Naoki Akanuma, MD, PhD
Resident
Pathology
School of Medicine

Publications (24)

Top publication keywords:
Stomach NeoplasmsCarcinoma, Squamous CellPancreas, ExocrineGastric MucosaIndocyanine GreenMetaplasiaAcinar CellsAdenocarcinomaAdenomatous Polyposis ColiChoristomaTransforming Growth Factor betaHyperplasiaAdenomaPancreatic DuctsEsophageal Neoplasms

• Assessment of large droplet fat in frozen sections of donor liver biopsies: utility and interobserver variability of the newly described Banff method compared to a simplified Average of Fields method.
  Journal of clinical pathology 2024 Kikuchi AT, Akanuma N, Choi WT, Gill RM, Kakar S
• Reconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onset.
  Nature communications 2024 Xu Y, Nipper MH, Dominguez AA, Ye Z, Akanuma N, Lopez K, Deng JJ, Arenas D, Sanchez A, Sharkey FE, Court CM, Singhi AD, Wang H, Fernandez-Zapico ME, Sun LZ, Zheng S, Chen Y, Liu J, Wang P
• TIP60 is required for tumorigenesis in non-small cell lung cancer.
  Cancer science 2023 Shibahara D, Akanuma N, Kobayashi IS, Heo E, Ando M, Fujii M, Jiang F, Prin PN, Pan G, Wong KK, Costa DB, Bararia D, Tenen DG, Watanabe H, Kobayashi SS
• Fundic Gland Polyps Lack DNA Content Abnormality Characteristic of Other Adenomatous Precursor Lesions in the Gastrointestinal Tract.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2023 Akanuma N, Rabinovitch PS, Mattis AN, Lauwers GY, Choi WT
• Paracrine Secretion of Transforming Growth Factor β by Ductal Cells Promotes Acinar-to-Ductal Metaplasia in Cultured Human Exocrine Pancreas Tissues.
  Pancreas 2017 Akanuma N, Liu J, Liou GY, Yin X, Bejar KR, Liu C, Sun LZ, Storz P, Wang P

