Nathaniel Harder, PhD
Postdoctoral Scholar
Medicine
School of Medicine

Publications (11)

Top publication keywords:
CeruloplasminDietary SugarsProtein Tyrosine Phosphatase, Non-Receptor Type 22Hepatolenticular DegenerationCopperSerum AlbuminEndocrine GlandsSkin AgingAspartameIronLipofuscinZincSweetening AgentsHigh Fructose Corn SyrupRejuvenation

• OS-01 Peptide Topical Formulation Improves Skin Barrier Function and Reduces Systemic Inflammation Markers: A Pilot 12-Week Clinical Trial.
  Journal of cosmetic dermatology 2025 Zonari A, Brace LE, Buhrer LB, Harder NHO, Harker C, Aronson AB, Tse CN, Oliveira CR, Boroni M, Carvalho JL
• Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging.
  International journal of cosmetic science 2025 Zonari A, Brace LE, Li F, Harder NHO, Harker C, Jacob C, Kaufman J, Chilukuri S, Oliveira CR, Boroni M, Carvalho JL
• Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation.
  Journal of cosmetic dermatology 2024 Zonari A, Brace LE, Harder NHO, Harker C, Oliveira CR, Boroni M, Carvalho JL
• The role of intestine in metabolic dysregulation in murine Wilson disease.
  Hepatology communications 2023 Sarode GV, Mazi TA, Neier K, Shibata NM, Jospin G, Harder NHO, Caceres A, Heffern MC, Sharma AK, More SK, Dave M, Schroeder SM, Wang L, LaSalle JM, Lutsenko S, Medici V
• Copper(II) Affects the Biochemical Behavior of Proinsulin C-peptide by Forming Ternary Complexes with Serum Albumin.
  Journal of the American Chemical Society 2023 San Juan JA, Chakarawet K, He Z, Fernandez RL, Stevenson MJ, Harder NHO, Janisse SE, Wang LP, Britt RD, Heffern MC

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• The role of intestine in metabolic dysregulation in murine Wilson disease.
  bioRxiv : the preprint server for biology 2023 Sarode GV, Mazi TA, Neier K, Shibata NM, Jospin G, Harder NHO, Heffern MC, Sharma AK, More SK, Dave M, Schroeder SM, Wang L, LaSalle JM, Lutsenko S, Medici V
• Fatty Acid Uptake in Liver Hepatocytes Induces Relocalization and Sequestration of Intracellular Copper.
  Frontiers in molecular biosciences 2022 Harder NHO, Lee HP, Flood VJ, San Juan JA, Gillette SK, Heffern MC
• Effects of Dietary Glucose and Fructose on Copper, Iron, and Zinc Metabolism Parameters in Humans.
  Nutrients 2020 Harder NHO, Hieronimus B, Stanhope KL, Shibata NM, Lee V, Nunez MV, Keim NL, Bremer A, Havel PJ, Heffern MC, Medici V
• Detecting liver disease via an endogenous pigment.
  Nature biomedical engineering 2020 O'Sullivan JJ, Harder NHO, Heffern MC
• PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling.
  Science signaling 2020 Yang S, Svensson MND, Harder NHO, Hsieh WC, Santelli E, Kiosses WB, Moresco JJ, Yates JR, King CC, Liu L, Stanford SM, Bottini N
• Metal-dependent hormone function: the emerging interdisciplinary field of metalloendocrinology.
  Metallomics : integrated biometal science 2019 Stevenson MJ, Uyeda KS, Harder NHO, Heffern MC