F, Michelson J, Cilio RM, Curry C, Gallagher RC, Gardner M, Kuperman R, Mendelsohn B, Sherr E…
• Diagnostic Yield of Exome Sequencing in a Diverse Pediatric and Prenatal Population is not Associated with Genetic Ancestry.
  medRxiv : the preprint server for health sciences 2023 Mavura Y, Sahin-Hodoglugil N, Hodoglugil U, Kvale M, Martin PM, Van Ziffle J, Devine WP, Ackerman SL, Koenig BA, Kwok PY, Norton ME, Slavotinek A, Risch N
• Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy.
  Nature communications 2023 Ollila HM, Sharon E, Lin L, Sinnott-Armstrong N, Ambati A, Yogeshwar SM, Hillary RP, Jolanki O, Faraco J, Einen M, Luo G, Zhang J, Han F, Yan H, Dong XS, Li J, Zhang J, Hong SC, Kim TW, Dauvilliers Y,…
• A large genome-wide association study of QT interval length utilizing electronic health records.
  Genetics 2022 Hoffmann TJ, Lu M, Oni-Orisan A, Lee C, Risch N, Iribarren C
• Polygenic Risk Score and Statin Relative Risk Reduction for Primary Prevention of Myocardial Infarction in a Real-World Population.
  Clinical pharmacology and therapeutics 2022 Oni-Orisan A, Haldar T, Cayabyab MAS, Ranatunga DK, Hoffmann TJ, Iribarren C, Krauss RM, Risch N
• Modest effect of statins on fasting glucose in a longitudinal electronic health record based cohort.
  Cardiovascular diabetology 2022 Haldar T, Oni-Orisan A, Hoffmann TJ, Schaefer C, Iribarren C, Krauss RM, Medina MW, Risch N
• Global priorities for large-scale biomarker-based prospective cohorts.
  Cell genomics 2022 Collins R, Balaconis MK, Brunak S, Chen Z, De Silva M, Gaziano JM, Ginsburg GS, Jha P, Kuri P, Metspalu A, Mulder N, Risch N
• Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia.
  Nature genetics 2022 Palmer DS, Howrigan DP, Chapman SB, Adolfsson R, Bass N, Blackwood D, Boks MPM, Chen CY, Churchhouse C, Corvin AP, Craddock N, Curtis D, Di Florio A, Dickerson F, Freimer NB, Goes FS, Jia X, Jones I, …
• The difficulties of broad data sharing in genomic medicine: Empirical evidence from diverse participants in prenatal and pediatric clinical genomics research.
  Genetics in medicine : official journal of the American College of Medical Genetics 2021 Norstad M, Outram S, Brown JEH, Zamora AN, Koenig BA, Risch N, Norton ME, Slavotinek A, Ackerman SL
• QT Interval Dynamics and Cardiovascular Outcomes: A Cohort Study in an Integrated Health Care Delivery System.
  Journal of the American Heart Association 2021 Mantri N, Lu M, Zaroff JG, Risch N, Hoffmann T, Oni-Orisan A, Lee C, Jorgenson E, Iribarren C
• Torsade de pointes: A nested case-control study in an integrated healthcare delivery system.
  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 2021 Mantri N, Lu M, Zaroff JG, Risch N, Hoffmann T, Oni-Orisan A, Lee C, Iribarren C
• Correction: Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder.
  Molecular psychiatry 2021 Jia X, Goes FS, Locke AE, Palmer D, Wang W, Cohen-Woods S, Genovese G, Jackson AU, Jiang C, Kvale M, Mullins N, Nguyen H, Pirooznia M, Rivera M, Ruderfer DM, Shen L, Thai K, Zawistowski M, Zhuang Y, …
• Effect of SLCO1B1 T521C on Statin-Related Myotoxicity With Use of Lovastatin and Atorvastatin.
  Clinical pharmacology and therapeutics 2021 Lu B, Sun L, Seraydarian M, Hoffmann TJ, Medina MW, Risch N, Iribarren C, Krauss RM, Oni-Orisan A
• A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts.
  Nature genetics 2021 Veturi Y, Lucas A, Bradford Y, Hui D, Dudek S, Theusch E, Verma A, Miller JE, Kullo I, Hakonarson H, Sleiman P, Schaid D, Stein CM, Edwards DRV, Feng Q, Wei WQ, Medina MW, Krauss RM, Hoffmann TJ, …
• Challenges in providing residual risks in carrier testing.
  Prenatal diagnosis 2021 Nussbaum RL, Slotnick RN, Risch NJ
• Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder.
  Molecular psychiatry 2021 Jia X, Goes FS, Locke AE, Palmer D, Wang W, Cohen-Woods S, Genovese G, Jackson AU, Jiang C, Kvale M, Mullins N, Nguyen H, Pirooznia M, Rivera M, Ruderfer DM, Shen L, Thai K, Zawistowski M, Zhuang Y, …
• Genetic ancestry, skin pigmentation, and the risk of cutaneous squamous cell carcinoma in Hispanic/Latino and non-Hispanic white populations.
  Communications biology 2020 Jorgenson E, Choquet H, Yin J, Hoffmann TJ, Banda Y, Kvale MN, Risch N, Schaefer C, Asgari MM
• A Large-Scale Association Study Detects Novel Rare Variants, Risk Genes, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility.
  Cancer research 2020 Emami NC, Cavazos TB, Rashkin SR, Cario CL, Graff RE, Tai CG, Mefford JA, Kachuri L, Wan E, Wong S, Aaronson D, Presti J, Habel LA, Shan J, Ranatunga DK, Chao CR, Ghai NR, Jorgenson E, Sakoda LC, …
• Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk.
  Nature communications 2020 Sieh W, Rothstein JH, Klein RJ, Alexeeff SE, Sakoda LC, Jorgenson E, McBride RB, Graff RE, McGuire V, Achacoso N, Acton L, Liang RY, Lipson JA, Rubin DL, Yaffe MJ, Easton DF, Schaefer C, Risch N, …
• The role of exome sequencing in newborn screening for inborn errors of metabolism.
  Nature medicine 2020 Adhikari AN, Gallagher RC, Wang Y, Currier RJ, Amatuni G, Bassaganyas L, Chen F, Kundu K, Kvale M, Mooney SD, Nussbaum RL, Randi SS, Sanford J, Shieh JT, Srinivasan R, Sunderam U, Tang H, Vaka D, Zou …
• Analysis of putative cis-regulatory elements regulating blood pressure variation.
  Human molecular genetics 2020 Nandakumar P, Lee D, Hoffmann TJ, Ehret GB, Arking D, Ranatunga D, Li M, Grove ML, Boerwinkle E, Schaefer C, Kwok PY, Iribarren C, Risch N, Chakravarti A
• Meta-Analysis of 26 638 Individuals Identifies Two Genetic Loci Associated With Left Ventricular Ejection Fraction.
  Circulation. Genomic and precision medicine 2020 Choquet H, Thai KK, Jiang C, Ranatunga DK, Hoffmann TJ, Go AS, Lindsay AC, Ehm MG, Waterworth DM, Risch N, Schaefer C
• A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness.
  Communications biology 2020 Choquet H, Melles RB, Yin J, Hoffmann TJ, Thai KK, Kvale MN, Banda Y, Hardcastle AJ, Tuft SJ, Glymour MM, Schaefer C, Risch N, Nair KS, Hysi PG, Jorgenson E
• The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.
  NPJ genomic medicine 2020 Oni-Orisan A, Haldar T, Ranatunga DK, Medina MW, Schaefer C, Krauss RM, Iribarren C, Risch N, Hoffmann TJ
• A brief history of human disease genetics.
  Nature 2020 Claussnitzer M, Cho JH, Collins R, Cox NJ, Dermitzakis ET, Hurles ME, Kathiresan S, Kenny EE, Lindgren CM, MacArthur DG, North KN, Plon SE, Rehm HL, Risch N, Rotimi CN, Shendure J, Soranzo N, McCarthy…
• A novel truncating variant in ring finger protein 113A (RNF113A) confirms the association of this gene with X-linked trichothiodystrophy.
  American journal of medical genetics. Part A 2019 Mendelsohn BA, Beleford DT, Abu-El-Haija A, Alsaleh NS, Rahbeeni Z, Martin PM, Rego S, Huang A, Capodanno G, Shieh JT, Van Ziffle J, Risch N, Alkuraya FS, Slavotinek AM
• Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.
  JAMA 2019 Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Hauser MA, Allingham RR, Aung T, Van Der Heide CJ, Taylor KD, Rotter JI, Wang SJ, Bonnemaijer PWM, Williams SE, Abdullahi SM, Abu-…
• Assessing the clinical impact of CYP2C9 pharmacogenetic variation on phenytoin prescribing practice and patient response in an integrated health system.
  Pharmacogenetics and genomics 2019 Fohner AE, Ranatunga DK, Thai KK, Lawson BL, Risch N, Oni-Orisan A, Jelalian AT, Rettie AE, Liu VX, Schaefer CA
• Genetic ancestry does not explain increased atopic dermatitis susceptibility or worse disease control among African American subjects in 2 large US cohorts.
  The Journal of allergy and clinical immunology 2019 Abuabara K, You Y, Margolis DJ, Hoffmann TJ, Risch N, Jorgenson E
• Telomere length and socioeconomic status at neighborhood and individual levels among 80,000 adults in the Genetic Epidemiology Research on Adult Health and Aging cohort.
