Neha Nirwan, PhD
Postdoctoral Scholar
Cardiovascular Research Inst
School of Medicine

Publications (5)

Top publication keywords:
GTP PhosphohydrolasesStructure-Activity RelationshipScattering, Small AngleEndonucleasesEscherichia coliEscherichia coli ProteinsX-Ray DiffractionAAA DomainGuanosine TriphosphateCryoelectron MicroscopyDNA, BacterialProtein MultimerizationCalcium ChannelsDNA Restriction EnzymesLactococcus lactis

• Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody.
  Nature communications 2022 Morgenstern TJ, Nirwan N, Hernández-Ochoa EO, Bibollet H, Choudhury P, Laloudakis YD, Ben Johny M, Bannister RA, Schneider MF, Minor DL, Colecraft HM
• Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC.
  Nature communications 2019 Nirwan N, Itoh Y, Singh P, Bandyopadhyay S, Vinothkumar KR, Amunts A, Saikrishnan K
• Hexameric assembly of the AAA+ protein McrB is necessary for GTPase activity.
  Nucleic acids research 2019 Nirwan N, Singh P, Mishra GG, Johnson CM, Szczelkun MD, Inoue K, Vinothkumar KR, Saikrishnan K
• Structural insights into DNA sequence recognition by Type ISP restriction-modification enzymes.
  Nucleic acids research 2016 Kulkarni M, Nirwan N, van Aelst K, Szczelkun MD, Saikrishnan K
• Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes.
  Nature chemical biology 2015 Chand MK, Nirwan N, Diffin FM, van Aelst K, Kulkarni M, Pernstich C, Szczelkun MD, Saikrishnan K