Nadia Roan, PhD
Professor
Urology
School of Medicine

We have demonstrated that genital and rectal fibroblasts, amongst the most abundant cells of the mucosa, potently increase HIV infection of T cells through at least two distinct mechanisms: promoting viral entry, and altering the cellular state of T cells to render them more permissive to viral replication. To characterize the molecular basis of how intrinsic and extrinsic perturbations can render some subsets of CD4+ T cells more susceptible than others to HIV infection, we are using a variety of global gene expression analysis approaches, including CyTOF and RNA-seq. These approaches are also being used to characterize the HIV latent reservoir and the nature of viral rebound upon antiretroviral treatment interruption. Another research interest in the lab is to understand how factors in seminal plasma affect reproductive health and susceptibility to sexually transmitted diseases.

• Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection.
  Nature communications 2024 Giron LB, Liu Q, Adeniji OS, Yin X, Kannan T, Ding J, Lu DY, Langan S, Zhang J, Azevedo JLLC, Li SH, Shalygin S, Azadi P, Hanna DB, Ofotokun I, Lazar J, Fischl MA, Haberlen S, Macatangay B, Adimora AA…
• Systems analysis of innate and adaptive immunity in Long COVID.
  Seminars in immunology 2024 Peluso MJ, Abdel-Mohsen M, Henrich TJ, Roan NR
• Mild HIV-specific selective forces overlaying natural CD4+ T cell dynamics explain the clonality and decay dynamics of HIV reservoir cells.
  medRxiv : the preprint server for health sciences 2024 Reeves DB, Rigau DN, Romero A, Zhang H, Simonetti FR, Varriale J, Hoh R, Zhang L, Smith KN, Montaner LJ, Rubin LH, Gange SJ, Roan NR, Tien PC, Margolick JB, Peluso MJ, Deeks SG, Schiffer JT, Siliciano…
• Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2.
  Nature immunology 2024 Yin K, Peluso MJ, Luo X, Thomas R, Shin MG, Neidleman J, Andrew A, Young KC, Ma T, Hoh R, Anglin K, Huang B, Argueta U, Lopez M, Valdivieso D, Asare K, Deveau TM, Munter SE, Ibrahim R, Ständker L, Lu …
• Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection.
  bioRxiv : the preprint server for biology 2023 Giron LB, Liu Q, Adeniji OS, Yin X, Kannan T, Ding J, Lu DY, Langan S, Zhang J, Azevedo JLLC, Li SH, Shalygin S, Azadi P, Hanna DB, Ofotokun I, Lazar J, Fischl MA, Haberlen S, Macatangay B, Adimora AA…
• Transient Anti-Interferon Auto Antibodies in the Airway Are Associated with Recovery in Mild COVID-19.
  Blood 2023 Benjamin R Babcock, Astrid Kosters, Nadia R Roan, Sulggi Lee, Eliver E.B. Ghosn
• The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency.
  Cell reports 2023 Sperber HS, Raymond KA, Bouzidi MS, Ma T, Valdebenito S, Eugenin EA, Roan NR, Deeks SG, Winning S, Fandrey J, Schwarzer R, Pillai SK
• HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing.
  Viruses 2023 Danielle E. Lyons, Priti Kumar, Nadia R. Roan, Patricia A. Defechereux, Cedric Feschotte, Ulrike C. Lange, Niren Murthy, Pauline Sameshima, Eric Verdin, Julie A. Ake, Matthew S. Parsons, Avindra Nath,…
• HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing.