  Environmental epidemiology (Philadelphia, Pa.) 2019 Alexeeff SE, Schaefer CA, Kvale MN, Shan J, Blackburn EH, Risch N, Ranatunga DK, Jorgenson E, Hoffmann TJ, Sakoda LC, Quesenberry CP, Van Den Eeden SK
• Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
  Nature communications 2019 Kilpeläinen TO, Bentley AR, Noordam R, Sung YJ, Schwander K, Winkler TW, Jakupovic H, Chasman DI, Manning A, Ntalla I, Aschard H, Brown MR, de Las Fuentes L, Franceschini N, Guo X, Vojinovic D, …
• The Clinical Sequencing Evidence-Generating Research Consortium: Integrating Genomic Sequencing in Diverse and Medically Underserved Populations.
  American journal of human genetics 2018 Amendola LM, Berg JS, Horowitz CR, Angelo F, Bensen JT, Biesecker BB, Biesecker LG, Cooper GM, East K, Filipski K, Fullerton SM, Gelb BD, Goddard KAB, Hailu B, Hart R, Hassmiller-Lich K, Joseph G, …
• Characterization of Statin Low-Density Lipoprotein Cholesterol Dose-Response Using Electronic Health Records in a Large Population-Based Cohort.
  Circulation. Genomic and precision medicine 2018 Oni-Orisan A, Hoffmann TJ, Ranatunga D, Medina MW, Jorgenson E, Schaefer C, Krauss RM, Iribarren C, Risch N
• A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.
  Genetics 2018 Hoffmann TJ, Choquet H, Yin J, Banda Y, Kvale MN, Glymour M, Schaefer C, Risch N, Jorgenson E
• A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.
  Nature communications 2018 Choquet H, Paylakhi S, Kneeland SC, Thai KK, Hoffmann TJ, Yin J, Kvale MN, Banda Y, Tolman NG, Williams PA, Schaefer C, Melles RB, Risch N, John SWM, Nair KS, Jorgenson E
• Newton E. Morton (1929-2018).
  American journal of human genetics 2018 Sherman SL, Rao DC, Keats BJ, Yee S, Spence MA, Hassold TJ, Chakravarti A, Elston RC, Crolla JA, Ennis S, Risch N
• Correction: Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.
  PLoS genetics 2018 Liang J, Le TH, Velez Edwards DR, Tayo BO, Gaulton KJ, Smith JA, Lu Y, Jensen RA, Chen G, Yanek LR, Schwander K, Tajuddin SM, Sofer T, Kim W, Kayima J, McKenzie CA, Fox E, Nalls MA, Young JH, Sun YV, …
• A large electronic-health-record-based genome-wide study of serum lipids.
  Nature genetics 2018 Hoffmann TJ, Theusch E, Haldar T, Ranatunga DK, Jorgenson E, Medina MW, Kvale MN, Kwok PY, Schaefer C, Krauss RM, Iribarren C, Risch N
• A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure.
  Nature communications 2017 Choquet H, Thai KK, Yin J, Hoffmann TJ, Kvale MN, Banda Y, Schaefer C, Risch N, Nair KS, Melles R, Jorgenson E
• Pierpont syndrome associated with the p.Tyr446Cys missense mutation in TBL1XR1.
  European journal of medical genetics 2017 Slavotinek A, Pua H, Hodoglugil U, Abadie J, Shieh J, Van Ziffle J, Kvale M, Lee H, Kwok PY, Risch N, Sabbadini M
• Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.
  PLoS genetics 2017 Liang J, Le TH, Edwards DRV, Tayo BO, Gaulton KJ, Smith JA, Lu Y, Jensen RA, Chen G, Yanek LR, Schwander K, Tajuddin SM, Sofer T, Kim W, Kayima J, McKenzie CA, Fox E, Nalls MA, Young JH, Sun YV, Lane …
• Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.
  Molecular psychiatry 2017 Jorgenson E, Thai KK, Hoffmann TJ, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Mertens J, Weisner C, Choquet H
• Structured mating: Patterns and implications.
  PLoS genetics 2017 Sebro R, Peloso GM, Dupuis J, Risch NJ
• Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.
  Nature communications 2017 Hoffmann TJ, Passarelli MN, Graff RE, Emami NC, Sakoda LC, Jorgenson E, Habel LA, Shan J, Ranatunga DK, Quesenberry CP, Chao CR, Ghai NR, Aaronson D, Presti J, Nordström T, Wang Z, Berndt SI, Chanock …
• Newborn Sequencing in Genomic Medicine and Public Health.
  Pediatrics 2017 Berg JS, Agrawal PB, Bailey DB, Beggs AH, Brenner SE, Brower AM, Cakici JA, Ceyhan-Birsoy O, Chan K, Chen F, Currier RJ, Dukhovny D, Green RC, Harris-Wai J, Holm IA, Iglesias B, Joseph G, Kingsmore SF…
• Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
  Nature genetics 2016 Hoffmann TJ, Ehret GB, Nandakumar P, Ranatunga D, Schaefer C, Kwok PY, Iribarren C, Chakravarti A, Risch N
• A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records.
  PLoS genetics 2016 Hoffmann TJ, Keats BJ, Yoshikawa N, Schaefer C, Risch N, Lustig LR
• Merging Electronic Health Record Data and Genomics for Cardiovascular Research: A Science Advisory From the American Heart Association.
  Circulation. Cardiovascular genetics 2016 Hall JL, Ryan JJ, Bray BE, Brown C, Lanfear D, Newby LK, Relling MV, Risch NJ, Roden DM, Shaw SY, Tcheng JE, Tenenbaum J, Wang TN, Weintraub WS, American Heart Association Professional and Public …
• Presidential Address: All in the Family, or "Gee, Our Old LaSalle Ran Great".
  American journal of human genetics 2016 Risch N
• Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration.
  European journal of human genetics : EJHG 2016 Jorgenson E, Melles RB, Hoffmann TJ, Jia X, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Shen L
• The Association of Refractive Error with Glaucoma in a Multiethnic Population.
  Ophthalmology 2015 Shen L, Melles RB, Metlapally R, Barcellos L, Schaefer C, Risch N, Herrinton LJ, Wildsoet C, Jorgenson E
• Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes.
  Investigative ophthalmology & visual science 2015 Shen L, Hoffmann TJ, Melles RB, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Jorgenson E
• Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.
  Genetics 2015 Lapham K, Kvale MN, Lin J, Connell S, Croen LA, Dispensa BP, Fang L, Hesselson S, Hoffmann TJ, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Matsuguchi T, McGuire WB, Miles S, Quesenberry CP, Rowell S…
• Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.
  Genetics 2015 Banda Y, Kvale MN, Hoffmann TJ, Hesselson SE, Ranatunga D, Tang H, Sabatti C, Croen LA, Dispensa BP, Henderson M, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Olberg D, Quesenberry CP, Rowell S, …
• Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.
  Genetics 2015 Kvale MN, Hesselson S, Hoffmann TJ, Cao Y, Chan D, Connell S, Croen LA, Dispensa BP, Eshragh J, Finn A, Gollub J, Iribarren C, Jorgenson E, Kushi LH, Lao R, Lu Y, Ludwig D, Mathauda GK, McGuire WB, …
• A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.
  Cancer discovery 2015 Hoffmann TJ, Van Den Eeden SK, Sakoda LC, Jorgenson E, Habel LA, Graff RE, Passarelli MN, Cario CL, Emami NC, Chao CR, Ghai NR, Shan J, Ranatunga DK, Quesenberry CP, Aaronson D, Presti J, Wang Z, …
• Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.
  Clinical pharmacology and therapeutics 2015 Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM
• Imputation of the rare HOXB13 G84E mutation and cancer risk in a large population-based cohort.
  PLoS genetics 2015 Hoffmann TJ, Sakoda LC, Shen L, Jorgenson E, Habel LA, Liu J, Kvale MN, Asgari MM, Banda Y, Corley D, Kushi LH, Quesenberry CP, Schaefer C, Van Den Eeden SK, Risch N, Witte JS
• Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families.
  Circulation. Cardiovascular genetics 2014 Shetty PB, Tang H, Feng T, Tayo B, Morrison AC, Kardia SL, Hanis CL, Arnett DK, Hunt SC, Boerwinkle E, Candidate Gene Association Resource (CARe) Consortium, Rao DC, Cooper RS, Risch N, Zhu X
• Familial recurrence of autism spectrum disorder: evaluating genetic and environmental contributions.
  The American journal of psychiatry 2014 Risch N, Hoffmann TJ, Anderson M, Croen LA, Grether JK, Windham GC
• Estimating genotype error rates from high-coverage next-generation sequence data.
  Genome research 2014 Wall JD, Tang LF, Zerbe B, Kvale MN, Kwok PY, Schaefer C, Risch N
• Evidence of reproductive stoppage in families with autism spectrum disorder: a large, population-based cohort study.
  JAMA psychiatry 2014 Hoffmann TJ, Windham GC, Anderson M, Croen LA, Grether JK, Risch N
• Genome-wide association and admixture analysis of glaucoma in the Women's Health Initiative.
  Human molecular genetics 2014 Hoffmann TJ, Tang H, Thornton TA, Caan B, Haan M, Millen AE, Thomas F, Risch N
• Multisystem component phenotypes of bipolar disorder for genetic investigations of extended pedigrees.
