Neel Singhal, MD, PhD
Associate Professor
Neurology
School of Medicine

I lead a basic science lab focused on identifying new pathways for neuroprotection and neuro-resilience by focusing on targets identified in human genome-wide association studies and models of ischemia tolerance including the uniquely resilient Arctic ground squirrel. Along with the Clelland lab, we are also doing exciting collaborative work in establishing new models of experimental research in patients and human tissues towards bringing CRISPR cures for neurodegenerative disease closer to clinical trials. We are also working towards more precise biomarkers for critical neurologic injuries along with the Amorim lab.

• Transcriptional and neuroprotective effects of hexokinase-2 inhibitors administered after stroke.
  Journal of neuroinflammation 2025 Won SJ, Uruk G, Mai N, Tu CL, Ogut D, Asatryan S, Mocanu E, Shon R, Kim K, Awakoaiye K, Arkelius K, Chang W, Singhal NS, Swanson RA
• Delirium in hospitalized COVID-19 patients is associated with dynamic changes in peripheral immune gene expression.
  GeroScience 2025 LaHue SC, Takegami N, Simmasalam R, Baqai A, Munoz E, Sikri A, de Courson TDB, Singhal NS, Eckalbar W, Langelier CR, Hendrickson CM, Calfee CS, Erle DJ, Krummel MF, Woodruff PG, Oskotsky T, Sirota M, …
• Higher circulating short-chain fatty acids are associated with good neurologic outcome after cardiac arrest.
  Critical care (London, England) 2025 Lieberman OJ, Yao V, Velasquez G, Otero M, Bao K, Peterson K, Kobeissy FH, Pan JZ, Guan Z, Hinson HE, Baranzini SE, Hemphill JC, Singhal NS, Amorim E
• Neurological Injury and Outcomes in Fentanyl-related Cardiac Arrest.
  Journal of addiction medicine 2025 Otero M, Shih J, Zhou B, Ghandi S, Talbott J, Singhal NS, Calabrese E, Randazzo D, Coffin PO, Hemphill JC, Amorim E
• PATJ regulates cell stress responses and vascular remodeling post-stroke.
  Redox biology 2025 Zhang M, Jiang WI, Arkelius K, Swanson RA, Ma DK, Singhal NS
• Discovery research in physiologically maintained deceased.
  Science (New York, N.Y.) 2025 Pet DB, Parent B, Singhal NS, Clelland CD
• Neurological Injury in Comatose Patients Following Substance-Use-Related Out-of-Hospital Cardiac Arrest: A Retrospective Cohort Study in a Safety Net Hospital.
  Neurocritical care 2025 Shih JJ, Otero M, Gandhi S, Talbott J, Zhou B, Vitt JR, Singhal NS, Randazzo D, Scheffler A, Hemphill JC, Amorim E
• Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis.
  Proceedings of the National Academy of Sciences of the United States of America 2025 Jiang WI, Cao Y, Xue Y, Ji Y, Winer BY, Chandra R, Zhang XF, Zhang M, Singhal NS, Pierce JT, Chen S, Ma DK
• Small RNA signatures of acute ischemic stroke in L1CAM positive extracellular vesicles.
  Scientific reports 2024 Manwani B, Brathaban N, Baqai A, Munshi Y, Ahnstedt HW, Zhang M, Arkelius K, Llera T, Amorim E, Elahi FM, Singhal NS
• Neuroprotectants.
  Ischemic Stroke Therapeutics 2024 Neel S. Singhal, Raymond A. Swanson, Midori A. Yenari
• ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke.
  Clinical and translational medicine 2024 Pan JZ, Wang Z, Sun W, Pan P, Li W, Sun Y, Chen S, Lin A, Tan W, He L, Greene J, Yao V, An L, Liang R, Li Q, Yu J, Zhang L, Kyritsis N, Fernandez XD, Moncivais S, Mendoza E, Fung P, Wang G, Niu X, Du …
• Management of Status Epilepticus and Indications for Inpatient Electroencephalography Monitoring.
