Nancy Phillips
Research Chemist
Pharmaceutical Chemistry
School of Pharmacy

Education & Training

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• PhD Organic Chemistry University of Virginia, Charlottesville, VA 1986
• BS Chemistry Antioch College, Yellow Springs, OH 1980

Publications (41)

Top publication keywords:
LipopolysaccharidesDecapodiformesBiofilmsHaemophilus influenzaeNeisseria meningitidisBiotinBacteria, AnaerobicBacterial ProteinsNeisseria gonorrhoeaeSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAzidesMeningococcal InfectionsAliivibrio fischeriGene Expression Regulation, BacterialLipid A

• Comparison of lipooligosaccharides from human challenge strains of Neisseria gonorrhoeae.
  Frontiers in microbiology 2023 John CM, Phillips NJ, Cardenas AJ, Criss AK, Jarvis GA
• Capture, Release, and Identification of Newly Synthesized Proteins for Improved Profiling of Functional Translatomes.
  Molecular & cellular proteomics : MCP 2023 Phillips NJ, Vinaithirthan BM, Oses-Prieto JA, Chalkley RJ, Burlingame AL
• Regulation of eIF4E guides a unique translational program to control erythroid maturation.
  Science advances 2022 Forester CM, Oses-Prieto JA, Phillips NJ, Miglani S, Pang X, Byeon GW, DeMarco R, Burlingame A, Barna M, Ruggero D
• Predominant phosphorylation patterns in Neisseria meningitidis lipid A determined by top-down MS/MS.
  Journal of lipid research 2020 John CM, Phillips NJ, Jarvis GA
• Novel Campylobacter concisus lipooligosaccharide is a determinant of inflammatory potential and virulence.
  Journal of lipid research 2018 Brunner K, John CM, Phillips NJ, Alber DG, Gemmell MR, Hansen R, Nielsen HL, Hold GL, Bajaj-Elliott M, Jarvis GA