  JAMA psychiatry 2014 Fears SC, Service SK, Kremeyer B, Araya C, Araya X, Bejarano J, Ramirez M, Castrillón G, Gomez-Franco J, Lopez MC, Montoya G, Montoya P, Aldana I, Teshiba TM, Abaryan Z, Al-Sharif NB, Ericson M, …
• Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.
  American journal of human genetics 2013 Franceschini N, Fox E, Zhang Z, Edwards TL, Nalls MA, Sung YJ, Tayo BO, Sun YV, Gottesman O, Adeyemo A, Johnson AD, Young JH, Rice K, Duan Q, Chen F, Li Y, Tang H, Fornage M, Keene KL, Andrews JS, …
• African American race but not genome-wide ancestry is negatively associated with atrial fibrillation among postmenopausal women in the Women's Health Initiative.
  American heart journal 2013 Perez MV, Hoffmann TJ, Tang H, Thornton T, Stefanick ML, Larson JC, Kooperberg C, Reiner AP, Caan B, Iribarren C, Risch N
• The epilepsy phenome/genome project.
  Clinical trials (London, England) 2013 EPGP Collaborative, Abou-Khalil B, Alldredge B, Bautista J, Berkovic S, Bluvstein J, Boro A, Cascino G, Consalvo D, Cristofaro S, Crumrine P, Devinsky O, Dlugos D, Epstein M, Fahlstrom R, Fiol M, …
• Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
  American journal of human genetics 2013 Coram MA, Duan Q, Hoffmann TJ, Thornton T, Knowles JW, Johnson NA, Ochs-Balcom HM, Donlon TA, Martin LW, Eaton CB, Robinson JG, Risch NJ, Zhu X, Kooperberg C, Li Y, Reiner AP, Tang H
• Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping.
  Journal of hypertension 2012 Shetty PB, Tang H, Tayo BO, Morrison AC, Hanis CL, Rao DC, Young JH, Fox ER, Boerwinkle E, Cooper RS, Risch NJ, Zhu X, Candidate Gene Association Resource (CARe) Consortium
• Estimating kinship in admixed populations.
  American journal of human genetics 2012 Thornton T, Tang H, Hoffmann TJ, Ochs-Balcom HM, Caan BJ, Risch N
• A brief note on the resemblance between relatives in the presence of population stratification.
  Heredity 2012 Sebro R, Risch NJ
• Cystic fibrosis mutations for p.F508del compound heterozygotes predict sweat chloride levels and pancreatic sufficiency.
  Clinical genetics 2011 Sebro R, Levy H, Schneck K, Dimmock D, Raby BA, Cannon CL, Broeckel U, Risch NJ
• Differentiating population stratification from genotyping error using family data.
  Annals of human genetics 2011 Sebro R, Lange C, Laird NM, Rogus JJ, Risch NJ
• Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm.
  Genomics 2011 Hoffmann TJ, Zhan Y, Kvale MN, Hesselson SE, Gollub J, Iribarren C, Lu Y, Mei G, Purdy MM, Quesenberry C, Rowell S, Shapero MH, Smethurst D, Somkin CP, Van den Eeden SK, Walter L, Webster T, Whitmer …
• Genetic heritability and shared environmental factors among twin pairs with autism.
  Archives of general psychiatry 2011 Hallmayer J, Cleveland S, Torres A, Phillips J, Cohen B, Torigoe T, Miller J, Fedele A, Collins J, Smith K, Lotspeich L, Croen LA, Ozonoff S, Lajonchere C, Grether JK, Risch N
• Charles Joseph Epstein, M.D., 1933–2011, in memoriam.
  American journal of human genetics 2011 Wynshaw-Boris A, Risch N, Motulsky A
• Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array.
  Genomics 2011 Hoffmann TJ, Kvale MN, Hesselson SE, Zhan Y, Aquino C, Cao Y, Cawley S, Chung E, Connell S, Eshragh J, Ewing M, Gollub J, Henderson M, Hubbell E, Iribarren C, Kaufman J, Lao RZ, Lu Y, Ludwig D, …
• History shaped the geographic distribution of genomic admixture on the island of Puerto Rico.
  PloS one 2011 Via M, Gignoux CR, Roth LA, Fejerman L, Galanter J, Choudhry S, Toro-Labrador G, Viera-Vera J, Oleksyk TK, Beckman K, Ziv E, Risch N, Burchard EG, Martínez-Cruzado JC
• Common variants in P2RY11 are associated with narcolepsy.
  Nature genetics 2010 Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, …
• Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.
  Journal of the American College of Cardiology 2010 Assimes TL, Hólm H, Kathiresan S, Reilly MP, Thorleifsson G, Voight BF, Erdmann J, Willenborg C, Vaidya D, Xie C, Patterson CC, Morgan TM, Burnett MS, Li M, Hlatky MA, Knowles JW, Thompson JR, Absher …
• Testing for non-random mating: evidence for ancestry-related assortative mating in the Framingham heart study.
  Genetic epidemiology 2010 Sebro R, Hoffman TJ, Lange C, Rogus JJ, Risch NJ
• Differences in albuminuria between Hispanics and whites: an evaluation by genetic ancestry and country of origin: the multi-ethnic study of atherosclerosis.
  Circulation. Cardiovascular genetics 2010 Peralta CA, Li Y, Wassel C, Choudhry S, Palmas W, Seldin MF, Risch N, Siscovick D, Arnett D, Psaty B, Shlipak MG
• Human genetic variation recognizes functional elements in noncoding sequence.
  Genome research 2009 Lomelin D, Jorgenson E, Risch N
• Characterizing the admixed African ancestry of African Americans.
  Genome biology 2009 Zakharia F, Basu A, Absher D, Assimes TL, Go AS, Hlatky MA, Iribarren C, Knowles JW, Li J, Narasimhan B, Sidney S, Southwick A, Myers RM, Quertermous T, Risch N, Tang H
• The Association of African Ancestry and elevated creatinine in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
  American journal of nephrology 2009 Peralta CA, Risch N, Lin F, Shlipak MG, Reiner A, Ziv E, Tang H, Siscovick D, Bibbins-Domingo K
• Ancestry-related assortative mating in Latino populations.
  Genome biology 2009 Risch N, Choudhry S, Via M, Basu A, Sebro R, Eng C, Beckman K, Thyne S, Chapela R, Rodriguez-Santana JR, Rodriguez-Cintron W, Avila PC, Ziv E, Gonzalez Burchard E
• Novel susceptibility locus at chromosome 6q16.3-22.31 in a family with GEFS+.
  Neurology 2009 Poduri A, Wang Y, Gordon D, Barral-Rodriguez S, Barker-Cummings C, Ulgen A, Chitsazzadeh V, Hill RS, Risch N, Hauser WA, Pedley TA, Walsh CA, Ottman R
• Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis.
  JAMA 2009 Risch N, Herrell R, Lehner T, Liang KY, Eaves L, Hoh J, Griem A, Kovacs M, Ott J, Merikangas KR
• Narcolepsy is strongly associated with the T-cell receptor alpha locus.
  Nature genetics 2009 Hallmayer J, Faraco J, Lin L, Hesselson S, Winkelmann J, Kawashima M, Mayer G, Plazzi G, Nevsimalova S, Bourgin P, Hong SC, Hong SS, Honda Y, Honda M, Högl B, Longstreth WT, Montplaisir J, Kemlink D, …
• Admixture mapping of quantitative trait loci for blood lipids in African-Americans.
  Human molecular genetics 2009 Basu A, Tang H, Lewis CE, North K, Curb JD, Quertermous T, Mosley TH, Boerwinkle E, Zhu X, Risch NJ
• Admixture mapping of quantitative trait loci for BMI in African Americans: evidence for loci on chromosomes 3q, 5q, and 15q.
  Obesity (Silver Spring, Md.) 2009 Basu A, Tang H, Arnett D, Gu CC, Mosley T, Kardia S, Luke A, Tayo B, Cooper R, Zhu X, Risch N
• Genome-wide distribution of ancestry in Mexican Americans.
  Human genetics 2008 Basu A, Tang H, Zhu X, Gu CC, Hanis C, Boerwinkle E, Risch N
• Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study.
  Human molecular genetics 2008 Assimes TL, Knowles JW, Basu A, Iribarren C, Southwick A, Tang H, Absher D, Li J, Fair JM, Rubin GD, Sidney S, Fortmann SP, Go AS, Hlatky MA, Myers RM, Risch N, Quertermous T
• Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region.
  Human genetics 2008 Choudhry S, Taub M, Mei R, Rodriguez-Santana J, Rodriguez-Cintron W, Shriver MD, Ziv E, Risch NJ, Burchard EG
• Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD.
  BMC medical genetics 2008 Knowles JW, Assimes TL, Boerwinkle E, Fortmann SP, Go A, Grove ML, Hlatky M, Iribarren C, Li J, Myers R, Risch N, Sidney S, Southwick A, Volcik KA, Quertermous T
• Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease.
  Human genetics 2008 Assimes TL, Knowles JW, Priest JR, Basu A, Volcik KA, Southwick A, Tabor HK, Hartiala J, Allayee H, Grove ML, Tabibiazar R, Sidney S, Fortmann SP, Go A, Hlatky M, Iribarren C, Boerwinkle E, Myers R, …
• Admixture mapping and the role of population structure for localizing disease genes.
  Advances in genetics 2008 Zhu X, Tang H, Risch N
• An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus.