  Viruses 2023 Lyons DE, Kumar P, Roan NR, Defechereux PA, Feschotte C, Lange UC, Murthy N, Sameshima P, Verdin E, Ake JA, Parsons MS, Nath A, Gianella S, Smith DM, Kallas EG, Villa TJ, Strange R, Mwesigwa B, Furler…
• Post-acute immunological and behavioral sequelae in mice after Omicron infection.
  bioRxiv : the preprint server for biology 2023 Ma T, Suryawanshi RK, Miller SR, Ly KK, Thomas R, Elphick N, Yin K, Luo X, Kaliss N, Chen IP, Montano M, Sreekumar B, Standker L, Münch J, Heath Damron F, Palop JJ, Ott M, Roan NR
• Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2.
  bioRxiv : the preprint server for biology 2023 Yin K, Peluso MJ, Luo X, Thomas R, Shin MG, Neidleman J, Andrew A, Young K, Ma T, Hoh R, Anglin K, Huang B, Argueta U, Lopez M, Valdivieso D, Asare K, Deveau TM, Munter SE, Ibrahim R, Ständker L, Lu S…
• Advances in HIV Research Using Mass Cytometry.
  Current HIV/AIDS reports 2023 George AF, Roan NR
• Corrigendum: Reliable estimation of CD8 T cell inhibition of in vitro HIV-1 replication.
  Frontiers in immunology 2023 Xu Y, Weideman AM, Abad-Fernandez M, Mollan KR, Kallon S, Samir S, Warren JA, Clutton G, Roan NR, Adimora AA, Archin N, Kuruc J, Gay C, Hudgens MG, Goonetilleke N
• PP 1.16 – 00100 Single-cell multiomics analysis reveals distinct mechanisms of HIV persistence in memory CD4+ T cell subsets from tissues.
  Journal of Virus Eradication 2022 J. Frouard, X. Luo, N. Roan
• PP 1.31 – 00161 Chimeric proviral/human transcription events at the BACH2 integration locus in cellular models for chronic HIV infection.
  Journal of Virus Eradication 2022 U. Lange, C. Schwarz, L. Brauckmann, J. Frouard, N.R. Roan
• Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons.
  mBio 2022 Kong W, Montano M, Corley MJ, Helmy E, Kobayashi H, Kinisu M, Suryawanshi R, Luo X, Royer LA, Roan NR, Ott M, Ndhlovu LC, Greene WC
• CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir.
  mBio 2022 Packard TA, Schwarzer R, Herzig E, Rao D, Luo X, Egedal JH, Hsiao F, Widera M, Hultquist JF, Grimmett ZW, Messer RJ, Krogan NJ, Deeks SG, Roan NR, Dittmer U, Hasenkrug KJ, Greene WC
• SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice.
  PloS one 2022 Lee KS, Wong TY, Russ BP, Horspool AM, Miller OA, Rader NA, Givi JP, Winters MT, Wong ZYA, Cyphert HA, Denvir J, Stoilov P, Barbier M, Roan NR, Amin MS, Martinez I, Bevere JR, Damron FH
• Female Genital Fibroblasts Diminish the In Vitro Efficacy of PrEP against HIV.
  Viruses 2022 George AF, McGregor M, Gingrich D, Neidleman J, Marquez RS, Young KC, Thanigaivelan KL, Greene WC, Tien PC, Deitchman AN, Spitzer TL, Roan NR
• Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV.
  eLife 2022 Ma T, McGregor M, Giron L, Xie G, George AF, Abdel-Mohsen M, Roan NR
• Subsets of Tissue CD4 T Cells Display Different Susceptibilities to HIV Infection and Death: Analysis by CyTOF and Single Cell RNA-seq.
  Frontiers in immunology 2022 Luo X, Frouard J, Zhang G, Neidleman J, Xie G, Sheedy E, Roan NR, Greene WC
• Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination.
  Nature 2022 Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Gascon R, Tsou CL, Garcia-Knight MA, Sotomayor-Gonzalez A, …
• Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood.
  BMC medicine 2022 Vallvé-Juanico J, George AF, Sen S, Thomas R, Shin MG, Kushnoor D, Vásquez JJ, Vo KC, Irwin JC, Roan NR, Combes AJ, Giudice LC
• Common and Divergent Features of T Cells from Blood, Gut, and Genital Tract of Antiretroviral Therapy-Treated HIV+ Women.
  Journal of immunology (Baltimore, Md. : 1950) 2022 Xie G, Moron-Lopez S, Siegel DA, Yin K, Polos A, Cohen J, Greenblatt RM, Tien PC, Lee SA, Yukl SA, Roan NR
• T-Cell Immune Dysregulation and Mortality in Women With Human Immunodeficiency Virus.