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• Fra-1 Regulates the Expression of HMGA1, Which is Associated with a Poor Prognosis in Human Esophageal Squamous Cell Carcinoma.
  Annals of surgical oncology 2016 Toyozumi T, Hoshino I, Takahashi M, Usui A, Akutsu Y, Hanari N, Murakami K, Kano M, Akanuma N, Suitoh H, Matsumoto Y, Sekino N, Komatsu A, Matsubara H
• TGF-β1 promotes acinar to ductal metaplasia of human pancreatic acinar cells.
  Scientific reports 2016 Liu J, Akanuma N, Liu C, Naji A, Halff GA, Washburn WK, Sun L, Wang P
• Treatment of near-infrared photodynamic therapy using a liposomally formulated indocyanine green derivative for squamous cell carcinoma.
  PloS one 2015 Maruyama T, Akutsu Y, Suganami A, Tamura Y, Fujito H, Ouchi T, Akanuma N, Isozaki Y, Takeshita N, Hoshino I, Uesato M, Toyota T, Hayashi H, Matsubara H
• Histone Demethylase LSD1 Inhibitors Prevent Cell Growth by Regulating Gene Expression in Esophageal Squamous Cell Carcinoma Cells.
  Annals of surgical oncology 2015 Hoshino I, Akutsu Y, Murakami K, Akanuma N, Isozaki Y, Maruyama T, Toyozumi T, Matsumoto Y, Suito H, Takahashi M, Sekino N, Komatsu A, Suzuki T, Matsubara H
• Detection of peritoneal dissemination with near-infrared fluorescence laparoscopic imaging using a liposomal formulation of a synthesized indocyanine green liposomal derivative.
  Anticancer research 2015 Hoshino I, Maruyama T, Fujito H, Tamura Y, Suganami A, Hayashi H, Toyota T, Akutsu Y, Murakami K, Isozaki Y, Akanuma N, Takeshita N, Toyozumi T, Komatsu A, Matsubara H
• Usefulness of microRNA‑375 as a prognostic and therapeutic tool in esophageal squamous cell carcinoma.
  International journal of oncology 2014 Isozaki Y, Hoshino I, Akutsu Y, Hanari N, Mori M, Nishimori T, Murakami K, Akanuma N, Takeshita N, Maruyama T, Toyozumi T, Takahashi M, Suito H, Matsubara H
• The outcome of laparoscopic surgery with and without short gastric vessel division for achalasia.
  International surgery 2014 Akutsu Y, Hanari N, Kono T, Uesato M, Hoshino I, Murakami K, Natsume T, Isozaki Y, Akanuma N, Toyozumi T, Suito H, Matsubara H
• Modulated electro-hyperthermia enhances dendritic cell therapy through an abscopal effect in mice.
  Oncology reports 2014 Qin W, Akutsu Y, Andocs G, Suganami A, Hu X, Yusup G, Komatsu-Akimoto A, Hoshino I, Hanari N, Mori M, Isozaki Y, Akanuma N, Tamura Y, Matsubara H
• Screening of alternative drugs to the tumor suppressor miR-375 in esophageal squamous cell carcinoma using the connectivity map.
  Oncology 2014 Isozaki Y, Hoshino I, Akutsu Y, Hanari N, Mori M, Nishimori T, Murakami K, Akanuma N, Toyozumi T, Takahashi M, Suito H, Takeshita N, Maruyama T, Suzuki A, Nakayama T, Matsubara H
• Giant esophageal gastrointestinal stromal tumor: report of a case.
  Surgery today 2014 Nakano A, Akutsu Y, Shuto K, Uesato M, Kono T, Hoshino I, Akanuma N, Maruyama T, Isozaki Y, Matsubara H
• A COX-2 inhibitor enhances the antitumor effects of chemotherapy and radiotherapy for esophageal squamous cell carcinoma.
  International journal of oncology 2014 Yusup G, Akutsu Y, Mutallip M, Qin W, Hu X, Komatsu-Akimoto A, Hoshino I, Hanari N, Mori M, Akanuma N, Isozaki Y, Matsubara H
• Incidence, risk factors and treatment outcomes of extravasation of cytotoxic agents in an outpatient chemotherapy clinic.
  Japanese journal of clinical oncology 2013 Sakaida E, Sekine I, Iwasawa S, Kurimoto R, Uehara T, Ooka Y, Akanuma N, Tada Y, Imai C, Oku T, Takiguchi Y
• The overall prevalence of metastasis in T1 esophageal squamous cell carcinoma: a retrospective analysis of 295 patients.
  Annals of surgery 2013 Akutsu Y, Uesato M, Shuto K, Kono T, Hoshino I, Horibe D, Sazuka T, Takeshita N, Maruyama T, Isozaki Y, Akanuma N, Matsubara H
• A phase 1/11 study of second-line chemotherapy with fractionated docetaxel and nedaplatin for 5-FU/cisplatin-resistant esophageal squamous cell carcinoma.
  Hepato-gastroenterology 2012 Akutsu Y, Shuto K, Kono T, Uesato M, Hoshino I, Shiratori T, Miyazawa Y, Isozaki Y, Akanuma N, Matsubara H
• miR-203 inhibits the migration and invasion of esophageal squamous cell carcinoma by regulating LASP1.
  International journal of oncology 2012 Takeshita N, Mori M, Kano M, Hoshino I, Akutsu Y, Hanari N, Yoneyama Y, Ikeda N, Isozaki Y, Maruyama T, Akanuma N, Miyazawa Y, Matsubara H
• Identification of novel molecular targets regulated by tumor suppressive miR-375 induced by histone acetylation in esophageal squamous cell carcinoma.
  International journal of oncology 2012 Isozaki Y, Hoshino I, Nohata N, Kinoshita T, Akutsu Y, Hanari N, Mori M, Yoneyama Y, Akanuma N, Takeshita N, Maruyama T, Seki N, Nishino N, Yoshida M, Matsubara H
• Primary esophageal adenocarcinoma arising from heterotopic gastric mucosa: report of a case.
  Surgery today 2012 Akanuma N, Hoshino I, Akutsu Y, Shuto K, Shiratori T, Kono T, Uesato M, Sato A, Isozaki Y, Maruyama T, Takeshita N, Matsubara H
• The number of pathologic lymph nodes involved is still a significant prognostic factor even after neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma.
  Journal of surgical oncology 2011 Akutsu Y, Shuto K, Kono T, Uesato M, Hoshino I, Shiratori T, Isozaki Y, Akanuma N, Uno T, Matsubara H
• [The present state and task of the Palliative Care Team at Tokyo Women's Medical University Yachiyo Medical Center].
  Gan to kagaku ryoho. Cancer & chemotherapy 2007 Imai K, Shirotani N, Hirai E, Akanuma N, Nishino T, Sato J, Kimura K, Egawa T, Shimono S