  Proceedings of the National Academy of Sciences of the United States of America 2007 DeLuca GC, Ramagopalan SV, Herrera BM, Dyment DA, Lincoln MR, Montpetit A, Pugliatti M, Barnardo MC, Risch NJ, Sadovnick AD, Chao M, Sotgiu S, Hudson TJ, Ebers GC
• A genome-wide scan in forty large pedigrees with multiple sclerosis.
  Journal of human genetics 2007 Willer CJ, Dyment DA, Cherny S, Ramagopalan SV, Herrera BM, Morrison KME, Sadovnick AD, Risch NJ, Ebers GC
• A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.
  Atherosclerosis 2007 Assimes TL, Knowles JW, Priest JR, Basu A, Borchert A, Volcik KA, Grove ML, Tabor HK, Southwick A, Tabibiazar R, Sidney S, Boerwinkle E, Go AS, Iribarren C, Hlatky MA, Fortmann SP, Myers RM, Kuhn H, …
• Narrowing the DYT6 dystonia region and evidence for locus heterogeneity in the Amish-Mennonites.
  American journal of medical genetics. Part A 2007 Saunders-Pullman R, Raymond D, Senthil G, Kramer P, Ohmann E, Deligtisch A, Shanker V, Greene P, Tabamo R, Huang N, Tagliati M, Kavanagh P, Soto-Valencia J, Aguiar Pde C, Risch N, Ozelius L, Bressman …
• Minimum incidence of primary cervical dystonia in a multiethnic health care population.
  Neurology 2007 Marras C, Van den Eeden SK, Fross RD, Benedict-Albers KS, Klingman J, Leimpeter AD, Nelson LM, Risch N, Karter AJ, Bernstein AL, Tanner CM
• Recent genetic selection in the ancestral admixture of Puerto Ricans.
  American journal of human genetics 2007 Tang H, Choudhry S, Mei R, Morgan M, Rodriguez-Cintron W, Burchard EG, Risch NJ
• Dissecting complex diseases in complex populations: asthma in latino americans.
  Proceedings of the American Thoracic Society 2007 Choudhry S, Seibold MA, Borrell LN, Tang H, Serebrisky D, Chapela R, Rodriguez-Santana JR, Avila PC, Ziv E, Rodriguez-Cintron W, Risch NJ, Burchard EG
• A genome scan in a single pedigree with a high prevalence of multiple sclerosis.
  Journal of neurology, neurosurgery, and psychiatry 2007 Dyment DA, Cader MZ, Herrera BM, Ramagopalan SV, Orton SM, Chao M, Willer CJ, Sadovnick AD, Risch N, Ebers GC
• Intragenic Cis and Trans modification of genetic susceptibility in DYT1 torsion dystonia.
  American journal of human genetics 2007 Risch NJ, Bressman SB, Senthil G, Ozelius LJ
• Obsessive-compulsive disorder is not a clinical manifestation of the DYT1 dystonia gene.
  American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007 Heiman GA, Ottman R, Saunders-Pullman RJ, Ozelius LJ, Risch NJ, Bressman SB
• Genome-wide linkage analysis of lipids in nondiabetic Chinese and Japanese from the SAPPHIRe family study.
  American journal of hypertension 2006 Hsiao CF, Chiu YF, Chiang FT, Ho LT, Lee WJ, Hung YJ, Chen YD, Donlon TA, Jorgenson E, Curb D, Risch N, Hsiung CA, SAPPHIRe Study Group
• Ancestry-environment interactions and asthma risk among Puerto Ricans.
  American journal of respiratory and critical care medicine 2006 Choudhry S, Burchard EG, Borrell LN, Tang H, Gomez I, Naqvi M, Nazario S, Torres A, Casal J, Martinez-Cruzado JC, Ziv E, Avila PC, Rodriguez-Cintron W, Risch NJ
• Global transcriptional response to interferon is a determinant of HCV treatment outcome and is modified by race.
  Hepatology (Baltimore, Md.) 2006 He XS, Ji X, Hale MB, Cheung R, Ahmed A, Guo Y, Nolan GP, Pfeffer LM, Wright TL, Risch N, Tibshirani R, Greenberg HB
• Twins of mistaken zygosity (TOMZ): evidence for genetic contributions to dietary patterns and physiologic traits.
  Twin research and human genetics : the official journal of the International Society for Twin Studies 2006 Gunderson EP, Tsai AL, Selby JV, Caan B, Mayer-Davis EJ, Risch N
• Reconstructing genetic ancestry blocks in admixed individuals.
  American journal of human genetics 2006 Tang H, Coram M, Wang P, Zhu X, Risch N
• Racial admixture and its impact on BMI and blood pressure in African and Mexican Americans.
  Human genetics 2006 Tang H, Jorgenson E, Gadde M, Kardia SL, Rao DC, Zhu X, Schork NJ, Hanis CL, Risch N
• Dissecting racial and ethnic differences.
  The New England journal of medicine 2006 Risch N
• LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.
  The New England journal of medicine 2006 Ozelius LJ, Senthil G, Saunders-Pullman R, Ohmann E, Deligtisch A, Tagliati M, Hunt AL, Klein C, Henick B, Hailpern SM, Lipton RB, Soto-Valencia J, Risch N, Bressman SB
• Functional genomics of membrane transporters in human populations.
  Genome research 2005 Urban TJ, Sebro R, Hurowitz EH, Leabman MK, Badagnani I, Lagpacan LL, Risch N, Giacomini KM
• Response to Zhang et al. (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45, 11-16.
  Neuron 2005 Glatt CE, Carlson E, Taylor TR, Risch N, Reus VI, Schaefer CA
• Population stratification confounds genetic association studies among Latinos.
  Human genetics 2005 Choudhry S, Coyle NE, Tang H, Salari K, Lind D, Clark SL, Tsai HJ, Naqvi M, Phong A, Ung N, Matallana H, Avila PC, Casal J, Torres A, Nazario S, Castro R, Battle NC, Perez-Stable EJ, Kwok PY, Sheppard…
• Latino populations: a unique opportunity for the study of race, genetics, and social environment in epidemiological research.
  American journal of public health 2005 González Burchard E, Borrell LN, Choudhry S, Naqvi M, Tsai HJ, Rodriguez-Santana JR, Chapela R, Rogers SD, Mei R, Rodriguez-Cintron W, Arena JF, Kittles R, Perez-Stable EJ, Ziv E, Risch N
• The whole side of it--an interview with Neil Risch by Jane Gitschier.
  PLoS genetics 2005 Risch N
• Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics.
  Genetic epidemiology 2005 Salari K, Choudhry S, Tang H, Naqvi M, Lind D, Avila PC, Coyle NE, Ung N, Nazario S, Casal J, Torres-Palacios A, Clark S, Phong A, Gomez I, Matallana H, Pérez-Stable EJ, Shriver MD, Kwok PY, Sheppard …
• The whole side of it--an interview with Neil Risch. Interview by Jane Gitschier.
  PLoS genetics 2005 Risch N
• Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance.
  Human molecular genetics 2005 Dyment DA, Herrera BM, Cader MZ, Willer CJ, Lincoln MR, Sadovnick AD, Risch N, Ebers GC
• Estimation of individual admixture: analytical and study design considerations.
  Genetic epidemiology 2005 Tang H, Peng J, Wang P, Risch NJ
• An autosomal genome-wide scan for loci linked to pre-diabetic phenotypes in nondiabetic Chinese subjects from the Stanford Asia-Pacific Program of Hypertension and Insulin Resistance Family Study.
  Diabetes 2005 Chiu YF, Chuang LM, Hsiao CF, Hung YJ, Lin MW, Chen YT, Grove J, Jorgenson E, Quertermous T, Risch N, Hsiung CA
• 2004 Curt Stern Award Address. The SNP endgame: a multidisciplinary approach.
  American journal of human genetics 2005 Risch N
• Admixture mapping for hypertension loci with genome-scan markers.
  Nature genetics 2005 Zhu X, Luke A, Cooper RS, Quertermous T, Hanis C, Mosley T, Gu CC, Tang H, Rao DC, Risch N, Weder A
• Haplotype structure and ethnic-specific allele frequencies at the OCTN locus: implications for the genetics of Crohn's disease.
  Inflammatory bowel diseases 2005 Urban TJ, Giacomini KM, Risch N
• Ethnicity and human genetic linkage maps.
  American journal of human genetics 2004 Jorgenson E, Tang H, Gadde M, Province M, Leppert M, Kardia S, Schork N, Cooper R, Rao DC, Boerwinkle E, Risch N
• Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies.
  American journal of human genetics 2004 Tang H, Quertermous T, Rodriguez B, Kardia SL, Zhu X, Brown A, Pankow JS, Province MA, Hunt SC, Boerwinkle E, Schork NJ, Risch NJ
• Assessing genetic contributions to phenotypic differences among 'racial' and 'ethnic' groups.
  Nature genetics 2004 Mountain JL, Risch N
• Mutation frequencies for glycogen storage disease Ia in the Ashkenazi Jewish population.
  American journal of medical genetics. Part A 2004 Ekstein J, Rubin BY, Anderson SL, Weinstein DA, Bach G, Abeliovich D, Webb M, Risch N
• Increased risk for recurrent major depression in DYT1 dystonia mutation carriers.
  Neurology 2004 Heiman GA, Ottman R, Saunders-Pullman RJ, Ozelius LJ, Risch NJ, Bressman SB
• TCR beta polymorphisms and multiple sclerosis.
