Natalia Jura, PhD
Professor
Cardiovascular Research Inst
School of Medicine

Websites

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• @@JuraLab_UCSF on Twitter (twitter.com)
• Jura Lab website (cvri.ucsf.edu)

Grants and Projects

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• Structural and Functional Studies of HER Receptors, NIH, 2021-2025
• The structural and functional basis of MET exon 14 activation and acquired drug resistance, NIH, 2019-2024
• Structural and functional investigation of the understudied HIPK1 kinase, NIH, 2020-2021
• Structural and Functional Studies of HER Receptor Tyrosine Kinases, NIH, 2014-2020
• FASEB SRC Protein Phosphorylation Networks in Health and Disease, NIH, 2018-2019

Publications (83)

Top publication keywords:
Neuregulin-1Receptor, ErbB-2Bone Morphogenetic Protein Receptors, Type IISignal TransductionActivin Receptors, Type IProto-Oncogene Proteins c-metReceptor, ErbB-3ErbB ReceptorsProtein DomainsReceptor Protein-Tyrosine KinasesLigandsProtein KinasesProtein MultimerizationCryoelectron MicroscopyUbiquitin

• Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation.
  eLife 2024 Trenker R, Diwanji D, Bingham T, Verba KA, Jura N
• Protein-protein interactions with G3BPs drive stress granule condensation and gene expression changes under cellular stress.
  bioRxiv : the preprint server for biology 2024 Liboy-Lugo JM, Espinoza CA, Sheu-Gruttadauria J, Park JE, Xu A, Jowhar Z, Gao AL, Carmona-Negrón JA, Wittmann T, Jura N, Floor SN
• Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation.
  bioRxiv : the preprint server for biology 2024 Trenker R, Diwanji D, Bingham T, Verba KA, Jura N
• Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.
  bioRxiv : the preprint server for biology 2023 Estevam GO, Linossi EM, Macdonald CB, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS
• Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma.
  Research square 2023 Daggubati V, Vykunta A, Choudhury A, Qadeer Z, Mirchia K, Saulnier O, Zakimi N, Hines K, Paul M, Wang L, Jura N, Xu L, Reiter J, Taylor M, Weiss W, Raleigh D