  The Journal of infectious diseases 2022 Peters BA, Moon JY, Hanna DB, Kutsch O, Fischl M, Moran CA, Adimora AA, Gange S, Roan NR, Michel KG, Augenbraun M, Sharma A, Landay A, Desai S, Kaplan RC
• Deep Phenotypic Analysis of Blood and Lymphoid T and NK Cells From HIV+ Controllers and ART-Suppressed Individuals.
  Frontiers in immunology 2022 George AF, Luo X, Neidleman J, Hoh R, Vohra P, Thomas R, Shin MG, Lee MJ, Blish CA, Deeks SG, Greene WC, Lee SA, Roan NR
• Cell-Extrinsic Priming Increases Permissiveness of CD4+ T Cells to Human Immunodeficiency Virus Infection by Increasing C-C Chemokine Receptor Type 5 Co-receptor Expression and Cellular Activation Status.
  Frontiers in microbiology 2021 Pedersen JG, Egedal JH, Packard TA, Thavachelvam K, Xie G, van der Sluis RM, Greene WC, Roan NR, Jakobsen MR
• Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells.
  PLoS pathogens 2021 Adeniji OS, Kuri-Cervantes L, Yu C, Xu Z, Ho M, Chew GM, Shikuma C, Tomescu C, George AF, Roan NR, Ndhlovu LC, Liu Q, Muthumani K, Weiner DB, Betts MR, Xiao H, Abdel-Mohsen M
• Tissue-specific differences in HIV DNA levels and mechanisms that govern HIV transcription in blood, gut, genital tract and liver in ART-treated women.
  Journal of the International AIDS Society 2021 Moron-Lopez S, Xie G, Kim P, Siegel DA, Lee S, Wong JK, Price JC, Elnachef N, Greenblatt RM, Tien PC, Roan NR, Yukl SA
• Reliable Estimation of CD8 T Cell Inhibition of In Vitro HIV-1 Replication.
  Frontiers in immunology 2021 Xu Y, Weideman AM, Abad-Fernandez M, Mollan KR, Kallon S, Samir S, Warren JA, Clutton G, Roan NR, Adimora AA, Archin N, Kuruc J, Gay C, Hudgens MG, Goonetilleke N
• Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo.
  Journal of virology 2021 Gramatica A, Schwarzer R, Brantley W, Varco-Merth B, Sperber HS, Hull PA, Montano M, Migueles SA, Rosenthal D, Hogan LE, Johnson JR, Packard TA, Grimmett ZW, Herzig E, Besnard E, Nekorchuk M, Hsiao F,…
• No detectable alloreactive transcriptional responses under standard sample preparation conditions during donor-multiplexed single-cell RNA sequencing of peripheral blood mononuclear cells.
  BMC biology 2021 McGinnis CS, Siegel DA, Xie G, Hartoularos G, Stone M, Ye CJ, Gartner ZJ, Roan NR, Lee SA
• Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells.
  Journal of virology 2020 Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S
• Impact of Biological Sex on Immune Activation and Frequency of the Latent HIV Reservoir During Suppressive Antiretroviral Therapy.
  The Journal of infectious diseases 2020 Falcinelli SD, Shook-Sa BE, Dewey MG, Sridhar S, Read J, Kirchherr J, James KS, Allard B, Ghofrani S, Stuelke E, Baker C, Roan NR, Eron JJ, Kuruc JD, Ramirez C, Gay C, Mollan KR, Margolis DM, Adimora …
• The HIV-1 latent reservoir is largely sensitive to circulating T cells.
  eLife 2020 Warren JA, Zhou S, Xu Y, Moeser MJ, MacMillan DR, Council O, Kirchherr J, Sung JM, Roan NR, Adimora AA, Joseph S, Kuruc JD, Gay CL, Margolis DM, Archin N, Brumme ZL, Swanstrom R, Goonetilleke N
• Reproductive tract immune cells from pregnant women or those using depot medroxyprogesterone acetate show no excess susceptibility to HIV-1: Results of an ex vivo fusion assay.