  Genes and immunity 2004 Dyment DA, Steckley JL, Morrison K, Willer CJ, Cader MZ, DeLuca GC, Sadovnick AD, Risch N, Ebers GC, Canadian Collaborative Study Group
• Tree-structured supervised learning and the genetics of hypertension.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Huang J, Lin A, Narasimhan B, Quertermous T, Hsiung CA, Ho LT, Grove JS, Olivier M, Ranade K, Risch NJ, Olshen RA
• Parent-of-origin effect in multiple sclerosis: observations in half-siblings.
  Lancet (London, England) 2004 Ebers GC, Sadovnick AD, Dyment DA, Yee IM, Willer CJ, Risch N
• An extended genome scan in 442 Canadian multiple sclerosis-affected sibships: a report from the Canadian Collaborative Study Group.
  Human molecular genetics 2004 Dyment DA, Sadovnick AD, Willer CJ, Armstrong H, Cader ZM, Wiltshire S, Kalman B, Risch N, Ebers GC, Canadian Collaborative Study Group
• Lack of evidence for an association between WNT2 and RELN polymorphisms and autism.
  American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004 Li J, Nguyen L, Gleason C, Lotspeich L, Spiker D, Risch N, Myers RM
• Crohn disease: frequency and nature of CARD15 mutations in Ashkenazi and Sephardi/Oriental Jewish families.
  American journal of human genetics 2004 Tukel T, Shalata A, Present D, Rachmilewitz D, Mayer L, Grant D, Risch N, Desnick RJ
• Genomic priorities and public health.
  Science (New York, N.Y.) 2003 Merikangas KR, Risch N
• Twin concordance and sibling recurrence rates in multiple sclerosis.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Willer CJ, Dyment DA, Risch NJ, Sadovnick AD, Ebers GC, Canadian Collaborative Study Group
• Immunology: hepatitis A virus link to atopic disease.
  Nature 2003 McIntire JJ, Umetsu SE, Macaubas C, Hoyte EG, Cinnioglu C, Cavalli-Sforza LL, Barsh GS, Hallmayer JF, Underhill PA, Risch NJ, Freeman GJ, DeKruyff RH, Umetsu DT
• Partial deficiency of the C-terminal-domain phosphatase of RNA polymerase II is associated with congenital cataracts facial dysmorphism neuropathy syndrome.
  Nature genetics 2003 Varon R, Gooding R, Steglich C, Marns L, Tang H, Angelicheva D, Yong KK, Ambrugger P, Reinhold A, Morar B, Baas F, Kwa M, Tournev I, Guerguelcheva V, Kremensky I, Lochmüller H, Müllner-Eidenböck A, …
• Natural variation in human membrane transporter genes reveals evolutionary and functional constraints.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Urban TJ, Kroetz DL, Ferrin TE, Clark AG, Risch N, Herskowitz I, Giacomini KM, Pharmacogenetics Of…
• Will the genomics revolution revolutionize psychiatry?
  The American journal of psychiatry 2003 Merikangas KR, Risch N
• The importance of race and ethnic background in biomedical research and clinical practice.
  The New England journal of medicine 2003 Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, Mountain JL, Pérez-Stable EJ, Sheppard D, Risch N
• Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease.
  Nature genetics 2003 Botstein D, Risch N
• Geographic distribution of disease mutations in the Ashkenazi Jewish population supports genetic drift over selection.
  American journal of human genetics 2003 Risch N, Tang H, Katzenstein H, Ekstein J
• Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide.
  Science (New York, N.Y.) 2003 Kim UK, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D
• A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins.
  American journal of hypertension 2003 Ranade K, Hinds D, Hsiung CA, Chuang LM, Chang MS, Chen YT, Pesich R, Hebert J, Chen YD, Dzau V, Olshen R, Curb D, Botstein D, Cox DR, Risch N
• A meta-analysis of genome-wide linkage scans for hypertension: the National Heart, Lung and Blood Institute Family Blood Pressure Program.
  American journal of hypertension 2003 Province MA, Kardia SL, Ranade K, Rao DC, Thiel BA, Cooper RS, Risch N, Turner ST, Cox DR, Hunt SC, Weder AB, Boerwinkle E, National Heart, Lung and Blood Institute Family Blood Pressure Program
• A model system for identifying genes underlying complex traits.
  Cold Spring Harbor symposia on quantitative biology 2003 Drayna D, Kim UK, Coon H, Jorgenson E, Risch N, Leppert M
• Diagnostic criteria for dystonia in DYT1 families.
  Neurology 2002 Bressman SB, Raymond D, Wendt K, Saunders-Pullman R, De Leon D, Fahn S, Ozelius L, Risch N
• On the twin risk in autism.
  American journal of human genetics 2002 Hallmayer J, Glasson EJ, Bower C, Petterson B, Croen L, Grether J, Risch N
• A multigenerational family with multiple sclerosis.
  Brain : a journal of neurology 2002 Dyment DA, Cader MZ, Willer CJ, Risch N, Sadovnick AD, Ebers GC
• Categorization of humans in biomedical research: genes, race and disease.
  Genome biology 2002 Risch N, Burchard E, Ziv E, Tang H
• Candidate-gene approaches for studying complex genetic traits: practical considerations.
  Nature reviews. Genetics 2002 Tabor HK, Risch NJ, Myers RM
• Behavioral phenotypic variation in autism multiplex families: evidence for a continuous severity gradient.
  American journal of medical genetics 2002 Spiker D, Lotspeich LJ, Dimiceli S, Myers RM, Risch N
• A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate.
  American journal of human genetics 2002 Ranade K, Jorgenson E, Sheu WH, Pei D, Hsiung CA, Chiang FT, Chen YD, Pratt R, Olshen RA, Curb D, Cox DR, Botstein D, Risch N
• No evidence to support CTLA-4 as a susceptibility gene in MS families: the Canadian Collaborative Study.
  Journal of neuroimmunology 2002 Dyment DA, Steckley JL, Willer CJ, Armstrong H, Sadovnick AD, Risch N, Ebers GC
• Myoclonus dystonia: possible association with obsessive-compulsive disorder and alcohol dependence.
  Neurology 2002 Saunders-Pullman R, Shriberg J, Heiman G, Raymond D, Wendt K, Kramer P, Schilling K, Kurlan R, Klein C, Ozelius LJ, Risch NJ, Bressman SB
• Dropped genetics paper lacked scientific merit.
  Nature 2002 Risch N, Piazza A, Cavalli-Sforza LL
• The glycine allele of a glycine/arginine polymorphism in the beta2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin.
  American journal of hypertension 2001 Ranade K, Shue WH, Hung YJ, Hsuing CA, Chiang FT, Pesich R, Hebert J, Olivier M, Chen YD, Pratt R, Olshen R, Curb D, Botstein D, Risch N, Cox DR
• Implications of multilocus inheritance for gene-disease association studies.
  Theoretical population biology 2001 Risch N
• Genetic variation in aldosterone synthase predicts plasma glucose levels.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Ranade K, Wu KD, Risch N, Olivier M, Pei D, Hsiao CF, Chuang LM, Ho LT, Jorgenson E, Pesich R, Chen YD, Dzau V, Lin A, Olshen RA, Curb D, Cox DR, Botstein D
• Birth order effects on nonverbal IQ scores in autism multiplex families.
  Journal of autism and developmental disorders 2001 Spiker D, Lotspeich LJ, Dimiceli S, Szatmari P, Myers RM, Risch N
• Genetic variation in the human urea transporter-2 is associated with variation in blood pressure.
  Human molecular genetics 2001 Ranade K, Wu KD, Hwu CM, Ting CT, Pei D, Pesich R, Hebert J, Chen YD, Pratt R, Olshen R, Masaki K, Risch N, Cox DR, Botstein D
• High-throughput genotyping with single nucleotide polymorphisms.
  Genome research 2001 Ranade K, Chang MS, Ting CT, Pei D, Hsiao CF, Olivier M, Pesich R, Hebert J, Chen YD, Dzau VJ, Curb D, Olshen R, Risch N, Cox DR, Botstein D
• The genetic epidemiology of cancer: interpreting family and twin studies and their implications for molecular genetic approaches.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001 Risch N
• Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes.
  Nature genetics 2001 Glatt CE, DeYoung JA, Delgado S, Service SK, Giacomini KM, Edwards RH, Risch N, Freimer NB
• The DYT1 mutation and nonfamilial primary torsion dystonia.
  Archives of neurology 2001 Bressman SB, Fahn S, Ozelius LJ, Kramer PL, Risch NJ
• Tay-Sachs screening in the Jewish Ashkenazi population: DNA testing is the preferred procedure.
  American journal of medical genetics 2001 Bach G, Tomczak J, Risch N, Ekstein J
• Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups.
  American journal of human genetics 2001 Mignot E, Lin L, Rogers W, Honda Y, Qiu X, Lin X, Okun M, Hohjoh H, Miki T, Hsu S, Leffell M, Grumet F, Fernandez-Vina M, Honda M, Risch N
• Familial aggregation of absolute pitch.
  American journal of human genetics 2000 Baharloo S, Service SK, Risch N, Gitschier J, Freimer NB
• Lack of association of the angiotensinogen-6 polymorphism with blood pressure levels in the comprehensive NHLBI Family Blood Pressure Program. National Heart, Lung and Blood Institute.
