Natasha Spottiswoode, MD, PhD
Assistant Professor
Medicine
School of Medicine

Infectious disease physician-scientist with a focused on unbiased diagnostics and developing treatments for uncommon infections.

Awards

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• CPPR Investigator Seed Award, Center for Pandemic Preparedness Response, 2023-2024
• Nina Ireland Award, NIPLH, 2022-2023
• Travel Bursary, Infectious Disease Week, 2022
• David J Sencer Scholarship, Centers for Disease Control and Prevention, 2020
• Poetry Award, Department of Medicine, UCSF, 2020

Education & Training

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• Medicine Residency University of California San Francisco Medical Center 06/2021
• BS Biology California State University Los Angeles 06/2018
• MD Medicine Columbia University Vagelos College of Physicians and Surgeons 05/2018
• DPhil Biomedical Sciences University of Oxford/National Institutes of Health 06/2014
• BSc Integrative Bioscience University of Oxford 09/2010
• Infectious Disease Fellowship University of California San Francisco

Websites

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• Posts on X @nspottiswoodemd (X.com)

Publications (30)

Top publication keywords:
Plasmodium bergheiBacteremiaSepsisBalamuthia mandrillarisMalaria, AvianPneumonia, BacterialHepcidinsCharadriiformesSpheniscidaeAmebiasisInfectious EncephalitisPlasmodium chabaudiActivinsDucksAnimals, Zoo

• Pulmonary FABP4 Is an Inverse Biomarker of Pneumonia in Critically Ill Children and Adults.
  American journal of respiratory and critical care medicine 2024 Lydon EC, Phan HV, Mick E, Spottiswoode N, Calfee CS, Mourani PM, Langelier CR
• Rewriting the Script.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2024 Spottiswoode N, Minter DJ, Friedman-Moraco R
• Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia.
  Nature communications 2024 Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC, COMET …
• Advancing Sepsis Endotyping Globally: Lessons From a Prospective Study in Uganda.
  Critical care medicine 2024 Neyton L, Spottiswoode N
• Challenges and advances in the medical treatment of granulomatous amebic encephalitis.
  Therapeutic advances in infectious disease 2024 Spottiswoode N, Haston JC, Hanners NW, Gruenberg K, Kim A, DeRisi JL, Wilson MR