  Contraception 2020 Seidman D, Cavrois M, Hilton JF, Roan NR, Averbach S, Takeda M, Chang E, Raman N, Greenblatt R, Shacklett BL, Smith-McCune K
• Sequence-independent recognition of the amyloid structural motif by GFP protein family.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Xu SCS, LoRicco JG, Bishop AC, James NA, Huynh WH, McCallum SA, Roan NR, Makhatadze GI
• Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy.
  Cell reports 2020 Colomb F, Giron LB, Kuri-Cervantes L, Adeniji OS, Ma T, Dweep H, Battivelli E, Verdin E, Palmer CS, Tateno H, Kossenkov AV, Roan NR, Betts MR, Abdel-Mohsen M
• Seminal Plasma-Derived Extracellular-Vesicle Fractions from HIV-Infected Men Exhibit Unique MicroRNA Signatures and Induce a Proinflammatory Response in Cells Isolated from the Female Reproductive Tract.
  Journal of virology 2020 Marques de Menezes EG, Jang K, George AF, Nyegaard M, Neidleman J, Inglis HC, Danesh A, Deng X, Afshari A, Kim YH, Billaud JN, Marson K, Pilcher CD, Pillai SK, Norris PJ, Roan NR
• Loss of Preexisting Immunological Memory Among Human Immunodeficiency Virus-Infected Women Despite Immune Reconstitution With Antiretroviral Therapy.
  The Journal of infectious diseases 2020 Thomas A, Hammarlund E, Gao L, Holman S, Michel KG, Glesby M, Villacres MC, Golub ET, Roan NR, French AL, Augenbraun MH, Slifka MK
• Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling.
  Human reproduction (Oxford, England) 2020 George AF, Jang KS, Nyegaard M, Neidleman J, Spitzer TL, Xie G, Chen JC, Herzig E, Laustsen A, Marques de Menezes EG, Houshdaran S, Pilcher CD, Norris PJ, Jakobsen MR, Greene WC, Giudice LC, Roan NR
• Measuring the contribution of γδ T cells to the persistent HIV reservoir.
  AIDS (London, England) 2020 James KS, Trumble I, Clohosey ML, Moeser M, Roan NR, Adimora AA, Joseph SB, Archin NM, Hudgens M, Soriano-Sarabia N
• Effects of the levonorgestrel-containing intrauterine device, copper intrauterine device, and levonorgestrel-containing oral contraceptive on susceptibility of immune cells from cervix, endometrium and blood to HIV-1 fusion measured ex vivo.
  PloS one 2019 Cavrois M, Hilton JF, Roan NR, Takeda M, Seidman D, Averbach S, Chang E, Raman N, Greenblatt R, Shacklett BL, Smith-McCune K
• HIV-induced production of CCL2 may promote rapid seeding of the latent HIV reservoir.
  The Journal of Immunology 2019 Thomas Alexander Packard, Eytan Herzig, Xiaoyu Luo, Johanne H Egedal, Zachary W Grimmett, Kim J Hasenkrug, Nadia Roan, Warner C Greene
• Quantifying Virus Escape from T Cells in the Latent HIV Reservoir.
  The Journal of Immunology 2019 Joanna A Warren, Shuntai Zhou, Yinyan Xu, Matthew Moeser, Jenn Kirchherr, Julia Sung, Nadia Roan, Adaora Adimora, JoAnn Kuruc, Cindy Gay, David Margolis, Nancie Archin, Ronald Swanstrom, Nilu …
• Single-cell Motility Analysis of Tethered Human Spermatozoa.
  Bio-protocol 2019 Skinner WM, Mannowetz N, Lishko PV, Roan NR
• Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function.
  Nature communications 2018 Laustsen A, Bak RO, Krapp C, Kjær L, Egedahl JH, Petersen CC, Pillai S, Tang HQ, Uldbjerg N, Porteus M, Roan NR, Nyegaard M, Denton PW, Jakobsen MR
• Potent and rapid activation of tropomyosin-receptor kinase A in endometrial stromal fibroblasts by seminal plasma.