  Journal of hypertension 2000 Province MA, Boerwinkle E, Chakravarti A, Cooper R, Fornage M, Leppert M, Risch N, Ranade K
• Searching for genetic determinants in the new millennium.
  Nature 2000 Risch NJ
• Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations.
  American journal of hypertension 2000 Ranade K, Hsuing AC, Wu KD, Chang MS, Chen YT, Hebert J, Chen YI, Olshen R, Curb D, Dzau V, Botstein D, Cox D, Risch N
• Searching for genes in complex diseases: lessons from systemic lupus erythematosus.
  The Journal of clinical investigation 2000 Risch N
• The DYT1 phenotype and guidelines for diagnostic testing.
  Neurology 2000 Bressman SB, Sabatti C, Raymond D, de Leon D, Klein C, Kramer PL, Brin MF, Fahn S, Breakefield X, Ozelius LJ, Risch NJ
• Gaucher disease: the origins of the Ashkenazi Jewish N370S and 84GG acid beta-glucosidase mutations.
  American journal of human genetics 2000 Diaz GA, Gelb BD, Risch N, Nygaard TG, Frisch A, Cohen IJ, Miranda CS, Amaral O, Maire I, Poenaru L, Caillaud C, Weizberg M, Mistry P, Desnick RJ
• Genetic analysis of vitamin D related genes in Canadian multiple sclerosis patients. Canadian Collaborative Study Group.
  Neurology 2000 Steckley JL, Dyment DA, Sadovnick AD, Risch N, Hayes C, Ebers GC
• Postnatal experiences and genetic effects on squirrel monkey social affinities and emotional distress.
  Hormones and behavior 1999 Lyons DM, Martel FL, Levine S, Risch NJ, Schatzberg AF
• Absence of linkage and linkage disequilibrium to chromosome 15q11-q13 markers in 139 multiplex families with autism.
  American journal of medical genetics 1999 Salmon B, Hallmayer J, Rogers T, Kalaydjieva L, Petersen PB, Nicholas P, Pingree C, McMahon W, Spiker D, Lotspeich L, Kraemer H, McCague P, Dimiceli S, Nouri N, Pitts T, Yang J, Hinds D, Myers RM, …
• A genomic screen of autism: evidence for a multilocus etiology.
  American journal of human genetics 1999 Risch N, Spiker D, Lotspeich L, Nouri N, Hinds D, Hallmayer J, Kalaydjieva L, McCague P, Dimiceli S, Pitts T, Nguyen L, Yang J, Harper C, Thorpe D, Vermeer S, Young H, Hebert J, Lin A, Ferguson J, …
• Search for the PARK3 founder haplotype in a large cohort of patients with Parkinson's disease from northern Germany.
  Annals of human genetics 1999 Klein C, Vieregge P, Hagenah J, Sieberer M, Doyle E, Jacobs H, Gasser T, Breakefield XO, Risch NJ, Ozelius LJ
• Exclusion of linkage to the HLA region in ninety multiplex sibships with autism.
  Journal of autism and developmental disorders 1999 Rogers T, Kalaydjieva L, Hallmayer J, Petersen PB, Nicholas P, Pingree C, McMahon WM, Spiker D, Lotspeich L, Kraemer H, McCague P, Dimiceli S, Nouri N, Peachy T, Yang J, Hinds D, Risch N, Myers RM
• Male homosexuality: absence of linkage to microsatellite markers at Xq28.
  Science (New York, N.Y.) 1999 Rice G, Anderson C, Risch N, Ebers G
• The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. II. Individual genotyping.
  Genome research 1999 Teng J, Risch N
• Sib-pair analysis of the collaborative study on the genetics of alcoholism data set.
  Genetic epidemiology 1999 Jorgenson E, Hinds D, Risch N
• Search for a founder mutation in idiopathic focal dystonia from Northern Germany.
  American journal of human genetics 1998 Klein C, Ozelius LJ, Hagenah J, Breakefield XO, Risch NJ, Vieregge P
• The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases I. DNA pooling.
  Genome research 1998 Risch N, Teng J
• Canadian collaborative project on genetic susceptibility to MS, phase 2: rationale and method. Canadian Collaborative Study Group.
  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1998 Sadovnick AD, Risch NJ, Ebers GC
• A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus.
  Nature genetics 1998 Concannon P, Gogolin-Ewens KJ, Hinds DA, Wapelhorst B, Morrison VA, Stirling B, Mitra M, Farmer J, Williams SR, Cox NJ, Bell GI, Risch N, Spielman RS
• Co-morbidity and familial aggregation of alcoholism and anxiety disorders.
  Psychological medicine 1998 Merikangas KR, Stevens DE, Fenton B, Stolar M, O'Malley S, Woods SW, Risch N
• De novo mutations (GAG deletion) in the DYT1 gene in two non-Jewish patients with early-onset dystonia.
  Human molecular genetics 1998 Klein C, Brin MF, de Leon D, Limborska SA, Ivanova-Smolenskaya IA, Bressman SB, Friedman A, Markova ED, Risch NJ, Breakefield XO, Ozelius LJ
• Are generalized and localization-related epilepsies genetically distinct?
  Archives of neurology 1998 Ottman R, Lee JH, Hauser WA, Risch N
• Effect of age at onset and parental disease status on sibling risks for MS.
  Neurology 1998 Sadovnick AD, Yee IM, Ebers GC, Risch NJ
• Clinical-genetic spectrum of primary dystonia.
  Advances in neurology 1998 Bressman SB, de Leon D, Raymond D, Ozelius LJ, Breakefield XO, Nygaard TG, Almasy L, Risch NJ, Kramer PL
• HLA-DQB1*0602 homozygosity increases relative risk for narcolepsy but not disease severity in two ethnic groups. US Modafinil in Narcolepsy Multicenter Study Group.
  Tissue antigens 1998 Pelin Z, Guilleminault C, Risch N, Grumet FC, Mignot E
• The gene (DYT1) for early-onset torsion dystonia encodes a novel protein related to the Clp protease/heat shock family.
  Advances in neurology 1998 Ozelius LJ, Hewett JW, Page CE, Bressman SB, Kramer PL, Shalish C, de Leon D, Brin MF, Raymond D, Jacoby D, Penney J, Risch NJ, Fahn S, Gusella JF, Breakefield XO
• The role of the DYT1 gene in secondary dystonia.
  Advances in neurology 1998 Bressman SB, de Leon D, Raymond D, Greene PE, Brin MF, Fahn S, Ozelius LJ, Breakefield XO, Kramer PL, Risch NJ
• Haemochromatosis, HFE and genetic complexity.
  Nature genetics 1997 Risch N
• Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
  JAMA 1997 Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM
• Idiopathic torsion dystonia linked to chromosome 8 in two Mennonite families.
  Annals of neurology 1997 Almasy L, Bressman SB, Raymond D, Kramer PL, Greene PE, Heiman GA, Ford B, Yount J, de Leon D, Chouinard S, Saunders-Pullman R, Brin MF, Kapoor RP, Jones AC, Shen H, Fahn S, Risch NJ, Nygaard TG
• Ethnic variation in the clinical expression of idiopathic torsion dystonia.
  Movement disorders : official journal of the Movement Disorder Society 1997 Almasy L, Bressman S, de Leon D, Risch N
• The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein.
  Nature genetics 1997 Ozelius LJ, Hewett JW, Page CE, Bressman SB, Kramer PL, Shalish C, de Leon D, Brin MF, Raymond D, Corey DP, Fahn S, Risch NJ, Buckler AJ, Gusella JF, Breakefield XO
• Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21.
  Nature genetics 1997 Mansfield TA, Simon DB, Farfel Z, Bia M, Tucci JR, Lebel M, Gutkin M, Vialettes B, Christofilis MA, Kauppinen-Makelin R, Mayan H, Risch N, Lifton RP
• Secondary dystonia and the DYTI gene.
  Neurology 1997 Bressman SB, de Leon D, Raymond D, Greene PE, Brin MF, Fahn S, Ozelius LJ, Breakefield XO, Kramer PL, Risch NJ
• Fine localization of the torsion dystonia gene (DYT1) on human chromosome 9q34: YAC map and linkage disequilibrium.
  Genome research 1997 Ozelius LJ, Hewett J, Kramer P, Bressman SB, Shalish C, de Leon D, Rutter M, Risch N, Brin MF, Markova ED, Limborska SA, Ivanova-Smolenskaya IA, McCormick MK, Fahn S, Buckler AJ, Gusella JF, …
• Association between migraine and stroke in a large-scale epidemiological study of the United States.
  Archives of neurology 1997 Merikangas KR, Fenton BT, Cheng SH, Stolar MJ, Risch N
• Genetic analyses of complex behavioral disorders.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Uhl GR, Gold LH, Risch N
• Segregation analysis of cryptogenic epilepsy and an empirical test of the validity of the results.
  American journal of human genetics 1997 Ottman R, Hauser WA, Barker-Cummings C, Lee JH, Risch N
• Evolving methods in genetic epidemiology. II. Genetic linkage from an epidemiologic perspective.
  Epidemiologic reviews 1997 Risch N
• Autism and the X chromosome. Multipoint sib-pair analysis.
  Archives of general psychiatry 1996 Hallmayer J, Hebert JM, Spiker D, Lotspeich L, McMahon WM, Petersen PB, Nicholas P, Pingree C, Lin AA, Cavalli-Sforza LL, Risch N, Ciaranello RD
• Exclusion of the DYT1 locus in familial torticollis.