  Neurologic clinics 2022 Fan JM, Singhal NS, Guterman EL
• Diabetes, stroke, and neuroresilience: looking beyond hyperglycemia.
  Annals of the New York Academy of Sciences 2021 Krinock MJ, Singhal NS
• Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells.
  eLife 2020 Singhal NS, Bai M, Lee EM, Luo S, Cook KR, Ma DK
• Resilience to Injury: A New Approach to Neuroprotection?
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Singhal NS, Sun CH, Lee EM, Ma DK
• Neuronal GDPGP1 and glycogen metabolism: friend or foe?
  The Journal of cell biology 2020 Singhal NS, Lee EM, Ma DK
• Endovascular Treatment of Stroke, Oral Anticoagulant-associated Intracerebral Hemorrhage, and Treatment of Extracranial Dissection.
  American journal of respiratory and critical care medicine 2016 Thabet AM, Kottapally M, Singhal NS
• Diagnosing Balamuthia mandrillaris Encephalitis With Metagenomic Deep Sequencing.
  Annals of neurology 2015 Wilson MR, Shanbhag NM, Reid MJ, Singhal NS, Gelfand JM, Sample HA, Benkli B, O'Donovan BD, Ali IK, Keating MK, Dunnebacke TH, Wood MD, Bollen A, DeRisi JL
• Sarcoid polyneuropathy masquerading as chronic inflammatory demyelinating polyneuropathy.
  Muscle & nerve 2015 Singhal NS, Irodenko VS, Margeta M, Layzer RB
• Immediate Hemorrhagic Transformation After Intravenous Tissue-Type Plasminogen Activator Injection in 2 Cocaine Users.
  Stroke 2015 Baud MO, Brown EG, Singhal NS, Hemphill JC
• Effect of rituximab in patients with leucine-rich, glioma-inactivated 1 antibody-associated encephalopathy.
  JAMA neurology 2014 Irani SR, Gelfand JM, Bettcher BM, Singhal NS, Geschwind MD
• A practical approach to neurologic evaluation in the intensive care unit.
  Journal of critical care 2014 Singhal NS, Josephson SA
• Unconscious processing of color and form in metacontrast masking.
  Attention, perception & psychophysics 2009 Ro T, Singhal NS, Breitmeyer BG, Garcia JO
• Inhibition of ADRP prevents diet-induced insulin resistance.
  American journal of physiology. Gastrointestinal and liver physiology 2008 Varela GM, Antwi DA, Dhir R, Yin X, Singhal NS, Graham MJ, Crooke RM, Ahima RS
• Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice.
  American journal of physiology. Endocrinology and metabolism 2008 Singhal NS, Patel RT, Qi Y, Lee YS, Ahima RS
• Hypothalamic control of energy homeostasis.
  Neurobiology of Obesity 2008 Neel S. Singhal, Rexford S. Ahima
• Central resistin induces hepatic insulin resistance via neuropeptide Y.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Singhal NS, Lazar MA, Ahima RS
• Brain adipocytokine action and metabolic regulation.
  Diabetes 2006 Ahima RS, Qi Y, Singhal NS, Jackson MB, Scherer PE
• Loss of resistin improves glucose homeostasis in leptin deficiency.
  Diabetes 2006 Qi Y, Nie Z, Lee YS, Singhal NS, Scherer PE, Lazar MA, Ahima RS
• Adipokines that link obesity and diabetes to the hypothalamus.
  Progress in brain research 2006 Ahima RS, Qi Y, Singhal NS
• Unconscious color priming occurs at stimulus- not percept-dependent levels of processing.
  Psychological science 2004 Breitmeyer BG, Ro T, Singhal NS
• Feedback contributions to visual awareness in human occipital cortex.
  Current biology : CB 2003 Ro T, Breitmeyer B, Burton P, Singhal NS, Lane D
• Effects of lithium chloride on induction and expression of methylphenidate sensitization.
  European journal of pharmacology 2001 Yang P, Singhal N, Modi G, Swann A, Dafny N