  Biology of reproduction 2018 Martin JW, Chen JC, Neidleman J, Tatsumi K, Hu J, Giudice LC, Greene WC, Roan NR
• Structure, function and antagonism of semen amyloids.
  Chemical communications (Cambridge, England) 2018 Röcker A, Roan NR, Yadav JK, Fändrich M, Münch J
• Semen inhibits Zika virus infection of cells and tissues from the anogenital region.
  Nature communications 2018 Müller JA, Harms M, Krüger F, Groß R, Joas S, Hayn M, Dietz AN, Lippold S, von Einem J, Schubert A, Michel M, Mayer B, Cortese M, Jang KS, Sandi-Monroy N, Deniz M, Ebner F, Vapalahti O, Otto M, …
• Resident T cells stand up to HIV.
  Science immunology 2018 Roan NR
• Establishing the HIV reservoir: HIV-susceptible cells and the signals that recruit them.
  The Journal of Immunology 2018 Thomas Alexander Packard, Xiaoyu Luo, Zachary W. Grimmett, Eytan Herzig, Nadia R. Roan, Warner C. Greene
• An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies.
  AIDS research and human retroviruses 2017 Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S
• Semen amyloids participate in spermatozoa selection and clearance.
  eLife 2017 Roan NR, Sandi-Monroy N, Kohgadai N, Usmani SM, Hamil KG, Neidleman J, Montano M, Ständker L, Röcker A, Cavrois M, Rosen J, Marson K, Smith JF, Pilcher CD, Gagsteiger F, Sakk O, O'Rand M, Lishko PV, …
• Establishing the HIV reservoir: HIV-susceptible cells and the signals that recruit them.
  The Journal of Immunology 2017 Thomas Alexander Packard, Eytan Herzig, Nadia R Roan, Warner C Greene
• Comparison of the effect of semen from HIV-infected and uninfected men on CD4+ T-cell infection.
  AIDS (London, England) 2016 Camus C, Matusali G, Bourry O, Mahe D, Aubry F, Bujan L, Pasquier C, Massip P, Ravel C, Zirafi O, Munch J, Roan NR, Pineau C, Dejucq-Rainsford N
• Gallic Acid Is an Antagonist of Semen Amyloid Fibrils That Enhance HIV-1 Infection.
  The Journal of biological chemistry 2016 LoRicco JG, Xu CS, Neidleman J, Bergkvist M, Greene WC, Roan NR, Makhatadze GI
• Amyloid formation: functional friend or fearful foe?
  Journal of internal medicine 2016 Bergman P, Roan NR, Römling U, Bevins CL, Münch J
• Evaluation of EPI-X4 as a urinary peptide biomarker for diagnosis and prognosis of late acute GvHD.
  Bone marrow transplantation 2016 Müller JA, Zirafi O, Roan NR, Lee SJ, Münch J
• Friend or Foe: Innate Sensing of HIV in the Female Reproductive Tract.
  Current HIV/AIDS reports 2016 Roan NR, Jakobsen MR
• Isolation and Culture of Human Endometrial Epithelial Cells and Stromal Fibroblasts.
  Bio-protocol 2015 Chen JC, Roan NR
• Improving preclinical models of HIV microbicide efficacy.
  Trends in microbiology 2015 Roan NR, Münch J
• Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides.
  Science translational medicine 2014 Zirafi O, Kim KA, Roan NR, Kluge SF, Müller JA, Jiang S, Mayer B, Greene WC, Kirchhoff F, Münch J
• Structural characterization of semen coagulum-derived SEM1(86-107) amyloid fibrils that enhance HIV-1 infection.
  Biochemistry 2014 French KC, Roan NR, Makhatadze GI
• Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection.
  Journal of virology 2014 Roan NR, Liu H, Usmani SM, Neidleman J, Müller JA, Avila-Herrera A, Gawanbacht A, Zirafi O, Chu S, Dong M, Kumar ST, Smith JF, Pollard KS, Fändrich M, Kirchhoff F, Münch J, Witkowska HE, Greene WC
• Interaction of fibronectin with semen amyloids synergistically enhances HIV infection.