  Annals of neurology 1996 Bressman SB, Warner TT, Almasy L, Uitti RJ, Greene PE, Heiman GA, Raymond D, Ford B, de Leon D, Fahn S, Kramer PL, Risch NJ, Maraganore DM, Nygaard TG, Harding AE
• Mapping quantitative-trait loci in humans by use of extreme concordant sib pairs: selected sampling by parental phenotypes.
  American journal of human genetics 1996 Zhang H, Risch N
• The future of genetic studies of complex human diseases.
  Science (New York, N.Y.) 1996 Risch N, Merikangas K
• Disequilibrium mapping: composite likelihood for pairwise disequilibrium.
  Genomics 1996 Devlin B, Risch N, Roeder K
• A full genome search in multiple sclerosis.
  Nature genetics 1996 Ebers GC, Kukay K, Bulman DE, Sadovnick AD, Rice G, Anderson C, Armstrong H, Cousin K, Bell RB, Hader W, Paty DW, Hashimoto S, Oger J, Duquette P, Warren S, Gray T, O'Connor P, Nath A, Auty A, Metz L,…
• A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis.
  Nature genetics 1996 Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, Dormishian F, Domingo R, Ellis MC, Fullan A, Hinton LM, Jones NL, Kimmel BE, Kronmal GS, Lauer P, Lee VK, Loeb DB, Mapa FA, McClelland …
• Evidence for genetic basis of multiple sclerosis. The Canadian Collaborative Study Group.
  Lancet (London, England) 1996 Sadovnick AD, Ebers GC, Dyment DA, Risch NJ
• A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.
  Nature genetics 1996 Hanis CL, Boerwinkle E, Chakraborty R, Ellsworth DL, Concannon P, Stirling B, Morrison VA, Wapelhorst B, Spielman RS, Gogolin-Ewens KJ, Shepard JM, Williams SR, Risch N, Hinds D, Iwasaki N, Ogata M, …
• The genetic attributable risk of breast and ovarian cancer.
  Cancer 1996 Claus EB, Schildkraut JM, Thompson WD, Risch NJ
• A manic depressive history.
  Nature genetics 1996 Risch N, Botstein D
• Clinical indicators of genetic susceptibility to epilepsy.
  Epilepsia 1996 Ottman R, Lee JH, Risch N, Hauser WA, Susser M
• Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations.
  American journal of human genetics 1996 Risch NJ, Zhang H
• Relations of genetic and environmental factors in the etiology of epilepsy.
  Annals of neurology 1996 Ottman R, Annegers JF, Risch N, Hauser WA, Susser M
• Affected-sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations.
  Genetic epidemiology 1996 Hauser ER, Boehnke M, Guo SW, Risch N
• Searching for susceptibility genes in schizophrenia by genetic linkage analysis.
  Cold Spring Harbor symposia on quantitative biology 1996 Wildenauer DB, Hallmayer J, Schwab SG, Albus M, Eckstein GN, Zill P, Hönig S, Strauss M, Borrmann M, Lichtermann D, Ebstein RP, Lerer B, Risch N, Maier W
• Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis.
  Nature genetics 1995 Schwab SG, Albus M, Hallmayer J, Hönig S, Borrmann M, Lichtermann D, Ebstein RP, Ackenheil M, Lerer B, Risch N
• A comparison of linkage disequilibrium measures for fine-scale mapping.
  Genomics 1995 Devlin B, Risch N
• A genetic basis for familial aggregation in multiple sclerosis. Canadian Collaborative Study Group.
  Nature 1995 Ebers GC, Sadovnick AD, Risch NJ
• Extreme discordant sib pairs for mapping quantitative trait loci in humans.
  Science (New York, N.Y.) 1995 Risch N, Zhang H
• Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7.
  Nature genetics 1995 Rowe RE, Wapelhorst B, Bell GI, Risch N, Spielman RS, Concannon P
• Localization of a gene for partial epilepsy to chromosome 10q.
  Nature genetics 1995 Ottman R, Risch N, Hauser WA, Pedley TA, Lee JH, Barker-Cummings C, Lustenberger A, Nagle KJ, Lee KS, Scheuer ML
• Birth cohort and familial risk of epilepsy: the effect of diminished recall in studies of lifetime prevalence.
  American journal of epidemiology 1995 Ottman R, Lee JH, Hauser WA, Risch N
• Genetic analysis of idiopathic torsion dystonia in Ashkenazi Jews and their recent descent from a small founder population.
  Nature genetics 1995 Risch N, de Leon D, Ozelius L, Kramer P, Almasy L, Singer B, Fahn S, Breakefield X, Bressman S
• Linkage and association studies in insulin-dependent diabetes with a new dinucleotide repeat polymorphism at the GAD65 locus.
  Autoimmunity 1995 Wapelhorst B, Bell GI, Risch N, Spielman RS, Concannon P
• Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease.
  Genetic epidemiology 1995 Almasy L, Tierney C, Risch N
• Dystonia in Ashkenazi Jews: clinical characterization of a founder mutation.
  Annals of neurology 1994 Bressman SB, de Leon D, Kramer PL, Ozelius LJ, Brin MF, Greene PE, Fahn S, Breakefield XO, Risch NJ
• Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease.
  Nature genetics 1994 Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gaskell PC, Rimmler JB, Locke PA, Conneally PM, Schmader KE
• Diminished recall and the cohort effect of major depression: a simulation study.
  Psychological medicine 1994 Giuffra LA, Risch N
• Genetic susceptibility to death from coronary heart disease in a study of twins.
  The New England journal of medicine 1994 Marenberg ME, Risch N, Berkman LF, Floderus B, de Faire U
• Autosomal dominant inheritance of early-onset breast cancer. Implications for risk prediction.
  Cancer 1994 Claus EB, Risch N, Thompson WD
• Comorbidity and co-transmission of alcoholism, anxiety and depression.
  Psychological medicine 1994 Merikangas KR, Risch NJ, Weissman MM
• Comments on the statistical aspects of the NRC's report on DNA typing.
  Journal of forensic sciences 1994 Devlin B, Risch N, Roeder K
• Feasibility of half-sibling designs for detecting a genetic component to a disease.
  Genetic epidemiology 1994 Tierney C, Merikangas KR, Risch N
• Male sexual orientation and genetic evidence.
  Science (New York, N.Y.) 1993 Risch N, Squires-Wheeler E, Keats BJ
• Linkage mapping of dopa-responsive dystonia (DRD) to chromosome 14q.
  Nature genetics 1993 Nygaard TG, Wilhelmsen KC, Risch NJ, Brown DL, Trugman JM, Gilliam TC, Fahn S, Weeks DE
• Population genetics of the HRAS1 minisatellite locus.
  American journal of human genetics 1993 Devlin B, Krontiris T, Risch N
• The calculation of breast cancer risk for women with a first degree family history of ovarian cancer.
  Breast cancer research and treatment 1993 Claus EB, Risch N, Thompson WD
• The genetics of infantile hypertrophic pyloric stenosis. A reanalysis.
  American journal of diseases of children (1960) 1993 Mitchell LE, Risch N
• Statistical evaluation of multiple-locus linkage data in experimental species and its relevance to human studies: application to nonobese diabetic (NOD) mouse and human insulin-dependent diabetes mellitus (IDDM).
  American journal of human genetics 1993 Risch N, Ghosh S, Todd JA
• An association between the risk of cancer and mutations in the HRAS1 minisatellite locus.
  The New England journal of medicine 1993 Krontiris TG, Devlin B, Karp DD, Robert NJ, Risch N
• Physical properties of VNTR data, and their impact on a test of allelic independence.
  American journal of human genetics 1993 Devlin B, Risch N
• NRC report on DNA typing.
  Science (New York, N.Y.) 1993 Devlin B, Risch N, Roeder K
• Correlates of genetic risk for non-syndromic cleft lip with or without cleft palate.
  Clinical genetics 1993 Mitchell LE, Risch N
• The A1 allele at the D2 dopamine receptor gene and alcoholism. A reappraisal.
  JAMA 1993 Gelernter J, Goldman D, Risch N
• Statistical evaluation of DNA fingerprinting: a critique of the NRC's report.
  Science (New York, N.Y.) 1993 Devlin B, Risch N, Roeder K
• Diminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees.
  Nature genetics 1993 Baron M, Freimer NF, Risch N, Lerer B, Alexander JR, Straub RE, Asokan S, Das K, Peterson A, Amos J
• Linkage studies of psychiatric disorders.
  European archives of psychiatry and clinical neuroscience 1993 Risch N, Merikangas KR
• Low-density lipoprotein cholesterol responsiveness to diet in normolipidemic subjects.
  Metabolism: clinical and experimental 1993 Cobb MM, Risch N
• Relationship between breast histopathology and family history of breast cancer.
  Cancer 1993 Claus EB, Risch N, Thompson WD, Carter D
• Risk factors predicting the incidence of second primary breast cancer among women diagnosed with a first primary breast cancer.
  American journal of epidemiology 1992 Bernstein JL, Thompson WD, Risch N, Holford TR
• The genetic epidemiology of second primary breast cancer.
  American journal of epidemiology 1992 Bernstein JL, Thompson WD, Risch N, Holford TR
• A note on Hardy-Weinberg equilibrium of VNTR data by using the Federal Bureau of Investigation's fixed-bin method.