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• Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3.
  Nature communications 2023 Torosyan H, Paul MD, Forget A, Lo M, Diwanji D, Pawlowski K, Krogan NJ, Jura N, Verba KA
• Trapping Tribbles: Nanobody-assisted structure of the TRIB2 pseudokinase.
  Structure (London, England : 1993) 2022 Santana FR, Linossi EM, Jura N
• Extensive conformational and physical plasticity protects HER2-HER3 tumorigenic signaling.
  Cell reports 2022 Campbell MR, Ruiz-Saenz A, Zhang Y, Peterson E, Steri V, Oeffinger J, Sampang M, Jura N, Moasser MM
• Structural basis for signaling by the HER3 pseudokinase receptor.
  The FASEB Journal 2022 Natalia Jura
• CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids.
  Nature communications 2022 Lo M, Sharir A, Paul MD, Torosyan H, Agnew C, Li A, Neben C, Marangoni P, Xu L, Raleigh DR, Jura N, Klein OD
• An effective strategy for ligand-mediated pulldown of the HER2/HER3/NRG1β heterocomplex and cryo-EM structure determination at low sample concentrations.
  Methods in enzymology 2022 Trenker R, Diwanji D, Verba KA, Jura N
• Efficient expression, purification, and visualization by cryo-EM of unliganded near full-length HER3.
  Methods in enzymology 2022 Diwanji D, Trenker R, Jura N, Verba KA
• Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2.
  Nature 2022 Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, …
• Piquing our interest: Insights into the role of PEAK3 in signaling and disease.
  Science signaling 2022 Paul MD, Torosyan H, Jura N
• Author Correction: Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface.
  Nature 2022 Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N
• Cryo-EM structures of the near full-length HER2/HER3 heterodimer reveal a novel allosteric mechanism of activation.
  Biophysical Journal 2022 Devan C. Diwanji, Raphael Trenker, Tarjani M. Thaker, Feng Wang, David A. Agard, Kliment A. Verba, Natalia Jura
• Extensive conformational and physical plasticity protects HER2-HER3 tumorigenic signaling.
  Cell reports 2022 Campbell MR, Ruiz-Saenz A, Zhang Y, Peterson E, Steri V, Oeffinger J, Sampang M, Jura N, Moasser MM
• Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers.
  Cell reports 2022 Campbell MR, Ruiz-Saenz A, Peterson E, Agnew C, Ayaz P, Garfinkle S, Littlefield P, Steri V, Oeffinger J, Sampang M, Shan Y, Shaw DE, Jura N, Moasser MM
• Preface.
  Methods in enzymology 2022 Jura N, Murphy JM
• Evolution of enhanced innate immune evasion by SARS-CoV-2.
  Nature 2021 Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, …
• Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.
  The Journal of clinical investigation 2021 Jin N, Keam B, Cho J, Lee MJ, Kim HR, Torosyan H, Jura N, Ng PK, Mills GB, Li H, Zeng Y, Barbash Z, Tarcic G, Kang H, Bauman JE, Kim MO, VanLandingham NK, Swaney DL, Krogan NJ, Johnson DE, Grandis JR
• Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface.
  Nature 2021 Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N
• A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
  Science (New York, N.Y.) 2021 Swaney DL, Ramms DJ, Wang Z, Park J, Goto Y, Soucheray M, Bhola N, Kim K, Zheng F, Zeng Y, McGregor M, Herrington KA, O'Keefe R, Jin N, VanLandingham NK, Foussard H, Von Dollen J, Bouhaddou M, Jimenez…
• Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.
  Nature communications 2021 Agnew C, Ayaz P, Kashima R, Loving HS, Ghatpande P, Kung JE, Underbakke ES, Shan Y, Shaw DE, Hata A, Jura N
• Mutant HER2 needs mutant HER3 to be an effective oncogene.
  Cell reports. Medicine 2021 Trenker R, Diwanji D, Jura N
• Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.
  bioRxiv : the preprint server for biology 2021 Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Ummadi M, Rojc A, Turner J, Obernier K, Braberg H, Soucheray M, Richards A, Chen KH, Harjai B, Memon D, …
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  Research square 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  bioRxiv : the preprint server for biology 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• State of the structure address on MET receptor activation by HGF.
  Biochemical Society transactions 2021 Linossi EM, Estevam GO, Oshima M, Fraser JS, Collisson EA, Jura N
• A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics.
  Scientific reports 2021 Knox J, Joly N, Linossi EM, Carmona-Negrón JA, Jura N, Pintard L, Zuercher W, Roy PJ
• Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.
