Navneet Matharu, PhD
Assoc Res -FY
Bioengineering
School of Pharmacy

Dr. Matharu holds joint appointment as Assistant Professor and Associate Researcher. Dr.Matharu's research interest is focused on applying ‘gene regulation and transcription logics’ to innovate therapeutic strategies for genetic disorders.

Awards

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• IGI-RIDER Award, IGI, UC Berkeley, 2019
• Catalayst Award, CTSI, UCSF, 2018
• Finalist ‘Regeneron Prize for Creative Innovation’, Regeneron Pharmaceuticals, 2018
• Charles J Epstein Trainee Award for Excellence in Human Genetics, American Society of Human Genetics, 2017
• Charles J Epstein Trainee Award for Excellence in Human Genetics, American Society of Human Genetics, 2017
• Mary Ann Koda Kimble Seed award for Innovation, School of Pharmacy, UCSF, 2017
• People’s choice award Postdoc Slam Competition, UCSF, 2016
• Young Scientist Award, Dr. KV Rao Scientific Society, India, Rao Scientific Society, India, 2011
• Senior Research Fellowship (SRF) in Life Sciences, CSIR, HRD ministry Govt of India, 2006-2010
• Junior Research Fellowship (JRF) in Life Sciences, CSIR, HRD ministry Govt of India, 2004-2006
• Gold Medal MSc Genetics, University of Delhi, 2004
• Monsanto Scholarship for meritorious student, University of Delhi, 2002-2004
• Gold Medal BSc Zoology, University of Delhi, 2002
• University Scholarship for meritoirus student, University of Delhi, 1999-2002

Education & Training

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• PhD Molecular Biology and Gene Regulation Centre for Cellular and Molecular Biology, CSIR, Jawaharlal Nehru University 2011
• Masters in Science Genetics University of Delhi 2004
• Bachelors in Science Zoology University of Delhi 2002

Interests

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• Genetic therapy
• gene regulation
• CRISPR

Publications (18)

Top publication keywords:
Chromatin Assembly and DisassemblyEmbryonic DevelopmentClustered Regularly Interspaced Short Palindromic RepeatsGene Expression RegulationPromoter Regions, GeneticZebrafishEnhancer Elements, GeneticVesicular Inhibitory Amino Acid Transport ProteinsPharmaceutical PreparationsGenes, HomeoboxZebrafish ProteinsHaploinsufficiencyGenetic Diseases, InbornHomeodomain ProteinsEpigenesis, Genetic

• Author Correction: Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation.
  Nature metabolism 2024 Inoue F, Eckalbar WL, Wang Y, Murphy KK, Matharu N, Vaisse C, Ahituv N
• Transcriptomic Mapping of Neural Diversity, Differentiation and Functional Trajectory in iPSC-Derived 3D Brain Organoid Models.
  Cells 2021 Kiaee K, Jodat YA, Bassous NJ, Matharu N, Shin SR
• Oestrogen engages brain MC4R signalling to drive physical activity in female mice.
  Nature 2021 Krause WC, Rodriguez R, Gegenhuber B, Matharu N, Rodriguez AN, Padilla-Roger AM, Toma K, Herber CB, Correa SM, Duan X, Ahituv N, Tollkuhn J, Ingraham HA
• Role of vertebrate GAGA associated factor (vGAF) in early development of zebrafish.
  Cells & development 2021 Matharu NK, Yadav S, Kumar M, Mishra RK
• Asymmetron: a toolkit for the identification of strand asymmetry patterns in biological sequences.
  Nucleic acids research 2021 Georgakopoulos-Soares I, Mouratidis I, Parada GE, Matharu N, Hemberg M, Ahituv N

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• Toward a neurospheroid niche model: optimizing embedded 3D bioprinting for fabrication of neurospheroid brain-like co-culture constructs.
  Biofabrication 2020 Li YE, Jodat YA, Samanipour R, Zorzi G, Zhu K, Hirano M, Chang K, Arnaout A, Hassan S, Matharu N, Khademhosseini A, Hoorfar M, Shin SR
• Modulating gene regulation to treat genetic disorders.
  Nature reviews. Drug discovery 2020 Matharu N, Ahituv N
• Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation.
  Nature metabolism 2019 Inoue F, Eckalbar WL, Wang Y, Murphy KK, Matharu N, Vaisse C, Ahituv N
• Reply to Liu et al.: Tissue specificity of SIM1 gene expression and erectile dysfunction.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Jorgenson E, Matharu N, Palmer MR, Yin J, Shan J, Hoffmann TJ, Thai KK, Zhou X, Hotaling JM, Jarvik GP, Ahituv N, Wessells H, Van Den Eeden SK
• CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency.
  Science (New York, N.Y.) 2018 Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N
• Genetic variation in the SIM1 locus is associated with erectile dysfunction.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Jorgenson E, Matharu N, Palmer MR, Yin J, Shan J, Hoffmann TJ, Thai KK, Zhou X, Hotaling JM, Jarvik GP, Ahituv N, Wessells H, Van Den Eeden SK
• Minor Loops in Major Folds: Enhancer-Promoter Looping, Chromatin Restructuring, and Their Association with Transcriptional Regulation and Disease.
  PLoS genetics 2015 Matharu N, Ahituv N
• Chromatin Insulators and Topological Domains: Adding New Dimensions to 3D Genome Architecture.
  Genes 2015 Matharu NK, Ahanger SH
• Mining the cis-regulatory elements of Hox clusters.
  Methods in molecular biology (Clifton, N.J.) 2014 Matharu NK, Mishra RK
• A functionally conserved Polycomb response element from mouse HoxD complex responds to heterochromatin factors.
  Scientific reports 2013 Vasanthi D, Nagabhushan A, Matharu NK, Mishra RK
• Homeotic gene regulation: a paradigm for epigenetic mechanisms underlying organismal development.
  Sub-cellular biochemistry 2013 Matharu NK, Dasari V, Mishra RK
• Tone up your chromatin and stay young.
  Journal of biosciences 2011 Matharu NK, Mishra RK
• Vertebrate homologue of Drosophila GAGA factor.
  Journal of molecular biology 2010 Matharu NK, Hussain T, Sankaranarayanan R, Mishra RK