  The Journal of infectious diseases 2014 Roan NR, Chu S, Liu H, Neidleman J, Witkowska HE, Greene WC
• Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen.
  Nature communications 2014 Usmani SM, Zirafi O, Müller JA, Sandi-Monroy NL, Yadav JK, Meier C, Weil T, Roan NR, Greene WC, Walther P, Nilsson KP, Hammarström P, Wetzel R, Pilcher CD, Gagsteiger F, Fändrich M, Kirchhoff F, Münch…
• Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts.
  Human reproduction (Oxford, England) 2014 Chen JC, Johnson BA, Erikson DW, Piltonen TT, Barragan F, Chu S, Kohgadai N, Irwin JC, Greene WC, Giudice LC, Roan NR
• Seminal plasma and semen amyloids enhance cytomegalovirus infection in cell culture.
  Journal of virology 2013 Tang Q, Roan NR, Yamamura Y
• Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses.
  Nature nanotechnology 2013 Yolamanova M, Meier C, Shaytan AK, Vas V, Bertoncini CW, Arnold F, Zirafi O, Usmani SM, Müller JA, Sauter D, Goffinet C, Palesch D, Walther P, Roan NR, Geiger H, Lunov O, Simmet T, Bohne J, …
• [Role of semen-derived amyloid fibrils as facilitators of HIV infection].
  Medecine sciences : M/S 2012 Roan NR, Cavrois M, Greene WC
• Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection.
  Cell host & microbe 2011 Roan NR, Müller JA, Liu H, Chu S, Arnold F, Stürzel CM, Walther P, Dong M, Witkowska HE, Kirchhoff F, Münch J, Greene WC
• Naturally occurring fragments from two distinct regions of the prostatic acid phosphatase form amyloidogenic enhancers of HIV infection.
  Journal of virology 2011 Arnold F, Schnell J, Zirafi O, Stürzel C, Meier C, Weil T, Ständker L, Forssmann WG, Roan NR, Greene WC, Kirchhoff F, Münch J
• Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI.
  Retrovirology 2010 Kim KA, Yolamanova M, Zirafi O, Roan NR, Staendker L, Forssmann WG, Burgener A, Dejucq-Rainsford N, Hahn BH, Shaw GM, Greene WC, Kirchhoff F, Münch J
• Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection).
  The Journal of biological chemistry 2009 Roan NR, Sowinski S, Münch J, Kirchhoff F, Greene WC
• T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Gondek DC, Roan NR, Starnbach MN
• The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection.
  Journal of virology 2008 Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F, Greene WC
• Conquering sexually transmitted diseases.
  Nature reviews. Immunology 2008 Starnbach MN, Roan NR
• Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Grotenbreg GM, Roan NR, Guillen E, Meijers R, Wang JH, Bell GW, Starnbach MN, Ploegh HL
• A seminal finding for understanding HIV transmission.
  Cell 2007 Roan NR, Greene WC
• Immune-mediated control of Chlamydia infection.
  Cellular microbiology 2007 Roan NR, Starnbach MN
• Antigen-specific CD8+ T cells respond to Chlamydia trachomatis in the genital mucosa.
  Journal of immunology (Baltimore, Md. : 1950) 2006 Roan NR, Starnbach MN
• Developmental regulation of Chlamydia trachomatis class I accessible protein-1, a CD8+ T cell antigen.
  The Journal of infectious diseases 2006 Balsara ZR, Roan NR, Steele LN, Starnbach MN
• Spt10-dependent transcriptional activation in Saccharomyces cerevisiae requires both the Spt10 acetyltransferase domain and Spt21.
  Molecular and cellular biology 2004 Hess D, Liu B, Roan NR, Sternglanz R, Winston F
• The Listeria monocytogenes lemA gene product is not required for intracellular infection or to activate fMIGWII-specific T cells.
  Infection and immunity 2003 D'Orazio SE, Velasquez M, Roan NR, Naveiras-Torres O, Starnbach MN