  Science advances 2021 Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Carvalho Martins L, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N,…
• Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.
  Communications biology 2021 Suryamohan K, Diwanji D, Stawiski EW, Gupta R, Miersch S, Liu J, Chen C, Jiang YP, Fellouse FA, Sathirapongsasuti JF, Albers PK, Deepak T, Saberianfar R, Ratan A, Washburn G, Mis M, Santhosh D, …
• Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.
  Cancer research 2021 Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GH, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, Penn LZ, Rape M, Roussel MF, Shokat KM, …
• Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking.
  bioRxiv : the preprint server for biology 2020 Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Martins LC, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N, …
• Expression and purification of active human kinases using Pichia pastoris as a general-purpose host.
  Protein expression and purification 2020 Abdel Aziz MH, Fan Y, Liu L, Moasser MM, Fu H, Jura N, Arkin MR
• Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
  Science (New York, N.Y.) 2020 Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor…
• The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia.
  Nature structural & molecular biology 2020 Titus EW, Deiter FH, Shi C, Wojciak J, Scheinman M, Jura N, Deo RC
• An International Multicenter Evaluation of Inheritance Patterns, Arrhythmic Risks, and Underlying Mechanisms of CASQ2-Catecholaminergic Polymorphic Ventricular Tachycardia.
  Circulation 2020 Ng K, Titus EW, Lieve KV, Roston TM, Mazzanti A, Deiter FH, Denjoy I, Ingles J, Till J, Robyns T, Connors SP, Steinberg C, Abrams DJ, Pang B, Scheinman MM, Bos JM, Duffett SA, van der Werf C, Maltret …
• A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
  Nature 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, …
• A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
  bioRxiv : the preprint server for biology 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, …
• Receptor tyrosine kinase activation: From the ligand perspective.
  Current opinion in cell biology 2020 Trenker R, Jura N
• The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region.
  The Journal of biological chemistry 2019 Agnew C, Liu L, Liu S, Xu W, You L, Yeung W, Kannan N, Jablons D, Jura N
• PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Lopez ML, Lo M, Kung JE, Dudkiewicz M, Jang GM, Von Dollen J, Johnson JR, Krogan NJ, Pawlowski K, Jura N
• Prospects for pharmacological targeting of pseudokinases.
  Nature reviews. Drug discovery 2019 Kung JE, Jura N
• The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia.
  bioRxiv 2019 Erron W. Titus, Frederick H. Deiter, Chenxu Shi, Julianne Wojciak, Melvin Scheinman, Natalia Jura, Rahul C. Deo
• More than the sum of the parts: Toward full-length receptor tyrosine kinase structures.
  IUBMB life 2019 Diwanji D, Thaker T, Jura N
• Functional role of PGAM5 multimeric assemblies and their polymerization into filaments.
  Nature communications 2019 Ruiz K, Thaker TM, Agnew C, Miller-Vedam L, Trenker R, Herrera C, Ingaramo M, Toso D, Frost A, Jura N
• The pseudokinase TRIB1 toggles an intramolecular switch to regulate COP1 nuclear export.
  The EMBO journal 2019 Kung JE, Jura N
• Overexpression-mediated activation of MET in the Golgi promotes HER3/ERBB3 phosphorylation.
  Oncogene 2018 Frazier NM, Brand T, Gordan JD, Grandis J, Jura N
• Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations.
  Cancer cell 2018 Pahuja KB, Nguyen TT, Jaiswal BS, Prabhash K, Thaker TM, Senger K, Chaudhuri S, Kljavin NM, Antony A, Phalke S, Kumar P, Mravic M, Stawiski EW, Vargas D, Durinck S, Gupta R, Khanna-Gupta A, Trabucco …
• Activating HER3 mutations in breast cancer.
  Oncotarget 2018 Mishra R, Alanazi S, Yuan L, Solomon T, Thaker TM, Jura N, Garrett JT
• Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras.
  Cell reports 2018 Liang SI, van Lengerich B, Eichel K, Cha M, Patterson DM, Yoon TY, von Zastrow M, Jura N, Gartner ZJ
• Regulation of Kinase Activity in the Caenorhabditis elegans EGF Receptor, LET-23.
  Structure (London, England : 1993) 2018 Liu L, Thaker TM, Freed DM, Frazier N, Malhotra K, Lemmon MA, Jura N
• Feedback regulation of RTK signaling in development.
  Developmental biology 2017 Neben CL, Lo M, Jura N, Klein OD
• Switching on BTK-One Domain at a Time.
  Structure (London, England : 1993) 2017 Agnew C, Jura N
