Nariman Naber, PhD
Research Biochemist
Biochemistry and Biophysics
School of Medicine

Publications (25)

Top publication keywords:
BenzodioxolesPolyphosphatesDictyosteliumNucleotidesChymotrypsinSpidersAdenosine TriphosphateSpin LabelsMyosinsPolyunsaturated AlkamidesMyosin Light ChainsMolecular Motor ProteinsElectron Spin Resonance SpectroscopyAdenosine DiphosphateMuscle Relaxation

• The role of the super-relaxed state of myosin in human metabolism.
  Metabolism open 2020 Wilson C, Naber N, Cooke R
• Piperine, an alkaloid inhibiting the super-relaxed state of myosin, binds to the myosin regulatory light chain.
  Archives of biochemistry and biophysics 2018 Tolkatchev D, Elnatan D, Nogara L, Ly T, Naber N, Haak K, Meech R, Cooke R, Kostyukova AS
• Piperine's mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Nogara L, Naber N, Pate E, Canton M, Reggiani C, Cooke R
• Spectroscopic Studies of the Super Relaxed State of Skeletal Muscle.
  PloS one 2016 Nogara L, Naber N, Pate E, Canton M, Reggiani C, Cooke R
• A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity.
  eLife 2014 Partridge JR, Lavery LA, Elnatan D, Naber N, Cooke R, Agard DA

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• The myosin inhibitor blebbistatin stabilizes the super-relaxed state in skeletal muscle.
  Biophysical journal 2014 Wilson C, Naber N, Pate E, Cooke R
• The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme.
  Journal of molecular biology 2014 Racki LR, Naber N, Pate E, Leonard JD, Cooke R, Narlikar GJ
• A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly.
  Nature 2013 Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ
• Conformational changes at the nucleotide site in the presence of bound ADP do not set the velocity of fast Drosophila myosins.
  Journal of muscle research and cell motility 2012 Eldred CC, Naber N, Pate E, Cooke R, Swank DM
• The loop 5 element structurally and kinetically coordinates dimers of the human kinesin-5, Eg5.
  Biophysical journal 2011 Waitzman JS, Larson AG, Cochran JC, Naber N, Cooke R, Jon Kull F, Pate E, Rice SE
• Analysis of the interaction of the Eg5 Loop5 with the nucleotide site.
  Journal of theoretical biology 2011 Harrington TD, Naber N, Larson AG, Cooke R, Rice SE, Pate E
• Slow myosin ATP turnover in the super-relaxed state in tarantula muscle.
  Journal of molecular biology 2011 Naber N, Cooke R, Pate E
• EPR spectra and molecular dynamics agree that the nucleotide pocket of myosin V is closed and that it opens on binding actin.
  Journal of molecular biology 2011 Purcell TJ, Naber N, Sutton S, Cooke R, Pate E
• Multiple conformations of the nucleotide site of Kinesin family motors in the triphosphate state.
  Journal of molecular biology 2011 Naber N, Larson A, Rice S, Cooke R, Pate E
• Nucleotide pocket thermodynamics measured by EPR reveal how energy partitioning relates myosin speed to efficiency.
  Journal of molecular biology 2010 Purcell TJ, Naber N, Franks-Skiba K, Dunn AR, Eldred CC, Berger CL, Málnási-Csizmadia A, Spudich JA, Swank DM, Pate E, Cooke R
• The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5.
  Biophysical journal 2010 Larson AG, Naber N, Cooke R, Pate E, Rice SE
• Combining EPR with fluorescence spectroscopy to monitor conformational changes at the myosin nucleotide pocket.
  Journal of molecular biology 2009 Naber N, Málnási-Csizmadia A, Purcell TJ, Cooke R, Pate E
• The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes.
  Nature 2009 Racki LR, Yang JG, Naber N, Partensky PD, Acevedo A, Purcell TJ, Cooke R, Cheng Y, Narlikar GJ
• The fate of free radicals in a cellulose based hydrogel: detection by electron paramagnetic resonance spectroscopy.
  Journal of pharmaceutical sciences 2009 Basumallick L, Ji JA, Naber N, Wang YJ
• The Kinesin-1 tail conformationally restricts the nucleotide pocket.
  Biophysical journal 2009 Wong YL, Dietrich KA, Naber N, Cooke R, Rice SE
• Structural dynamics of the actomyosin complex probed by a bifunctional spin label that cross-links SH1 and SH2.
  Biophysical journal 2008 Thompson AR, Naber N, Wilson C, Cooke R, Thomas DD
• Dynamics of the nucleotide pocket of myosin measured by spin-labeled nucleotides.
  Biophysical journal 2006 Naber N, Purcell TJ, Pate E, Cooke R
• Conformational variations in an infectious protein determine prion strain differences.
  Nature 2004 Tanaka M, Chien P, Naber N, Cooke R, Weissman JS
• Closing of the nucleotide pocket of kinesin-family motors upon binding to microtubules.
  Science (New York, N.Y.) 2003 Naber N, Minehardt TJ, Rice S, Chen X, Grammer J, Matuska M, Vale RD, Kollman PA, Car R, Yount RG, Cooke R, Pate E
• EPR spectroscopy shows a microtubule-dependent conformational change in the kinesin switch 1 domain.
  Biophysical journal 2003 Naber N, Rice S, Matuska M, Vale RD, Cooke R, Pate E