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• Revealing nascent proteomics in signaling pathways and cell differentiation.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Forester CM, Zhao Q, Phillips NJ, Urisman A, Chalkley RJ, Oses-Prieto JA, Zhang L, Ruggero D, Burlingame AL
• Innate immune response to lipooligosaccharide: pivotal regulator of the pathobiology of invasive Neisseria meningitidis infections.
  Pathogens and disease 2017 John CM, Phillips NJ, Stein DC, Jarvis GA
• Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Anandan A, Evans GL, Condic-Jurkic K, O'Mara ML, John CM, Phillips NJ, Jarvis GA, Wills SS, Stubbs KA, Moraes I, Kahler CM, Vrielink A
• Analysis of Bacterial Lipooligosaccharides by MALDI-TOF MS with Traveling Wave Ion Mobility.
  Journal of the American Society for Mass Spectrometry 2016 Phillips NJ, John CM, Jarvis GA
• Lipooligosaccharide Structures of Invasive and Carrier Isolates of Neisseria meningitidis Are Correlated with Pathogenicity and Carriage.
  The Journal of biological chemistry 2015 John CM, Phillips NJ, Din R, Liu M, Rosenqvist E, Høiby EA, Stein DC, Jarvis GA
• Comparative analyses of proteins from Haemophilus influenzae biofilm and planktonic populations using metabolic labeling and mass spectrometry.
  BMC microbiology 2014 Post DM, Held JM, Ketterer MR, Phillips NJ, Sahu A, Apicella MA, Gibson BW
• Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals.
  Infection and immunity 2012 John CM, Liu M, Phillips NJ, Yang Z, Funk CR, Zimmerman LI, Griffiss JM, Stein DC, Jarvis GA
• Proteomic analysis of Neisseria gonorrhoeae biofilms shows shift to anaerobic respiration and changes in nutrient transport and outermembrane proteins.
  PloS one 2012 Phillips NJ, Steichen CT, Schilling B, Post DM, Niles RK, Bair TB, Falsetta ML, Apicella MA, Gibson BW
• The lipid A from Vibrio fischeri lipopolysaccharide: a unique structure bearing a phosphoglycerol moiety.
  The Journal of biological chemistry 2011 Phillips NJ, Adin DM, Stabb EV, McFall-Ngai MJ, Apicella MA, Gibson BW
• Characterization of htrB and msbB mutants of the light organ symbiont Vibrio fischeri.
  Applied and environmental microbiology 2007 Adin DM, Phillips NJ, Gibson BW, Apicella MA, Ruby EG, McFall-Ngai MJ, Hall DB, Stabb EV
• Characterization of lipid A acylation patterns in Francisella tularensis, Francisella novicida, and Francisella philomiragia using multiple-stage mass spectrometry and matrix-assisted laser desorption/ionization on an intermediate vacuum source linear ion trap.
  Analytical chemistry 2007 Schilling B, McLendon MK, Phillips NJ, Apicella MA, Gibson BW
• Novel modification of lipid A of Francisella tularensis.
  Infection and immunity 2004 Phillips NJ, Schilling B, McLendon MK, Apicella MA, Gibson BW
• Matrix-assisted laser desorption/ionization-time of flight-mass spectrometry of lipopolysaccharide species separated by slab-polyacrylamide gel electrophoresis: high-resolution separation and molecular weight determination of lipooligosaccharides from Vibrio fischeri strain HMK.
  Electrophoresis 2004 Pupo E, Phillips NJ, Gibson BW, Apicella MA, Hardy E
• Nontypeable Haemophilus influenzae strain 2019 produces a biofilm containing N-acetylneuraminic acid that may mimic sialylated O-linked glycans.
  Infection and immunity 2004 Greiner LL, Watanabe H, Phillips NJ, Shao J, Morgan A, Zaleski A, Gibson BW, Apicella MA
• The msbB mutant of Neisseria meningitidis strain NMB has a defect in lipooligosaccharide assembly and transport to the outer membrane.
  Infection and immunity 2003 Post DM, Ketterer MR, Phillips NJ, Gibson BW, Apicella MA
• The lbgAB gene cluster of Haemophilus ducreyi encodes a beta-1,4-galactosyltransferase and an alpha-1,6-DD-heptosyltransferase involved in lipooligosaccharide biosynthesis.
  Infection and immunity 2002 Tullius MV, Phillips NJ, Scheffler NK, Samuels NM, Munson Jr RS, Hansen EJ, Stevens-Riley M, Campagnari AA, Gibson BW
• Haemophilus influenzae type b strain A2 has multiple sialyltransferases involved in lipooligosaccharide sialylation.
  The Journal of biological chemistry 2002 Jones PA, Samuels NM, Phillips NJ, Munson RS, Bozue JA, Arseneau JA, Nichols WA, Zaleski A, Gibson BW, Apicella MA
• Intracellular survival of Neisseria gonorrhoeae in male urethral epithelial cells: importance of a hexaacyl lipid A.