• EGF and NRG induce phosphorylation of HER3/ERBB3 by EGFR using distinct oligomeric mechanisms.
  Proceedings of the National Academy of Sciences of the United States of America 2017 van Lengerich B, Agnew C, Puchner EM, Huang B, Jura N
• Structural Basis for the Non-catalytic Functions of Protein Kinases.
  Structure (London, England : 1993) 2016 Kung JE, Jura N
• Src defines a new pool of EGFR substrates.
  Nature structural & molecular biology 2015 Michael N, Jura N
• Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor.
  Molecular and cellular biology 2015 Kovacs E, Das R, Wang Q, Collier TS, Cantor A, Huang Y, Wong K, Mirza A, Barros T, Grob P, Jura N, Bose R, Kuriyan J
• Structural Features of the Kinase Domain.
  Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease 2015 Dániel Süveges, Natalia Jura
• Science Signaling Podcast: 2 December 2014.
  Science Signaling 2014 N. Jura, P. Littlefield, A. M. VanHook
• Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
  Science signaling 2014 Littlefield P, Liu L, Mysore V, Shan Y, Shaw DE, Jura N
• A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.
  The Biochemical journal 2014 Murphy JM, Zhang Q, Young SN, Reese ML, Bailey FP, Eyers PA, Ungureanu D, Hammaren H, Silvennoinen O, Varghese LN, Chen K, Tripaydonis A, Jura N, Fukuda K, Qin J, Nimchuk Z, Mudgett MB, Elowe S, Gee …
• Regulation of the HER3/ErbB3 Pseudokinase Domain by an ATP-Competitive Inhibitor.
  Biophysical Journal 2014 Peter Littlefield, Mark M. Moasser, Natalia Jura
• Single Molecule Imaging of Human Epidermal Growth Factor Receptors.
  Biophysical Journal 2014 Bettina van Lengerich, Bo Huang, Natalia Jura
• EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.
  Cancer cell 2013 Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA
• EGFR lung cancer mutants get specialized.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Littlefield P, Jura N
• Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
  Molecular cell 2011 Jura N, Zhang X, Endres NF, Seeliger MA, Schindler T, Kuriyan J
• Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Jura N, Shan Y, Cao X, Shaw DE, Kuriyan J
• Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment.
  Journal of End-to-End-testing 2009 Natalia Jura, Nicholas F. Endres, Kate Engel, Sebastian Deindl, Rahul Das, Meindert H. Lamers, David E. Wemmer, Xuewu Zhang, John Kuriyan
• Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment.
  Journal of End-to-End-testing 2009 Natalia Jura, Nicholas F. Endres, Kate Engel, Sebastian Deindl, Rahul Das, Meindert H. Lamers, David E. Wemmer, Xuewu Zhang, John Kuriyan
• Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment.
  Cell 2009 Natalia Jura, Nicholas F. Endres, Kate Engel, Sebastian Deindl, Rahul Das, Meindert H. Lamers, David E. Wemmer, Xuewu Zhang, John Kuriyan
• Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.
  Cell 2009 Jura N, Endres NF, Engel K, Deindl S, Das R, Lamers MH, Wemmer DE, Zhang X, Kuriyan J
• Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
  Nature 2007 Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J
• Mapping cellular routes of Ras: a ubiquitin trail.
  Cell cycle (Georgetown, Tex.) 2006 Jura N, Bar-Sagi D
• A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen.
  Gastroenterology 2006 Archer H, Jura N, Keller J, Jacobson M, Bar-Sagi D
• Differential modification of Ras proteins by ubiquitination.
  Molecular cell 2006 Jura N, Scotto-Lavino E, Sobczyk A, Bar-Sagi D
• An ex vivo model for functional studies of myofibroblasts.
  Laboratory investigation; a journal of technical methods and pathology 2005 Kilarski WW, Jura N, Gerwins P
• Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis.
  Infection and immunity 2005 Mezyk-Kopec R, Bzowska M, Potempa J, Bzowska M, Jura N, Sroka A, Black RA, Bereta J
• Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between.
  Cell research 2005 Jura N, Archer H, Bar-Sagi D
• Tumour necrosis factor-alpha stimulates expression of TNF-alpha converting enzyme in endothelial cells.
  European journal of biochemistry 2004 Bzowska M, Jura N, Lassak A, Black RA, Bereta J
• Inactivation of Src family kinases inhibits angiogenesis in vivo: implications for a mechanism involving organization of the actin cytoskeleton.
  Experimental cell research 2003 Kilarski WW, Jura N, Gerwins P
• hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl.
  Current biology : CB 2003 Hall AB, Jura N, DaSilva J, Jang YJ, Gong D, Bar-Sagi D