  American journal of human genetics 1992 Devlin B, Risch N
• Corrections to "Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs".
  American journal of human genetics 1992 Risch N
• Ethnic differentiation at VNTR loci, with special reference to forensic applications.
  American journal of human genetics 1992 Devlin B, Risch N
• Influence of dietary fat, apolipoprotein E phenotype, and sex on plasma lipoprotein levels.
  Circulation 1992 Cobb MM, Teitlebaum H, Risch N, Jekel J, Ostfeld A
• Mode of inheritance of nonsyndromic cleft lip with or without cleft palate: a reanalysis.
  American journal of human genetics 1992 Mitchell LE, Risch N
• Strong allelic association between the torsion dystonia gene (DYT1) andloci on chromosome 9q34 in Ashkenazi Jews.
  American journal of human genetics 1992 Ozelius LJ, Kramer PL, de Leon D, Risch N, Bressman SB, Schuback DE, Brin MF, Kwiatkowski DJ, Burke RE, Gusella JF
• Genetic linkage: interpreting lod scores.
  Science (New York, N.Y.) 1992 Risch N
• On the probability of matching DNA fingerprints.
  Science (New York, N.Y.) 1992 Risch NJ, Devlin B
• Genetic Analysis Workshop 7: summary of the melanoma workshop.
  Cytogenetics and cell genetics 1992 Risch N, Sherman S
• Genetic relationship between nevus count or nevus density and cutaneous malignant melanoma.
  Cytogenetics and cell genetics 1992 Claus EB, Giuffra L, Rogers J, Risch N
• Model misspecification and multipoint linkage analysis.
  Human heredity 1992 Risch N, Giuffra L
• No association between an allele at the D2 dopamine receptor gene (DRD2) and alcoholism.
  JAMA 1991 Gelernter J, O'Malley S, Risch N, Kranzler HR, Krystal J, Merikangas K, Kennedy JL, Kidd KK
• Estimation of morbid risk and age at onset with missing information.
  American journal of human genetics 1991 Cupples LA, Risch N, Farrer LA, Myers RH
• A note on multiple testing procedures in linkage analysis.
  American journal of human genetics 1991 Risch N
• Developments in gene mapping with linkage methods.
  Current opinion in genetics & development 1991 Risch N
• Estimation of allele frequencies for VNTR loci.
  American journal of human genetics 1991 Devlin B, Risch N, Roeder K
• Genetic analysis of breast cancer in the cancer and steroid hormone study.
  American journal of human genetics 1991 Claus EB, Risch N, Thompson WD
• No excess of homozygosity at loci used for DNA fingerprinting.
  Science (New York, N.Y.) 1990 Devlin B, Risch N, Roeder K
• The impact of phenotypic variation on genetic analysis: application to X-linkage in manic-depressive illness.
  Acta psychiatrica Scandinavica 1990 Baron M, Hamburger R, Sandkuyl LA, Risch N, Mandel B, Endicott J, Belmaker RH, Ott J
• Sensitivity of chromosomal mosaicism detection by different tissue culture methods.
  Prenatal diagnosis 1990 Richkind KE, Risch NJ
• Age at onset as an indicator of familial risk of breast cancer.
  American journal of epidemiology 1990 Claus EB, Risch NJ, Thompson WD
• Using age of onset to distinguish between subforms of breast cancer.
  Annals of human genetics 1990 Claus EB, Risch NJ, Thompson WD
• Segregation analysis of idiopathic torsion dystonia in Ashkenazi Jews suggests autosomal dominant inheritance.
  American journal of human genetics 1990 Risch NJ, Bressman SB, deLeon D, Brin MF, Burke RE, Greene PE, Shale H, Claus EB, Cupples LA, Fahn S
• Dystonia gene in Ashkenazi Jewish population is located on chromosome 9q32-34.
  Annals of neurology 1990 Kramer PL, de Leon D, Ozelius L, Risch N, Bressman SB, Brin MF, Schuback DE, Burke RE, Kwiatkowski DJ, Shale H
• Linkage strategies for genetically complex traits. I. Multilocus models.
  American journal of human genetics 1990 Risch N
• Linkage strategies for genetically complex traits. II. The power of affected relative pairs.
  American journal of human genetics 1990 Risch N
• Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs.
  American journal of human genetics 1990 Risch N
• Genetic linkage and complex diseases, with special reference to psychiatric disorders.
  Genetic epidemiology 1990 Risch N
• Idiopathic dystonia among Ashkenazi Jews: evidence for autosomal dominant inheritance.
  Annals of neurology 1989 Bressman SB, de Leon D, Brin MF, Risch N, Burke RE, Greene PE, Shale H, Fahn S
• Evaluating genetic association among ovarian, breast, and endometrial cancer: evidence for a breast/ovarian cancer relationship.
  American journal of human genetics 1989 Schildkraut JM, Risch N, Thompson WD
• Human gene for torsion dystonia located on chromosome 9q32-q34.
  Neuron 1989 Ozelius L, Kramer PL, Moskowitz CB, Kwiatkowski DJ, Brin MF, Bressman SB, Schuback DE, Falk CT, Risch N, de Leon D
• Description of X-linkage pedigrees.
  Genetic epidemiology 1989 Risch N
• Genetic analysis of the affective disorders: summary of GAW5.
  Genetic epidemiology 1989 Rice J, Risch N
• Genetics of IDDM: evidence for complex inheritance with HLA.
  Genetic epidemiology 1989 Risch N
• Linkage and mode of inheritance in complex traits.
  Progress in clinical and biological research 1989 Risch N, Claus E, Giuffra L
• Linkage detection tests under heterogeneity.
  Genetic epidemiology 1989 Risch N
• The Continuous Performance Test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families.
  Psychiatry research 1988 Cornblatt BA, Risch NJ, Faris G, Friedman D, Erlenmeyer-Kimling L
• A new statistical test for linkage heterogeneity.
  American journal of human genetics 1988 Risch N
• Inheritance of idiopathic torsion dystonia among Ashkenazi Jews.
  Advances in neurology 1988 Bressman SB, de Leon D, Brin MF, Risch N, Shale H, Burke RE, Greene PE, Fahn S
• Migraine and depression: association and familial transmission.
  Journal of psychiatric research 1988 Merikangas KR, Risch NJ, Merikangas JR, Weissman MM, Kidd KK
• Spontaneous mutation and parental age in humans.
  American journal of human genetics 1987 Risch N, Reich EW, Wishnick MM, McCarthy JG
• Genetic linkage between X-chromosome markers and bipolar affective illness.
  Nature 1987 Baron M, Risch N, Hamburger R, Mandel B, Kushner S, Newman M, Drumer D, Belmaker RH
• Assessing the role of HLA-linked and unlinked determinants of disease.
  American journal of human genetics 1987 Risch N
• The spectrum concept of schizophrenia: evidence for a genetic-environmental continuum.
  Journal of psychiatric research 1987 Baron M, Risch N
• The relationship between maternal age and chromosome size in autosomal trisomy.
  American journal of human genetics 1986 Risch N, Stein Z, Kline J, Warburton D
• Assessing the role of X-linked inheritance in bipolar-related major affective disorder.
  Journal of psychiatric research 1986 Risch N, Baron M, Mendlewicz J
• Conditional linkage analysis of multiple sclerosis data.
  Genetic epidemiology. Supplement 1986 Risch N
• Genetic analysis workshop IV: summary of the multiple sclerosis workshop.
  Genetic epidemiology. Supplement 1986 Risch N
• Genetic analysis of plasma amine oxidase activity in schizophrenia.
  Psychiatry research 1985 Baron M, Risch N, Levitt M, Gruen R
• Genetic analysis of platelet monoamine oxidase activity in families of schizophrenic patients.
  Journal of psychiatric research 1985 Baron M, Risch N, Levitt M, Gruen R
• Segregation analysis of schizophrenia and related disorders.
  American journal of human genetics 1984 Risch N, Baron M
• Segregation analysis incorporating linkage markers. I. Single-locus models with an application to type I diabetes.
  American journal of human genetics 1984 Risch N
• Genetic Analysis Workshop II: multiple-locus segregation analysis incorporating linkage markers.
  Genetic epidemiology 1984 Risch N
• The effects of reduced fertility, method of ascertainment, and a second unlinked locus on affected sib-pair marker allele sharing.
  American journal of medical genetics 1983 Risch N
• Estimating morbidity risks in relatives: the effect of reduced fertility.
  Behavior genetics 1983 Risch N
• A general model for disease-marker association.
  Annals of human genetics 1983 Risch N
• X-linkage and genetic heterogeneity in bipolar-related major affective illness: reanalysis of linkage data.
  Annals of human genetics 1982 Risch N, Baron M
• Age at onset in bipolar-related major affective illness: clinical and genetic implications.
  Journal of psychiatric research 1982 Baron M, Risch N, Mendlewicz J
• X-linkage in affective and schizoaffective disorders: genetic and diagnostic implications.
  Neuropsychobiology 1982 Baron M, Risch N
• X-linkage in bipolar affective illness. Perspectives on genetic heterogeneity, pedigree analysis and the X-chromosome map.
  Journal of affective disorders 1981 Baron M, Rainer JD, Risch N
• Application of a recombination model in calculating the variance of sib pair genetic identity.
  Annals of human genetics 1979 Risch N, Lange K
• An alternative model of recombination and interference.
  Annals of human genetics 1979 Risch N, Lange K