  Infection and immunity 2002 Post DM, Phillips NJ, Shao JQ, Entz DD, Gibson BW, Apicella MA
• Mass spectral characterization of lipooligosaccharides from Haemophilus influenzae 2019.
  Biochemistry 2000 Gaucher SP, Cancilla MT, Phillips NJ, Gibson BW, Leary JA
• Gonococcal lipooligosaccharide is a ligand for the asialoglycoprotein receptor on human sperm.
  Molecular microbiology 2000 Harvey HA, Porat N, Campbell CA, Jennings M, Gibson BW, Phillips NJ, Apicella MA, Blake MS
• Characterization of chimeric lipopolysaccharides from Escherichia coli strain JM109 transformed with lipooligosaccharide synthesis genes (lsg) from Haemophilus influenzae.
  The Journal of biological chemistry 2000 Phillips NJ, Miller TJ, Engstrom JJ, Melaugh W, McLaughlin R, Apicella MA, Gibson BW
• Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity.
  Biochemistry 1998 Prakobphol A, Thomsson KA, Hansson GC, Rosen SD, Singer MS, Phillips NJ, Medzihradszky KF, Burlingame AL, Leffler H, Fisher SJ
• Characterization of a transposon Tn916-generated mutant of Haemophilus ducreyi 35000 defective in lipooligosaccharide biosynthesis.
  Journal of bacteriology 1997 Gibson BW, Campagnari AA, Melaugh W, Phillips NJ, Apicella MA, Grass S, Wang J, Palmer KL, Munson RS
• Characterization of two transposon mutants from Haemophilus influenzae type b with altered lipooligosaccharide biosynthesis.
  Biochemistry 1996 Phillips NJ, McLaughlin R, Miller TJ, Apicella MA, Gibson BW
• Determining Structures and Functions of Surface Glycolipids in Pathogenic Haemophilus Bacteria by Electrospray Ionization Mass Spectrometry.
  Biochemical and Biotechnological Applications of Electrospray Ionization Mass Spectrometry 1996 Bradford W. Gibson, Nancy J. Phillips, William Melaugh, Jeffrey J. Engstrom
• Mass Spectrometry as a Tool to Determine the Structures and Heterogeneity of Bacterial Lipooligosaccharides (LOS).
  Mass Spectrometry in the Biological Sciences 1996 William Melaugh, Jeffrey J. Engstrom, Seppo Auriola, Nancy J. Phillips, Bradford W. Gibson
• Structure of the major oligosaccharide from the lipooligosaccharide of Haemophilus ducreyi strain 35000 and evidence for additional glycoforms.
  Biochemistry 1994 Melaugh W, Phillips NJ, Campagnari AA, Tullius MV, Gibson BW
• Meningococcal group A lipooligosaccharides (LOS): preliminary structural studies and characterization of serotype-associated and conserved LOS epitopes.
  Infection and immunity 1994 Kim JJ, Phillips NJ, Gibson BW, Griffiss JM, Yamasaki R
• Lipooligosaccharides in Pathogenic Haemophilus and Neisseria Species.
  Mass Spectrometry for the Characterization of Microorganisms 1993 Bradford W. Gibson, Nancy J. Phillips, Constance M. John, William Melaugh
• S15.27 Structural determination of the lipooligosaccharides ofHoemophilus ducreyi and possible therapeutic targets.
  Glycoconjugate Journal 1993 W. Melaugh, N. J. Phillips, M. Tullius, A. Campagnari, J. M. Griffiss, B. W. Gibson
• S19.3 Structural and immunochemical characterization ofHaemophilus influenzae lipooligosaccharides.
  Glycoconjugate Journal 1993 N. J. Phillips, W. Melaugh, R. McLaughlin, M. A. Apicella, B. W. Gibson
• Investigation of the structural heterogeneity of lipooligosaccharides from pathogenic Haemophilus and Neisseria species and of R-type lipopolysaccharides from Salmonella typhimurium by electrospray mass spectrometry.
  Journal of bacteriology 1993 Gibson BW, Melaugh W, Phillips NJ, Apicella MA, Campagnari AA, Griffiss JM
• Structural studies of the lipooligosaccharides from Haemophilus influenzae type b strain A2.
  Biochemistry 1993 Phillips NJ, Apicella MA, Griffiss JM, Gibson BW
• Partial characterization of the major lipooligosaccharide from a strain of Haemophilus ducreyi, the causative agent of chancroid, a genital ulcer disease.
  The Journal of biological chemistry 1992 Melaugh W, Phillips NJ, Campagnari AA, Karalus R, Gibson BW
• Structural characterization of the cell surface lipooligosaccharides from a nontypable strain of Haemophilus influenzae.
  Biochemistry 1992 Phillips NJ, Apicella MA, Griffiss JM, Gibson BW
• Structural models for the cell surface lipooligosaccharides of Neisseria gonorrhoeae and Haemophilus influenzae.
  Biomedical & environmental mass spectrometry 1990 Phillips NJ, John CM, Reinders LG, Gibson BW, Apicella MA, Griffiss JM