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• In host evolution of beta lactam resistance during active treatment for Pseudomonas aeruginosa bacteremia.
  Frontiers in cellular and infection microbiology 2023 Spottiswoode N, Hao S, Sanchez-Guerrero E, Detweiler AM, Mekonen H, Neff N, Macmillan H, Schwartz BS, Engel J, DeRisi JL, Miller SA, Langelier CR
• Clinical and biological heterogeneity of multisystem inflammatory syndrome in adults following SARS-CoV-2 infection: a case series.
  Frontiers in medicine 2023 Barth KE, Spottiswoode N, Hurabielle C, Subbaraj L, COMET Consortium, Calfee CS, Matthay MA, French S, Connolly A, Hewitt SM, Vannella KM, Barnett C, Langelier CR, Patterson S
• Successful Treatment of Balamuthia mandrillaris Granulomatous Amebic Encephalitis with Nitroxoline.
  Emerging infectious diseases 2023 Spottiswoode N, Pet D, Kim A, Gruenberg K, Shah M, Ramachandran A, Laurie MT, Zia M, Fouassier C, Boutros CL, Lu R, Zhang Y, Servellita V, Bollen A, Chiu CY, Wilson MR, Valdivia L, DeRisi JL
• Maribavir for Cytomegalovirus Treatment in the Real World-Not a Silver Bullet.
  Open forum infectious diseases 2022 Fung M, DeVoe C, Spottiswoode N, Doernberg SB
• Prevalence of type-1 interferon autoantibodies in adults with non-COVID-19 acute respiratory failure.
  Respiratory research 2022 Ghale R, Spottiswoode N, Anderson MS, Mitchell A, Wang G, Calfee CS, DeRisi JL, Langelier CR
• Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children.
  Nature communications 2022 Mick E, Tsitsiklis A, Spottiswoode N, Caldera S, Serpa PH, Detweiler AM, Neff N, Pisco AO, Li LM, Retallack H, Ratnasiri K, Williamson KM, Soesanto V, Simões EAF, Smith C, Abuogi L, Kistler A, Wagner …
• Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells.
  American journal of physiology. Lung cellular and molecular physiology 2022 Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA
• Pneumonia surveillance with culture-independent metatranscriptomics in HIV-positive adults in Uganda: a cross-sectional study.
  The Lancet. Microbe 2022 Spottiswoode N, Bloomstein JD, Caldera S, Sessolo A, McCauley K, Byanyima P, Zawedde J, Kalantar K, Kaswabuli S, Rutishauser RL, Lieng MK, Davis JL, Moore J, Jan A, Iwai S, Shenoy M, Sanyu I, DeRisi …
• Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.
  Nature communications 2021 Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, …
• Upper airway gene expression reveals a more robust innate and adaptive immune response to SARS-CoV-2 in children compared with older adults.
  Research square 2021 Mick E, Tsitsiklis A, Spottiswoode N, Caldera S, Serpa PH, Detweiler AM, Neff N, Pisco AO, Li LM, Retallack H, Ratnasiri K, Williamson KM, Soesanto V, Simões EAF, Kistler A, Wagner BD, DeRisi JL, …
• COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.
  Research square 2021 Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, …
• Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses.
  Nature communications 2020 Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Castañeda G, DeRisi JL, Detweiler AM, Hao SL, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, …
• Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19.
  EClinicalMedicine 2020 Shah SJ, Barish PN, Prasad PA, Kistler A, Neff N, Kamm J, Li LM, Chiu CY, Babik JM, Fang MC, Abe-Jones Y, Alipanah N, Alvarez FN, Botvinnik OB, Castaneda G, CZB CLIAhub Consortium, Dadasovich RM, …
• Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2.
  medRxiv : the preprint server for health sciences 2020 Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Calfee CS, Castañeda G, DeRisi JL, Detweiler AM, Hao S, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, …
• Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: a comparison of patients with and without COVID-19.
  medRxiv : the preprint server for health sciences 2020 Shah SJ, Barish PN, Prasad PA, Kistler AL, Neff N, Kamm J, Li LM, Chiu CY, Babick JM, Fang MC, Abe-Jones Y, Alipanah N, Alvarez FN, Botvinnik OB, Davis JM, Castenada GD, Consortium C, Dadasovich RM, …
• Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity.
  Cell chemical biology 2020 Vanaerschot M, Murithi JM, Pasaje CFA, Ghidelli-Disse S, Dwomoh L, Bird M, Spottiswoode N, Mittal N, Arendse LB, Owen ES, Wicht KJ, Siciliano G, Bösche M, Yeo T, Kumar TRS, Mok S, Carpenter EF, …
• ANALYSIS OF PLASMODIUM LINEAGES IDENTIFIED IN CAPTIVE PENGUINS (SPHENISCIFORMES SPP.), EIDERS (SOMATERIA SPP.), AND INCA TERNS (LAROSTERNA INCA) IN A NORTH AMERICAN ZOOLOGICAL COLLECTION.
  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 2020 Spottiswoode N, Bartlett SL, Conley KJ, Seimon TA, Griffin DO, Sykes JM
• Nontyphoidal Salmonella as a Cause of Mediastinal Abscess after Aortic Valve Replacement: A Case Report and Review of Postoperative Salmonella Infections.
  Case reports in infectious diseases 2018 Spottiswoode N, Peluso MJ, Deuse T, Babik JM
• Role of Activins in Hepcidin Regulation during Malaria.
  Infection and immunity 2017 Spottiswoode N, Armitage AE, Williams AR, Fyfe AJ, Biswas S, Hodgson SH, Llewellyn D, Choudhary P, Draper SJ, Duffy PE, Drakesmith H
• Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study.
  The American journal of tropical medicine and hygiene 2016 Brickley EB, Spottiswoode N, Kabyemela E, Morrison R, Kurtis JD, Wood AM, Drakesmith H, Fried M, Duffy PE
• Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum.
  Cell host & microbe 2015 Gulati S, Ekland EH, Ruggles KV, Chan RB, Jayabalasingham B, Zhou B, Mantel PY, Lee MC, Spottiswoode N, Coburn-Flynn O, Hjelmqvist D, Worgall TS, Marti M, Di Paolo G, Fidock DA
• Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts.
  Nature communications 2014 Otto TD, Rayner JC, Böhme U, Pain A, Spottiswoode N, Sanders M, Quail M, Ollomo B, Renaud F, Thomas AW, Prugnolle F, Conway DJ, Newbold C, Berriman M
• Iron, anemia and hepcidin in malaria.
  Frontiers in pharmacology 2014 Spottiswoode N, Duffy PE, Drakesmith H
• Implications of malaria on iron deficiency control strategies.
  Advances in nutrition (Bethesda, Md.) 2012 Spottiswoode N, Fried M, Drakesmith H, Duffy PE
• Hepcidin regulation by innate immune and infectious stimuli.
  Blood 2011 Armitage AE, Eddowes LA, Gileadi U, Cole S, Spottiswoode N, Selvakumar TA, Ho LP, Townsend AR, Drakesmith H